Search Results - "GORDEN, Phillip"

Partial and Generalized Lipodystrophy: Comparison of Baseline Characteristics and Response to Metreleptin by Diker-Cohen, Talia, Cochran, Elaine, Gorden, Phillip, Brown, Rebecca J

“…Context: Lipodystrophies are extreme forms of metabolic syndrome. Metreleptin was approved in the United States for generalized lipodystrophy (GLD) but not…”
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The liver diseases of lipodystrophy: The long-term effect of leptin treatment by Safar Zadeh, Elika, Lungu, Andreea O, Cochran, Elaine K, Brown, Rebecca J, Ghany, Marc G, Heller, Theo, Kleiner, David E, Gorden, Phillip

“…Background & Aims Lipodystrophies are hypoleptinemic conditions characterized by fat loss, severe insulin resistance, hypertriglyceridemia, and ectopic fat…”
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Mutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver disease by Payne, Felicity, Lim, Koini, Girousse, Amandine, Brown, Rebecca J., Kory, Nora, Robbins, Ann, Xue, Yali, Sleigh, Alison, Cochran, Elaine, Adams, Claire, Borman, Arundhati Dev, Russel-Jones, David, Gorden, Phillip, Semple, Robert K., Saudek, Vladimir, O'Rahilly, Stephen, Walther, Tobias C., Barroso, Inês, Savage, David B.

“…Phosphatidylcholine (PC) is the major glycerophospholipid in eukaryotic cells and is an essential component in all cellular membranes. The biochemistry of de…”
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Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis by Semple, Robert K, Sleigh, Alison, Murgatroyd, Peter R, Adams, Claire A, Bluck, Les, Jackson, Sarah, Vottero, Alessandra, Kanabar, Dipak, Charlton-Menys, Valentine, Durrington, Paul, Soos, Maria A, Carpenter, T Adrian, Lomas, David J, Cochran, Elaine K, Gorden, Phillip, O'Rahilly, Stephen, Savage, David B

“…Metabolic dyslipidemia is characterized by high circulating triglyceride (TG) and low HDL cholesterol levels and is frequently accompanied by hepatic…”
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Localization of Insulinomas to Regions of the Pancreas by Intraarterial Calcium Stimulation: The NIH Experience by Guettier, Jean-Marc, Kam, Anthony, Chang, Richard, Skarulis, Monica C., Cochran, Craig, Alexander, H. Richard, Libutti, Steven K., Pingpank, James F., Gorden, Phillip

“…Context: Selective intraarterial calcium injection of the major pancreatic arteries with hepatic venous sampling [calcium arterial stimulation (CaStim)] has…”
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Insulinoma: pathophysiology, localization and management by Shin, Joyce J, Gorden, Phillip, Libutti, Steven K

“…Insulinoma is a rare neuroendocrine tumor that causes oversecretion of insulin and, as a result, patients present with symptoms of hypoglycemia. Fortunately,…”
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Long-Term Efficacy of Leptin Replacement in Patients With Generalized Lipodystrophy by JAVOR, Edward D, COCHRAN, Elaine K, MUSSO, Carla, YOUNG, Janice Ryan, DEPAOLI, Alex M, GORDEN, Phillip

“…Long-Term Efficacy of Leptin Replacement in Patients With Generalized Lipodystrophy Edward D. Javor 1 , Elaine K. Cochran 1 , Carla Musso 1 , Janice Ryan Young…”
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Plasma Adiponectin as a Marker of Insulin Receptor Dysfunction by Semple, Robert K., Cochran, Elaine K., Soos, Maria A., Burling, Keith A., Savage, David B., Gorden, Phillip, O'Rahilly, Stephen

“…Plasma Adiponectin as a Marker of Insulin Receptor Dysfunction Clinical utility in severe insulin resistance Robert K. Semple , MB, PHD 1 , Elaine K. Cochran ,…”
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Incidence and management of postoperative hyperglycemia in patients undergoing insulinoma resection by Nockel, Pavel, Tirosh, Amit, El Lakis, Mustapha, Gaitanidis, Apostolos, Merkel, Roxanne, Patel, Dhaval, Nilubol, Naris, Sadowski, Samira M., Cochran, Craig, Gorden, Phillip, Kebebew, Electron

“…Purpose It has been proposed that rebound hyperglycemia after resection of insulinoma indicates a biochemical cure. However, there is scant objective data in…”
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Effects of Recombinant Human Leptin (Metreleptin) on Nocturnal Luteinizing Hormone Secretion in Lipodystrophy Patients by Abel, Brent S, Muniyappa, Ranganath, Stratton, Pamela, Skarulis, Monica C, Gorden, Phillip, Brown, Rebecca J

“…Leptin replacement in patients with leptin gene mutations improves hypogonadotropic hypogonadism. The effects of leptin replacement on luteinizing hormone (LH)…”
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The global burden of lipodystrophy, a rare disease by Meehan, Cristina A., Cochran, Elaine, Gorden, Phillip, Brown, Rebecca J.

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Localization of Insulinoma Using 68Ga-DOTATATE PET/CT Scan by Nockel, Pavel, Babic, Bruna, Millo, Corina, Herscovitch, Peter, Patel, Dhaval, Nilubol, Naris, Sadowski, Samira, Cochran, Craig, Gorden, Phillip, Kebebew, Electron

“…Context:The reliable localization of insulinoma is critical for the successful surgical treatment.Objective:This study compared the accuracy of 68Gallium…”
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Phenotypic and Genetic Heterogeneity in Congenital Generalized Lipodystrophy by Agarwal, Anil K., Simha, Vinaya, Oral, Elif Arioglu, Moran, Stephanie A., Gorden, Phillip, O’Rahilly, Stephen, Zaidi, Zohra, Gurakan, Figen, Arslanian, Silva A., Klar, Aharon, Ricker, Alyne, White, Neil H., Bindl, Lutz, Herbst, Karen, Kennel, Kurt, Patel, Shailesh B., Al-Gazali, Lihadh, Garg, Abhimanyu

“…Congenital generalized lipodystrophy (CGL) is a rare autosomal recessive disorder characterized by near complete absence of adipose tissue from birth…”
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Paradoxical Elevation of High–Molecular Weight Adiponectin in Acquired Extreme Insulin Resistance Due to Insulin Receptor Antibodies by Semple, Robert K, Halberg, Nils H, Burling, Keith, Soos, Maria A, Schraw, Todd, Luan, Jian'an, Cochran, Elaine K, Dunger, David B, Wareham, Nicholas J, Scherer, Philipp E, Gorden, Phillip, O'Rahilly, Stephen

“…Paradoxical Elevation of High–Molecular Weight Adiponectin in Acquired Extreme Insulin Resistance Due to Insulin Receptor Antibodies Robert K. Semple 1 , Nils…”
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JCL roundtable: Diagnosis and clinical management of lipodystrophy by Brown, William Virgil, MD, Garg, Abhimanyu, MD, Gorden, Phillip, MD, Shamburek, Robert, MD

“…Abstract Lipodystrophy comes in several forms, some involving the complete failure to develop adipose tissue and others with a partial absence in various…”
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Efficacy of Recombinant Methionyl Human Leptin Therapy for the Extreme Insulin Resistance of the Rabson-Mendenhall Syndrome by Cochran, Elaine, Young, Janice Ryan, Sebring, Nancy, DePaoli, Alex, Oral, Elif Arioglu, Gorden, Phillip

“…Recombinant methionyl human leptin (r-metHuLeptin) therapy has shown clear efficacy in the treatment of severe insulin resistance associated with lipodystrophy…”
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Spectrum of Renal Diseases Associated with Extreme Forms of Insulin Resistance by Musso, Carla, Javor, Edward, Cochran, Elaine, Balow, James E, Gorden, Phillip

“…Diabetic nephropathy is the leading cause of ESRD in the United States. Why the pathogenic mechanisms lead to nephropathy in certain patients with type 1 and 2…”
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The long-term effect of recombinant methionyl human leptin therapy on hyperandrogenism and menstrual function in female and pituitary function in male and female hypoleptinemic lipodystrophic patients by Musso, Carla, Cochran, Elaine, Javor, Edward, Young, Janice, DePaoli, Alex M., Gorden, Phillip

“…Lipodystrophy patients are hypoleptinemic and insulin resistant. Women have enlarged polycystic ovaries, hyperandrogenism, and amenorrhea. We have determined…”
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Other Antibodies Resulting in Diabetes Mellitus: Type B Insulin Resistance and Insulin Autoimmune Syndrome by Cochran, Elaine, Brown, Rebecca J., Gorden, Phillip

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Adipose-derived circulating miRNAs regulate gene expression in other tissues by Thomou, Thomas, Mori, Marcelo A., Dreyfuss, Jonathan M., Konishi, Masahiro, Sakaguchi, Masaji, Wolfrum, Christian, Rao, Tata Nageswara, Winnay, Jonathon N., Garcia-Martin, Ruben, Grinspoon, Steven K., Gorden, Phillip, Kahn, C. Ronald

“…Adipose tissue is a major site of energy storage and has a role in the regulation of metabolism through the release of adipokines. Here we show that mice with…”
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