Search Results - "GOODMAN, L"
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Separating host and microbiome contributions to drug pharmacokinetics and toxicity
Published in Science (American Association for the Advancement of Science) (08-02-2019)“…The gut microbiota is implicated in the metabolism of many medical drugs, with consequences for interpersonal variation in drug efficacy and toxicity. However,…”
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Vitamin B12 as a Modulator of Gut Microbial Ecology
Published in Cell metabolism (04-11-2014)“…The microbial mechanisms and key metabolites that shape the composition of the human gut microbiota are largely unknown, impeding efforts to manipulate…”
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Vaccine side-effects and SARS-CoV-2 infection after vaccination in users of the COVID Symptom Study app in the UK: a prospective observational study
Published in The Lancet infectious diseases (01-07-2021)“…The Pfizer-BioNTech (BNT162b2) and the Oxford-AstraZeneca (ChAdOx1 nCoV-19) COVID-19 vaccines have shown excellent safety and efficacy in phase 3 trials. We…”
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Minireview: Kisspeptin/Neurokinin B/Dynorphin (KNDy) Cells of the Arcuate Nucleus: A Central Node in the Control of Gonadotropin-Releasing Hormone Secretion
Published in Endocrinology (Philadelphia) (01-08-2010)“…Recently, a subset of neurons was identified in the arcuate nucleus of the hypothalamus that colocalize three neuropeptides, kisspeptin, neurokinin B, and…”
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Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels
Published in Nature communications (18-05-2020)“…Gut microbes are linked to host metabolism, but specific mechanisms remain to be uncovered. Ceramides, a type of sphingolipid (SL), have been implicated in the…”
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The Long-Term Stability of the Human Gut Microbiota
Published in Science (American Association for the Advancement of Science) (05-07-2013)“…A low-error 16S ribosomal RNA amplicon sequencing method, in combination with whole-genome sequencing of >500 cultured isolates, was used to characterize…”
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Mechanisms of Toll-like Receptor 4 Endocytosis Reveal a Common Immune-Evasion Strategy Used by Pathogenic and Commensal Bacteria
Published in Immunity (Cambridge, Mass.) (17-11-2015)“…Microbe-induced receptor trafficking has emerged as an essential means to promote innate immune signal transduction. Upon detection of bacterial…”
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Uterine transplant: from imagination to implementation
Published in BJOG : an international journal of obstetrics and gynaecology (01-10-2019)Get full text
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Human nutrition, the gut microbiome and the immune system
Published in Nature (London) (16-06-2011)“…Marked changes in socio-economic status, cultural traditions, population growth and agriculture are affecting diets worldwide. Understanding how our diet and…”
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Neuroendocrine control of gonadotropin‐releasing hormone: Pulsatile and surge modes of secretion
Published in Journal of neuroendocrinology (01-05-2022)“…The concept that different systems control episodic and surge secretion of gonadotropin‐releasing hormone (GnRH) was well established by the time that GnRH was…”
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Translocation of a gut pathobiont drives autoimmunity in mice and humans
Published in Science (American Association for the Advancement of Science) (09-03-2018)“…Despite multiple associations between the microbiota and immune diseases, their role in autoimmunity is poorly understood. We found that translocation of a gut…”
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The antibody horror show: an introductory guide for the perplexed
Published in New biotechnology (25-10-2018)“…•Commercial antibodies are vital to biological research but still trouble users.•Unique identifiability of antibody and supplier, and batch validation are…”
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B vitamin acquisition by gut commensal bacteria
Published in PLoS pathogens (01-01-2020)“…About the Authors: Emily E. Putnam Affiliation: Department of Microbial Pathogenesis and Microbial Sciences Institute, Yale University School of Medicine, New…”
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FlyBase: introduction of the Drosophila melanogaster Release 6 reference genome assembly and large-scale migration of genome annotations
Published in Nucleic acids research (28-01-2015)“…Release 6, the latest reference genome assembly of the fruit fly Drosophila melanogaster, was released by the Berkeley Drosophila Genome Project in 2014; it…”
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FlyBase: updates to the Drosophila melanogaster knowledge base
Published in Nucleic acids research (08-01-2021)“…Abstract FlyBase (flybase.org) is an essential online database for researchers using Drosophila melanogaster as a model organism, facilitating access to a…”
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Carbapenem and colistin resistance in Enterobacteriaceae in Southeast Asia: Review and mapping of emerging and overlapping challenges
Published in International journal of antimicrobial agents (01-10-2019)“…•Data from 258 studies on carbapenem and polymyxin resistance in Southeast Asia were analysed.•Carbapenem-resistant E. coli and Klebsiella were reported in 8…”
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Antimicrobial peptide resistance mediates resilience of prominent gut commensals during inflammation
Published in Science (American Association for the Advancement of Science) (09-01-2015)“…Resilience to host inflammation and other perturbations is a fundamental property of gut microbial communities, yet the underlying mechanisms are not well…”
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Metabolic and fitness determinants for in vitro growth and intestinal colonization of the bacterial pathogen Campylobacter jejuni
Published in PLoS biology (19-05-2017)“…Campylobacter jejuni is one of the leading infectious causes of food-borne illness around the world. Its ability to persistently colonize the intestinal tract…”
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Extensive personal human gut microbiota culture collections characterized and manipulated in gnotobiotic mice
Published in Proceedings of the National Academy of Sciences - PNAS (12-04-2011)“…The proportion of the human gut bacterial community that is recalcitrant to culture remains poorly defined. In this report, we combine high-throughput…”
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