Search Results - "GOMEZ, Generosa"

1,2,3-triazenes and 1,2,3-triazoles as antileishmanial, antitrypanosomal, and antiplasmodial agents by Seck, Insa, Ciss, Ismaïla, Diédhiou, Adama, Baldé, Mamadou, Ka, Seydou, Ba, Lalla A., Ndoye, Samba F., Figadère, Bruno, Seon-Meniel, Blandine, Gomez, Generosa, Cojean, Sandrine, Pomel, Sébastien, Loiseau, Philippe M., Fall, Yagamare, Seck, Matar

“…Trypanosomiasis, leishmaniasis, and malaria are tropical diseases that affect poor populations and the commonly-used drugs are toxic and can be subject to drug…”
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Synthesis of a novel analog of calcitriol and its biological evaluation as antitumor agent by Ferronato, María Julia, Obiol, Diego Javier, Alonso, Eliana Noelia, Guevara, Josefina Alejandra, Grioli, Silvina Mariela, Mascaró, Marilina, Rivadulla, Marcos Lois, Martínez, Andrea, Gómez, Generosa, Fall, Yagamare, Quevedo, Mario Alfredo, Curino, Alejandro Carlos, Facchinetti, María Marta

“…[Display omitted] •ML-344 is a novel calcitriol analog with amide and carboxyl groups in its side chain.•ML-344 has antitumor activity in cell lines…”
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Access to a Library of 1,3-disubstituted-1,2,3-triazenes and Evaluation of their Antimicrobial Properties by Seck, Insa, Ndoye, Samba F, Ba, Lalla A, Fall, Alioune, Diop, Abdoulaye, Ciss, Ismaïla, Ba, Abda, Sall, Cheikh, Diop, Amadou, Boye, Cheikh S, Gomez, Generosa, Fall, Yagamare, Seck, Matar

“…Due to the rapid development of microbial resistance, finding new molecules became urgent to counteract this problem. The objective of this work is to access…”
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The UVB1 Vitamin D analogue inhibits colorectal carcinoma progression by Ferronato, María Julia, Alonso, Eliana Noelia, Gandini, Norberto Ariel, Fermento, María Eugenia, Villegas, María Emilia, Quevedo, Mario Alfredo, Arévalo, Julián, López Romero, Alejandro, Rivadulla, Marcos Lois, Gómez, Generosa, Fall, Yagamare, Facchinetti, María Marta, Curino, Alejandro Carlos

“…[Display omitted] •UVB1 induces apoptotic cell death of HCT116 colorectal carcinoma cells.•UVB1 inhibits cellular migration and invasion in colorectal…”
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Vitamin D Analogue: Potent Antiproliferative Effects on Cancer Cell Lines and Lack of Hypercalcemic Activity by Ferronato, María Julia, Salomón, Débora Gisele, Fermento, María Eugenia, Gandini, Norberto Ariel, López Romero, Alejandro, Rivadulla, Marcos Lois, Pérez-García, Xenxo, Gómez, Generosa, Pérez, Manuel, Fall, Yagamare, Facchinetti, María Marta, Curino, Alejandro Carlos

“…The active form of vitamin D3, 1α,25(OH)2D3, plays a major role in maintaining calcium/phosphate homeostasis. In addition, it is a potent antiproliferative and…”
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Design, Synthesis, and Biological Evaluation of New Type of Gemini Analogues with a Cyclopropane Moiety in Their Side Chain by Gómez-Bouzó, Uxía, Peluso-Iltis, Carole, Santalla, Hugo, Quevedo, Mario Alfredo, Verlinden, Lieve, Verstuyf, Annemieke, Fall, Yagamare, Gómez, Generosa, Rochel, Natacha

“…We synthesized two new gemini analogues, UG-480 and UG-481, that incorporate a modified longer side chain containing a cyclopropane group. The evaluation of…”
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Synthesis and biological evaluation of a new vitamin D2 analogue by Gándara, Zoila, Pérez, Manuel, Salomón, Débora G., Ferronato, María J., Fermento, María E., Curino, Alejandro C., Facchinetti, María M., Gómez, Generosa, Fall, Yagamare

“…A new vitamin D2 analogue was synthesized using the Julia–Kocienski olefination. It has antiproliferative effects on cell lines from squamous cell carcinomas…”
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In silico studies using radial distribution function approach for predicting affinity of 1α,25-dihydroxyvitamin D3 analogues for Vitamin D receptor by GONZALEZ, Maykel Pérez, PUENTE, Miguel, FALL, Yagamare, GOMEZ, Generosa

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Design and efficient synthesis of novel vitamin D analogues bearing an aniline moiety in their side chains by Obelleiro, Antonio, Gómez-Bouzó, Uxía, Gómez, Generosa, Fall, Yagamare, Santalla, Hugo

“…[Display omitted] •This convergent strategy could allow the obtaining of various derived analogues efficiently.•N-Alkylation allows the formation of analogues…”
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Quantitative structure-activity relationship studies of vitamin D receptor affinity for analogues of 1α,25-dihydroxyvitamin D3. 1: WHIM descriptors by PEREZ GONZALEZ, Maykel, SUAREZ, Pedro Lois, FALL, Yagamare, GOMEZ, Generosa

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New Experimental and Computational Tools for Drug Discovery. Part - IX by Gómez, Generosa, Fall, Yagamare, González-Díaz, Humbert

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QSAR, docking, and CoMFA studies of GSK3 inhibitors by García, Isela, Fall, Yagamare, Gómez, Generosa

“…GSK-3 inhibitors are interesting candidates to develop Anti-Alzheimer compounds. GSK-3β are also interesting as Anti-parasitic compounds active against…”
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Using topological indices to predict anti-Alzheimer and anti-parasitic GSK-3 inhibitors by multi-target QSAR in silico screening by García, Isela, Fall, Yagamare, Gómez, Generosa

“…Plasmodium falciparum, Leishmania, Trypanosomes, are the causers of diseases such as malaria, leishmaniasis and African trypanosomiasis that nowadays are the…”
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From Hydrindane to Decalin: A Mild Transformation through a Dyotropic Ring Expansion by Santalla, Hugo, Faza, Olalla Nieto, Gómez, Generosa, Fall, Yagamare, Silva López, Carlos

“…An unexpected ring expansion converting hydrindane cores into decalins has been observed. The process occurs under very mild conditions and with exquisite…”
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First total synthesis of 6-epi-phomonol by Garrido, Fátima, Santalla, Hugo, Gómez, Generosa, Fall, Yagamare

“…[Display omitted] •Use of commercially available starting material.•Stereoselective Michael addition.•Stereoselective ketone reduction. We describe a new and…”
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First computational chemistry multi-target model for anti-Alzheimer, anti-parasitic, anti-fungi, and anti-bacterial activity of GSK-3 inhibitors in vitro, in vivo, and in different cellular lines by García, Isela, Fall, Yagamare, Gómez, Generosa, González-Díaz, Humberto

“…In the work described here, we developed the first multi-target quantitative structure–activity relationship (QSAR) model able to predict the results of 42…”
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Ionic liquid-supported TEMPO as catalyst in the oxidation of alcohols to aldehydes and ketones by Fall, Alioune, Sene, Massene, Gaye, Mohamed, Gómez, Generosa, Fall, Yagamare

“…We describe an efficient synthesis of an ionic liquid-supported TEMPO which was used for the oxidation of alcohols to aldehydes and ketones. The predictable…”
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QSAR & complex network study of the HMGR inhibitors structural diversity by García, Isela, Diop, Yagamare Fall, Gómez, Generosa

“…Efficient drugs such as statins or mevinic acids are inhibitors of the rate-limiting enzyme of cholesterol biosynthesis, 3-hydroxy-3-methyl-glutaryl coenzyme A…”
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Synthesis of new triazolium-based ionic liquids and their use in the Morita–Baylis–Hillman reaction by Fall, Alioune, Seck, Insa, Diouf, Ousmane, Gaye, Mohamed, Seck, Matar, Gómez, Generosa, Fall, Yagamare

“…[Display omitted] A series of 1,3,4-trialkyl-1,2,3-triazolium ionic liquids were synthesized via click chemistry and used as reaction media for the…”
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Easy Access to Polyfunctionalized Chiral Decalins by Santalla, Hugo, Gándara, Zoila, Gómez-Bouzó, Uxía, Gómez, Generosa, Fall, Yagamare

“…An unexpected ring expansion that converts hydrindanes into decalins via an unprecedented dyotropic reaction involving a mesylate group has been observed, and…”
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