Search Results - "GOODERHAM, N. J"

Interleukin-6 mediated upregulation of CYP1B1 and CYP2E1 in colorectal cancer involves DNA methylation, miR27b and STAT3 by Patel, S A A, Bhambra, U, Charalambous, M P, David, R M, Edwards, R J, Lightfoot, T, Boobis, A R, Gooderham, N J

“…Background: The pro-inflammatory cytokine interleukin-6 (IL6) promotes colorectal cancer (CRC) development. It is also known to regulate cytochrome P450…”
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Impact of Structural and Metabolic Variations on the Toxicity and Carcinogenicity of Hydroxy- and Alkoxy-Substituted Allyl- and Propenylbenzenes by Rietjens, I. M. C. M, Cohen, S. M, Fukushima, S, Gooderham, N. J, Hecht, S, Marnett, L. J, Smith, R. L, Adams, T. B, Bastaki, M, Harman, C. G, Taylor, S. V

“…The metabolic fate of a compound is determined by numerous factors including its chemical structure. Although the metabolic options for a variety of functional…”
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Expression of COX-2, NF-κB-p65, NF-κB-p50 and IKKα in malignant and adjacent normal human colorectal tissue by Charalambous, M P, Lightfoot, T, Speirs, V, Horgan, K, Gooderham, N J

“…BACKGROUND: Cyclooxygenase-2 (COX-2) is selectively over-expressed in colorectal tumours. The mechanism of COX-2 induction in these tumours is not fully…”
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Upregulation of cyclooxygenase-2 is accompanied by increased expression of nuclear factor-κB and IκB kinase-α in human colorectal cancer epithelial cells by CHARALAMBOUS, M. P, MAIHÖFNER, C, BHAMBRA, U, LIGHTFOOT, T, GOODERHAM, N. J

“…Cyclooxygenase-2 (COX-2) is selectively overexpressed in colorectal tumours. The mechanism of COX-2 induction is not fully understood, but requires de novo…”
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Increased expression of circulating miRNA-93 in women with polycystic ovary syndrome may represent a novel, non-invasive biomarker for diagnosis by Sathyapalan, T., David, R., Gooderham, N. J., Atkin, S. L.

“…MicroRNAs (miRNA) are a novel class of small noncoding single-stranded RNA molecules that regulate gene expression. There is increasing evidence of their…”
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Mechanisms of action of the carcinogenic heterocyclic amine PhIP by Gooderham, N.J., Creton, S., Lauber, S.N., Zhu, H.

“…Formed during the cooking of meat, the heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4-5- b]pyridine (PhIP) is mutagenic and carcinogenic. Although the…”
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Using microRNA profiles to predict and evaluate hepatic carcinogenic potential by Gooderham, N.J., Koufaris, C.

“…•Substantial evidence supports a role for microRNAs in liver carcinogenesis.•In the last few years numerous studies have examined the effects of…”
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Metabolic phenotype-microRNA data fusion analysis of the systemic consequences of Roux-en-Y gastric bypass surgery by Wu, Q, Li, J V, Seyfried, F, le Roux, C W, Ashrafian, H, Athanasiou, T, Fenske, W, Darzi, A, Nicholson, J K, Holmes, E, Gooderham, N J

“…Background/Objectives: Bariatric surgery offers sustained marked weight loss and often remission of type 2 diabetes, yet the mechanisms of establishment of…”
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The cooked meat-derived mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) elicits estrogenic-like microRNA responses in breast cancer cells by Papaioannou, M.D., Koufaris, C., Gooderham, N.J.

“…The cooking of meat results in the generation of heterocyclic amines (HCA), the most abundant of which is 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine…”
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A Mechanistic Basis for the Role of Cycle Arrest in the Genetic Toxicology of the Dietary Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by Creton, S., Zhu, H., Gooderham, N. J.

“…The heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), formed during the cooking of meat, induces tumors of the prostate, colon, and…”
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Early events in the mammalian response to DNA double-strand breaks by Riches, Lucy C., Lynch, Anthony M., Gooderham, Nigel J.

“…Physical and chemical agents that induce DNA double-strand breaks (DSBs) are among the most potent mutagens. The mammalian cell response to DSB comprises a…”
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Transdifferentiated rat pancreatic progenitor cells (AR42J-B13/H) respond to phenobarbital in a rat hepatocyte-specific manner by Osborne, M, Haltalli, M, Currie, R, Wright, J, Gooderham, N.J

“…Abstract Phenobarbital (PB) is known to produce species-specific effects in the rat and mouse, being carcinogenic in certain mouse strains, but only in rats if…”
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CYP1A2-catalyzed conversion of dietary heterocyclic amines to their proximate carcinogens is their major route of metabolism in humans by BOOBIS, A. R, LYNCH, A. M, MURRAY, S, DE LA TORRE, R, SOLANS, A, FARRE, M, SEGURA, J, GOODERHAM, N. J, DAVIES, D. S

“…The contribution of CYP1A2 to the metabolism of the dietary heterocyclic amines, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and…”
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Food-Derived Heterocyclic Amine Mutagens: Variable Metabolism and Significance to Humans by GOODERHAM, Nigel J, MURRAY, Stephen, LYNCH, Anthony M, YADOLLAHI-FARSANI, Masoud, KAICUN ZHAO, BOOBIS, Alan R, DAVIES, Donald S

“…The cooking of meat has been found to generate compounds that possess extreme mutagenicity when examined in short term tests. This observation led to the…”
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Interaction of the transactivating protein HIV-1 tat with sulphated polysaccharides by Watson, Keith, Gooderham, Nigel J, Davies, Donald S, Edwards, Robert J

“…Endogenous sulphated polysaccharides such as heparin have been shown to inhibit the infectivity of HIV-1 in vitro. However, these naturally occurring polymers,…”
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Mutational spectra of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) at the Chinese hamster hprt locus by YADOLLAHI-FARSANI, M, GOODERHAM, N. J, DAVIES, D. S, BOOBIS, A. R

“…The mutagenic 'fingerprint' of the cooked food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) was determined in a Chinese hamster cell line…”
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The food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine activates S-phase checkpoint and apoptosis, and induces gene mutation in human lymphoblastoid TK6 cells by HUIJUN ZHU, BOOBIS, A. R, GOODERHAM, N. J

“…The mutagenic heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-blpyridine (PhIP) is formed at parts per billion levels when meat is cooked. It is…”
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Metabolism of the food derived mutagen and carcinogen 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) by human liver microsomes by Zhao, K, Murray, S, Davies, D S, Boobis, A R, Gooderham, N J

“…Animal studies have shown that 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) undergoes both activation to a genotoxic metabolite and detoxication,…”
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Extra-nuclear location of histones in activated human peripheral blood lymphocytes and cultured T-cells by Watson, Keith, Edwards, Robert J., Shaunak, Sunil, Parmelee, David C., Sarraf, Catherine, Gooderham, Nigel J., Davies, Donald S.

“…Dextrin-2-sulphate (D2S) is a sulphated polysaccharide which inhibits human immunodeficiency virus type 1 infection of T-cells by binding to the cell surface…”
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Heterocyclic amines: evaluation of their role in diet associated human cancer by GOODERHAM, N. J., MURRAY, S., LYNCH, A. M., EDWARDS, R. J., YADOLLAHI‐FARSANI, M., BRATT, C., RICH, K. J., ZHAO, K., MURRAY, B. P., BHADRESA, S., CROSBIE, S. J., BOOBIS, A. R., DAVIES, D. S.

“…1Heterocyclic amines are formed in parts per billion levels when meat is cooked. 2The heterocyclic amines MeIQx and PhIP are efficiently absorbed into the…”
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