Search Results - "GONELLI, Arianna"

MDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer by Tisato, Veronica, Voltan, Rebecca, Gonelli, Arianna, Secchiero, Paola, Zauli, Giorgio

“…The two murine double minute (MDM) family members MDM2 and MDMX are at the center of an intense clinical assessment as molecular target for the management of…”
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Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging by Simioni, Carolina, Zauli, Giorgio, Martelli, Alberto M, Vitale, Marco, Sacchetti, Gianni, Gonelli, Arianna, Neri, Luca M

“…Physical exercise is considered to be one of the beneficial factors of a proper lifestyle and is nowadays seen as an indispensable element for good health,…”
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Mitochondria-Targeted Antioxidants, an Innovative Class of Antioxidant Compounds for Neurodegenerative Diseases: Perspectives and Limitations by Fields, Matteo, Marcuzzi, Annalisa, Gonelli, Arianna, Celeghini, Claudio, Maximova, Natalia, Rimondi, Erika

“…Neurodegenerative diseases comprise a wide spectrum of pathologies characterized by progressive loss of neuronal functions and structures. Despite having…”
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Retinal Alterations Predict Early Prodromal Signs of Neurodegenerative Disease by Casciano, Fabio, Zauli, Enrico, Celeghini, Claudio, Caruso, Lorenzo, Gonelli, Arianna, Zauli, Giorgio, Pignatelli, Angela

“…Neurodegenerative diseases are an increasingly common group of diseases that occur late in life with a significant impact on personal, family, and economic…”
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Sex/Gender-Specific Imbalance in CVD: Could Physical Activity Help to Improve Clinical Outcome Targeting CVD Molecular Mechanisms in Women? by Vaccarezza, Mauro, Papa, Veronica, Milani, Daniela, Gonelli, Arianna, Secchiero, Paola, Zauli, Giorgio, Gemmati, Donato, Tisato, Veronica

“…In the last two decades, new insights have been gained regarding sex/gender-related differences in cardiovascular disease (CVD). CVD represents the leading…”
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Classical and Innovative Evidence for Therapeutic Strategies in Retinal Dysfunctions by Caruso, Lorenzo, Fields, Matteo, Rimondi, Erika, Zauli, Giorgio, Longo, Giovanna, Marcuzzi, Annalisa, Previati, Maurizio, Gonelli, Arianna, Zauli, Enrico, Milani, Daniela

“…The human retina is a complex anatomical structure that has no regenerative capacity. The pathogenesis of most retinopathies can be attributed to inflammation,…”
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Association between circulatory levels of adipokines and bone mineral density in postmenopausal women by Cervellati, Carlo, Bonaccorsi, Gloria, Bergamini, Carlo M, Fila, Enrica, Greco, Pantaleo, Valacchi, Giuseppe, Massari, Leo, Gonelli, Arianna, Tisato, Veronica

“…OBJECTIVE:Epidemiological evidence indicates that excess fat may be beneficial for bone health, offering protective effects against the onset of postmenopausal…”
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New Applications of JAK/STAT Inhibitors in Pediatrics: Current Use of Ruxolitinib by Marcuzzi, Annalisa, Rimondi, Erika, Melloni, Elisabetta, Gonelli, Arianna, Grasso, Antonio Giacomo, Barbi, Egidio, Maximova, Natalia

“…Janus kinases (JAK) are a family of tyrosine kinases (JAK1, JAK2, JAK3, and TYK2) that transduce cytokine-mediated signals through the JAK-STAT metabolic…”
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The IMMENSE Study: The Interplay Between iMMune and ENdothelial Cells in Mediating Cardiovascular Risk in Systemic Lupus Erythematosus by Bortoluzzi, Alessandra, Chighizola, Cecilia Beatrice, Fredi, Micaela, Raschi, Elena, Bodio, Caterina, Privitera, Daniela, Gonelli, Arianna, Silvagni, Ettore, Govoni, Marcello, Cavazzana, Ilaria, Airò, Paolo, Meroni, Pier Luigi, Tincani, Angela, Franceschini, Franco, Piantoni, Silvia, Casciano, Fabio

“…Patients with systemic lupus erythematosus (SLE) have a significant increase in cardiovascular (CV) risk although they display a preserved number of…”
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The MDM2 inhibitor Nutlins as an innovative therapeutic tool for the treatment of haematological malignancies by Secchiero, Paola, di Iasio, Maria Grazia, Gonelli, Arianna, Zauli, Giorgio

“…At variance to solid tumors, which show percentage of p53 deletions and/or mutations close to 50%, more than 80% of haematological malignancies express…”
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Characterization Methods for Nanoparticle-Skin Interactions: An Overview by Dzyhovskyi, Valentyn, Romani, Arianna, Pula, Walter, Bondi, Agnese, Ferrara, Francesca, Melloni, Elisabetta, Gonelli, Arianna, Pozza, Elena, Voltan, Rebecca, Sguizzato, Maddalena, Secchiero, Paola, Esposito, Elisabetta

“…Research progresses have led to the development of different kinds of nanoplatforms to deliver drugs through different biological membranes. Particularly,…”
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Antiangiogenic Activity of the MDM2 Antagonist Nutlin-3 by Secchiero, Paola, Corallini, Federica, Gonelli, Arianna, Dell’Eva, Raffaella, Vitale, Marco, Capitani, Silvano, Albini, Adriana, Zauli, Giorgio

“…Nutlin-3, a nongenotoxic activator of the p53 pathway, dose-dependently (range 0.1 to 10 μmol/L) inhibited the formation of capillaries in an in vivo matrigel…”
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Enhanced Anti-Melanoma Activity of Nutlin-3a Delivered via Ethosomes: Targeting p53-Mediated Apoptosis in HT144 Cells by Romani, Arianna, Lodi, Giada, Casciano, Fabio, Gonelli, Arianna, Secchiero, Paola, Zauli, Giorgio, Bortolini, Olga, Valacchi, Giuseppe, Ragno, Daniele, Bondi, Agnese, Benedusi, Mascia, Esposito, Elisabetta, Voltan, Rebecca

“…This study evaluated ethosomes as a novel nanodelivery system for nutlin-3a, a known MDM2 inhibitor and activator of the p53 pathway, to improve nutlin-3a's…”
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Functional integrity of the p53-mediated apoptotic pathway induced by the nongenotoxic agent nutlin-3 in B-cell chronic lymphocytic leukemia (B-CLL) by Secchiero, Paola, Barbarotto, Elisa, Tiribelli, Mario, Zerbinati, Carlotta, di Iasio, Maria Grazia, Gonelli, Arianna, Cavazzini, Francesco, Campioni, Diana, Fanin, Renato, Cuneo, Antonio, Zauli, Giorgio

“…Deletions and/or mutations of p53 are relatively rare and late events in the natural history of B-cell chronic lymphocytic leukemia (B-CLL). However, it is…”
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TRAIL promotes the survival and proliferation of primary human vascular endothelial cells by activating the Akt and ERK pathways by SECCHIERO, Paola, GONELLI, Arianna, CARNEVALE, Edvige, MILANI, Daniela, PANDOLFI, Assunta, ZELLA, Davide, ZAULI, Giorgio

“…TRAIL protein is expressed in the medial smooth cell layer of aorta and pulmonary artery, whereas endothelial cells express all TRAIL receptors (TRAIL-Rs). The…”
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Effects of Hypoxia and Bed Rest on Markers of Cardiometabolic Risk: Compensatory Changes in Circulating TRAIL and Glutathione Redox Capacity by Biolo, Gianni, Di Girolamo, Filippo G, McDonnell, Adam, Fiotti, Nicola, Mearelli, Filippo, Situlin, Roberta, Gonelli, Arianna, Dapas, Barbara, Giordano, Mauro, Lainscak, Mitja, Grassi, Gabriele, Zauli, Giorgio, Secchiero, Paola, Mekjavic, Igor

“…In chronic diseases, hypoxia and physical inactivity are associated with atherosclerosis progression. In contrast, a lower mortality from coronary artery…”
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Vaginal Lactoferrin Modulates PGE2, MMP-9, MMP-2, and TIMP-1 Amniotic Fluid Concentrations by Bellini, Tiziana, Contini, Carlo, Dallocchio, Franco, Vesce, Fortunato, Volta, Carlo Alberto, Gonelli, Arianna, Manfrinato, Maria Cristina, Cervellati, Carlo, Maritati, Martina, Trentini, Alessandro, Greco, Pantaleo

“…Inflammation plays an important role in pregnancy, and cytokine and matrix metalloproteases (MMPs) imbalance has been associated with premature rupture of…”
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TRAIL counteracts the proadhesive activity of inflammatory cytokines in endothelial cells by down-modulating CCL8 and CXCL10 chemokine expression and release by Secchiero, Paola, Corallini, Federica, di Iasio, Maria Grazia, Gonelli, Arianna, Barbarotto, Elisa, Zauli, Giorgio

“…Exposure of endothelial cells to recombinant tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induced a modest (2-fold) increase of HL-60…”
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Upregulation of SOCS-1 by Nutlin-3 in acute myeloid leukemia cells but not in primary normal cells by Tisato, Veronica, Norcio, Alessia, Celeghini, Claudio, Milani, Daniela, Gonelli, Arianna, Secchiero, Paola

“…It has been shown that SOCS-1 plays an important role in the proper control of cytokine/growth factor responses and acts as a tumor suppressor in acute myeloid…”
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Tumor necrosis factor–related apoptosis-inducing ligand induces monocytic maturation of leukemic and normal myeloid precursors through a caspase-dependent pathway by Secchiero, Paola, Gonelli, Arianna, Mirandola, Prisco, Melloni, Elisabetta, Zamai, Loris, Celeghini, Claudio, Milani, Daniela, Zauli, Giorgio

“…Treatment of the human HL-60 cell line with tumor necrosis factor (TNF)–related apoptosis-inducing ligand (TRAIL) resulted in rapid (6-24 hours) cytotoxicity…”
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