Search Results - "GORUS, F. K"

BMI is an important driver of β-cell loss in type 1 diabetes upon diagnosis in 10 to 18-year-old children by Lauria, A, Barker, A, Schloot, N, Hosszufalusi, N, Ludvigsson, J, Mathieu, C, Mauricio, D, Nordwall, M, Van der Schueren, B, Mandrup-Poulsen, T, A Scherbaum, W, Weets, I, K Gorus, F, Wareham, N, D Leslie, R, Pozzilli, P

“…ObjectiveBody weight-related insulin resistance probably plays a role in progression to type 1 diabetes, but has an uncertain impact following diagnosis. In…”
Get full text

Predictive power of screening for antibodies against insulinoma-associated protein 2 beta (IA-2β) and zinc transporter-8 to select first-degree relatives of type 1 diabetic patients with risk of rapid progression to clinical onset of the disease: implications for prevention trials by De Grijse, J., Asanghanwa, M., Nouthe, B., Albrecher, N., Goubert, P., Vermeulen, I., Van Der Meeren, S., Decochez, K., Weets, I., Keymeulen, B., Lampasona, V., Wenzlau, J., Hutton, J. C., Pipeleers, D., Gorus, F. K.

“…Aims/hypothesis We investigated whether screening for insulinoma-associated protein (IA-2) beta (IA-2β) autoantibodies (IA-2βA) and zinc transporter-8 (ZnT8)…”
Get full text

Screening for insulinoma antigen 2 and zinc transporter 8 autoantibodies: a cost‐effective and age‐independent strategy to identify rapid progressors to clinical onset among relatives of type 1 diabetic patients by Gorus, F. K., Balti, E. V., Vermeulen, I., Demeester, S., Van Dalem, A., Costa, O., Dorchy, H., Tenoutasse, S., Mouraux, T., De Block, C., Gillard, P., Decochez, K., Wenzlau, J. M., Hutton, J. C., Pipeleers, D. G., Weets, I.

“…Summary In first‐degree relatives of type 1 diabetic patients, we investigated whether diabetes risk assessment solely based on insulinoma antigen 2 (IA‐2) and…”
Get full text

An important minority of prediabetic first-degree relatives of type 1 diabetic patients derives from seroconversion to persistent autoantibody positivity after 10 years of age by Vermeulen, I., Weets, I., Costa, O., Asanghanwa, M., Verhaeghen, K., Decochez, K., Ruige, J., Casteels, K., Wenzlau, J., Hutton, J. C., Pipeleers, D. G., Gorus, F. K.

“…Aims/hypothesis The appearance of autoantibodies (Abs) before diabetes onset has mainly been studied in young children. However, most patients develop type 1…”
Get full text

In antibody-positive first-degree relatives of patients with type 1 diabetes, HLA-A24 and HLA-B18, but not HLA-B39, are predictors of impending diabetes with distinct HLA-DQ interactions by Mbunwe, E., Van der Auwera, B. J., Weets, I., Van Crombrugge, P., Crenier, L., Coeckelberghs, M., Seret, N., Decochez, K., Vandemeulebroucke, E., Gillard, P., Keymeulen, B., van Schravendijk, C., Wenzlau, J. M., Hutton, J. C., Pipeleers, D. G., Gorus, F. K.

“…Aims/hypothesis Secondary type 1 diabetes prevention trials require selection of participants with impending diabetes. HLA-A and - B alleles have been reported…”
Get full text

Proinsulin levels and the proinsulin:C-peptide ratio complement autoantibody measurement for predicting type 1 diabetes by TRUYEN, I, DE PAUW, P, GORUS, F. K, JØRGENSEN, P. N, VAN SCHRAVENDIJK, C, UBANI, O, DECOCHEZ, K, VANDEMEULEBROUCKE, E, WEETS, I, MAO, R, PIPELEERS, D. G

“…We investigated whether random proinsulin levels and proinsulin:C-peptide ratio (PI:C) complement immune and genetic markers for identifying relatives at high…”
Get full text

Immune responses against islet allografts during tapering of immunosuppression – a pilot study in 5 subjects by Huurman, V. A. L., van der Torren, C. R., Gillard, P., Hilbrands, R., van der Meer‐Prins, E. P. M. W., Duinkerken, G., Gorus, F. K., Claas, F. H. J., Keymeulen, B., Roelen, D. L., Pipeleers, D. G., Roep, B. O.

“…Summary Transplantation of isolated islet of Langerhans cells has great potential as a cure for type 1 diabetes but continuous immune suppressive therapy often…”
Get full text

Hyperglycaemic clamp test for diabetes risk assessment in IA-2-antibody-positive relatives of type 1 diabetic patients by Vandemeulebroucke, E, Keymeulen, B, Decochez, K, Weets, I, De Block, C, Féry, F, Van de Velde, U, Vermeulen, I, De Pauw, P, Mathieu, C, Pipeleers, D. G, Gorus, F. K

“…Aims/hypothesis The aim of the study was to investigate the use of hyperglycaemic clamp tests to identify individuals who will develop diabetes among…”
Get full text

Insulin treatment in IA-2A-positive relatives of type 1 diabetic patients by Vandemeulebroucke, E, Gorus, F.K, Decochez, K, Weets, I, Keymeulen, B, De Block, C, Tits, J, Pipeleers, D.G, Mathieu, C

“…Abstract Aims We examined whether parenteral regular insulin can prevent diabetes in IA-2 antibody-positive (IA-2A+) relatives of type 1 diabetic patients,…”
Get full text

Combined positivity for HLA DQ2/DQ8 and IA-2 antibodies defines population at high risk of developing type 1 diabetes by DECOCHEZ, K, TRUYEN, I, GORUS, F. K, VAN DER AUWERA, B, WEETS, I, VANDEMEULEBROUCKE, E, DE LEEUW, I. H, KEYMEULEN, B, MATHIEU, C, ROTTIERS, R, PIPELEERS, D. G

“…Prevention trials in first-degree relatives of type 1 diabetic patients are hampered by large interindividual differences in progression rate to diabetes. We…”
Get full text

Cardiac Troponins I and T Are Biological Markers of Left Ventricular Dysfunction in Septic Shock by ver Elst, Kristien M, Spapen, Herbert D, Nguyen, Duc Nam, Garbar, Christian, Huyghens, Luc P, Gorus, Frans K

“…Cardiac depression in severe sepsis and septic shock is characterized by left ventricular (LV) failure. To date, it is unclear whether clinically unrecognized…”
Get full text

Total error profiling of a proinsulin time-resolved fluorescence immunoassay by De Pauw, P.E., Mackin, R.B., Goubert, P., Van Schravendijk, C., Gorus, F.K.

“…We applied total error profiling to evaluate the conversion of a known proinsulin (PI) enzyme-linked immunosorbent assay (ELISA) into a time-resolved…”
Get full text

Beta‐cell, thyroid, gastric, adrenal and coeliac autoimmunity and HLA‐DQ types in type 1 diabetes by De Block, C. E. M., De Leeuw, I. H., Vertommen, J. J. F., Rooman, R. P. A., Du Caju, M. V. L., Van Campenhout, C. M., Weyler, J. J., Winnock, F., Van Autreve, J., Gorus, F. K.

“…The autoimmune attack in type 1 diabetes is not only targeted to β cells. We assessed the prevalence of thyroid peroxidase (aTPO), parietal cell (PCA),…”
Get full text

Sex- and season-dependent differences in C-peptide levels at diagnosis of immune-mediated type 1 diabetes by WEETS, I, TRUYEN, I, GORUS, F. K, VERSCHRAEGEN, I, VAN DER AUWERA, B, DE SCHEPPER, J, DORCHY, H, LEBRETHON, M.-C, VAN GAAL, L, VAN ROOY, P, PIPELEERS, D. G

“…The incidence of type 1 diabetes varies according to age, sex and season of diagnosis. We investigated whether these and other clinical, biological and…”
Get full text

Seasonality in clinical onset of Type 1 diabetes in Belgian patients above the age of 10 is restricted to HLA-DQ2/DQ8-negative males, which explains the male to female excess in incidence by WEETS, I, KAUFMAN, L, PIPELEERS, D. G, GORUS, F. K, VAN DER AUWERA, B, CRENIER, L, ROOMAN, R. P. A, DE BLOCK, C, CASTEELS, K, WEBER, E, COECKELBERGHS, M, LARON, Z

“…Type 1 diabetes arises from an interplay between environmental and genetic factors. The reported seasonality at diagnosis supports the hypothesis that…”
Get full text

Age-dependent decline of β-cell function in type 1 diabetes after diagnosis: a multi-centre longitudinal study by Barker, A., Lauria, A., Schloot, N., Hosszufalusi, N., Ludvigsson, J., Mathieu, C., Mauricio, D., Nordwall, M., Van der Schueren, B., Mandrup-Poulsen, T., Scherbaum, W. A., Weets, I., Gorus, F. K., Wareham, N., Leslie, R. D., Pozzilli, P.

“…Aims C‐peptide secretion is currently the only available clinical biomarker to measure residual β‐cell function in type 1 diabetes. However, the natural…”
Get full text

The age at diagnosis of type 1 diabetes continues to decrease in Belgian boys but not in girls: a 15-year survey by Weets, I., Rooman, R., Coeckelberghs, M., De Block, C., Van Gaal, L., Kaufman, J.-M., Keymeulen, B., Mathieu, C., Weber, E., Pipeleers, D. G., Gorus, F. K.

“…Background The age at clinical onset of type 1 diabetes is decreasing. Preliminary Belgian data suggested that this anticipation occurred preferentially in…”
Get full text

Implantation of standardized beta-cell grafts in a liver segment of IDDM patients : graft and recipient characteristics in two cases of insulin-independence under maintenance immunosuppression for prior kidney graft by KEYMEULEN, B, LING, Z, PIPELEERS, D. G, GORUS, F. K, DELVAUX, G, BOUWENS, L, GRUPPING, A, HENDRIECKX, C, PIPELEERS-MARICHAL, M, VAN SCHRAVENDIJK, C, SALMELA, K

Get full text

Male-to-female excess in diabetes diagnosed in early adulthood is not specific for the immune-mediated form nor is it HLA-DQ restricted : possible relation to increased body mass index by WEETS, I, VAN AUTREVE, J, DORCHY, H, QUARTIER, E, GORUS, F. K, VAN DER AUWERA, B. J, SCHUIT, F. C, DU CAJU, M. V. L, DECOCHEZ, K, DE LEEUW, I. H, KEYMEULEN, B, MATHIEU, C, ROTTIERS, R

“…AIMS/HYPOTHESIS. We investigated whether the reported HLA-DQ/DR restricted male-to-female (M:F) excess in Type I (insulin-dependent) diabetes mellitus also…”
Get full text

Adiponectin levels do not predict clinical onset of type 1 diabetes in antibody-positive relatives by Truyen, I, De Grijse, J, Van Schravendijk, C, De Smet, D, Decochez, K, Vandemeulebroucke, E, Giri, M, Keymeulen, B, Mathieu, C, Van Gaal, L, De Pauw, P, Weets, I, Pipeleers, D. G, Gorus, F. K

“…Aims/Hypothesis Insulin resistance has been proposed as a risk factor for type 1 diabetes. We investigated whether adiponectin, an insulin sensitiser, can…”
Get full text