Search Results - "GOODMAN, Craig"

Role of mTORC1 in mechanically induced increases in translation and skeletal muscle mass by Goodman, Craig A

“…Skeletal muscle mass is, in part, regulated by the rate of mRNA translation (i.e., protein synthesis). The conserved serine/threonine kinase, mTOR (the…”
Get full text

Rapamycin Affects Palmitate-Induced Lipotoxicity in Osteoblasts by Modulating Apoptosis and Autophagy by Al Saedi, Ahmed, A. Goodman, Craig, E. Myers, Damian, Hayes, Alan, Duque, Gustavo

“…Abstract Bone marrow fat infiltration is one of the hallmarks of aging and osteoporotic bones. Marrow adipocytes produce substantial amounts of palmitic acid…”
Get full text

The role of mTORC1 in regulating protein synthesis and skeletal muscle mass in response to various mechanical stimuli by Goodman, Craig A

“…Skeletal muscle plays a fundamental role in mobility, disease prevention, and quality of life. Skeletal muscle mass is, in part, determined by the rates of…”
Get more information

More is more? rDNA gene dosage is correlated with resistance exercise‐induced ribosome biogenesis by Goodman, Craig A.

Get full text

The role of raptor in the mechanical load‐induced regulation of mTOR signaling, protein synthesis, and skeletal muscle hypertrophy by You, Jae-Sung, Mcnally, Rachel M., Jacobs, Brittany L., Privett, Rachel E., Gundermann, David M., Lin, Kuan-Hung, Steinert, Nate D., Goodman, Craig A., Hornberger, Troy A.

“…ABSTRACT It is well known that an increase in mechanical loading can induce skeletal muscle hypertrophy, and a long standing model in the field indicates that…”
Get full text

PGC‐1α overexpression by in vivo transfection attenuates mitochondrial deterioration of skeletal muscle caused by immobilization by Kang, Chounghun, Goodman, Craig A., Hornberger, Troy A., Ji, Li Li

“…ABSTRACT Prolonged immobilization (IM) causes skeletal muscle atrophy characterized by mitochondrial deterioration and proteolysis. Muscle remobilization (RM)…”
Get full text

Measuring protein synthesis with SUnSET: a valid alternative to traditional techniques? by Goodman, Craig A, Hornberger, Troy A

“…Protein synthesis rates commonly are measured using isotopic tracers to quantify the incorporation of a labeled amino acid into muscle proteins. Here we…”
Get full text

Chemotherapy-Induced Myopathy: The Dark Side of the Cachexia Sphere by Campelj, Dean G., Goodman, Craig A., Rybalka, Emma

“…Cancer cachexia is a debilitating multi-factorial wasting syndrome characterised by severe skeletal muscle wasting and dysfunction (i.e., myopathy). In the…”
Get full text

Novel insights into the regulation of skeletal muscle protein synthesis as revealed by a new nonradioactive in vivo technique by Goodman, Craig A, Mabrey, Danielle M, Frey, John W, Miu, Man Hing, Schmidt, Enrico K, Pierre, Philippe, Hornberger, Troy A

“…In this study, the principles of surface sensing of translation (SUnSET) were used to develop a nonradioactive method for ex vivo and in vivo measurements of…”
Get full text

The role of skeletal muscle mTOR in the regulation of mechanical load‐induced growth by Goodman, Craig A., Frey, John W., Mabrey, Danielle M., Jacobs, Brittany L., Lincoln, Hannah C., You, Jae‐Sung, Hornberger, Troy A.

“…Non‐Technical Summary  Chronic mechanical loading (CML) of skeletal muscle induces growth and this effect can be blocked by the drug rapamycin. Rapamycin is…”
Get full text

The Hippo Signaling Pathway in the Regulation of Skeletal Muscle Mass and Function by Watt, Kevin I, Goodman, Craig A, Hornberger, Troy A, Gregorevic, Paul

“…The Hippo signaling pathway regulates the activity of the proteins Yes-associated protein (Yap) and transcriptional co-activator with PDZ-binding motif (Taz)…”
Get full text

A critical discussion on the relationship between E3 ubiquitin ligases, protein degradation, and skeletal muscle wasting: it's not that simple by Hughes, David C, Goodman, Craig A, Baehr, Leslie M, Gregorevic, Paul, Bodine, Sue C

“…Ubiquitination is an important post-translational modification (PTM) for protein substrates, whereby ubiquitin is added to proteins through the coordinated…”
Get more information

CORP: Gene delivery into murine skeletal muscle using in vivo electroporation by Hughes, David C, Hardee, Justin P, Waddell, David S, Goodman, Craig A

“…The strategy of gene delivery into skeletal muscles has provided exciting avenues in identifying new potential therapeutics toward muscular disorders and…”
Get full text

Smad3 Induces Atrogin-1, Inhibits mTOR and Protein Synthesis, and Promotes Muscle Atrophy In Vivo by Goodman, Craig A, McNally, Rachel M, Hoffmann, F. Michael, Hornberger, Troy A

“…Myostatin, a member of the TGF superfamily, is sufficient to induce skeletal muscle atrophy. Myostatin-induced atrophy is associated with increases in…”
Get full text

Role of oxidative stress in oxaliplatin‐induced enteric neuropathy and colonic dysmotility in mice by McQuade, Rachel M, Carbone, Simona E, Stojanovska, Vanesa, Rahman, Ahmed, Gwynne, Rachel M, Robinson, Ainsley M, Goodman, Craig A, Bornstein, Joel C, Nurgali, Kulmira

“…Background and Purpose Oxaliplatin is a platinum‐based chemotherapeutic drug used as a first‐line therapy for colorectal cancer. However, its use is associated…”
Get full text

Recent progress toward understanding the molecular mechanisms that regulate skeletal muscle mass by Goodman, Craig A., Mayhew, David L., Hornberger, Troy A.

“…The maintenance of muscle mass is critical for health and issues associated with the quality of life. Over the last decade, extensive progress has been made…”
Get full text

Resistance Exercise-Induced Hypertrophy: A Potential Role for Rapamycin-Insensitive mTOR by Ogasawara, Riki, Jensen, Thomas E, Goodman, Craig A, Hornberger, Troy A

“…The mechanistic target of rapamycin (mTOR) exerts both rapamycin-sensitive and rapamycin-insensitive signaling events, and the rapamycin-sensitive components…”
Get full text

Yes-Associated Protein is up-regulated by mechanical overload and is sufficient to induce skeletal muscle hypertrophy by Goodman, Craig A., Dietz, Jason M., Jacobs, Brittany L., McNally, Rachel M., You, Jae-Sung, Hornberger, Troy A.

“…•We examined YAP protein expression and mTORC1 activation in overloaded muscles.•We also examined the effect of transient YAP overexpression on muscle fiber…”
Get full text

Detecting the vitamin D receptor (VDR) protein in mouse and human skeletal muscle: Strain-specific, species-specific and inter-individual variation by Lalunio, Hannah, Parker, Lewan, Hanson, Erik D., Gregorevic, Paul, Levinger, Itamar, Hayes, Alan, Goodman, Craig A.

“…Vitamin D, and its receptor (VDR), play roles in muscle development/function, however, VDR detection in muscle has been controversial. Using different sample…”
Get full text

FKBP25 regulates myoblast viability and migration and is differentially expressed in in vivo models of muscle adaptation by Cree, Tabitha, Gomez, Tania Ruz, Timpani, Cara A, Rybalka, Emma, Price, John T, Goodman, Craig A

“…FKBP25 (FKBP3 gene) is a dual-domain PPIase protein that consists of a C-terminal PPIase domain and an N-terminal basic tilted helix bundle (BTHB). The PPIase…”
Get full text