Correlation between cognitive deficits and Aβ deposits in transgenic APP+PS1 mice

Correlation between cognitive deficits and Aβ deposits in transgenic APP+PS1 mice

Doubly transgenic mAPP+mPS1 mice (15-16 months) had impaired cognitive function in a spatial learning and memory task that combined features of a water maze and a radial arm maze. Nontransgenic mice learned a new platform location each day during 4 consecutive acquisition trials, and exhibited memor...

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Bibliographic Details
Published in:Neurobiology of aging Vol. 22; no. 3; pp. 377 - 385
Main Authors: GORDON, Marcia N, KING, David L, ARENDASH, Gary W, DIAMOND, David M, JANTZEN, Paul T, BOYETT, Kristal V, HOPE, Caroline E, HATCHER, Jaime M, DICARLO, Giovanni, GOTTSCHALL, W. Paul E, MORGAN, Dave
Format: Journal Article
Language:English
Published: London Elsevier Science 01-05-2001
Subjects:
Biological and medical sciences
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Medical sciences
Neurology
Nervous system diseases
Alzheimer disease
Memory
Rodentia
Transgenic animal
Presenilin
Amyloid precursor protein
Cerebral disorder
Learning
Vertebrata
Mammalia
Acquisition process
Mouse
Central nervous system disease
Degenerative disease
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Summary:Doubly transgenic mAPP+mPS1 mice (15-16 months) had impaired cognitive function in a spatial learning and memory task that combined features of a water maze and a radial arm maze. Nontransgenic mice learned a new platform location each day during 4 consecutive acquisition trials, and exhibited memory for this location in a retention trial administered 30 min later. In contrast, transgenic mice were, on average, unable to improve their performance in finding the hidden platform over trials. The cognitive performance of individual mice within the transgenic group were inversely related to the amount of A beta deposited in the frontal cortex and hippocampus. These findings imply that mAPP+mPS1 transgenic mice develop deficits in cognitive ability as A beta deposits increase. These data argue that radial arm water maze testing of doubly transgenic mice may be a useful behavioral endpoint in evaluating the functional consequences of potential AD therapies, especially those designed to reduce A beta load.
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ISSN:0197-4580
1558-1497
DOI:10.1016/S0197-4580(00)00249-9