Search Results - "GOUDSMIT, Jaap"

The paramount importance of serological surveys of SARS-CoV-2 infection and immunity by Goudsmit, Jaap

Get full text

Biological age in healthy elderly predicts aging-related diseases including dementia by Wu, Julia W., Yaqub, Amber, Ma, Yuan, Koudstaal, Wouter, Hofman, Albert, Ikram, M. Arfan, Ghanbari, Mohsen, Goudsmit, Jaap

“…Application of biological age as a measure of an individual´s health status offers new perspectives into extension of both lifespan and healthspan. While…”
Get full text

Antibody Recognition of a Highly Conserved Influenza Virus Epitope by Ekiert, Damian C, Bhabha, Gira, Elsliger, Marc-André, Friesen, Robert H.E, Jongeneelen, Mandy, Throsby, Mark, Goudsmit, Jaap, Wilson, Ian A

“…Influenza virus presents an important and persistent threat to public health worldwide, and current vaccines provide immunity to viral isolates similar to the…”
Get full text

External validity of phase III trials on vaccines against SARS-CoV-2 to a middle-aged and elderly Western European population by Terzikhan, Natalie, Hofman, Albert, Goudsmit, Jaap, Ikram, Mohammad Arfan

“…Initial results from various phase-III trials on vaccines against SARS-CoV-2 are promising. For proper translation of these results to clinical guidelines, it…”
Get full text

Potent peptidic fusion inhibitors of influenza virus by Kadam, Rameshwar U., Juraszek, Jarek, Brandenburg, Boerries, Buyck, Christophe, Schepens, Wim B. G., Kesteleyn, Bart, Stoops, Bart, Vreeken, Rob J., Vermond, Jan, Goutier, Wouter, Tang, Chan, Vogels, Ronald, Friesen, Robert H. E., Goudsmit, Jaap, van Dongen, Maria J. P., Wilson, Ian A.

“…Influenza therapeutics with new targets and mechanisms of action are urgently needed to combat potential pandemics, emerging viruses, and constantly mutating…”
Get full text

A small-molecule fusion inhibitor of influenza virus is orally active in mice by van Dongen, Maria J P, Kadam, Rameshwar U, Juraszek, Jarek, Lawson, Edward, Brandenburg, Boerries, Schmitz, Frederike, Schepens, Wim B G, Stoops, Bart, van Diepen, Harry A, Jongeneelen, Mandy, Tang, Chan, Vermond, Jan, van Eijgen-Obregoso Real, Alida, Blokland, Sven, Garg, Divita, Yu, Wenli, Goutier, Wouter, Lanckacker, Ellen, Klap, Jaco M, Peeters, Daniëlle C G, Wu, Jin, Buyck, Christophe, Jonckers, Tim H M, Roymans, Dirk, Roevens, Peter, Vogels, Ronald, Koudstaal, Wouter, Friesen, Robert H E, Raboisson, Pierre, Dhanak, Dashyant, Goudsmit, Jaap, Wilson, Ian A

“…Recent characterization of broadly neutralizing antibodies (bnAbs) against influenza virus identified the conserved hemagglutinin (HA) stem as a target for…”
Get full text

Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cells by Throsby, Mark, van den Brink, Edward, Jongeneelen, Mandy, Poon, Leo L M, Alard, Philippe, Cornelissen, Lisette, Bakker, Arjen, Cox, Freek, van Deventer, Els, Guan, Yi, Cinatl, Jindrich, ter Meulen, Jan, Lasters, Ignace, Carsetti, Rita, Peiris, Malik, de Kruif, John, Goudsmit, Jaap

“…The hemagglutinin (HA) glycoprotein is the principal target of protective humoral immune responses to influenza virus infections but such antibody responses…”
Get full text

Immune age and biological age as determinants of vaccine responsiveness among elderly populations: the Human Immunomics Initiative research program by Goudsmit, Jaap, van den Biggelaar, Anita Huiberdina Johanna, Koudstaal, Wouter, Hofman, Albert, Koff, Wayne Chester, Schenkelberg, Theodore, Alter, Galit, Mina, Michael Joseph, Wu, Julia Wei

“…The Human Immunomics Initiative (HII), a joint project between the Harvard T.H. Chan School of Public Health and the Human Vaccines Project (HVP), focuses on…”
Get full text

Mechanisms of hemagglutinin targeted influenza virus neutralization by Brandenburg, Boerries, Koudstaal, Wouter, Goudsmit, Jaap, Klaren, Vincent, Tang, Chan, Bujny, Miriam V, Korse, Hans J W M, Kwaks, Ted, Otterstrom, Jason J, Juraszek, Jarek, van Oijen, Antoine M, Vogels, Ronald, Friesen, Robert H E

“…Human monoclonal antibodies have been identified which neutralize broad spectra of influenza A or B viruses. Here, we dissect the mechanisms by which such…”
Get full text

common solution to group 2 influenza virus neutralization by Friesen, Robert H. E., Lee, Peter S., Stoop, Esther J. M., Hoffman, Ryan M. B., Ekiert, Damian C., Bhabha, Gira, Yu, Wenli, Juraszek, Jarek, Koudstaal, Wouter, Jongeneelen, Mandy, Korse, Hans J. W. M., Ophorst, Carla, Brinkman-van der Linden, Els C. M., Throsby, Mark, Kwakkenbos, Mark J., Bakker, Arjen Q., Beaumont, Tim, Spits, Hergen, Kwaks, Ted, Vogels, Ronald, Ward, Andrew B., Goudsmit, Jaap, Wilson, Ian A.

“…The discovery and characterization of broadly neutralizing antibodies (bnAbs) against influenza viruses have raised hopes for the development of monoclonal…”
Get full text

Recombinant Adenovirus Serotype 26 (Ad26) and Ad35 Vaccine Vectors Bypass Immunity to Ad5 and Protect Nonhuman Primates against Ebolavirus Challenge by GEISBERT, Thomas W, BAILEY, Michael, CUSTERS, Jerome, VELLINGA, Jort, HENDRIKS, Jenny, JAHRLING, Peter, ROEDERER, Mario, GOUDSMIT, Jaap, KOUP, Richard, SULLIVAN, Nancy J, HENSLEY, Lisa, ASIEDU, Clement, GEISBERT, Joan, STANLEY, Daphne, HONKO, Anna, JOHNSON, Joshua, MULANGU, Sabue, GRAZIA PAU, Maria

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Comparative Seroprevalence and Immunogenicity of Six Rare Serotype Recombinant Adenovirus Vaccine Vectors from Subgroups B and D by ABBINK, Peter, LEMCKERT, Angelique A. C, O'BRIEN, Kara L, CARVILLE, Angela, MANSFIELD, Keith G, GOUDSMIT, Jaap, HAVENGA, Menzo J. E, BAROUCH, Dan H, EWALD, Bonnie A, LYNCH, Diana M, DENHOLTZ, Matthew, SMITS, Shirley, HOLTERMAN, Lennart, DAMEN, Irma, VOGELS, Ronald, THORNER, Anna R

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

A pan-influenza monoclonal antibody neutralizes H5 strains and prophylactically protects through intranasal administration by Beukenhorst, Anna L., Frallicciardi, Jacopo, Rice, Keira L., Koldijk, Martin H., Moreira de Mello, Joana C., Klap, Jaco M., Hadjichrysanthou, Christoforos, Koch, Clarissa M., da Costa, Kelly A. S., Temperton, Nigel, de Jong, Babette A., Vietsch, Helene, Ziere, Bertjan, Julg, Boris, Koudstaal, Wouter, Goudsmit, Jaap

“…Avian A(H5N1) influenza virus poses an elevated zoonotic threat to humans, and no pharmacological products are currently registered for fast-acting…”
Get full text

Neutralization of West Nile virus by cross-linking of its surface proteins with Fab fragments of the human monoclonal antibody CR4354 by Kaufmann, Bärbel, Vogt, Matthew R., Goudsmit, Jaap, Holdaway, Heather A., Aksyuk, Anastasia A., Chipman, Paul R., Kuhn, Richard J., Diamond, Michael S., Rossmann, Michael G., Rice, Charles M.

“…Many flaviviruses are significant human pathogens, with the humoral immune response playing an essential role in restricting infection and disease. CR4354, a…”
Get full text

Relating influenza virus membrane fusion kinetics to stoichiometry of neutralizing antibodies at the single-particle level by Otterstrom, Jason J, Brandenburg, Boerries, Koldijk, Martin H, Juraszek, Jarek, Tang, Chan, Mashaghi, Samaneh, Kwaks, Ted, Goudsmit, Jaap, Vogels, Ronald, Friesen, Robert H E, van Oijen, Antoine M

“…The ability of antibodies binding the influenza hemagglutinin (HA) protein to neutralize viral infectivity is of key importance in the design of…”
Get full text

Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer by Alba, Raul, Bradshaw, Angela C., Parker, Alan L., Bhella, David, Waddington, Simon N., Nicklin, Stuart A., van Rooijen, Nico, Custers, Jerome, Goudsmit, Jaap, Barouch, Dan H., McVey, John H., Baker, Andrew H.

“…Recent studies have demonstrated the importance of coagulation factor X (FX) in adenovirus (Ad) serotype 5–mediated liver transduction in vivo. FX binds to the…”
Get full text

Protection against H5N1 Influenza Virus Induced by Matrix-M Adjuvanted Seasonal Virosomal Vaccine in Mice Requires Both Antibodies and T Cells by Cox, Freek, Baart, Matthijs, Huizingh, Jeroen, Tolboom, Jeroen, Dekking, Liesbeth, Goudsmit, Jaap, Saeland, Eirikur, Radošević, Katarina

“…It remains important to develop the next generation of influenza vaccines that can provide protection against vaccine mismatched strains and to be prepared for…”
Get full text

Ad35 and ad26 vaccine vectors induce potent and cross-reactive antibody and T-cell responses to multiple filovirus species by Zahn, Roland, Gillisen, Gert, Roos, Anna, Koning, Marina, van der Helm, Esmeralda, Spek, Dirk, Weijtens, Mo, Grazia Pau, Maria, Radošević, Katarina, Weverling, Gerrit Jan, Custers, Jerome, Vellinga, Jort, Schuitemaker, Hanneke, Goudsmit, Jaap, Rodríguez, Ariane

“…Filoviruses cause sporadic but highly lethal outbreaks of hemorrhagic fever in Africa in the human population. Currently, no drug or vaccine is available for…”
Get full text

Vector Choice Determines Immunogenicity and Potency of Genetic Vaccines against Angola Marburg Virus in Nonhuman Primates by GEISBERT, Thomas W, BAILEY, Michael, SULLIVAN, Nancy J, GEISBERT, Joan B, ASIEDU, Clement, ROEDERER, Mario, GRAZIA-PAU, Maria, CUSTERS, Jerome, JAHRLING, Peter, GOUDSMIT, Jaap, KOUP, Richard

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Protective Immune Responses to a Recombinant Adenovirus Type 35 Tuberculosis Vaccine in Two Mouse Strains: CD4 and CD8 T-Cell Epitope Mapping and Role of Gamma Interferon by Radošević, Katarina, Wieland, Catharina W, Rodriguez, Ariane, Weverling, Gerrit Jan, Mintardjo, Ratna, Gillissen, Gert, Vogels, Ronald, Skeiky, Yasir A.W, Hone, David M, Sadoff, Jerald C, van der Poll, Tom, Havenga, Menzo, Goudsmit, Jaap

“…There is an urgent need for an efficacious vaccine against tuberculosis (TB). Cellular immune responses are key to an effective protective response against TB…”
Get full text