Search Results - "GOODHEART, MICHAEL J."

Using Genomic Variation to Distinguish Ovarian High-Grade Serous Carcinoma from Benign Fallopian Tubes by Gonzalez-Bosquet, Jesus, Cardillo, Nicholas D, Reyes, Henry D, Smith, Brian J, Leslie, Kimberly K, Bender, David P, Goodheart, Michael J, Devor, Eric J

“…The preoperative diagnosis of pelvic masses has been elusive to date. Methods for characterization such as CA-125 have had limited specificity. We hypothesize…”
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Biobehavioral modulation of the exosome transcriptome in ovarian carcinoma by Lutgendorf, Susan K., Thaker, Premal H., Arevalo, Jesusa M., Goodheart, Michael J., Slavich, George M., Sood, Anil K., Cole, Steve W.

“…BACKGROUND Social factors in the patient macroenvironment have been shown to influence molecular events in the tumor microenvironment and thereby influence…”
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Integration of Genomic and Clinical Retrospective Data to Predict Endometrioid Endometrial Cancer Recurrence by Gonzalez-Bosquet, Jesus, Gabrilovich, Sofia, McDonald, Megan E, Smith, Brian J, Leslie, Kimberly K, Bender, David D, Goodheart, Michael J, Devor, Eric

“…Endometrial cancer (EC) incidence and mortality continues to rise. Molecular profiling of EC promises improvement of risk assessment and treatment selection…”
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Identification of Novel Fusion Transcripts in High Grade Serous Ovarian Cancer by Newtson, Andreea, Reyes, Henry, Devor, Eric J, Goodheart, Michael J, Bosquet, Jesus Gonzalez

“…Fusion genes are structural chromosomal rearrangements resulting in the exchange of DNA sequences between genes. This results in the formation of a new…”
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Social Influences on Clinical Outcomes of Patients With Ovarian Cancer by Lutgendorf, Susan K, De Geest, Koen, Bender, David, Ahmed, Amina, Goodheart, Michael J, Dahmoush, Laila, Zimmerman, M Bridget, Penedo, Frank J, Lucci, 3rd, Joseph A, Ganjei-Azar, Parvin, Thaker, Premal H, Mendez, Luis, Lubaroff, David M, Slavich, George M, Cole, Steven W, Sood, Anil K

“…Previous research has demonstrated relationships of social support with disease-related biomarkers in patients with ovarian cancer. However, the clinical…”
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Robotic surgery in supermorbidly obese patients with endometrial cancer by Stephan, Jean-Marie, MD, Goodheart, Michael J., MD, McDonald, Megan, MD, Hansen, Jean, DO, Reyes, Henry D., MD, Button, Anna, MS, Bender, David, MD

“…Objective Morbid obesity is a known risk factor for the development of endometrial cancer. Several studies have demonstrated the overall feasibility of…”
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Identification of Novel lncRNAs in Ovarian Cancer and Their Impact on Overall Survival by Cardillo, Nicholas, Russo, Douglas, Newtson, Andreea, Reyes, Henry, Lyons, Yasmin, Devor, Eric, Bender, David, Goodheart, Michael J, Gonzalez-Bosquet, Jesus

“…Long non-coding RNA's (lncRNA) are RNA sequences that do not encode proteins and are greater than 200 nucleotides in length. They regulate complex cellular…”
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Creation and validation of models to predict response to primary treatment in serous ovarian cancer by Gonzalez Bosquet, Jesus, Devor, Eric J., Newtson, Andreea M., Smith, Brian J., Bender, David P., Goodheart, Michael J., McDonald, Megan E., Braun, Terry A., Thiel, Kristina W., Leslie, Kimberly K.

“…Nearly a third of patients with high-grade serous ovarian cancer (HGSC) do not respond to initial therapy and have an overall poor prognosis. However, there…”
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Mitochondria in epithelial ovarian carcinoma exhibit abnormal phenotypes and blunted associations with biobehavioral factors by Bindra, Snehal, McGill, Marlon A., Triplett, Marina K., Tyagi, Anisha, Thaker, Premal H., Dahmoush, Laila, Goodheart, Michael J., Ogden, R. Todd, Owusu-Ansah, Edward, R Karan, Kalpita, Cole, Steve, Sood, Anil K., Lutgendorf, Susan K., Picard, Martin

“…Malignant tumor cells exhibit mitochondrial alterations and are also influenced by biobehavioral processes, but the intersection of biobehavioral factors and…”
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Wnt Signaling Regulates Airway Epithelial Stem Cells in Adult Murine Submucosal Glands by Lynch, Thomas J., Anderson, Preston J., Xie, Weiliang, Crooke, Adrianne K., Liu, Xiaoming, Tyler, Scott R., Luo, Meihui, Kusner, David M., Zhang, Yulong, Neff, Traci, Burnette, Daniel C., Walters, Katherine S., Goodheart, Michael J., Parekh, Kalpaj R., Engelhardt, John F.

“…Wnt signaling is required for lineage commitment of glandular stem cells (SCs) during tracheal submucosal gland (SMG) morphogenesis from the surface airway…”
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The role of LEF1 in endometrial gland formation and carcinogenesis by Shelton, Dawne N, Fornalik, Hubert, Neff, Traci, Park, Soo Yeun, Bender, David, DeGeest, Koen, Liu, Xiaoming, Xie, Weiliang, Meyerholz, David K, Engelhardt, John F, Goodheart, Michael J

“…Endometrial carcinoma is the most common gynecologic cancer, yet the mechanisms underlying this disease process are poorly understood. We hypothesized that…”
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Molecular Characterization of Non-responders to Chemotherapy in Serous Ovarian Cancer by McDonald, Megan E, Salinas, Erin A, Devor, Eric J, Newtson, Andreea M, Thiel, Kristina W, Goodheart, Michael J, Bender, David P, Smith, Brian J, Leslie, Kimberly K, Gonzalez-Bosquet, Jesus

“…Nearly one-third of patients with high-grade serous ovarian cancer (HGSC) do not respond to initial treatment with platinum-based therapy. Genomic and clinical…”
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Population Substructure Has Implications in Validating Next-Generation Cancer Genomics Studies with TCGA by Miller, Marina D, Devor, Eric J, Salinas, Erin A, Newtson, Andreea M, Goodheart, Michael J, Leslie, Kimberly K, Gonzalez-Bosquet, Jesus

“…In the era of large genetic and genomic datasets, it has become crucially important to validate results of individual studies using data from publicly…”
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p53 mutation status is a primary determinant of placenta-specific protein 1 expression in serous ovarian cancers by Devor, Eric J, Gonzalez-Bosquet, Jesus, Warrier, Akshaya, Reyes, Henry D, Ibik, Nonye V, Schickling, Brandon M, Newtson, Andreea, Goodheart, Michael J, Leslie, Kimberly K

“…Placenta-specific protein 1 (PLAC1) expression is co-opted in numerous human cancers. As a consequence of PLAC1 expression, tumor cells exhibit enhanced…”
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A Prediction Model for Preoperative Risk Assessment in Endometrial Cancer Utilizing Clinical and Molecular Variables by Salinas, Erin A, Miller, Marina D, Newtson, Andreea M, Sharma, Deepti, McDonald, Megan E, Keeney, Matthew E, Smith, Brian J, Bender, David P, Goodheart, Michael J, Thiel, Kristina W, Devor, Eric J, Leslie, Kimberly K, Gonzalez Bosquet, Jesus

“…The utility of comprehensive surgical staging in patients with low risk disease has been questioned. Thus, a reliable means of determining risk would be quite…”
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Cullin-5, a ubiquitin ligase scaffold protein, is significantly underexpressed in endometrial adenocarcinomas and is a target of miR-182 by DEVOR, ERIC J, SCHICKLING, BRANDON M, REYES, HENRY D, WARRIER, AKSHAYA, LINDSAY, BRITTANY, GOODHEART, MICHAEL J, SANTILLAN, DONNA A, LESLIE, KIMBERLY K

“…Altered expression of cullin-5 (CUL5), a member of the cullin-RING E3 ubiquitin ligase family, has been implicated in a number of types of cancers including…”
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In situ profiling reveals metabolic alterations in the tumor microenvironment of ovarian cancer after chemotherapy by Corvigno, Sara, Badal, Sunil, Spradlin, Meredith L., Keating, Michael, Pereira, Igor, Stur, Elaine, Bayraktar, Emine, Foster, Katherine I., Bateman, Nicholas W., Barakat, Waleed, Darcy, Kathleen M., Conrads, Thomas P., Maxwell, G. Larry, Lorenzi, Philip L., Lutgendorf, Susan K., Wen, Yunfei, Zhao, Li, Thaker, Premal H., Goodheart, Michael J., Liu, Jinsong, Fleming, Nicole, Lee, Sanghoon, Eberlin, Livia S., Sood, Anil K.

“…In this study, we investigated the metabolic alterations associated with clinical response to chemotherapy in patients with ovarian cancer. Pre- and…”
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CGRP induction in cystic fibrosis airways alters the submucosal gland progenitor cell niche in mice by Xie, Weiliang, Fisher, John T, Lynch, Thomas J, Luo, Meihui, Evans, Turan I A, Neff, Traci L, Zhou, Weihong, Zhang, Yulong, Ou, Yi, Bunnett, Nigel W, Russo, Andrew F, Goodheart, Michael J, Parekh, Kalpaj R, Liu, Xiaoming, Engelhardt, John F

“…In cystic fibrosis (CF), a lack of functional CF transmembrane conductance regulator (CFTR) chloride channels causes defective secretion by submucosal glands…”
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Uterine Clostridium perfringens infection related to gynecologic malignancy by Kremer, Kevin M., McDonald, Megan E., Goodheart, Michael J.

“…Uterine gas gangrene caused by Clostridium perfringens is a serious, often life-threatening infection that is rarely encountered in the practice of gynecologic…”
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Endometrial Cancer by Leslie, Kimberly K., MD, Thiel, Kristina W., PhD, Goodheart, Michael J., MD, De Geest, Koen, MD, Jia, Yichen, Yang, Shujie, PhD

“…Despite the questions and barriers, the incorporation of molecular therapy into treatment regimens in endometrial cancer is an exciting area of investigation…”
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