Search Results - "GOLOR, Georg"

Effect of the Phosphate Binders Sevelamer Carbonate and Calcium Acetate on the Pharmacokinetics of Roxadustat After Concomitant or Time-separated Administration in Healthy Individuals by Groenendaal-van de Meent, Dorien, Kerbusch, Virginie, Barroso-Fernandez, Begona, den Adel, Martin, van Dijk, Jan, Golor, Georg, Schaddelee, Marloes

“…Roxadustat, a hypoxia-inducible factor prolyl hydroxylase inhibitor, treats anemia in chronic kidney disease. Hyperphosphatemia, a common complication in…”
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First‐in‐human study of the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple oral doses of SAR247799, a selective G‐protein‐biased sphingosine‐1 phosphate receptor‐1 agonist for endothelial protection by Bergougnan, Luc, Armani, Sara, Golor, Georg, Tardat, Agnes, Vitse, Olivier, Hurbin, Fabrice, Scemama, Michel, Poitiers, Franck, Radzik, David, Gaudin, Christophe, Hovsepian, Lionel, Muslin, Anthony J., Kirkesseli, Stephane, Deutsch, Paul, Parkar, Ashfaq A.

“…Aims SAR247799 is a selective G‐protein‐biased sphingosine‐1 phosphate receptor‐1 (S1P1) agonist with potential to restore endothelial function in vascular…”
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Multiple daytime administration of the selective orexin-2 receptor antagonist JNJ-42847922 induces somnolence in healthy subjects without residual central effects by van der Ark, Peter D, Golor, Georg, van Nueten, Luc, Nandy, Partha, de Boer, Peter

“…Background: Pharmacokinetics, pharmacodynamics and general safety and tolerability of JNJ-42847922, a selective orexin-2 receptor antagonist, were assessed in…”
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The Hypoxia-Inducible Factor Prolyl-Hydroxylase Inhibitor Roxadustat (FG-4592) and Warfarin in Healthy Volunteers: A Pharmacokinetic and Pharmacodynamic Drug–Drug Interaction Study by Groenendaal-van de Meent, Dorien, den Adel, Martin, Rijnders, Sanne, Krebs-Brown, Axel, Kerbusch, Virginie, Golor, Georg, Schaddelee, Marloes

“…Abstract Purpose Roxadustat is a small-molecule hypoxia-inducible factor prolyl-hydroxylase inhibitor in late-stage clinical development for the treatment of…”
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Effect of the Proton Pump Inhibitor Esomeprazole on the Oral Absorption and Pharmacokinetics of Nilotinib by Yin, Ophelia Q. P., Gallagher, Neil, Fischer, Deirdre, Demirhan, Eren, Zhou, Wei, Golor, Georg, Schran, Horst

“…Nilotinib (Tasigna), a highly selective and potent BCR‐ABL tyrosine kinase inhibitor (TkI), is administered orally and has pH‐dependent aqueous solubility,…”
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Effect of Multiple Doses of Omeprazole on the Pharmacokinetics, Safety, and Tolerability of Roxadustat in Healthy Subjects by Groenendaal-van de Meent, Dorien, den Adel, Martin, van Dijk, Jan, Barroso-Fernandez, Begona, El Galta, Rachid, Golor, Georg, Schaddelee, Marloes

“…Background and Objectives Roxadustat is an orally active hypoxia-inducible factor prolyl hydroxylase inhibitor for the treatment of anemia in chronic kidney…”
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A first-in-man study to evaluate the safety, tolerability, and pharmacokinetics of pasireotide (SOM230), a multireceptor-targeted somatostatin analog, in healthy volunteers by Golor, Georg, Hu, Ke, Ruffin, Matthieu, Buchelt, Alexandra, Bouillaud, Emmanuel, Wang, Yanfeng, Maldonado, Mario

“…Pasireotide (SOM230) is a multireceptor-targeted somatostatin analog with high binding affinity for four of the five somatostatin receptor subtypes (sst(1,2,3)…”
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Safety and pharmacokinetics of olokizumab, an anti-IL-6 monoclonal antibody, administered to healthy male volunteers: A randomized phase I study by Kretsos, Kosmas, Golor, Georg, Jullion, Astrid, Hickling, Matthew, McCabe, Suzanne, Shaw, Stevan, Jose, Joby, Oliver, Ruth

“…Interleukin‐6 (IL‐6) is implicated in the pathophysiology of several inflammatory conditions. Olokizumab, a humanized anti‐IL‐6 monoclonal antibody,…”
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Safety of Hydroxocobalamin in Healthy Volunteers in a Randomized, Placebo-Controlled Study by Uhl, Wolfgang, Nolting, Arno, Golor, Georg, Ludwig Rost, Karl, Kovar, Andreas

“…Introduction. This randomized, double-blind, placebo-controlled, ascending-dose study was conducted in healthy volunteers to evaluate the safety of the…”
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The Prokinetic Cinitapride Has No Clinically Relevant Pharmacokinetic Interaction and Effect on QT during Coadministration with Ketoconazole by ROBERT, Marta, SALVA, Miquel, SEGARRA, Rosa, PAVESI, Marco, ESBRI, Ramon, ROBERTS, David, GOLOR, Georg

“…The present clinical trial was designed to evaluate the possible pharmacokinetic and electrocardiographic interactions of the gastroenteric prokinetic drug…”
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Multiple-dose clinical pharmacology of the selective orexin-1 receptor antagonist ACT-539313 by Kaufmann, Priska, Ort, Marion, Golor, Georg, Kornberger, Rüdiger, Dingemanse, Jasper

“…Compounds that selectively target orexin-1 receptors may be beneficial for the treatment of various disorders. The role of selective orexin-1 receptor…”
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Safety and Pharmacokinetics of Single and Multiple Ascending Doses of the Novel Oral Human GLP-1 Analogue, Oral Semaglutide, in Healthy Subjects and Subjects with Type 2 Diabetes by Granhall, Charlotte, Donsmark, Morten, Blicher, Thalia M., Golor, Georg, Søndergaard, Flemming L., Thomsen, Mette, Bækdal, Tine A.

“…Background Oral semaglutide is a novel tablet containing the human glucagon-like peptide-1 (GLP‑1) analogue semaglutide, co-formulated with the absorption…”
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First‐in‐human study with ACT‐539313, a novel selective orexin‐1 receptor antagonist by Kaufmann, Priska, Ort, Marion, Golor, Georg, Kornberger, Rüdiger, Dingemanse, Jasper

“…Aims The orexin system is involved in anxiety behaviour and corresponding physiological reactions and constitutes a target for treatment of anxiety disorders…”
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Clinical Pharmacokinetics of Alamifovir and Its Metabolites by CHAN, Clark, ABU-RADDAD, Eyas, WISE, Stephen D, GOLOR, Georg, WATANABE, Hikari, SASAKI, Akira, KWEE POO YEO, SOON, Danny, SINHA, Vikram P, FLANAGAN, Shawn D, HE, Minxia M

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Management of hyperglycemia associated with pasireotide (SOM230): Healthy volunteer study by Breitschaft, Astrid, Hu, Ke, Hermosillo Reséndiz, Karina, Darstein, Christelle, Golor, Georg

“…Abstract Aims Pasireotide, a multireceptor-targeted somatostatin analogue with efficacy in Cushing's disease and acromegaly, can affect glucose metabolism due…”
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Lixisenatide reduces postprandial hyperglycaemia via gastrostatic and insulinotropic effects by Becker, Reinhard H. A., Stechl, Jens, Steinstraesser, Axel, Golor, Georg, Pellissier, Franck

“…Background Lixisenatide is a once‐daily, prandial, short‐acting glucagon‐like peptide‐1 receptor agonist. Its main antidiabetic effect is to delay gastric…”
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Effect of Semaglutide on the Pharmacokinetics of Metformin, Warfarin, Atorvastatin and Digoxin in Healthy Subjects by Hausner, Helene, Derving Karsbøl, Julie, Holst, Anders G., Jacobsen, Jacob B., Wagner, Frank-Dietrich, Golor, Georg, Anderson, Thomas W.

“…Background and Objective Semaglutide is a glucagon-like peptide-1 analogue in development for the once-weekly treatment of type 2 diabetes mellitus. Its effect…”
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Kinetics and inductive potency of 1,2,3,4,6,7,8-heptachlorodibenzo- p-dioxin (h 7cdd) in rats by Golor, Georg, Yamashita, Keisuke, Körner, Wolfgang, Hagenmaier, Hanspaul, Neubert, Diether

“…The kinetic properties and the inductive potency of 1,2,3,4,6,7,8-heptachlorodibenzo- p-dioxin (H7CDD) were studied in Wistar rats following subcutaneous…”
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Tissue concentrations and induction of a hepatic monooxygenase in male Wistar rats after repeated doses of defined polychlorinated dibenzo-p-dioxin and dibenzofuran (PCDDs and PCDFs) mixtures by KÖRNER, Wolfgang, GOLOR, Georg, SCHULZ, Thomas, WIESMÜLLER, Thomas, HAGENMAIER, Hanspaul, NEUBERT, Diether

“…Two groups of male Wistar rats were treated 16 times (every 3rd day) subcutaneously with a defined mixture of polychlorinated dibenzo-p-dioxins (PCDDs) or of…”
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Pharmacodynamic interaction between intravenous nitroglycerin and oral sacubitril/valsartan (LCZ696) in healthy subjects by Schuehly, Uwe, Ayalasomayajula, Surya, Buchbjerg, Jeppe, Pal, Parasar, Golor, Georg, Prescott, Margaret F., Sunkara, Gangadhar, Hinder, Markus, Langenickel, Thomas H.

“…Purpose Sacubitril/valsartan (LCZ696) and nitroglycerin share the second messenger cGMP and lower blood pressure. Given the potential for co-administration of…”
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