Search Results - "GOTO, Kiyoto"
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Human Cytochrome P450 1A2 Involvement in the Formation of Reactive Metabolites from a Species-Specific Hepatotoxic Pyrazolopyrimidine Derivative, 5-n-Butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimidine
Published in Chemical research in toxicology (01-02-2009)“…5-n-Butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimidine) (OT-7100) is a pyrazolopyrimidine derivative with potential analgesic effects. Exclusively…”
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Two Novel Resveratrol Trimers, Leachianols A and B, from Sophora leachiana
Published in Chemical & pharmaceutical bulletin (1994)“…Two novel resveratrol trimers, named leachianols A (1) and B (2), were isolated from the roots of Sophora leachiana. Their structures were determined by…”
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Synthesis and Biological Activity of the Metabolites of Diethyl 4-[(4-Bromo-2-cyanophenyl)carbamoyl]benzylphosphonate (NO-1886)
Published in Chemical & pharmaceutical bulletin (01-03-1996)“…Five metabolites of diethyl 4-[(4-bromo-2-cyanophenyl)carbamoyl]benzylphosphonate (NO-1886) (1) were synthesized to confirm their proposed structures. The…”
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Human Cytochrome P450 1A2 Involvement in the Formation of Reactive Metabolites from a Species-Specific Hepatotoxic Pyrazolopyrimidine Derivative, 5-n-Butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimidin e
Published in Chemical research in toxicology (12-01-2009)“…5-n-Butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimidin e) (OT-7100) is a pyrazolopyrimidine derivative with potential analgesic effects…”
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NOVEL ISOCOUMARIN DERIVATIVES FROM ACHLYS TRIPHYLLA (BERBERIDACEAE)
Published in Chemical & pharmaceutical bulletin (25-07-1990)“…Three new phenolic compounds with a novel skeleton were isolated from the underground parts of Achlys triphylla (Berberidaceae). The structures were…”
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Synthetic studies on diterpenoid quinones with interleukin-1 inhibitory activity. Total synthesis of (.+-.)- and (+)-triptoquinone A
Published in Journal of organic chemistry (01-01-1994)Get full text
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Enantioselective total synthesis and structure determination of the mercapturic acid sulfoxide conjugate
Published in Bioorganic & medicinal chemistry letters (05-08-1997)“…A practical and enantioselective total synthesis of the mercapturic acid sulfoxide 4, a metabolite of anti-inflammatory drug DUP 697 1, has been accomplished…”
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Diastereoselective oxidation of mercapturates to mercapturate sulfoxides
Published in Bioorganic & medicinal chemistry letters (23-04-1996)“…An efficient and highly diastereoselective synthesis of mercapturate sulfoxides 2 based on the substrate contorolled asymmetric S-oxidation has been…”
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Structure Elucidation and Synthesis of a Metabolite of Antiinflammatory Drug DUP 697
Published in Heterocycles (1996)Get full text
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A General and Efficient Synthesis of Optically Pure S-Arylmercapturates
Published in Heterocycles (01-06-1995)Get full text
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