Search Results - "GOUNARIDES, JOHN S."

M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth by Cortés-Cros, Marta, Hemmerlin, Christelle, Ferretti, Stephane, Zhang, Juan, Gounarides, John S., Yin, Hong, Muller, Alban, Haberkorn, Anne, Chene, Patrick, Sellers, William R., Hofmann, Francesco

“…Many cancer cells have increased rates of aerobic glycolysis, a phenomenon termed the Warburg effect. In addition, in tumors there is a predominance of…”
Get full text

Metabolic Implications of Dietary Trans-fatty Acids by Dorfman, Suzanne E, Laurent, Didier, Gounarides, John S, Li, Xue, Mullarkey, Tara L, Rocheford, Erik C, Sari-Sarraf, Farid, Hirsch, Erica A, Hughes, Thomas E, Commerford, S. Renee

“…Dietary trans‐fatty acids are associated with increased risk of cardiovascular disease and have been implicated in the incidence of obesity and type 2 diabetes…”
Get full text

Effect of Dexamethasone on Glucose Tolerance and Fat Metabolism in a Diet-Induced Obesity Mouse Model by Gounarides, John S, Korach-André, Marion, Killary, Karen, Argentieri, Gregory, Turner, Oliver, Laurent, Didier

“…Prolonged exposure to elevated glucocorticoid levels is known to produce insulin resistance (IR), a hallmark of diabetes mellitus. Although not fully…”
Get full text

Direct Bacterial Killing In Vitro by Recombinant Nod2 Is Compromised by Crohn's Disease-Associated Mutations by Perez, Laurent–Herve, Butler, Matt, Creasey, Tammy, Dzink–Fox, JoAnn L, Gounarides, John S, Petit, Stephanie, Ropenga, Anna, Ryder, Neil, Smith, Kathryn, Smith, Philip, Parkinson, Scott J

Get full text

S1770a Direct Bacterial Killing In Vitro by Recombinant NOD2 is Compromised by Crohn's Disease-Associated Mutations by Perez, Laurent-Herve, Butler, Matt, Creasey, Tammy, Dzink-Fox, JoAnn L, Gounarides, John S, Petit, Stephanie, Ropenga, Anna, Ryder, Neil, Smith, Kathryn, Smith, Philip, Parkinson, Scott J

Get full text

Influence of peroxynitrite on energy metabolism and cardiac function in a rat ischemia-reperfusion model by Lee, Warren H, Gounarides, John S, Roos, Eric S, Wolin, Michael S

“…Ischemia-reperfusion generates peroxynitrite (ONOO-), which interacts with many of the systems altered by ischemia-reperfusion. This study examines the…”
Get more information

Erratum: Metabolic Implications of Dietary Trans‐fatty Acids by Dorfman, Suzanne E., Laurent, Didier, Gounarides, John S., Li, Xue, Mullarkey, Tara L., Rocheford, Erik C., Sari‐Sarraf, Farid, Hirsch, Erica A., Hughes, Thomas E., Commerford, S. Renee

Get full text

Change in lactate production in Myc-transformed cells precedes apoptosis and can be inhibited by Bcl-2 overexpression by Papas, Klearchos K, Sun, Lei, Roos, Eric S, Gounarides, John S, Shapiro, Michael, Nalin, Carlo M

“…As a result of Myc-dependent transcription of the LDH-A gene, Myc-transformed cells (Rat1-Myc) exhibit increased lactate production rates (LPR) even under…”
Get full text

Sequence-specific assignments of the inner lipoyl domain of human pyruvate dehydrogenase by Nirmala, N R, Gounarides, J S

Get full text

Heterologously expressed inner lipoyl domain of dihydrolipoyl acetyltransferase inhibits ATP-dependent inactivation of pyruvate dehydrogenase complex by JACKSON, John C., VINLUAN, Christine C., DRAGLAND, Carol J., SUNDARARAJAN, Vijayayakumar, YAN, Bing, GOUNARIDES, John S., NIRMALA, Nanguneri R., TOPIOL, Sid, RAMAGE, Paul, BLUME, John E., AICHER, Thomas D., BELL, Philip A., MANN, William R.

“…The activity of the pyruvate dehydrogenase multienzyme complex (PDC), which catalyses the oxidation of pyruvate to acetyl-CoA within the mitochondrion, is…”
Get full text

High resolution MAS-NMR in combinatorial chemistry by Shapiro, Michael J., Gounarides, John S.

“…High‐resolution magic angle spinning (hr‐MAS) NMR is a powerful tool for characterizing organic reactions on solid support. Because magic angle spinning…”
Get full text

High resolution MAS-NMR in combinatorial chemistry : Analytical methods for the combinatorial sciences by SHAPIRO, Michael J, GOUNARIDES, John S

Get full text

NMR Spectroscopy in β Cell Engineering and Islet Transplantation by PAPAS, KLEARCHOS K., COLTON, CLARK K., GOUNARIDES, JOHN S., ROOS, ERIC S., JAREMA, MARY ANN C., SHAPIRO, MICHAEL J., CHENG, LEO L., CLINE, GARY W., SHULMAN, GERALD I., WU, HAIYAN, BONNER-WEIR, SUSAN, WEIR, GORDON C.

“…: Islet transplantation is a promising method for restoring normoglycemia and alleviating the long term complications of diabetes. Widespread application of…”
Get full text

Heterologously expressed inner lipoyl domain of dihydrolipoyl acetyltransferase inhibits ATP-dependent inactivation of pyruvate dehydrogenase complex. Identification of important amino acid residues by Jackson, J C, Vinluan, C C, Dragland, C J, Sundararajan, V, Yan, B, Gounarides, J S, Nirmala, N R, Topiol, S, Ramage, P, Blume, J E, Aicher, T D, Bell, P A, Mann, W R

“…The activity of the pyruvate dehydrogenase multienzyme complex (PDC), which catalyses the oxidation of pyruvate to acetyl-CoA within the mitochondrion, is…”
Get full text

On-resin macrocyclization of peptides via intramolecular SNAr reactions by FOTSCH, C, KUMARAVEL, G, SHARMA, S. K, WU, A. D, GOUNARIDES, J. S, NIRMALA, N. R, PETTER, R. C

“…On-resin macrocyclization via an SNAr reaction is employed in the synthesis of tocinoic acid analogs. Specifically, an N-terminal nitrofluorobenzene is…”
Get full text

On-resin macrocyclization of peptides via intramolecular S nAr reactions by Fotsch, Christopher, Kumaravel, G., Sharma, Sushil K., Wu, Arthur D., Gounarides, John S., Nirmala, N.R., Petter, Russell C.

“…On-resin macrocyclization via an S nAr reaction is employed in the synthesis of tocinoic acid analogs. Specifically, an N-terminal nitrofluorobenzene is…”
Get full text

The conformation of a-factor is not influenced by the S-prenylation of Cys12 by Gounarides, J S, Broido, M S, Xue, C B, Becker, J M, Naider, F R

“…Two-Dimensional NMR was used to examine the solution conformation of the lipopeptide a-factor, YIIKGVFWDPAC (S-farnesyl) OCH3, from the yeast Saccharomyces…”
Get more information

Nuclear magnetic resonance chromatography: applications of pulse field gradient diffusion NMR to mixture analysis and ligand–receptor interactions by Gounarides, John S., Chen, Aidi, Shapiro, Michael J.

“…Pulse field gradient (PFG) diffusion NMR spectroscopy is a non-invasive method for the spectroscopic separation and identification of compounds of interest…”
Get full text