Search Results - "GORONZY, J. J"

The immunology of rheumatoid arthritis by Weyand, Cornelia M., Goronzy, Jörg J.

“…The immunopathogenesis of rheumatoid arthritis (RA) spans decades, beginning with the production of autoantibodies against post-translationally modified…”
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Mechanisms underlying T cell ageing by Goronzy, Jörg J., Weyand, Cornelia M.

“…T cell ageing has a pivotal role in rendering older individuals vulnerable to infections and cancer and in impairing the response to vaccination. Easy…”
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Understanding immunosenescence to improve responses to vaccines by Goronzy, Jörg J, Weyand, Cornelia M

“…In the older adult, the benefits of vaccination to prevent infectious disease are limited, mainly because of the adaptive immune system's inability to generate…”
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Immunometabolism in the development of rheumatoid arthritis by Weyand, Cornelia M., Goronzy, Jörg J.

“…In rheumatoid arthritis (RA), breakdown of self‐tolerance and onset of clinical disease are separated in time and space, supporting a multi‐hit model in which…”
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Successful and Maladaptive T Cell Aging by Goronzy, Jörg J., Weyand, Cornelia M.

“…Throughout life, the T cell system adapts to shifting resources and demands, resulting in a fundamentally restructured immune system in older individuals. Here…”
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Immune mechanisms in medium and large-vessel vasculitis by Weyand, Cornelia M., Goronzy, Jörg J.

“…Key Points Giant cell arteritis (GCA), the most frequent form of large-vessel vasculitis, occurs in a strictly defined tissue context and requires corruption…”
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Aging of the Immune System. Mechanisms and Therapeutic Targets by Weyand, Cornelia M, Goronzy, Jörg J

“…Beginning with the sixth decade of life, the human immune system undergoes dramatic aging-related changes, which continuously progress to a state of…”
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Diversity and clonal selection in the human T-cell repertoire by Qi, Qian, Liu, Yi, Cheng, Yong, Glanville, Jacob, Zhang, David, Lee, Ji-Yeun, Olshen, Richard A., Weyand, Cornelia M., Boyd, Scott D., Goronzy, Jörg J.

“…T-cell receptor (TCR) diversity, a prerequisite for immune system recognition of the universe of foreign antigens, is generated in the first two decades of…”
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Immunometabolism in early and late stages of rheumatoid arthritis by Weyand, Cornelia M., Goronzy, Jörg J.

“…Key Points A fundamental abnormality in rheumatoid arthritis (RA) is the inappropriate growth of immune cells and stromal cells, imposing high metabolic…”
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Naive T cell maintenance and function in human aging by Goronzy, Jörg J, Fang, Fengqin, Cavanagh, Mary M, Qi, Qian, Weyand, Cornelia M

“…In studies of immune aging, naive T cells frequently take center stage. Describing the complexity of the human naive T cell repertoire remains a daunting task;…”
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Influence of immune aging on vaccine responses by Gustafson, Claire E., Kim, Chulwoo, Weyand, Cornelia M., Goronzy, Jörg J.

“…Impaired vaccine responses in older individuals are associated with alterations in both the quantity and quality of the T-cell compartment with age. As…”
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Hallmarks of the aging T‐cell system by Zhang, Huimin, Weyand, Cornelia M., Goronzy, Jörg J.

“…The adaptive immune system has the enormous challenge to protect the host through the generation and differentiation of pathogen‐specific short‐lived effector…”
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Inhibition of JAK-STAT Signaling Suppresses Pathogenic Immune Responses in Medium and Large Vessel Vasculitis by Zhang, Hui, Watanabe, Ryu, Berry, Gerald J, Tian, Lu, Goronzy, Jörg J, Weyand, Cornelia M

“…BACKGROUND:Giant cell arteritis, a chronic autoimmune disease of the aorta and its large branches, is complicated by aneurysm formation, dissection, and…”
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Vessel-Specific Toll-Like Receptor Profiles in Human Medium and Large Arteries by PRYSHCHEP, Olga, MA-KRUPA, Wei, YOUNGE, Brian R, GORONZY, Jörg J, WEYAND, Cornelia M

“…Inflammatory vasculopathies, ranging from the vasculitides (Takayasu arteritis, giant cell arteritis, and polyarteritis nodosa) to atherosclerosis, display…”
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Immunoinhibitory checkpoint deficiency in medium and large vessel vasculitis by Zhang, Hui, Watanabe, Ryu, Berry, Gerald J., Vaglio, Augusto, Liao, Yaping Joyce, Warrington, Kenneth J., Goronzy, Jörg J., Weyand, Cornelia M.

“…Giant cell arteritis (GCA) causes autoimmune inflammation of the aorta and its large branches, resulting in aortic arch syndrome, blindness, and stroke. CD4⁺ T…”
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Immune aging and autoimmunity by Goronzy, Jörg J., Weyand, Cornelia M.

“…Age is an important risk for autoimmunity, and many autoimmune diseases preferentially occur in the second half of adulthood when immune competence has…”
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Autophagy in autoimmune disease by Yang, Zhen, Goronzy, Jörg J., Weyand, Cornelia M.

“…Autophagy is a protective and life-sustaining process in which cytoplasmic components are packaged into double-membrane vesicles and targeted to lysosomes for…”
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The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease by Shirai, Tsuyoshi, Nazarewicz, Rafal R, Wallis, Barbara B, Yanes, Rolando E, Watanabe, Ryu, Hilhorst, Marc, Tian, Lu, Harrison, David G, Giacomini, John C, Assimes, Themistocles L, Goronzy, Jörg J, Weyand, Cornelia M

“…Abnormal glucose metabolism and enhanced oxidative stress accelerate cardiovascular disease, a chronic inflammatory condition causing high morbidity and…”
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Chronic inflammation in the etiology of disease across the life span by Furman, David, Campisi, Judith, Verdin, Eric, Carrera-Bastos, Pedro, Targ, Sasha, Franceschi, Claudio, Ferrucci, Luigi, Gilroy, Derek W., Fasano, Alessio, Miller, Gary W., Miller, Andrew H., Mantovani, Alberto, Weyand, Cornelia M., Barzilai, Nir, Goronzy, Jorg J., Rando, Thomas A., Effros, Rita B., Lucia, Alejandro, Kleinstreuer, Nicole, Slavich, George M.

“…Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain…”
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Metabolic signatures of T-cells and macrophages in rheumatoid arthritis by Weyand, Cornelia M, Zeisbrich, Markus, Goronzy, Jörg J

“…Highlights • In the autoimmune disease, rheumatoid arthritis (RA), abnormal metabolic programs have been identified in arthritogenic T-cells and in…”
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