Search Results - "GOLEC, Julian"

Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR by Reaper, Philip M, Griffiths, Matthew R, Long, Joanna M, Charrier, Jean-Damien, MacCormick, Somhairle, Charlton, Peter A, Golec, Julian M C, Pollard, John R

“…A specific and potent inhibitor of the DNA damage response kinase ATR can exploit synthetic lethality between ATR and the related kinase ATM to sensitize…”
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Discovery of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase as Potential Anticancer Agents by Charrier, Jean-Damien, Durrant, Steven J, Golec, Julian M. C, Kay, David P, Knegtel, Ronald M. A, MacCormick, Somhairle, Mortimore, Michael, O'Donnell, Michael E, Pinder, Joanne L, Reaper, Philip M, Rutherford, Alistair P, Wang, Paul S. H, Young, Stephen C, Pollard, John R

“…DNA-damaging agents are among the most frequently used anticancer drugs. However, they provide only modest benefit in most cancers. This may be attributed to a…”
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Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA by Swan, Michael K., Legris, Valerie, Tanner, Adam, Reaper, Philip M., Vial, Sarah, Bordas, Rebecca, Pollard, John R., Charlton, Peter A., Golec, Julian M. C., Bertrand, Jay A.

“…Bloom's syndrome is an autosomal recessive genome‐instability disorder associated with a predisposition to cancer, premature aging and developmental…”
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Impact of insecticide programs on pests, the predatory mite Phytoseiulus persimilis, and staked tomato profitability by Bilbo, Tom R., Owens, David R., Golec, Julian R., Walgenbach, James F.

“…BACKGROUND Various insecticides are available to manage diverse pest complexes in commercial vegetable production, but knowledge gaps exist regarding their…”
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Banks Grass Mite (Acari: Tetranychidae) Suppression May Add to the Benefit of Drought-Tolerant Corn Hybrids Exposed to Water Stress by Ruckert, Alice, Golec, Julian R., Barnes, Cody L., Ramirez, Ricardo A.

“…Spider mite (Acari: Tetranychidae) outbreaks are common on corn grown in the arid West. Hot and dry conditions reduce mite development time, increase…”
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Potentiation of tumor responses to DNA damaging therapy by the selective ATR inhibitor VX-970 by Hall, Amy B, Newsome, Dave, Wang, Yuxin, Boucher, Diane M, Eustace, Brenda, Gu, Yong, Hare, Brian, Johnson, Mac A, Milton, Sean, Murphy, Cheryl E, Takemoto, Darin, Tolman, Crystal, Wood, Mark, Charlton, Peter, Charrier, Jean-Damien, Furey, Brinley, Golec, Julian, Reaper, Philip M, Pollard, John R

“…Platinum-based DNA-damaging chemotherapy is standard-of-care for most patients with lung cancer but outcomes remain poor. This has been attributed, in part, to…”
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Effects of Legume Species and Plant Growth Stage on Attraction, Fecundity, and Development of the Kudzu Bug (Heteroptera: Plataspidae) by Yang, Liu, Hu, Xing Ping, Golec, Julian R, Zeng, Xinnian

“…The kudzu bug, Megacopta cribraria (F.) (Heteroptera: Plataspidae), is an invasive pest of soybeans in the southeastern United States. Two greenhouse choice…”
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VX-166: a novel potent small molecule caspase inhibitor as a potential therapy for sepsis by Weber, Peter, Wang, Ping, Maddens, Stephane, Wang, Paul Sh, Wu, Rongqian, Miksa, Michael, Dong, Weifeng, Mortimore, Michael, Golec, Julian M C, Charlton, Peter

“…Prevention of lymphocyte apoptosis by caspase inhibition has been proposed as a novel treatment approach in sepsis. However, it has not been clearly…”
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Cerambycid Communities and Their Associated Hymenopteran Parasitoids From Major Hardwood Trees in Delaware: Implications for Biocontrol of Invasive Longhorned Beetles by Golec, Julian R, Aparicio, Ellen, Wang, Xingeng, Duan, Jian J, Fuester, Roger W, Tatman, Daria, Kula, Robert R

“…Cerambycidae provide important ecological services in forests yet cause economic damage when they infest living trees. Parasitoids can regulate woodborer…”
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Influence of Temperature on the Reproductive and Developmental Biology of Ontsira mellipes (Hymenoptera: Braconidae): Implications for Biological Control of the Asian Longhorned Beetle (Coleoptera: Cerambycidae) by Golec, Julian R, Duan, Jian J, Hough-Goldstein, Judith

“…Ontsira mellipes Ashmead (Hymenoptera: Braconidae) is a North American parasitoid species that develops on the invasive pest, Anoplophora glabripennis…”
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VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo by Miller, Karen M, Harrington, Elizabeth A, Bebbington, David, Moore, Jeff, Rasmussen, Richele K, Ajose-Adeogun, Abi O, Nakayama, Tomoko, Graham, Joanne A, Demur, Cecile, Hercend, Thierry, Diu-Hercend, Anita, Su, Michael, Golec, Julian M C

“…The Aurora kinases are essential for the regulation of chromosome segregation and cytokinesis during mitosis. Aberrant expression and activity of these kinases…”
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Life History, Reproductive Biology, and Larval Development of Ontsira mellipes (Hymenoptera: Braconidae), a Newly Associated Parasitoid of the Invasive Asian Longhorned Beetle (Coleoptera: Cerambycidae) by Golec, Julian R, Duan, Jian J, Aparicio, Ellen, Hough-Goldstein, Judith

“…The invasive Asian longhorned beetle, Anoplophora glabripennis (Motschulsky), is a destructive xylophagous forest pest species originating from Asia. Several…”
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Laboratory adaptation of a native North American parasitoid to an exotic wood-boring beetle: implications for biological control of invasive pests by Golec, Julian R., Duan, Jian J., Rim, Kaitlin, Hough-Goldstein, Judith, Aparicio, Ellen A.

“…Numerous researchers have observed native parasitic Hymenoptera attacking exotic pest species, yet few have documented their potential to adapt to novel hosts…”
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The discovery of the potent aurora inhibitor MK-0457 (VX-680) by Bebbington, David, Binch, Hayley, Charrier, Jean-Damien, Everitt, Simon, Fraysse, Damien, Golec, Julian, Kay, David, Knegtel, Ronald, Mak, Chau, Mazzei, Francesca, Miller, Andrew, Mortimore, Michael, O’Donnell, Michael, Patel, Sanjay, Pierard, Francoise, Pinder, Joanne, Pollard, John, Ramaya, Sharn, Robinson, Daniel, Rutherford, Alistair, Studley, John, Westcott, James

“…The identification of a novel series of Aurora kinase inhibitors and exploitation of their SAR, which led to the discovery of MK-0457 (VX-680), is described…”
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Synthesis and in vitro evaluation of a series of diketopiperazine inhibitors of plasminogen activator inhibitor-1 by Folkes, Adrian, Roe, Michael B, Sohal, Sukhjit, Golec, Julian, Faint, Richard, Brooks, Teresa, Charlton, Peter

“…We have synthesized and evaluated a series of diketopiperazine-based inhibitors of PAI-1. These studies resulted in the identification of 34 which inhibited…”
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Effect of biopesticides on different Tetranychus urticae Koch (Acari: Tetranychidae) life stages by Golec, Julian R., Hoge, Brianna, Walgenbach, James F.

“…Tetranychus urticae Koch management in many specialty crops relies on intensive pesticide use and has led to rapid evolution of acaricide-resistant…”
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Host selection and potential non-target risk of Dastarcus helophoroides, a larval parasitoid of the Asian longhorned beetle, Anoplophora glabripennis by Rim, Kaitlin, Golec, Julian R., Duan, Jian J.

“…•Parasitoid Dastarcus helophoroides (DH) evolved with Asian longhorned beetle (ALB).•DH attacks not only ALB but also a novel buprestid host, emerald ash borer…”
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Novel Inhibitors of Plasminogen Activator Inhibitor-1: Development of New Templates From Diketopiperazines by Wang, Shouming, Golec, Julian, Miller, Warren, Milutinovic, Sandra, Folkes, Adrian, Williams, Susannah, Brooks, Teresa, Hardman, Kevin, Charlton, Peter, Wren, Stephen, Spencer, John

“…Several isoquinoline-based templates were identified from the studies of the conformational effects of the diketopiperazine structures for PAI-1 inhibition…”
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Mortality factors of Anoplophora glabripennis (Coleoptera: Cerambycidae) infesting Salix and Populus in central, northwest, and northeast China by Golec, Julian R., Li, Fei, Cao, Liangming, Wang, Xiaoyi, Duan, Jian J.

“…•Mortality factors of endemic A. glabripennis populations investigated in China.•Undetermined factors, on average, killed 59.3% of eggs across all sites and…”
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Rational Design of 5‑(4-(Isopropylsulfonyl)­phenyl)-3-(3-(4-((methylamino)­methyl)­phenyl)­isoxazol-5-yl)­pyrazin-2-amine (VX-970, M6620): Optimization of Intra- and Intermolecular Polar Interactions of a New Ataxia Telangiectasia Mutated and Rad3-Related (ATR) Kinase Inhibitor by Knegtel, Ronald, Charrier, Jean-Damien, Durrant, Steven, Davis, Chris, O’Donnell, Michael, Storck, Pierre, MacCormick, Somhairle, Kay, David, Pinder, Joanne, Virani, Anisa, Twin, Heather, Griffiths, Matthew, Reaper, Philip, Littlewood, Peter, Young, Steve, Golec, Julian, Pollard, John

“…The DNA damage response (DDR) is a DNA damage surveillance and repair mechanism that can limit the effectiveness of radiotherapy and DNA-damaging chemotherapy,…”
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