Search Results - "GORES, Gregory"

Hepatocellular carcinoma: clinical frontiers and perspectives by Bruix, Jordi, Gores, Gregory J, Mazzaferro, Vincenzo

“…Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death and is currently the main event leading to death in patients with…”
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Cholangiocarcinoma by Razumilava, Nataliya, MD, Gores, Gregory J, Prof

“…Summary Cholangiocarcinoma represents a diverse group of epithelial cancers united by late diagnosis and poor outcomes. Specific diagnostic and therapeutic…”
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Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease by Malhi, Harmeet, Gores, Gregory J

“…Nonalcoholic fatty liver disease (NAFLD) is characterized by insulin resistance, which results in elevated serum concentration of free fatty acids (FFAs)…”
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Systemic therapies for intrahepatic cholangiocarcinoma by Kelley, Robin Kate, Bridgewater, John, Gores, Gregory J., Zhu, Andrew X.

“…Intrahepatic cholangiocarcinoma (iCCA) is a highly lethal hepatobiliary neoplasm whose incidence is increasing. Largely neglected for decades as a rare…”
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Emerging Molecular Therapeutic Targets for Cholangiocarcinoma by Rizvi, Sumera, Gores, Gregory J

“…Abstract Cholangiocarcinomas (CCAs) are diverse epithelial tumors arising from the liver or large bile ducts with features of cholangiocyte differentiation,…”
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Life and death by death receptors by Guicciardi, Maria Eugenia, Gores, Gregory J

“…Death receptors are members of the tumor necrosis factor receptor superfamily characterized by a cytoplasmic region known as the "death domain" that enables…”
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Classification, Diagnosis, and Management of Cholangiocarcinoma by Razumilava, Nataliya, Gores, Gregory J

“…Cholangiocarcinomas (CCAs) are tumors that develop along the biliary tract. Depending on their site of origin, they have different features and require…”
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Apoptosis as a mechanism for liver disease progression by Guicciardi, Maria Eugenia, Gores, Gregory J

“…Hepatocyte injury is ubiquitous in clinical practice, and the mode of cell death associated with this injury is often apoptosis, especially by death receptors…”
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A global view of hepatocellular carcinoma: trends, risk, prevention and management by Yang, Ju Dong, Hainaut, Pierre, Gores, Gregory J., Amadou, Amina, Plymoth, Amelie, Roberts, Lewis R.

“…Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-related death worldwide. Risk factors for HCC include chronic hepatitis B and…”
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Cholangiocarcinoma: Advances in pathogenesis, diagnosis, and treatment by Blechacz, Boris, Gores, Gregory J.

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Lytic cell death in metabolic liver disease by Gautheron, Jérémie, Gores, Gregory J., Rodrigues, Cecília M.P.

“…Regulated cell death is intrinsically associated with inflammatory liver disease and is pivotal in governing outcomes of metabolic liver disease. Different…”
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Cholangiocarcinoma — evolving concepts and therapeutic strategies by Ilyas, Sumera I., Khan, Shahid A., Hallemeier, Christopher L., Kelley, Robin K., Gores, Gregory J.

“…Key Points Each anatomical subtype of cholangiocarcinoma, intrahepatic (iCCA), perihilar (pCCA) and distal (dCCA), has a distinct epidemiology, biology, and…”
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Cellular and Molecular Mechanisms of Liver Injury by Malhi, Harmeet, Gores, Gregory J

“…Derangements in apoptosis of liver cells are mechanistically important in the pathogenesis of end-stage liver disease. Vulnerable hepatocytes can undergo…”
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Alcohol-associated liver disease: The time to act is now by Malhi, Harmeet, Gores, Gregory J

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Desmoplastic stroma and cholangiocarcinoma: Clinical implications and therapeutic targeting by Sirica, Alphonse E., Gores, Gregory J.

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Hepatocyte death: a clear and present danger by Malhi, Harmeet, Guicciardi, Maria Eugenia, Gores, Gregory J

“…The hepatocyte is especially vulnerable to injury due to its central role in xenobiotic metabolism including drugs and alcohol, participation in lipid and…”
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The mTOR pathway in hepatic malignancies by Bhat, Mamatha, Sonenberg, Nahum, Gores, Gregory J.

“…The mechanistic/mammalian target of rapamycin (mTOR) pathway plays a critical role in cellular metabolism, growth, and proliferation and has been evaluated as…”
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Intrahepatic Cholangiocarcinoma: Continuing Challenges and Translational Advances by Sirica, Alphonse E., Gores, Gregory J., Groopman, John D., Selaru, Florin M., Strazzabosco, Mario, Wei Wang, Xin, Zhu, Andrew X.

“…Intrahepatic cholangiocarcinoma (iCCA) has over the last 10‐20 years become the focus of increasing concern, largely due to its rising incidence and high…”
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Animal Models of Nonalcoholic Steatohepatitis: Eat, Delete, and Inflame by Ibrahim, Samar H., Hirsova, Petra, Malhi, Harmeet, Gores, Gregory J.

“…With the obesity epidemic, nonalcoholic fatty liver disease (NAFLD) has become a public health problem with increasing prevalence. The mechanism of disease…”
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Introducing the Editorial Fellow and the Fellows' Corner by Malhi, Harmeet, Gores, Gregory J

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