Search Results - "GORINA, ROSER"

β2 integrin-mediated crawling on endothelial ICAM-1 and ICAM-2 is a prerequisite for transcellular neutrophil diapedesis across the inflamed blood-brain barrier by Gorina, Roser, Lyck, Ruth, Vestweber, Dietmar, Engelhardt, Britta

“…In acute neuroinflammatory states such as meningitis, neutrophils cross the blood-brain barrier (BBB) and contribute to pathological alterations of cerebral…”
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Neutrophils mediate blood-spinal cord barrier disruption in demyelinating neuroinflammatory diseases by Aubé, Benoit, Lévesque, Sébastien A, Paré, Alexandre, Chamma, Émilie, Kébir, Hania, Gorina, Roser, Lécuyer, Marc-André, Alvarez, Jorge I, De Koninck, Yves, Engelhardt, Britta, Prat, Alexandre, Côté, Daniel, Lacroix, Steve

“…Disruption of the blood-brain and blood-spinal cord barriers (BBB and BSCB, respectively) and immune cell infiltration are early pathophysiological hallmarks…”
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Induction of COX-2 Enzyme and Down-regulation of COX-1 Expression by Lipopolysaccharide (LPS) Control Prostaglandin E2 Production in Astrocytes by Font-Nieves, Miriam, Sans-Fons, M. Glòria, Gorina, Roser, Bonfill-Teixidor, Ester, Salas-Pérdomo, Angélica, Márquez-Kisinousky, Leonardo, Santalucia, Tomàs, Planas, Anna M.

“…Pathological conditions and pro-inflammatory stimuli in the brain induce cyclooxygenase-2 (COX-2), a key enzyme in arachidonic acid metabolism mediating the…”
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HIV-1 Nef interferes with T-lymphocyte circulation through confined environments in vivo by Stolp, Bettina, Imle, Andrea, Coelho, Fernanda Matos, Hons, Miroslav, Gorina, Roser, Lyck, Ruth, Stein, Jens V, Fackler, Oliver T

“…HIV-1 negative factor (Nef) elevates virus replication and contributes to immune evasion in vivo. As one of its established in vitro activities, Nef interferes…”
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Antioxidant CR-6 protects against reperfusion injury after a transient episode of focal brain ischemia in rats by Pérez-Asensio, Fernando J, de la Rosa, Xavier, Jiménez-Altayó, Francesc, Gorina, Roser, Martínez, Emili, Messeguer, Àngel, Vila, Elisabet, Chamorro, Àngel, Planas, Anna M

“…Oxidative and nitrosative stress are targets for intervention after ischemia/reperfusion. The aim of this study was to explore the effect of CR-6, a vitamin-E…”
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Activation of Matrix Metalloproteinase-3 and Agrin Cleavage in Cerebral Ischemia/Reperfusion by SOLÉ, SÒNIA, PETEGNIEF, VALÉRIE, GORINA, ROSER, CHAMORRO, ÁNGEL, PLANAS, ANNA M

“…Matrix metalloproteinase-3 (MMP-3) degrades components of the extracellular matrix and may participate in the pathogenesis of stroke. Here we examine the…”
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Exposure of glia to pro-oxidant agents revealed selective Stat1 activation by H2O2 and Jak2-independent antioxidant features of the Jak2 inhibitor AG490 by Gorina, Roser, Sanfeliu, Coral, Galitó, Aida, Messeguer, Àngel, Planas, Anna M.

“…The JAK/STAT pathway is activated in response to cytokines and growth factors. In addition, oxidative stress can activate this pathway, but the causative…”
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AG490 prevents cell death after exposure of rat astrocytes to hydrogen peroxide or proinflammatory cytokines: involvement of the Jak2/STAT pathway by Gorina, Roser, Petegnief, Valérie, Chamorro, Ángel, Planas, Anna M.

“…Janus kinases/STAT pathway mediates cellular responses to certain oxidative stress stimuli and cytokines. Here we examine the activation of Stat1 and Stat3 in…”
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Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFκB signaling, MAPK, and Jak1/Stat1 pathways by Gorina, Roser, Font-Nieves, Miriam, Márquez-Kisinousky, Leonardo, Santalucia, Tomàs, Planas, Anna M.

“…There is increasing evidence that astrocytes play important roles in immune regulation in the brain. Astrocytes express toll‐like receptors (TLR) and build up…”
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Brain-derived antigens in lymphoid tissue of patients with acute stroke by Planas, Anna M, Gómez-Choco, Manuel, Urra, Xabier, Gorina, Roser, Caballero, Miguel, Chamorro, Ángel

“…In experimental animals, the presence of brain-derived constituents in cervical lymph nodes has been associated with the activation of local lymphocytes poised…”
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The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury by Enzmann, Gaby, Mysiorek, Caroline, Gorina, Roser, Cheng, Yu-Jung, Ghavampour, Sharang, Hannocks, Melanie-Jane, Prinz, Vincent, Dirnagl, Ulrich, Endres, Matthias, Prinz, Marco, Beschorner, Rudi, Harter, Patrick N., Mittelbronn, Michel, Engelhardt, Britta, Sorokin, Lydia

“…The migration of polymorphonuclear granulocytes (PMN) into the brain parenchyma and release of their abundant proteases are considered the main causes of…”
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beta 2 Integrin-Mediated Crawling on Endothelial ICAM-1 and ICAM-2 Is a Prerequisite for Transcellular Neutrophil Diapedesis across the Inflamed Blood-Brain Barrier by Gorina, Roser, Lyck, Ruth, Vestweber, Dietmar, Engelhardt, Britta

“…In acute neuroinflammatory states such as meningitis, neutrophils cross the blood-brain barrier (BBB) and contribute to pathological alterations of cerebral…”
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Astrocytes are very sensitive to develop innate immune responses to lipid-carried short interfering RNA by Gorina, Roser, Santalucia, Tomàs, Petegnief, Valérie, Ejarque-Ortiz, Aroa, Saura, Josep, Planas, Anna M.

“…Short interfering RNA (siRNA) inhibits the synthesis of specific proteins through RNA interference (RNAi). However, siRNA can induce innate immune responses…”
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Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NF Delta kB signaling, MAPK, and Jak1/Stat1 pathways by Gorina, Roser, Font-Nieves, Miriam, Marquez-Kisinousky, Leonardo, Santalucia, Tomas, Planas, Anna M

“…There is increasing evidence that astrocytes play important roles in immune regulation in the brain. Astrocytes express toll-like receptors (TLR) and build up…”
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Exposure of glia to pro‐oxidant agents revealed selective Stat1 activation by H 2 O 2 and Jak2‐independent antioxidant features of the Jak2 inhibitor AG490 by Gorina, Roser, Sanfeliu, Coral, Galitó, Aida, Messeguer, Àngel, Planas, Anna M.

“…The JAK/STAT pathway is activated in response to cytokines and growth factors. In addition, oxidative stress can activate this pathway, but the causative…”
Get full text