Search Results - "GOURDON, Pontus"

Structure and transport mechanism of P5B-ATPases by Li, Ping, Wang, Kaituo, Salustros, Nina, Grønberg, Christina, Gourdon, Pontus

“…In human cells, P5B-ATPases execute the active export of physiologically important polyamines such as spermine from lysosomes to the cytosol, a function linked…”
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Copper binding leads to increased dynamics in the regulatory N-terminal domain of full-length human copper transporter ATP7B by Orädd, Fredrik, Steffen, Jonas Hyld, Gourdon, Pontus, Andersson, Magnus

“…ATP7B is a human copper-transporting P 1B -type ATPase that is involved in copper homeostasis and resistance to platinum drugs in cancer cells. ATP7B consists…”
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The structure and function of P5A-ATPases by Li, Ping, Bågenholm, Viktoria, Hägglund, Per, Lindkvist-Petersson, Karin, Wang, Kaituo, Gourdon, Pontus

“…Endoplasmic reticulum (ER) membrane resident P5A-ATPases broadly affect protein biogenesis and quality control, and yet their molecular function remains…”
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Crystal Structure of Na⁺, K⁺-ATPase in the Na⁺-Bound State by Nyblom, Maria, Poulsen, Hanne, Gourdon, Pontus, Reinhard, Linda, Andersson, Magnus, Lindahl, Erik, Fedosova, Natalya, Nissen, Poul

“…The Na⁺, K⁺—adenosine triphosphatase (ATPase) maintains the electrochemical gradients of Na⁺ and K⁺ across the plasma membrane—a prerequisite for electrical…”
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Human adipose glycerol flux is regulated by a pH gate in AQP10 by Gotfryd, Kamil, Mósca, Andreia Filipa, Missel, Julie Winkel, Truelsen, Sigurd Friis, Wang, Kaituo, Spulber, Mariana, Krabbe, Simon, Hélix-Nielsen, Claus, Laforenza, Umberto, Soveral, Graça, Pedersen, Per Amstrup, Gourdon, Pontus

“…Obesity is a major threat to global health and metabolically associated with glycerol homeostasis. Here we demonstrate that in human adipocytes, the decreased…”
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Permeability and ammonia selectivity in aquaporin TIP2;1: linking structure to function by Lindahl, Viveca, Gourdon, Pontus, Andersson, Magnus, Hess, Berk

“…Aquaporin TIP2;1 is a protein channel permeable to both water and ammonia. The structural origin of ammonia selectivity remains obscure, but experiments have…”
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Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding by Wang, Kaituo, Dagil, Robert, Lavstsen, Thomas, Misra, Sandeep K., Spliid, Charlotte B., Wang, Yong, Gustavsson, Tobias, Sandoval, Daniel R., Vidal-Calvo, Elena Ethel, Choudhary, Swati, Agerbaek, Mette Ø, Lindorff-Larsen, Kresten, Nielsen, Morten A., Theander, Thor G., Sharp, Joshua S., Clausen, Thomas Mandel, Gourdon, Pontus, Salanti, Ali

“…Placental malaria can have severe consequences for both mother and child and effective vaccines are lacking. Parasite-infected red blood cells sequester in the…”
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X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release by Gotfryd, Kamil, Boesen, Thomas, Mortensen, Jonas S., Khelashvili, George, Quick, Matthias, Terry, Daniel S., Missel, Julie W., LeVine, Michael V., Gourdon, Pontus, Blanchard, Scott C., Javitch, Jonathan A., Weinstein, Harel, Loland, Claus J., Nissen, Poul, Gether, Ulrik

“…Neurotransmitter:sodium symporters (NSS) are conserved from bacteria to man and serve as targets for drugs, including antidepressants and psychostimulants…”
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Crystal structure of a copper-transporting PIB-type ATPase by Gourdon, Pontus, Liu, Xiang-Yu, Skjørringe, Tina, Morth, J. Preben, Møller, Lisbeth Birk, Pedersen, Bjørn Panyella, Nissen, Poul

“…Heavy-metal homeostasis and detoxification is crucial for cell viability. P-type ATPases of the class IB (PIB) are essential in these processes, actively…”
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Structures of Atm1 provide insight into [2Fe-2S] cluster export from mitochondria by Li, Ping, Hendricks, Amber L., Wang, Yong, Villones, Rhiza Lyne E., Lindkvist-Petersson, Karin, Meloni, Gabriele, Cowan, J. A., Wang, Kaituo, Gourdon, Pontus

“…In eukaryotes, iron-sulfur clusters are essential cofactors for numerous physiological processes, but these clusters are primarily biosynthesized in…”
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Structure of the human ClC-1 chloride channel by Wang, Kaituo, Preisler, Sarah Spruce, Zhang, Liying, Cui, Yanxiang, Missel, Julie Winkel, Grønberg, Christina, Gotfryd, Kamil, Lindahl, Erik, Andersson, Magnus, Calloe, Kirstine, Egea, Pascal F, Klaerke, Dan Arne, Pusch, Michael, Pedersen, Per Amstrup, Zhou, Z Hong, Gourdon, Pontus

“…ClC-1 protein channels facilitate rapid passage of chloride ions across cellular membranes, thereby orchestrating skeletal muscle excitability. Malfunction of…”
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Crystal Structure of an Ammonia-Permeable Aquaporin by Kirscht, Andreas, Kaptan, Shreyas S, Bienert, Gerd Patrick, Chaumont, François, Nissen, Poul, de Groot, Bert L, Kjellbom, Per, Gourdon, Pontus, Johanson, Urban

“…Aquaporins of the TIP subfamily (Tonoplast Intrinsic Proteins) have been suggested to facilitate permeation of water and ammonia across the vacuolar membrane…”
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Light stimulates growth of proteorhodopsin-containing marine Flavobacteria by González, José M, Pedrós-Alió, Carlos, Pinhassi, Jarone, Gourdon, Pontus, Gómez-Consarnau, Laura, Pascher, Torbjörn, Coll-Lladó, Montserrat, Neutze, Richard

“…Proteorhodopsins are bacterial light-dependent proton pumps. Their discovery within genomic material from uncultivated marine bacterioplankton caused…”
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Structure and mechanism of Zn2+-transporting P-type ATPases by Wang, Kaituo, Sitsel, Oleg, Meloni, Gabriele, Autzen, Henriette Elisabeth, Andersson, Magnus, Klymchuk, Tetyana, Nielsen, Anna Marie, Rees, Douglas C., Nissen, Poul, Gourdon, Pontus

“…The X-ray crystal structures of a zinc-ion-transporting P-type ATPase are solved in a zinc-free, phosphoenzyme ‘ground’ state and in a transition state of…”
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Diverse roles of the metal binding domains and transport mechanism of copper transporting P-type ATPases by Guo, Zongxin, Orädd, Fredrik, Bågenholm, Viktoria, Grønberg, Christina, Ma, Jian Feng, Ott, Peter, Wang, Yong, Andersson, Magnus, Pedersen, Per Amstrup, Wang, Kaituo, Gourdon, Pontus

“…Copper transporting P-type (P 1B-1 -) ATPases are essential for cellular homeostasis. Nonetheless, the E1-E1P-E2P-E2 states mechanism of P 1B-1 -ATPases…”
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Structural basis of ion uptake in copper-transporting P1B-type ATPases by Salustros, Nina, Grønberg, Christina, Abeyrathna, Nisansala S., Lyu, Pin, Orädd, Fredrik, Wang, Kaituo, Andersson, Magnus, Meloni, Gabriele, Gourdon, Pontus

“…Copper is essential for living cells, yet toxic at elevated concentrations. Class 1B P-type (P 1B -) ATPases are present in all kingdoms of life, facilitating…”
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Cryo-EM structure supports a role of AQP7 as a junction protein by Huang, Peng, Venskutonytė, Raminta, Prasad, Rashmi B., Ardalani, Hamidreza, de Maré, Sofia W., Fan, Xiao, Li, Ping, Spégel, Peter, Yan, Nieng, Gourdon, Pontus, Artner, Isabella, Lindkvist-Petersson, Karin

“…Aquaglyceroporin 7 (AQP7) facilitates glycerol flux across the plasma membrane with a critical physiological role linked to metabolism, obesity, and associated…”
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The rapid “teabag” method for high-end purification of membrane proteins by Hering, Jenny, Missel, Julie Winkel, Zhang, Liying, Gunnarsson, Anders, Castaldo, Marie, Pedersen, Per Amstrup, Ek, Margareta, Gourdon, Pontus, Snijder, Harm Jan

“…Overproduction and purification of membrane proteins are generally challenging and time-consuming procedures due to low expression levels, misfolding, and low…”
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Structural and functional analysis of aquaporin-2 mutants involved in nephrogenic diabetes insipidus by Hagströmer, Carl Johan, Hyld Steffen, Jonas, Kreida, Stefan, Al-Jubair, Tamim, Frick, Anna, Gourdon, Pontus, Törnroth-Horsefield, Susanna

“…Aquaporins are water channels found in the cell membrane, where they allow the passage of water molecules in and out of the cells. In the kidney collecting…”
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Structure and ion-release mechanism of PIB-4-type ATPases by Grønberg, Christina, Hu, Qiaoxia, Mahato, Dhani Ram, Longhin, Elena, Salustros, Nina, Duelli, Annette, Lyu, Pin, Bågenholm, Viktoria, Eriksson, Jonas, Rao, Komal Umashankar, Henderson, Domhnall Iain, Meloni, Gabriele, Andersson, Magnus, Croll, Tristan, Godaly, Gabriela, Wang, Kaituo, Gourdon, Pontus

“…Transition metals, such as zinc, are essential micronutrients in all organisms, but also highly toxic in excessive amounts. Heavy-metal transporting P-type (P…”
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