Search Results - "GOODFRIEND, THEODORE L"

Epoxy-Keto Derivative of Linoleic Acid Stimulates Aldosterone Secretion by Goodfriend, Theodore L, Ball, Dennis L, Egan, Brent M, Campbell, William B, Nithipatikom, Kasem

“…ABSTRACT—Plasma levels of aldosterone are not always predictable from the activity of renin and the concentration of potassium. Among the unexplained are…”
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DASH Diet Lowers Blood Pressure and Lipid-Induced Oxidative Stress in Obesity by Lopes, Heno F, Martin, Kelley L, Nashar, Khaled, Morrow, Jason D, Goodfriend, Theodore L, Egan, Brent M

“…ABSTRACT—Evidence suggests that obesity may raise blood pressure (BP) through oxidative stress–sensitive mechanisms and that the Dietary Approaches to Stop…”
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Activation of the antioxidant response element by specific oxidized metabolites of linoleic acid by Wang, Rui, Kern, Jonathan T, Goodfriend, Theodore L, Ball, Dennis L, Luesch, Hendrik

“…Abstract Linoleic acid is required for normal mammalian health and development, but is also prone to oxidation, yielding metabolites with biological effects…”
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Aldosterone and aldosterone: renin ratio associations with insulin resistance and blood pressure in African Americans by Huan, Yonghong, Deloach, Stephanie, Keith, Scott W, Goodfriend, Theodore L, Falkner, Bonita

“…African Americans have more hypertension and hypertension-related morbidity than whites. Aldosterone, in presence of a high salt intake, contributes to…”
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Aldosterone—A Hormone of Cardiovascular Adaptation and Maladaptation by Goodfriend, Theodore L.

“…Aldosterone stimulates reabsorption of sodium, sustaining blood volume and pressure in the face of salt deprivation or extracellular fluid depletion. The…”
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Increasing plasma fatty acids elevates F2-isoprostanes in humans: implications for the cardiovascular risk factor cluster by Stojiljkovic, Milos P, Lopes, Heno F, Zhang, Da, Morrow, Jason D, Goodfriend, Theodore L, Egan, Brent M

“…OBJECTIVE To determine whether raised concentrations of non-esterified fatty acids (NEFAs) may contribute to the cardiovascular risk factor cluster by…”
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Hemodynamic effects of lipids in humans by Stojiljkovic, M P, Zhang, D, Lopes, H F, Lee, C G, Goodfriend, T L, Egan, B M

“…Evidence suggests lipid abnormalities may contribute to elevated blood pressure, increased vascular resistance, and reduced arterial compliance among…”
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Resistant Hypertension, Obesity, Sleep Apnea, and Aldosterone: Theory and Therapy by Goodfriend, Theodore L, Calhoun, David A

“…ABSTRACT—Hypertension resistant to 2 antihypertensive drugs is more common among obese patients than among lean patients. The case we describe and the…”
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Experimentally induced gestational androgen excess disrupts glucoregulation in rhesus monkey dams and their female offspring by Abbott, David H, Bruns, Cristin R, Barnett, Deborah K, Dunaif, Andrea, Goodfriend, Theodore L, Dumesic, Daniel A, Tarantal, Alice F

“…Discrete fetal androgen excess during early gestation in rhesus monkeys (Macaca mulatta) promotes endocrine antecedents of adult polycystic ovary syndrome…”
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Obesity, sleep apnea, aldosterone, and hypertension by Goodfriend, Theodore L.

“…The pathogenesis of hypertension associated with obesity is unclear. This review provides evidence supporting excess visceral fat as an early aspect, and…”
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Treating Resistant Hypertension With a Neglected Old Drug by Goodfriend, Theodore L

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Response to Unexpected Therapeutic Response to Spironolactone: A Prospective Debate on Aldosterone and Potassium Ion in Hypertension by Goodfriend, Theodore L

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Relationships Among Plasma Aldosterone, High-Density Lipoprotein Cholesterol, and Insulin in Humans by Goodfriend, Theodore L, Egan, Brent, Stepniakowski, Konrad, Ball, Dennis L

“…To investigate the pathogenesis of hypertension in patients with obesity and insulin resistance and to explore the role of plasma lipids, we studied 30…”
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Angiotensin Receptors and Their Antagonists by Goodfriend, Theodore L, Elliott, Mary E, Catt, Kevin J

“…Angiotensins are peptide hormones derived from the protein precursor angiotensinogen by the sequential actions of proteolytic enzymes (Figure 1). The classic…”
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Insulin resistance and cardiovascular disease by Egan, Brent M, Greene, Eddie L, Goodfriend, Theodore L

“…Cardiovascular risk factors cluster in obese individuals. Insulin resistance emerges as a common pathogenetic denominator underlying the risk factor cluster…”
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Pioglitazone improves insulin action and normalizes menstrual cycles in a majority of prenatally androgenized female rhesus monkeys by Zhou, Rao, Bruns, Cristin M., Bird, Ian M., Kemnitz, Joseph W., Goodfriend, Theodore L., Dumesic, Daniel A., Abbott, David H.

“…To determine whether pioglitazone will improve menstrual cyclicity in a fetal programming model for polycystic ovary syndrome. Eight prenatally androgenized…”
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An oxidized metabolite of linoleic acid increases intracellular calcium in rat adrenal glomerulosa cells by Payet, Marcel D, Goodfriend, Theodore L, Bilodeau, Lyne, Mackendale, Cherilu, Chouinard, Lucie, Gallo-Payet, Nicole

“…EKODE, an epoxy-keto derivative of linoleic acid, was previously shown to stimulate aldosterone secretion in rat adrenal glomerulosa cells. In the present…”
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Acute Hyperlipidemia Increases Oxidative Stress More in African Americans Than in White Americans by Lopes, Heno F, Morrow, Jason D, Stoijiljkovic, Milos P, Goodfriend, Theodore L, Egan, Brent M

“…Oxidative stress emerges as a potential factor in the pathogenesis of hypertension and a common signal transduction mechanism by which various risk factors…”
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Oleic Acid Inhibits Endothelial Nitric Oxide Synthase by a Protein Kinase C-Independent Mechanism by Davda, Rajesh K, Stepniakowski, Konrad T, Lu, Gang, Ullian, Michael E, Goodfriend, Theodore L, Egan, Brent M

“…Many obese hypertensive individuals have a cluster of cardiovascular risk factors. This cluster includes plasma nonesterified fatty acid concentrations and…”
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An oxidized metabolite of linoleic acid stimulates corticosterone production by rat adrenal cells by Bruder, Eric D, Ball, Dennis L, Goodfriend, Theodore L, Raff, Hershel

“…Oxidized derivatives of linoleic acid have the potential to alter steroidogenesis. One such derivative is 12,13-epoxy-9- keto-10-(trans)-octadecenoic acid…”
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