Search Results - "GORELICK, R. J"

Characterization of human immunodeficiency virus type 1 dimeric RNA from wild-type and protease-defective virions by FU, W, GORELICK, R. J, REIN, A

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Zinc Finger Structures in the Human Immunodeficiency Virus Type 1 Nucleocapsid Protein Facilitate Efficient Minus- and Plus-Strand Transfer by Guo, J, Wu, T, Anderson, J, Kane, B F, Johnson, D G, Gorelick, R J, Henderson, L E, Levin, J G

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Point Mutants of Moloney Murine Leukemia Virus that Fail to Package Viral RNA: Evidence for Specific RNA Recognition by a "Zinc Finger-Like" Protein Sequence by Gorelick, Robert J., Henderson, Louis E., Hanser, Janet P., Rein, Alan

“…All retroviruses encode a nucleic acid-binding or nucleocapsid protein that is believed to be associated with RNA in the virion. Further, all retroviral…”
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The two zinc fingers in the human immunodeficiency virus type 1 nucleocapsid protein are not functionally equivalent by GORELICK, R. J, CHABOT, D. J, REIN, A, HENDERSON, L. E, ARTHUR, L. O

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Noninfectious human immunodeficiency virus type 1 mutants deficient in genomic RNA by GORELICK, R. J, NIGIDA, S. M, BESS, J. W, ARTHUR, L. O, HENDERSON, L. E, REIN, A

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HIV-1 Nucleocapsid Protein Induces ``Maturation'' of Dimeric Retroviral RNA in vitro by Feng, Ya-Xiong, Copeland, Terry D., Henderson, Louis E., Gorelick, Robert J., Bosche, William J., Levin, Judith G., Rein, Alan

“…After a retrovirus particle is released from the cell, the dimeric genomic RNA undergoes a change in conformation. We have previously proposed that this…”
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Human immunodeficiency virus type 1 nucleocapsid protein reduces reverse transcriptase pausing at a secondary structure near the murine leukemia virus polypurine tract by Wu, W, Henderson, L E, Copeland, T D, Gorelick, R J, Bosche, W J, Rein, A, Levin, J G

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Vif is a RNA chaperone that could temporally regulate RNA dimerization and the early steps of HIV-1 reverse transcription by Henriet, S, Sinck, L, Bec, G, Gorelick, R.J, Marquet, R, Paillart, J.-C

“…HIV-1 Vif (viral infectivity factor) is associated with the assembly complexes and packaged at low level into the viral particles, and is essential for viral…”
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Evidence that a central domain of nucleocapsid protein is required for RNA packaging in murine leukemia virus by REIN, A, HARVIN, D. P, MIRRO, J, ERNST, S. M, GORELICK, R. J

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Genetic analysis of the zinc finger in the Moloney murine leukemia virus nucleocapsid domain: replacement of zinc-coordinating residues with other zinc-coordinating residues yields noninfectious particles containing genomic RNA by Gorelick, R J, Chabot, D J, Ott, D E, Gagliardi, T D, Rein, A, Henderson, L E, Arthur, L O

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Mechanistic Insights into the Kinetics of HIV-1 Nucleocapsid Protein-facilitated tRNA Annealing to the Primer Binding Site by Hargittai, Michele R.S., Gorelick, Robert J., Rouzina, Ioulia, Musier-Forsyth, Karin

“…HIV-1 reverse transcriptase uses human tRNALys,3 as a primer to initiate reverse transcription. Prior to initiation, the 3′ 18 nucleotides of this tRNA are…”
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Protection of Macaca nemestrina from Disease following Pathogenic Simian Immunodeficiency Virus (SIV) Challenge: Utilization of SIV Nucleocapsid Mutant DNA Vaccines with and without an SIV Protein Boost by Gorelick, R J, Benveniste, R E, Lifson, J D, Yovandich, J L, Morton, W R, Kuller, L, Flynn, B M, Fisher, B A, Rossio, J L, Piatak, Jr, M, Bess, Jr, J W, Henderson, L E, Arthur, L O

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Alteration of zinc-binding residues of simian immunodeficiency virus p8(NC) results in subtle differences in gag processing and virion maturation associated with degradative loss of mutant NC by Yovandich, J L, Chertova, E N, Kane, B P, Gagliardi, T D, Bess, Jr, J W, Sowder, 2nd, R C, Henderson, L E, Gorelick, R J

“…In all retroviruses analyzed to date (except for the spumaretroviruses), the Zn(2+)-coordinating residues of nucleocapsid (NC) perform or assist in crucial…”
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Placement of tRNA primer on the primer-binding site requires pol gene expression in avian but not murine retroviruses by Fu, W. (Veterans Administration Medical Center, Washington, DC.), Ortiz-Conde, B.A, Gorelick, R.J, Hughes, S.H, Rein, A

“…In an early step in the retroviral infectious process, reverse transcriptase copies the genomic RNA of the virus into complementary minus-strand DNA. The…”
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Wild-type and mutant HIV type 1 nucleocapsid proteins increase the proportion of long cDNA transcripts by viral reverse transcriptase by Drummond, J E, Mounts, P, Gorelick, R J, Casas-Finet, J R, Bosche, W J, Henderson, L E, Waters, D J, Arthur, L O

“…HIV-1 nucleocapsid, p7, contains two retroviral zinc fingers, which are both necessary for efficient packaging of genomic RNA and infectivity. The nucleocapsid…”
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Structural Determinants of HIV-1 Nucleocapsid Protein for cTAR DNA Binding and Destabilization, and Correlation with Inhibition of Self-primed DNA Synthesis by Beltz, Hervé, Clauss, Céline, Piémont, Etienne, Ficheux, Damien, Gorelick, Robert J., Roques, Bernard, Gabus, Caroline, Darlix, Jean-Luc, de Rocquigny, Hugues, Mély, Yves

“…The nucleocapsid protein (NC) of human immunodeficiency virus type 1 (HIV-1) is formed of two highly conserved CCHC zinc fingers flanked by small basic…”
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Specific Zinc-Finger Architecture Required for HIV-1 Nucleocapsid Protein's Nucleic Acid Chaperone Function by Williams, Mark C., Gorelick, Robert J., Musier-Forsyth, Karin

“…The nucleocapsid protein (NC) of HIV type 1 (HIV-1) is a nucleic acid chaperone that facilitates the rearrangement of nucleic acid secondary structure during…”
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Mechanism for Nucleic Acid Chaperone Activity of HIV-1 Nucleocapsid Protein Revealed by Single Molecule Stretching by Williams, Mark C., Rouzina, Ioulia, Wenner, Jay R., Gorelick, Robert J., Musier-Forsyth, Karin, Bloomfield, Victor A.

“…The nucleocapsid protein (NC) of HIV type 1 is a nucleic acid chaperone that facilitates the rearrangement of nucleic acids into conformations containing the…”
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Coupled Integration of Human Immunodeficiency Virus Type 1 cDNA Ends by Purified Integrase In Vitro: Stimulation by the Viral Nucleocapsid Protein by Carteau, S, Gorelick, R J, Bushman, F D

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Amino Acid Substitutions in Gag Protein at Non-cleavage Sites Are Indispensable for the Development of a High Multitude of HIV-1 Resistance against Protease Inhibitors by Gatanaga, Hiroyuki, Suzuki, Yasuhiro, Tsang, Hsinyi, Yoshimura, Kazuhisa, Kavlick, Mark F., Nagashima, Kunio, Gorelick, Robert J., Mardy, Sek, Tang, Chun, Summers, Michael F., Mitsuya, Hiroaki

“…Amino acid substitutions in human immunodeficiency virus type 1 (HIV-1) Gag cleavage sites have been identified in HIV-1 isolated from patients with AIDS…”
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