Search Results - "GOOD, ROBERT A."

Impaired Degradation of Inhibitory Subunit of NF-κB (IκB) and β-Catenin as a Result of Targeted Disruption of the β-TrCP1 Gene by Nakayama, Keiko, Hatakeyama, Shigetsugu, Maruyama, Shun-ichiro, Kikuchi, Akira, Onoé, Kazunori, Good, Robert A., Nakayama, Keiichi I.

“…β-TrCP1 (also known as Fbw1a or FWD1) is the F-box protein component of an Skp1/Cul1/F-box (SCF)-type ubiquitin ligase complex. Although biochemical studies…”
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Uncoupling Protein 2 Plays an Important Role in Nitric Oxide Production of Lipopolysaccharide-Stimulated Macrophages by Kizaki, Takako, Suzuki, Kenji, Hitomi, Yoshiaki, Taniguchi, Naoyuki, Saitoh, Daizoh, Watanabe, Kenji, Onoé, Kazunori, Day, Noorbibi K., Good, Robert A., Ohno, Hideki

“…The expression of uncoupling protein 2 (UCP2) was reduced in macrophages after stimulation with lipopolysaccharide (LPS). The physiological consequence and the…”
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Innate immunity and its role against infections by Uthaisangsook, Suwannee, Day, Noorbibi K, Bahna, Sami L, Good, Robert A, Haraguchi, Soichi

“…This article reviews current concepts of the innate immune system that offers protection against infections. It offers an overview for the readers to…”
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Caloric restriction attenuates Aβ-deposition in Alzheimer transgenic models by Patel, Nilay V., Gordon, Marcia N., Connor, Karen E., Good, Robert A., Engelman, Robert W., Mason, Jerimiah, Morgan, David G., Morgan, Todd E., Finch, Caleb E.

“…Dietary influences on Alzheimer disease (AD) are gaining recognition. Because many aging processes are attenuated in laboratory mammals by caloric restriction…”
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Pyogenic Bacterial Infections in Humans with IRAK-4 Deficiency by Picard, Capucine, Puel, Anne, Bonnet, Marion, Ku, Cheng-Lung, Bustamante, Jacinta, Yang, Kun, Soudais, Claire, Dupuis, Stéphanie, Feinberg, Jacqueline, Fieschi, Claire, Elbim, Carole, Hitchcock, Remi, Lammas, David, Davies, Graham, Al-Ghonaium, Abdulaziz, Al-Rayes, Hassan, Al-Jumaah, Sulaiman, Al-Hajjar, Sami, Al-Mohsen, Ibrahim Zaid, Frayha, Husn H., Rucker, Rajivi, Hawn, Thomas R., Aderem, Alan, Tufenkeji, Haysam, Haraguchi, Soichi, Day, Noorbibi K., Good, Robert A., Gougerot-Pocidalo, Marie-Anne, Ozinsky, Adrian, Casanova, Jean-Laurent

“…Members of the Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) superfamily share an intracytoplasmic Toll-IL-1 receptor (TIR) domain, which…”
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Effective Treatment of Autoimmune Disease and Progressive Renal Disease by Mixed Bone-Marrow Transplantation That Establishes a Stable Mixed Chimerism in BXSB Recipient Mice by Wang, Bingyan, Yamamoto, Yoshihisa, El-Badri, Nagwa S., Good, Robert A.

“…Male BXSB mice spontaneously develop autoimmune disease with features similar to systemic lupus erythematosus. To determine whether this autoimmune disease can…”
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Immunodeficiency, radiosensitivity, and the XCIND syndrome by Gatti, Richard A., Boder, Elena, Good, Robert A.

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Immunologic Reconstitution Following Bone Marrow Transplantation for X-Linked Hyper IgM Syndrome by Duplantier, John E., Seyama, Kuniaki, Day, Noorbibi K., Hitchcock, Remi, Nelson, Robert P., Ochs, Hans D., Haraguchi, Soichi, Klemperer, Martin R., Good, Robert A.

“…X-linked hyper IgM syndrome (XHIM), caused by mutations of the CD40 ligand (CD40L) gene, is characterized by recurrent bacterial and opportunistic infections,…”
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Immunosuppressive retroviral peptides: immunopathological implications for immunosuppressive influences of retroviral infections by Haraguchi, Soichi, Good, Robert A., Cianciolo, George J., Engelman, Robert W., Day, Noorbibi K.

“…Studies of the effects of retroviruses on the immune system, which date back through thirty years of investigations, are reviewed. In the earliest published…”
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Dietary lipids and calorie restriction affect mammary tumor incidence and gene expression in mouse mammary tumor virus/v-Ha-ras transgenic mice by Fernandes, G. (University of Texas Health Science Center, San Antonio, TX.), Chandrasekar, B, Troyer, D.A, Venkatraman, J.T, Good, R.A

“…We have studied the effects of food restriction (FR) and substitution of fish oil (FO; omega 3) for corn oil (CO; omega 6) on breast tumor incidence and…”
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Identification of Mutations in the c-mpl Gene in Congenital Amegakaryocytic Thrombocytopenia by Ihara, Kenji, Ishii, Eiichi, Eguchi, Mariko, Takada, Hidetoshi, Suminoe, Aiko, Good, Robert A., Hara, Toshiro

“…Congenital amegakaryocytic thrombocytopenia (CAMT) is a rare disorder expressed in infancy and characterized by isolated thrombocytopenia and…”
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Respiratory distress due to minocycline-induced pulmonary lupus by Christodoulou, C S, Emmanuel, P, Ray, R A, Good, R A, Schnapf, B M, Cawkwell, G D

“…Minoeycline, a semisynthetic tetracycline, is often used to treat acne and rheumatoid arthritis. It has been considered an unlikely drug to be associated with…”
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Prevention of Development of Autoimmune Disease in BXSB Mice by Mixed Bone Marrow Transplantation by Bing-Yan Wang, Cherry, Nagwa S. El-Badri, Robert A. Good

“…Transplantations of fully allogeneic, autoimmune-resistant T-cell-depleted marrow (TCDM) plus syngeneic, autoimmune-prone TCDM into lethally irradiated BXSB…”
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A potent immunosuppressive retroviral peptide: cytokine patterns and signaling pathways by Haraguchi, Soichi, Good, Robert A., Day-Good, Noorbibi K.

“…A synthetic bioactive peptide composed of 17 amino acids (CKS-17) homologous to a highly conserved region of human and animal retroviral transmembrane envelope…”
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Ubiquitin-Dependent Degradation of Iκ Bα is Mediated by a Ubiquitin Ligase Skp1/Cul 1/F-Box Protein FWD1 by Hatakeyama, Shigetsugu, Kitagawa, Masatoshi, Nakayama, Keiko, Shirane, Michiko, Matsumoto, Masaki, Hattori, Kimihiko, Higashi, Hideaki, Nakano, Hiroyasu, Okumura, Ko, Onoé, Kazunori, Good, Robert A., Nakayama, Kei-ichi

“…Activation of the transcription factor nuclear factor kappa B (NF-κ B) is controlled by proteolysis of its inhibitory subunit (Iκ B) via the…”
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Autoimmune disease: is it a disorder of the microenvironment? by El-Badri, Nagwa S., Hakki, Amal, Ferrari, Annabella, Shamekh, Rania, Good, Robert A.

“…Systemic lupus erythematosus (SLE) is a common systemic autoimmune disease that involves several vital organs including the cardiovascular system, joints, and…”
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Purified Hematopoietic Stem Cells without Facilitating Cells can Repopulate Fully Allogeneic Recipients across Entire Major Histocompatibility Complex Transplantation Barrier in Mice by Wang, Bing-yan, El-Badri, Nagwa S., Good, Cherry, and Robert A.

“…We report herein the successful long term engraftment of highly purified hematopoietic stem cells (HSCs) without any facilitating cells in fully allogeneic…”
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Age-associated increase of basal corticosterone levels decreases ED2high, NF-κBhigh activated macrophages by Kizaki, Takako, Ookawara, Tomomi, Iwabuchi, Kazuya, Onoé, Kazunori, Day, Noorbibi K., Good, Robert A., Maruyama, Naoki, Haga, Shukoh, Matsuura, Nobuo, Ohira, Yoshinobu, Ohno, Hideki

“…The proportion of cells with a high density of ED2 (ED2high cells) in peritoneal cells from old rats was significantly lower than that from young rats. The…”
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Immunodeficiency, radiosensitivity, and the XCIND syndrome by Gatti, Richard A, Boder, Elena, Good, Robert A

“…Through the analysis of a rare disorder called ataxia-telangiectasia (A-T), many important biological lessons have been gleaned. Today, it is clear that the…”
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Cellular immunology in a historical perspective by Good, Robert A.

“…Bruton's XLA and DiGeorge syndrome patients show that two basic immune systems are distinct from each other in humans − thymus‐dependent cell‐mediated…”
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