Search Results - "GOMER, C. J"

Photodynamic Therapy by Dougherty, Thomas J., Gomer, Charles J., Jori, Giulio, Kessel, David, Korbelik, Mladen, Moan, Johan, Peng, Qian

“…Photodynamic therapy involves administration of a tumorlocalizing photosensitizing agent, which may require metabolic synthesis (i.e., a prodrug), followed by…”
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Antiangiogenic treatment enhances photodynamic therapy responsiveness in a mouse mammary carcinoma by FERRARIO, A, VON TIEHL, K. F, RUCKER, N, SCHWARZ, M. A, GILL, P. S, GOMER, C. J

“…Photodynamic therapy (PDT) is a promising cancer treatment that induces localized tumor destruction via the photochemical generation of cytotoxic singlet…”
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Preclinical examination of first and second generation photosensitizers used in photodynamic therapy by Gomer, C J

“…Numerous photosensitizers with absorption peaks spanning the 600-800 nm "therapeutic window" have been and continue to be synthesized. Structural modifications…”
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Clinical and preclinical photodynamic therapy by Fisher, A M, Murphree, A L, Gomer, C J

“…Photodynamic therapy (PDT) is a treatment modality that utilizes a photosensitizing drug activated by laser generated light, and is proving effective for…”
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Photodynamic therapy-mediated oxidative stress can induce expression of heat shock proteins by GOMER, C. J, RYTER, S. W, FERRARIO, A, RUCKER, N, WONG, S, FISHER, A. M. R

“…Photodynamic therapy (PDT) is an experimental cancer therapy inducing tumor tissue damage via photosensitizer-mediated oxidative cytotoxicity. A previous…”
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Photodynamic therapy-mediated oxidative stress as a molecular switch for the temporal expression of genes ligated to the human heat shock promoter by LUNA, M. C, FERRARIO, A, WONG, S, FISHER, A. M. R, GOMER, C. J

“…Oxidative stress associated with photodynamic therapy (PDT) is a transcriptional inducer of genes encoding stress proteins, including those belonging to the…”
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Properties and Applications of Photodynamic Therapy by Gomer, Charles J., Rucker, Natalie, Ferrario, Angela, Wong, Sam

“…Photodynamic therapy (PDT) is the treatment of malignant lesions with visible light following the systemic administration of a tumor-localizing…”
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Photodynamic therapy sensitivity is not altered in human tumor cells after abrogation of p53 function by FISHER, A. M. R, FERRARIO, A, RUCKER, N, SHA ZHANG, GOMER, C. J

“…Photodynamic therapy (PDT) is an effective local cancer treatment that induces cytotoxicity through the intracellular generation of reactive oxygen species…”
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Tissue distribution and photosensitizing properties of mono-L-aspartyl chlorin e6 in a mouse tumor model by GOMER, C. J, FERRARIO, A

“…Mono-L-aspartyl chlorin e6 (NPe6) is a photosensitizer that possesses properties such as chemical purity and a major absorption band at 664 nm which are…”
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Photodynamic therapy mediated induction of early response genes by LUNA, M. C, WONG, S, GOMER, C. J

“…Photodynamic therapy (PDT) generates reactive oxygen species which initiate the cytotoxic events of this tumor treatment. We demonstrate that PDT mediated…”
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Glucose regulated protein induction and cellular resistance to oxidative stress mediated by porphyrin photosensitization by GOMER, C. J, FERRARIO, A, RUCKER, N, WONG, S, LEE, A. S

“…Photodynamic therapy (PDT) utilizes a tumor localizing porphyrin photosensitizer in the clinical treatment of cancer. At a mechanistic level, porphyrin…”
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Nuclear factor kappa B binding activity in mouse L1210 cells following photofrin II-mediated photosensitization by Ryter, S W, Gomer, C J

“…Clinical photodynamic therapy (PDT) uses the photosensitizer photofrin II to produce singlet molecular oxygen and other reactive oxygen intermediates for…”
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Metabolic properties and photosensitizing responsiveness of mono-L-aspartyl chlorin e6 in a mouse tumor model by FERRARIO, A, KESSEL, D, GOMER, C. J

“…A mouse mammary tumor model was used to evaluate metabolic properties of the photosensitizer mono-L-aspartyl chlorin e6 (NPe6) and to determine the optimal…”
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Photodynamic therapy in the treatment of malignancies by Gomer, C J

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Loss of p53 function confers high-level multidrug resistance in neuroblastoma cell lines by KESHELAVA, Nino, ZUO, Juan J, PING CHEN, WAIDYARATNE, Sitara N, LUNA, Marian C, GOMER, Charles J, TRICHE, Timothy J, REYNOLDS, C. Patrick

“…Neuroblastomas can acquire a sustained high-level drug resistance during chemotherapy and especially myeloablative chemoradiotherapy. p53 mutations are rare in…”
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Decreased expression and function of α-2 macroglobulin receptor/low density lipoprotein receptor-related protein in photodynamic therapy-resistant mouse tumor cells by LUNA, M. C, FERRARIO, A, RUCKER, N, GOMER, C. J

“…Parental and photodynamic therapy (PDT)-resistant mouse, radiation-induced fibrosarcoma cell lines were evaluated using mRNA differential display in an attempt…”
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Establishment of a Chinese hamster ovary cell line that expresses grp78 antisense transcripts and suppresses A23187 induction of both GRP78 and GRP94 by Li, L J, Li, X, Ferrario, A, Rucker, N, Liu, E S, Wong, S, Gomer, C J, Lee, A S

“…GRP78, a 78,000 dalton protein residing in the endoplasmic reticulum, is postulated to play important roles in protein folding and cell survival during calcium…”
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Differential cell photosensitivity following porphyrin photodynamic therapy by GOMER, C. J, RUCKER, N, MURPHREE, A. L

“…Experiments were performed to determine if differences in porphyrin photosensitivity could be observed for cells with varying efficiency in DNA damage repair,…”
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Increased transcription and translation of heme oxygenase in Chinese hamster fibroblasts following photodynamic stress or Photofrin II incubation by Gomer, C J, Luna, M, Ferrario, A, Rucker, N

“…Porphyrin mediated photosensitization can enhance the transcription and translation of several oxidative stress genes. In this study, we report on the enhanced…”
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Isolation and initial characterization of mouse tumor cells resistant to porphyrin-mediated photodynamic therapy by LUNA, M. C, GOMER, C. J

“…Photodynamic therapy (PDT)-resistant variants of the RIF-1 mouse tumor cell line have been isolated following a protocol of repeated porphyrin incubation and…”
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