Search Results - "GOULD, ERNEST A."
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ICTV Virus Taxonomy Profile: Flaviviridae
Published in Journal of general virology (01-01-2017)“…The Flaviviridae is a family of small enveloped viruses with RNA genomes of 9000-13 000 bases. Most infect mammals and birds. Many flaviviruses are…”
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Proposed revision to the taxonomy of the genus Pestivirus, family Flaviviridae
Published in Journal of general virology (01-08-2017)“…We propose the creation of seven new species in the genus Pestivirus (family Flaviviridae) in addition to the four existing species, and naming species in a…”
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Proposed update to the taxonomy of the genera Hepacivirus and Pegivirus within the Flaviviridae family
Published in Journal of general virology (01-11-2016)“…Proposals are described for the assignment of recently reported viruses, infecting rodents, bats and other mammalian species, to new species within the…”
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New insights into flavivirus evolution, taxonomy and biogeographic history, extended by analysis of canonical and alternative coding sequences
Published in PloS one (26-02-2015)“…To generate the most diverse phylogenetic dataset for the flaviviruses to date, we determined the genomic sequences and phylogenetic relationships of 14…”
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Novel virus discovery and genome reconstruction from field RNA samples reveals highly divergent viruses in dipteran hosts
Published in PloS one (18-11-2013)“…We investigated whether small RNA (sRNA) sequenced from field-collected mosquitoes and chironomids (Diptera) can be used as a proxy signature of viral…”
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Sandfly-borne phleboviruses of Eurasia and Africa: Epidemiology, genetic diversity, geographic range, control measures
Published in Antiviral research (01-10-2013)“…•We provide a comprehensive review of phleboviruses vectored by sandflies in the Old World.•Toscana virus is the agent with the greatest known virulence for…”
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Single-stranded positive-sense RNA viruses generated in days using infectious subgenomic amplicons
Published in Journal of general virology (01-11-2014)“…Reverse genetics is a key methodology for producing genetically modified RNA viruses and deciphering cellular and viral biological properties, but methods…”
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Vaccine strategies for the control and prevention of Japanese encephalitis in Mainland China, 1951-2011
Published in PLoS neglected tropical diseases (01-08-2014)“…Japanese encephalitis (JE) is arguably one of the most serious viral encephalitis diseases worldwide. China has a long history of high prevalence of Japanese…”
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How Did Zika Virus Emerge in the Pacific Islands and Latin America?
Published in mBio (11-10-2016)“…The unexpected emergence of Zika virus (ZIKV) in the Pacific Islands and Latin America and its association with congenital Zika virus syndrome (CZVS) (which…”
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Molecular evolution of the insect-specific flaviviruses
Published in Journal of general virology (01-02-2012)“…There has been an explosion in the discovery of ‘insect-specific’ flaviviruses and/or their related sequences in natural mosquito populations. Herein we review…”
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Characterisation of Zika virus infection in primary human astrocytes
Published in BMC neuroscience (20-02-2018)“…The recent Zika virus (ZIKV) outbreak has linked ZIKV with microcephaly and other central nervous system pathologies in humans. Astrocytes are among the first…”
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Effect of chemical stabilizers on the thermostability and infectivity of a representative panel of freeze dried viruses
Published in PloS one (29-04-2015)“…As a partner of the European Virus Archive (EVA) FP7 project, our laboratory maintains a large collection of freeze-dried viruses. The distribution of these…”
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Development and characterization of recombinant tick-borne encephalitis virus expressing mCherry reporter protein: A new tool for high-throughput screening of antiviral compounds, and neutralizing antibody assays
Published in Antiviral research (01-01-2021)“…The flavivirus, tick-borne encephalitis virus (TBEV) is transmitted by Ixodes spp. ticks and may cause severe and potentially lethal neurological tick-borne…”
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Induction and suppression of tick cell antiviral RNAi responses by tick-borne flaviviruses
Published in Nucleic acids research (18-08-2014)“…Arboviruses are transmitted by distantly related arthropod vectors such as mosquitoes (class Insecta) and ticks (class Arachnida). RNA interference (RNAi) is…”
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Structure and functionality in flavivirus NS-proteins: Perspectives for drug design
Published in Antiviral research (01-08-2010)“…Flaviviridae are small enveloped viruses hosting a positive-sense single-stranded RNA genome. Besides yellow fever virus, a landmark case in the history of…”
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Attenuation of tick-borne encephalitis virus using large-scale random codon re-encoding
Published in PLoS pathogens (01-03-2015)“…Large-scale codon re-encoding (i.e. introduction of a large number of synonymous mutations) is a novel method of generating attenuated viruses. Here, it was…”
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The Crystal Structures of Chikungunya and Venezuelan Equine Encephalitis Virus nsP3 Macro Domains Define a Conserved Adenosine Binding Pocket
Published in Journal of Virology (01-07-2009)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Chikungunya virus adapts to tiger mosquito via evolutionary convergence: a sign of things to come?
Published in Virology journal (27-02-2008)“…Since 2004, several million indigenous cases of Chikungunya virus disease occurred in Africa, the Indian Ocean, India, Asia and, recently, Europe. The virus,…”
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Random codon re-encoding induces stable reduction of replicative fitness of Chikungunya virus in primate and mosquito cells
Published in PLoS pathogens (01-02-2013)“…Large-scale codon re-encoding represents a powerful method of attenuating viruses to generate safe and cost-effective vaccines. In contrast to specific…”
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"ISA-Lation" of Single-Stranded Positive-Sense RNA Viruses from Non-Infectious Clinical/Animal Samples
Published in PloS one (25-09-2015)“…Isolation of viral pathogens from clinical and/or animal samples has traditionally relied on either cell cultures or laboratory animal model systems. However,…”
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