Search Results - "GOMES, Erica M"

A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species by Zong, Hongliang, Gozman, Alexander, Caldas-Lopes, Eloisi, Taldone, Tony, Sturgill, Eric, Brennan, Sarah, Ochiana, Stefan O., Gomes-DaGama, Erica M., Sen, Siddhartha, Rodina, Anna, Koren, John, Becker, Michael W., Rudin, Charles M., Melnick, Ari, Levine, Ross L., Roboz, Gail J., Nimer, Stephen D., Chiosis, Gabriela, Guzman, Monica L.

“…Acute myeloid leukemia (AML) is a heterogeneous and fatal disease with an urgent need for improved therapeutic regimens given that most patients die from…”
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Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90 by Moulick, Kamalika, Ahn, James H, Zong, Hongliang, Rodina, Anna, Cerchietti, Leandro, Gomes DaGama, Erica M, Caldas-Lopes, Eloisi, Beebe, Kristin, Perna, Fabiana, Hatzi, Katerina, Vu, Ly P, Zhao, Xinyang, Zatorska, Danuta, Taldone, Tony, Smith-Jones, Peter, Alpaugh, Mary, Gross, Steven S, Pillarsetty, Nagavarakishore, Ku, Thomas, Lewis, Jason S, Larson, Steven M, Levine, Ross, Erdjument-Bromage, Hediye, Guzman, Monica L, Nimer, Stephen D, Melnick, Ari, Neckers, Len, Chiosis, Gabriela

“…The inhibitor PU-H71 preferentially targets tumor-enriched Hsp90 complexes. Affinity purification using PU-H71 reveals cancer-specific protein networks in…”
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Second-Generation Anti–Carcinoembryonic Antigen Designer T Cells Resist Activation-Induced Cell Death, Proliferate on Tumor Contact, Secrete Cytokines, and Exhibit Superior Antitumor Activity In vivo: A Preclinical Evaluation by Emtage, Peter C R, Lo, Agnes S Y, Gomes, Erica M, Liu, David L, Gonzalo-Daganzo, Rosa M, Junghans, Richard P

“…Purpose: This report describes the development and preclinical qualification tests of second-generation anti-carcinoembryonic (CEA) designer T cells for use in…”
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Heat shock protein 90 inhibitors in the treatment of cancer: current status and future directions by Jhaveri, Komal, Ochiana, Stefan O, Dunphy, Mark Ps, Gerecitano, John F, Corben, Adriana D, Peter, Radu I, Janjigian, Yelena Y, Gomes-DaGama, Erica M, Koren, 3rd, John, Modi, Shanu, Chiosis, Gabriela

“…Heat shock protein 90 (HSP90) serves as a critical facilitator for oncogene addiction. There has been augmenting enthusiasm in pursuing HSP90 as an anticancer…”
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Affinity Purification Probes of Potential Use To Investigate the Endogenous Hsp70 Interactome in Cancer by Rodina, Anna, Taldone, Tony, Kang, Yanlong, Patel, Pallav D, Koren, John, Yan, Pengrong, DaGama Gomes, Erica M, Yang, Chenghua, Patel, Maulik R, Shrestha, Liza, Ochiana, Stefan O, Santarossa, Cristina, Maharaj, Ronnie, Gozman, Alexander, Cox, Marc B, Erdjument-Bromage, Hediye, Hendrickson, Ronald C, Cerchietti, Leandro, Melnick, Ari, Guzman, Monica L, Chiosis, Gabriela

“…Heat shock protein 70 (Hsp70) is a family of proteins with key roles in regulating malignancy. Cancer cells rely on Hsp70 to inhibit apoptosis, regulate…”
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Antitumor Activity of an Oncolytic Adenoviral-CD40 Ligand (CD154) Transgene Construct in Human Breast Cancer Cells by GOMES, Erica M, RODRIGUES, Margret S, TONG, Alex W, PHADKE, Anagha P, BUTCHER, Lindsay D, STARLING, Cherry, CHEN, Salina, DONGKUN CHANG, HERNANDEZ-ALCOCEBA, Ruben, NEWMAN, Joseph T, STONE, Marvin J

“…Purpose: CD40 ligand (CD40L, CD154) plays a central role in immunoregulation and also directly modulates epithelial cell growth and differentiation. We…”
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Growth Inhibition of Human Multiple Myeloma Cells by an Oncolytic Adenovirus Carrying the CD40 Ligand Transgene by FERNANDES, Margret S, GOMES, Erica M, BUTCHER, Lindsay D, HERNANDEZ-ALCOCEBA, Reuben, DONGKUN CHANG, KANSOPON, Joe, NEWMAN, Joseph, STONE, Marvin J, TONG, Alex W

“…Purpose: The growth-inhibitory activity of recombinant CD40 ligand (CD40L) is well documented in human multiple myeloma (MM). We examined MM-targeted delivery…”
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Synthesis and evaluation of cell-permeable biotinylated PU-H71 derivatives as tumor Hsp90 probes by Taldone, Tony, Rodina, Anna, DaGama Gomes, Erica M, Riolo, Matthew, Patel, Hardik J, Alonso-Sabadell, Raul, Zatorska, Danuta, Patel, Maulik R, Kishinevsky, Sarah, Chiosis, Gabriela

“…The attachment of biotin to a small molecule provides a powerful tool in biology. Here, we present a systematic approach to identify biotinylated analogues of…”
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Phase I Trial of Anti-PSMA Designer CAR-T Cells in Prostate Cancer: Possible Role for Interacting Interleukin 2-T Cell Pharmacodynamics as a Determinant of Clinical Response by Junghans, Richard P., Ma, Qiangzhong, Rathore, Ritesh, Gomes, Erica M., Bais, Anthony J., Lo, Agnes S.Y., Abedi, Mehrdad, Davies, Robin A., Cabral, Howard J., Al-Homsi, A. Samer, Cohen, Stephen I.

“…BACKGROUND Chimeric antigen receptor (CAR)‐modified “designer” T cells (dTc, CAR‐T) against PSMA selectively target antigen‐expressing cells in vitro and…”
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Advanced generation anti-prostate specific membrane antigen designer T Cells for prostate cancer immunotherapy by Ma, Qiangzhong, Gomes, Erica M., Lo, Agnes Shuk-Yee, Junghans, Richard P.

“…BACKGROUND Adoptive immunotherapy by infusion of designer T cells (dTc) engineered with chimeric antigen receptors (CARs) for tumoricidal activity represents a…”
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Cell Density Plays a Critical Role in Ex Vivo Expansion of T Cells for Adoptive Immunotherapy by Gomes, Erica M., Wang, Yawen, Lo, Agnes Shuk-Yee, Junghans, Richard P., Ma, Qiangzhong

“…The successful ex vivo expansion of a large numbers of T cells is a prerequisite for adoptive immunotherapy. In this study, we found that cell density had…”
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Synthesis of purine-scaffold fluorescent probes for heat shock protein 90 with use in flow cytometry and fluorescence microscopy by Taldone, Tony, Gomes-DaGama, Erica M., Zong, Hongliang, Sen, Siddhartha, Alpaugh, Mary L., Zatorska, Danuta, Alonso-Sabadell, Raul, Guzman, Monica L., Chiosis, Gabriela

“…Fluorescent ligands for the heat shock protein 90 (Hsp90) were synthesized containing either fluorescein isothiocyanate (FITC), 4-nitrobenzo[1,2,5]oxadiazole…”
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Monitoring afatinib treatment in HER2-positive gastric cancer with 18F-FDG and 89Zr-trastuzumab PET by Janjigian, Yelena Y, Viola-Villegas, Nerissa, Holland, Jason P, Divilov, Vadim, Carlin, Sean D, Gomes-DaGama, Erica M, Chiosis, Gabriela, Carbonetti, Gregory, de Stanchina, Elisa, Lewis, Jason S

“…We evaluated the ability of the PET imaging agent (89)Zr-trastuzumab to delineate HER2-positive gastric cancer and to monitor the pharmacodynamic effects of…”
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Abstract 5444: Development of a noninvasive assay to determine drug concentration in tumor during hsp90 inhibitor therapy by Taldone, Tony, Pillarsetty, Nagavarakishore, Dunphy, Mark PS, Gerecitano, John F., Caldas-Lopes, Eloisi, Beattie, Brad, Peter, Radu I., Kang, Yanlong, Rodina, Anna, Yan, Pengrong, DaGama Gomes, Erica M., Bolaender, Alexander, Pressl, Christina, Punzalan, Blesida, Ku, Anson, Ku, Thomas, Shah, Smit, Uddin, Mohammad, Chen, Mei H., Santos, Elmer, Koziorowski, Jacek, Corben, Adriana, Modi, Shanu, Jhaveri, Komal, Lin, Oscar, Vakiani, Efsevia, Janjigian, Yelena, Zanzonico, Pat, Hudis, Clifford, Larson, Steven M., Lewis, Jason S., Chiosis, Gabriela

“…As molecularly targeted agents assume a more prominent role in anticancer therapy there is a growing need to determine in a noninvasive manner whether the…”
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Growth Inhibition of Human Multiple Myeloma Cells by a CD40 Ligand (CD40L, CD154) Transgene - Oncolytic Virus Construct by Rodrigues, Margret S., Gomes, Erica M., Hernandez, Reuben, Chang, Jack, Kansopon, Joe, Newman, Joseph, Stone, Marvin J., Tong, Alex W.

“…Human multiple myeloma (MM) remains incurable despite recent advances in induction therapy. To explore biotherapeutic approaches that may potentially enhance…”
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Monitoring Afatinib Treatment in HER2-Positive Gastric Cancer with 18 F-FDG and 89 Zr-Trastuzumab PET by Janjigian, Yelena Y., Viola-Villegas, Nerissa, Holland, Jason P., Divilov, Vadim, Carlin, Sean D., Gomes-DaGama, Erica M., Chiosis, Gabriela, Carbonetti, Gregory, de Stanchina, Elisa, Lewis, Jason S.

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Monitoring Afatinib Treatment in HER2-Positive Gastric Cancer with ^sup 18^F-FDG and ^sup 89^Zr-Trastuzumab PET by Janjigian, Yelena Y, Viola-Villegas, Nerissa, Holland, Jason P, Divilov, Vadim, Carlin, Sean D, Gomes-DaGama, Erica M, Chiosis, Gabriela, Carbonetti, Gregory, de Stanchina, Elisa, Lewis, Jason S

“…We evaluated the ability of the PET imaging agent ...-trastuzumab to delineate HER2-positive gastric cancer and to monitor the pharmacodynamic effects of the…”
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Abstract 1263: Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90 by Gomes-DaGama, Erica M., Moulick, Kamalika, Ahn, James H., Zong, Hongliang, Rodina, Anna, Cerchietti, Leandro, Lopes-Vazquez, Maria E. Caldas, Beebe, Kristin, Perna, Fabiana, Katerina, Chatzi, Vu, Ly P., Zhao, Xinyang, Zatorska, Danuta, Taldone, Tony, Smith-Jones, Peter, Alpaugh, Mary, Gross, Steven S., Pillarsetty, Nagavarakishore, Ku, Thomas, Lewis, Jason S., Larson, Steven M., Ross, Levine, Erdjument-Bromage, Hediye, Guzman, Monica L., Nimer, Stephen D., Melnick, Ari M., Neckers, Len, Chiosis, Gabriela

“…Most cancers are characterized by multiple molecular alterations, but identification of the key proteins involved in these signaling pathways is currently…”
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Influence of laser irradiation on the push-out bond strength between a glass fiber post and root dentin by Gomes, Karla G.F., DDS, MS, Faria, Natália S., DDS, MS, Neto, Walter R., DDS, MS, PhD, Colucci, Vivian, DDS, MS, PhD, Gomes, Erica A., DDS, MS, PhD

“…Abstract Statement of problem A major issue related to the failure of endodontically treated teeth restored with an intraradicular post is gradual debonding of…”
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A Novel Dentin Push-out Bond Strength Model That Uses Micro–Computed Tomography by Brito-Júnior, Manoel, PhD, MD, DDS, Leoni, Graziela Bianchi, MD, DDS, Pereira, Rodrigo Dantas, MD, DDS, Faria-e-Silva, André Luis, PhD, MD, DDS, Gomes, Erica Alves, PhD, MD, DDS, Silva-Sousa, Yara Teresinha, PhD, MD, DDS, Sousa-Neto, Manoel Damião, PhD, MD, DDS

“…Abstract Introduction Current push-out experimental methods used in endodontic research should be improved. This study introduced a novel dentin push-out bond…”
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