Search Results - "GORELIK, Gabriela"

Stimulatory and Inhibitory Killer Ig-Like Receptor Molecules Are Expressed and Functional on Lupus T Cells by Basu, Dhiman, Liu, Ying, Wu, Ailing, Yarlagadda, Sushma, Gorelik, Gabriela J, Kaplan, Mariana J, Hewagama, Anura, Hinderer, Robert C, Strickland, Faith M, Richardson, Bruce C

“…T cells from lupus patients have hypomethylated DNA and overexpress genes normally suppressed by DNA methylation that contribute to disease pathogenesis. We…”
Get full text

Decreased ERK and JNK signaling contribute to gene overexpression in “senescent” CD4+CD28– T cells through epigenetic mechanisms by Chen, Yingxuan, Gorelik, Gabriela J., Strickland, Faith M., Richardson, Bruce C.

“…Decreased ERK and JNK signaling in CD4+CD28− T cells decreases DNA methyltransferase levels causes demethylation and overexpression of genes normally…”
Get full text

Omission of Author Name in the Article by Gorelik et al (Arthritis Rheum, September 2012) by Gorelik, Gabriela J., Yarlagadda, Sushma, Richardson, Bruce C.

Get full text

Integrative study of hypothalamus–pituitary–thyroid–immune system interaction: thyroid hormone-mediated modulation of lymphocyte activity through the protein kinase C signaling pathway by Klecha, Alicia J, Genaro, Ana M, Gorelik, Gabriela, Barreiro Arcos, María Laura, Silberman, Dafne Magalí, Schuman, Mariano, Garcia, Silvia I, Pirola, Carlos, Cremaschi, Graciela A

“…Thyroid hormones play critical roles in differentiation, growth and metabolism, but their participation in immune system regulation has not been completely…”
Get full text

Cross Interaction Between OGT and mTOR in T Cells and its Consequences in Autoimmunity by Castrillo, Savannah Danielle, Gorelik, Gabriela

“…Abstract only…”
Get full text

Oxidative Stress, T Cell DNA Methylation, and Lupus by Li, YePeng, Gorelik, Gabriela, Strickland, Faith M., Richardson, Bruce C.

“…Objective Lupus develops when genetically predisposed people encounter environmental agents, such as ultraviolet light, silica, infections, and cigarette…”
Get full text

Chronic stress influences the immune system through the thyroid axis by Cremaschi, Graciela A., Gorelik, Gabriela, Klecha, Alicia J., Lysionek, Alexis E., Genaro, Ana M.

“…The aim of the present work was to analyze the effect of chronic stress on thyroid axis and its influence on the immune response. For this purpose a murine…”
Get full text

Protein kinase Cδ oxidation contributes to ERK inactivation in lupus T cells by Gorelik, Gabriela J., Yarlagadda, Sushma, Richardson, Bruce C.

“…Objective CD4+ T cells from patients with active lupus have impaired ERK pathway signaling that decreases DNA methyltransferase expression, resulting in DNA…”
Get full text

Modulatory effects on myocardial physiology induced by an anti-Trypanosoma cruzi monoclonal antibody involve recognition of major antigenic epitopes from β1-adrenergic and M2-muscarinic cholinergic receptors without requiring receptor cross-linking by Cremaschi, Graciela, Fernández, Marisa M, Gorelik, Gabriela, Goin, Juan C, Fossati, Carlos A, Zwirner, Norberto W, Malchiodi, Emilio L

Get full text

Aberrant T cell ERK pathway signaling and chromatin structure in lupus by Gorelik, Gabriela, Richardson, Bruce

“…Abstract Human systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibodies to nuclear components with subsequent immune complex…”
Get full text

T cell PKCδ kinase inactivation induces lupus-like autoimmunity in mice by Gorelik, Gabriela, Sawalha, Amr H, Patel, Dipak, Johnson, Kent, Richardson, Bruce

“…Abstract Genetic and environmental factors contribute to the onset and progression of lupus. CD4 + T cells from patients with active lupus show a decreased ERK…”
Get full text

Overexpression of X-Linked genes in T cells from women with lupus by Hewagama, Anura, Gorelik, Gabriela, Patel, Dipak, Liyanarachchi, Punsisi, Joseph McCune, W, Somers, Emily, Gonzalez-Rivera, Tania, The Michigan Lupus Cohort, Strickland, Faith, Richardson, Bruce

“…Abstract Women develop lupus more frequently than men and the reason remains incompletely understood. Evidence that men with Klinefelter's Syndrome (XXY)…”
Get full text

Impaired T cell protein kinase C delta activation decreases ERK pathway signaling in idiopathic and hydralazine-induced lupus by Gorelik, Gabriela, Fang, Jing Yuan, Wu, Ailing, Sawalha, Amr H, Richardson, Bruce

“…T cells from patients with lupus or treated with the lupus-inducing drug hydralazine have defective ERK phosphorylation. The reason for the impaired signal…”
Get full text

Key role of ERK pathway signaling in lupus by Gorelik, Gabriela, Richardson, Bruce

“…Systemic lupus erythematosus is a poorly understood autoimmune disease, characterized by autoantibodies to nuclear antigens and immune complex deposition in…”
Get full text

Protein Kinase C[delta] Mutations May Contribute to Lupus Through Effects on T Cells: Comment on the Article by Belot et al by Richardson, Bruce, Strickland, Faith M, Sawalha, Amr H, Gorelik, Gabriela

Get full text

Protein kinase C[delta] oxidation contributes to ERK inactivation in lupus T cells by Gorelik, Gabriela J, Yarlagadda, Sushma, Richardson, Bruce C

“…Objective CD4+ T cells from patients with active lupus have impaired ERK pathway signaling that decreases DNA methyltransferase expression, resulting in DNA…”
Get full text

Protein Kinase Cδ Mutations May Contribute to Lupus Through Effects on T Cells: Comment on the Article by Belot et al by Richardson, Bruce, Strickland, Faith M., Sawalha, Amr H., Gorelik, Gabriela

Get full text

PKCδ nitrosylation impairs ERK pathway signaling in lupus T cells (129.9) by Gorelik, Gabriela, Wu, Ailing, Richardson, Bruce

“…T cells from lupus patients or treated with hydralazine have defective PKC-ERK pathway signaling, causing decreased DNA methyltransferase levels, DNA…”
Get full text

Thyroid hormones increase inducible nitric oxide synthase gene expression downstream from PKC-zeta in murine tumor T lymphocytes by Barreiro Arcos, María Laura, Gorelik, Gabriela, Klecha, Alicia, Genaro, Ana María, Cremaschi, Graciela A

“…Regulation of cell proliferation by thyroid hormone (TH) has been demonstrated, but the effect of THs and the mechanisms involved in lymphocyte activity have…”
Get more information

Overexpression of X-Linked genes in T cells from women with lupus: Epigenetics: The Host and the immune response in autoimmunity by HEWAGAMA, Anura, GORELIK, Gabriela, PATEL, Dipak, LIYANARACHCHI, Punsisi, MCCUNE, W. Joseph, SOMERS, Emily, GONZALEZ-RIVERA, Tania, LUPUS COHORT, The Michigan, STRICKLAND, Faith, RICHARDSON, Bruce

Get full text