Search Results - "GOTO, Yuki"

The RaPID Platform for the Discovery of Pseudo-Natural Macrocyclic Peptides by Goto, Yuki, Suga, Hiroaki

“…Conspectus Although macrocyclic peptides bearing exotic building blocks have proven their utility as pharmaceuticals, the sources of macrocyclic peptide drugs…”
Get full text

Selection-Based Discovery of Druglike Macrocyclic Peptides by Passioura, Toby, Katoh, Takayuki, Goto, Yuki, Suga, Hiroaki

“…Macrocyclic peptides are an emerging class of therapeutics that can modulate protein-protein interactions. In contrast to the heavily automated high-throughput…”
Get full text

Engineering of RiPP pathways for the production of artificial peptides bearing various non-proteinogenic structures by Goto, Yuki, Suga, Hiroaki

“…Peptides bearing non-proteinogenic structures characteristic of natural products have great potential as leads of pharmaceuticals. In the biosynthetic pathways…”
Get full text

Minimal lactazole scaffold for in vitro thiopeptide bioengineering by Vinogradov, Alexander A., Shimomura, Morito, Goto, Yuki, Ozaki, Taro, Asamizu, Shumpei, Sugai, Yoshinori, Suga, Hiroaki, Onaka, Hiroyasu

“…Lactazole A is a cryptic thiopeptide from Streptomyces lactacystinaeus , encoded by a compact 9.8 kb biosynthetic gene cluster. Here, we establish a platform…”
Get full text

Posttranslational chemical installation of azoles into translated peptides by Tsutsumi, Haruka, Kuroda, Tomohiro, Kimura, Hiroyuki, Goto, Yuki, Suga, Hiroaki

“…Azoles are five-membered heterocycles often found in the backbones of peptidic natural products and synthetic peptidomimetics. Here, we report a method of…”
Get full text

Post-translational backbone-acyl shift yields natural product-like peptides bearing hydroxyhydrocarbon units by Kuroda, Tomohiro, Huang, Yichao, Nishio, Soichiro, Goto, Yuki, Suga, Hiroaki

“…Hydroxyhydrocarbon (Hhc) moieties in the backbone of peptidic natural products can exert a substantial influence on the bioactivities of the products, making…”
Get full text

Ribosomal Formation of Thioamide Bonds in Polypeptide Synthesis by Maini, Rumit, Kimura, Hiroyuki, Takatsuji, Ryo, Katoh, Takayuki, Goto, Yuki, Suga, Hiroaki

“…It has been well established that the ribosome can accept various nucleophiles on the Xacyl-tRNA in the A site during elongation, where X can be amino,…”
Get full text

Experimental and Theoretical Heterodyne-Detected Sum Frequency Generation Spectroscopy of Isotopically Pure and Diluted Water Surfaces by Yamaguchi, Shoichi, Takayama, Tetsuyuki, Goto, Yuki, Otosu, Takuhiro, Yagasaki, Takuma

“…The χ(2) (second-order nonlinear optical susceptibility) spectrum of the water surface has been a matter of debate for a few decades. Here, we report that we…”
Get full text

Expanding the amino acid repertoire of ribosomal polypeptide synthesis via the artificial division of codon boxes by Iwane, Yoshihiko, Hitomi, Azusa, Murakami, Hiroshi, Katoh, Takayuki, Goto, Yuki, Suga, Hiroaki

“…In ribosomal polypeptide synthesis the library of amino acid building blocks is limited by the manner in which codons are used. Of the proteinogenic amino…”
Get full text

Dissection of goadsporin biosynthesis by in vitro reconstitution leading to designer analogues expressed in vivo by Ozaki, Taro, Yamashita, Kona, Goto, Yuki, Shimomura, Morito, Hayashi, Shohei, Asamizu, Shumpei, Sugai, Yoshinori, Ikeda, Haruo, Suga, Hiroaki, Onaka, Hiroyasu

“…Goadsporin (GS) is a member of ribosomally synthesized and post-translationally modified peptides (RiPPs), containing an N-terminal acetyl moiety, six azoles…”
Get full text

In Vitro Selection of Thioether-Closed Macrocyclic Peptide Ligands by Means of the RaPID System by Katoh, Takayuki, Goto, Yuki, Suga, Hiroaki

“…The Random nonstandard Peptides Integrated Discovery (RaPID) system enables efficient screening of macrocyclic peptides with high affinities against target…”
Get more information

Solid-Phase-Based Synthesis of Lactazole-Like Thiopeptides by Zhang, Yue, Vinogradov, Alexander A., Chang, Jun Shi, Goto, Yuki, Suga, Hiroaki

“…A strategy for the synthesis of de novo discovered lactazole-like thiopeptides is reported. The approach revolves around a convergent and scalable preparation…”
Get full text

A New Automotive VLC System Using Optical Communication Image Sensor by Goto, Yuki, Takai, Isamu, Yamazato, Takaya, Okada, Hiraku, Fujii, Toshiaki, Kawahito, Shoji, Arai, Shintaro, Yendo, Tomohiro, Kamakura, Koji

“…As a new technology for next-generation vehicle-to-everything (V2X) communication, visible-light communication (VLC) using light-emitting diode (LED)…”
Get full text

De Novo Discovery of Thiopeptide Pseudo-natural Products Acting as Potent and Selective TNIK Kinase Inhibitors by Vinogradov, Alexander A., Zhang, Yue, Hamada, Keisuke, Chang, Jun Shi, Okada, Chikako, Nishimura, Hirotaka, Terasaka, Naohiro, Goto, Yuki, Ogata, Kazuhiro, Sengoku, Toru, Onaka, Hiroyasu, Suga, Hiroaki

“…Bioengineering of ribosomally synthesized and post-translationally modified peptides (RiPPs) is an emerging approach to explore the diversity of pseudo-natural…”
Get full text

Elaboration of Pseudo-natural Products Using Artificial In Vitro Biosynthesis Systems by Goto, Yuki

“…Peptidic natural products often consist of not only proteinogenic building blocks but also unique non-proteinogenic structures such as macrocyclic scaffolds…”
Get full text

Artificial In Vitro Biosynthesis Systems for the Development of Pseudo-Natural Products by Goto, Yuki, Suga, Hiroaki

“…Recent advances in genome databases have allowed discovery of novel classes of natural products and their biosynthetic enzymes. Given the potentials and…”
Get full text

A Post-translational Cyclodehydratase, PatD, Tolerates Sequence Variation in the C-terminal Region of Substrate Peptides by Goto, Yuki, Suga, Hiroaki

“…A mutagenesis study of the downstream recognition sequence (dRS) in the substrate peptide of a post-translational cyclodehydratase, PatD, was conducted by…”
Get full text

Coherent cyclotron emission with a helical wavefront from multi-electron system accelerated by the circularly polarized wave by Goto, Yuki, Kubo, Shin, Tsujimura, Toru Ii

“…In this study, we calculated coherent electron cyclotron emission (ECE) with helical wavefront from a multi-electron system which passes through a magnetic…”
Get full text

Highly selective inhibition of histone demethylases by de novo macrocyclic peptides by Kawamura, Akane, Münzel, Martin, Kojima, Tatsuya, Yapp, Clarence, Bhushan, Bhaskar, Goto, Yuki, Tumber, Anthony, Katoh, Takayuki, King, Oliver N. F., Passioura, Toby, Walport, Louise J., Hatch, Stephanie B., Madden, Sarah, Müller, Susanne, Brennan, Paul E., Chowdhury, Rasheduzzaman, Hopkinson, Richard J., Suga, Hiroaki, Schofield, Christopher J.

“…The JmjC histone demethylases (KDMs) are linked to tumour cell proliferation and are current cancer targets; however, very few highly selective inhibitors for…”
Get full text

Exploring the Post-translational Enzymology of PaaA by mRNA Display by Fleming, Steven R, Himes, Paul M, Ghodge, Swapnil V, Goto, Yuki, Suga, Hiroaki, Bowers, Albert A

“…PaaA is a RiPP enzyme that catalyzes the transformation of two glutamic acid residues within a substrate peptide into the bicyclic core of Pantocin A. Here,…”
Get full text