Search Results - "GONG, Sylvia"

Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity by Dávalos-Salas, Mercedes, Montgomery, Magdalene K., Reehorst, Camilla M., Nightingale, Rebecca, Ng, Irvin, Anderton, Holly, Al-Obaidi, Sheren, Lesmana, Analia, Scott, Cameron M., Ioannidis, Paul, Kalra, Hina, Keerthikumar, Shivakumar, Tögel, Lars, Rigopoulos, Angela, Gong, Sylvia J., Williams, David S., Yoganantharaja, Prusoth, Bell-Anderson, Kim, Mathivanan, Suresh, Gibert, Yann, Hiebert, Scott, Scott, Andrew M., Watt, Matthew J., Mariadason, John M.

“…Histone deacetylase 3 ( Hdac3 ) regulates the expression of lipid metabolism genes in multiple tissues, however its role in regulating lipid metabolism in the…”
Get full text

Physiological and transcriptomic effects of hexafluoropropylene oxide dimer acid in Caenorhabditis elegans during development by Feng, Zuying, McLamb, Flannery, Vu, Jeanne P., Gong, Sylvia, Gersberg, Richard M., Bozinovic, Goran

“…Per- and polyfluoroalkyl substances (PFAS) are chemicals resistant to degradation. While such a feature is desirable in consumer and industrial products, some…”
Get full text

18F-FDG PET/CT biomarkers as predictors of long term outcomes and survival rates in patients with high risk malignant pulmonary masses/nodules treated with stereotactic ablative radiotherapy by Boktor, Raef R., Berlangieri, Salvatore U., Lau, Eddie, Lim, Adeline, Gong, Sylvia J., Li, Xia, Scott, Andrew M.

“…Stereotactic ablative body radiotherapy (SABR) is a standard treatment option for patients with malignant pulmonary masses (including primary and metastatic…”
Get full text

A phase 1 safety and bioimaging trial of antibody DS-8895a against EphA2 in patients with advanced or metastatic EphA2 positive cancers by Gan, Hui K., Parakh, Sagun, Lee, F. T., Tebbutt, Niall C., Ameratunga, Malaka, Lee, Sze Ting, O’Keefe, Graeme J., Gong, Sylvia J., Vanrenen, Christine, Caine, Jaren, Giovannetti, Mara, Murone, Carmel, Scott, Fiona E., Guo, Nancy, Burvenich, Ingrid J. G., Paine, Cameron, Macri, Mary J., Kotsuma, Masakatsu, Senaldi, Giorgio, Venhaus, Ralph, Scott, Andrew M.

“…Ephrin type-A 2 (EphA2) is a transmembrane receptor expressed in epithelial cancers. We report on a phase I dose escalation and biodistribution study of…”
Get full text

Hypoxia-targeted radiotherapy dose painting for head and neck cancer using (18)F-FMISO PET: a biological modeling study by Chang, Joe H, Wada, Morikatsu, Anderson, Nigel J, Lim Joon, Daryl, Lee, Sze Ting, Gong, Sylvia J, Gunawardana, Dishan H, Sachinidis, John, O'Keefe, Graeme, Gan, Hui K, Khoo, Vincent, Scott, Andrew M

“…This study investigates the use of (18)F-fluoromisonidazole (FMISO) PET-guided radiotherapy dose painting for potentially overcoming the radioresistant effects…”
Get more information

An Anti-VEGF-B Antibody Reduces Abnormal Tumor Vasculature and Enhances the Effects of Chemotherapy by Janes, Peter W, Parslow, Adam C, Cao, Diana, Rigopoulos, Angela, Lee, Fook-Thean, Gong, Sylvia J, Cartwright, Glenn A, Burvenich, Ingrid J G, Eriksson, Ulf, Johns, Terrance G, Scott, Fiona E, Scott, Andrew M

“…The vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are key regulators of blood vessel formation, including in tumors, where their…”
Get full text

Phase I Imaging and Pharmacodynamic Trial of CS-1008 in Patients With Metastatic Colorectal Cancer by Ciprotti, Marika, Tebbutt, Niall C, Lee, Fook-Thean, Lee, Sze-Ting, Gan, Hui K, McKee, David C, O'Keefe, Graeme J, Gong, Sylvia J, Chong, Geoffrey, Hopkins, Wendie, Chappell, Bridget, Scott, Fiona E, Brechbiel, Martin W, Tse, Archie N, Jansen, Mendel, Matsumura, Manabu, Kotsuma, Masakatsu, Watanabe, Rira, Venhaus, Ralph, Beckman, Robert A, Greenberg, Jonathan, Scott, Andrew M

“…CS-1008 (tigatuzumab) is a humanized, monoclonal immunoglobulin G1 (IgG1) agonistic antibody to human death receptor 5. The purpose of this study was to…”
Get full text

Comparison of [11 C]choline Positron Emission Tomography With T2- and Diffusion-Weighted Magnetic Resonance Imaging for Delineating Malignant Intraprostatic Lesions by Chang, Joe H., MBChB, Lim Joon, Daryl, FRANZCR, Davis, Ian D., MBBS, PhD, Lee, Sze Ting, FRACP, Hiew, Chee-Yan, FRANZCR, Esler, Stephen, FRANZCR, Gong, Sylvia J., PhD, Wada, Morikatsu, FRANZCR, Clouston, David, MBBS, PhD, O'Sullivan, Richard, FRANZCR, Goh, Yin P., MBBS, Bolton, Damien, MD, Scott, Andrew M., MD, Khoo, Vincent, MD

“…Purpose The purpose of this study was to compare the accuracy of [11 C]choline positron emission tomography (CHOL-PET) with that of the combination of…”
Get full text

First clinical study of a pegylated diabody 124I-labeled PEG-AVP0458 in patients with tumor-associated glycoprotein 72 positive cancers by Scott, Andrew M, Akhurst, Timothy, Lee, Fook-Thean, Ciprotti, Marika, Davis, Ian D, Weickhardt, Andrew J, Gan, Hui K, Hicks, Rodney J, Lee, Sze Ting, Pece Kocovski, Guo, Nancy, Oh, Maggie, Mileshkin, Linda, Williams, Scott, Murphy, Declan, Pathmaraj, Kunthi, O'Keefe, Graeme J, Gong, Sylvia J, Pedersen, John S, Scott, Fiona E, Wheatcroft, Michael P, Hudson, Peter J

“…Through protein engineering and a novel pegylation strategy, a diabody specific to tumor-associated glycoprotein 72 (TAG-72) (PEG-AVP0458) has been created to…”
Get full text

Subacute Ischemic Stroke Is Associated With Focal 11C PiB Positron Emission Tomography Retention But Not With Global Neocortical Aβ Deposition by LY, John V, ROWE, Christopher C, SAUNDER, Tim, ACKERMAN, Uwe, TOCHON-DANGUY, Henri, DONNAN, Geoffrey A, VILLEMAGNE, Victor L, ZAVALA, Jorge A, MA, Henry, SAHATHEVAN, Ramesh, O'KEEFE, Graeme, GONG, Sylvia J, GUNAWAN, Rico, CHURILOV, Leonid

“…Conflicting evidence exists as to whether focal cerebral ischemia contributes to cerebral amyloid deposition. We aimed to look at Aβ deposits, detected by…”
Get full text

Histopathological correlation of (11)C-choline PET scans for target volume definition in radical prostate radiotherapy by Chang, Joe H, Joon, Daryl Lim, Lee, Sze Ting, Gong, Sylvia J, Scott, Andrew M, Davis, Ian D, Clouston, David, Bolton, Damien, Hamilton, Christopher S, Khoo, Vincent

“…To evaluate the accuracy of (11)C-choline PET scans in defining dominant intraprostatic lesions (DILs) for radiotherapy target volume definition. Eight men…”
Get full text

Diffusion-weighted MRI, 11C-choline PET and 18F-fluorodeoxyglucose PET for predicting the Gleason score in prostate carcinoma by Chang, Joe H., Lim Joon, Daryl, Lee, Sze Ting, Hiew, Chee-Yan, Esler, Stephen, Gong, Sylvia J., Wada, Morikatsu, Clouston, David, O’Sullivan, Richard, Goh, Yin P., Tochon-Danguy, Henri, Chan, J. Gordon, Bolton, Damien, Scott, Andrew M., Khoo, Vincent, Davis, Ian D.

“…Objectives To evaluate the accuracy of transrectal ultrasound-guided (TRUS) biopsy, diffusion-weighted (DW) magnetic resonance imaging (MRI), 11 C-choline…”
Get full text

First clinical study of a pegylated diabody 124 I-labeled PEG-AVP0458 in patients with tumor-associated glycoprotein 72 positive cancers by Scott, Andrew M, Akhurst, Timothy, Lee, Fook-Thean, Ciprotti, Marika, Davis, Ian D, Weickhardt, Andrew J, Gan, Hui K, Hicks, Rodney J, Lee, Sze Ting, Kocovski, Pece, Guo, Nancy, Oh, Maggie, Mileshkin, Linda, Williams, Scott, Murphy, Declan, Pathmaraj, Kunthi, O'Keefe, Graeme J, Gong, Sylvia J, Pedersen, John S, Scott, Fiona E, Wheatcroft, Michael P, Hudson, Peter J

“…Through protein engineering and a novel pegylation strategy, a diabody specific to tumor-associated glycoprotein 72 (TAG-72) (PEG-AVP0458) has been created to…”
Get full text

Cerebral β-amyloid detected by Pittsburgh compound B positron emission topography predisposes to recombinant tissue plasminogen activator-related hemorrhage by Ly, John V., Rowe, Christopher C., Villemagne, Victor L., Zavala, Jorge A., Ma, Henry, O'Keefe, Graeme, Gong, Sylvia J., Gunawan, Rico, Churilov, Leonid, Saunder, Tim, Ackerman, Uwe, Tochon-Danguy, Henri, Donnan, Geoffrey A.

“…Cerebral amyloid angiopathy (CAA) may be an important predisposing factor for the hemorrhagic complications of recombinant tissue‐type plasminogen activator…”
Get full text

Intensity Modulated Radiation Therapy Dose Painting for Localized Prostate Cancer Using 11C-choline Positron Emission Tomography Scans by Chang, Joe H., Lim Joon, Daryl, Lee, Sze Ting, Gong, Sylvia J., Anderson, Nigel J., Scott, Andrew M., Davis, Ian D., Clouston, David, Bolton, Damien, Hamilton, Christopher S., Khoo, Vincent

“…To demonstrate the technical feasibility of intensity modulated radiation therapy (IMRT) dose painting using 11C-choline positron emission tomography PET scans…”
Get full text

In Vitro and In Vivo Evaluation of 89 Zr-DS-8273a as a Theranostic for Anti-Death Receptor 5 Therapy by Burvenich, Ingrid J G, Lee, Fook-Thean, Guo, Nancy, Gan, Hui K, Rigopoulos, Angela, Parslow, Adam C, O'Keefe, Graeme J, Gong, Sylvia J, Tochon-Danguy, Henri, Rudd, Stacey E, Donnelly, Paul S, Kotsuma, Masakatsu, Ohtsuka, Toshiaki, Senaldi, Giorgio, Scott, Andrew M

“…DS-8273a, an anti-human death receptor 5 (DR5) agonistic antibody, has cytotoxic activity against human cancer cells and induces apoptosis after specific…”
Get full text

In Vitro and In Vivo Evaluation of 89Zr-DS-8273a as a Theranostic for Anti-Death Receptor 5 Therapy by Burvenich, Ingrid J G, Lee, Fook-Thean, Guo, Nancy, Gan, Hui K, Rigopoulos, Angela, Parslow, Adam C, O'Keefe, Graeme J, Gong, Sylvia J, Tochon-Danguy, Henri, Rudd, Stacey E, Donnelly, Paul S, Kotsuma, Masakatsu, Ohtsuka, Toshiaki, Senaldi, Giorgio, Scott, Andrew M

“…Background: DS-8273a, an anti-human death receptor 5 (DR5) agonistic antibody, has cytotoxic activity against human cancer cells and induces apoptosis after…”
Get full text

Acute Hpfo-Da Exposure Induces Spinal Deformations and Arrhythmia, and Alters Expression of Genes Involved in Cardiac, Vascular, Neural, and Visual Systems during Zebrafish (Danio rerio) Early Development by Gong, Sylvia

“…Hexafluoropropylene oxide-dimer acid (HFPO-DA, trade name GenX), a widespread per- and polyfluoroalkyl substance (PFAS), belongs to a group of synthetic…”
Get full text

Locomotion and brain gene expression exhibit sex-specific non-monotonic dose-response to HFPO-DA during Drosophila melanogaster lifespan by Vu, Jeanne P., McLamb, Flannery, Feng, Zuying, Griffin, Lindsey, Gong, Sylvia, Shea, Damian, Szuch, Mary A., Scott, Savannah, Gersberg, Richard M., Bozinovic, Goran

“…Legacy per- and polyfluoroalkyl substances (PFAS), known for their environmental persistence and bio-accumulative properties, have been phased out in the U.S…”
Get full text

Toxicity assessment of hexafluoropropylene oxide-dimer acid on morphology, heart physiology, and gene expression during zebrafish (Danio rerio) development by Gong, Sylvia, McLamb, Flannery, Shea, Damian, Vu, Jeanne P., Vasquez, Miguel F., Feng, Zuying, Bozinovic, Kesten, Hirata, Ken K., Gersberg, Richard M., Bozinovic, Goran

“…  Hexafluoropropylene oxide-dimer acid (HFPO-DA) is one of the emerging replacements for the “forever” carcinogenic and toxic long-chain PFAS. HFPO-DA is a…”
Get full text