Search Results - "GOLDSTEIN, L. J"

Small bowel mucosal injury is reduced in healthy subjects treated with celecoxib compared with ibuprofen plus omeprazole, as assessed by video capsule endoscopy by GOLDSTEIN, J. L., EISEN, G. M., LEWIS, B., GRALNEK, I. M., AISENBERG, J., BHADRA, P., BERGER, M. F.

“…SUMMARY Background  Small bowel mucosal injury associated with non‐selective non‐steroidal anti‐inflammatory drugs is being increasingly recognized. Aim  To…”
Get full text

Clinical trial: the incidence of NSAID‐associated endoscopic gastric ulcers in patients treated with PN 400 (naproxen plus esomeprazole magnesium) vs. enteric‐coated naproxen alone by Goldstein, J. L., Hochberg, M. C., Fort, J. G., Zhang, Y., Hwang, C., Sostek, M.

“…Aliment Pharmacol Ther 2010; 32: 401–413 Summary Background  Gastroprotective co‐therapy may reduce the risk of nonsteroidal anti‐inflammatory drug…”
Get full text

Regulation of SREBP Processing and Membrane Lipid Production by Phospholipids in Drosophila by Dobrosotskaya, I. Y., Seegmiller, A. C., Brown, M. S., Goldstein, J. L., Rawson, R. B.

“…Animal cells exert exquisite control over the physical and chemical properties of their membranes, but the mechanisms are obscure. We show that…”
Get full text

Risk factors associated with a decrease ≥2 g/dL in haemoglobin and/or ≥10% haematocrit in osteoarthritis patients taking celecoxib or a nonselective NSAID plus a PPI in a large randomised controlled trial (CONDOR) by Lanas, A., Goldstein, J. L., Chan, F. K. L., Wilcox, C. M., Peura, D. A., Li, C., Sands, G. H., Scheiman, J. M.

“…Summary Background Nonsteroidal anti‐inflammatory drugs are associated with gastrointestinal (GI) damage. The Celecoxib vs. Omeprazole and Diclofenac for…”
Get full text

Haemoglobin decreases in NSAID users over time: an analysis of two large outcome trials by Goldstein, J. L., Chan, F. K. L., Lanas, A., Wilcox, C. M., Peura, D., Sands, G. H., Berger, M. F., Nguyen, H., Scheiman, J. M.

“…Aliment Pharmacol Ther 2011; 34: 808–816 Summary Background  Nonsteroidal anti‐inflammatory drugs (NSAIDs) have been associated with clinically significant…”
Get full text

The clinical investigator: bewitched, bothered, and bewildered--but still beloved by Goldstein, J L, Brown, M S

Get full text

Underutilization of preventive strategies in patients receiving NSAIDs by Sturkenboom, M. C. J. M., Burke, T. A., Dieleman, J. P., Tangelder, M. J. D., Lee, F., Goldstein, J. L.

“…Background. Multiple treatment guidelines for non-steroidal anti-inflammatory drugs (NSAIDs) suggest that patients with one or more risk factors for…”
Get full text

The impact of low‐dose aspirin on endoscopic gastric and duodenal ulcer rates in users of a non‐selective non‐steroidal anti‐inflammatory drug or a cyclo‐oxygenase‐2‐selective inhibitor by GOLDSTEIN, J. L., LOWRY, S. C., LANZA, F. L., SCHWARTZ, H. I., DODGE, W. E.

“…Summary Background The effect of low‐dose aspirin on endoscopic ulcer incidence in cyclo‐oxygenase‐2‐selective inhibitor or non‐selective non‐steroidal…”
Get full text

Clinical trial: healing of NSAID‐associated gastric ulcers in patients continuing NSAID therapy – a randomized study comparing ranitidine with esomeprazole by GOLDSTEIN, J. L., JOHANSON, J. F., HAWKEY, C. J., SUCHOWER, L. J., BROWN, K. A.

“…Summary Background  The use of non‐steroidal anti‐inflammatory drugs (NSAID) is associated with an increased risk of gastric ulcer (GU) development. Methods …”
Get full text

Clinical trial: gastric acid suppression in Hispanic adults with symptomatic gastro‐oesophageal reflux disease – comparator study of esomeprazole, lansoprazole and pantoprazole by Morgan, D., Pandolfino, J., Katz, P. O., Goldstein, J. L., Barker, P. N., Illueca, M.

“…Aliment Pharmacol Ther 2010; 32: 200–208 Summary Background  Hispanic‐Americans are a rapidly growing population in the United States, yet gastro‐oesophageal…”
Get full text

Channelling bias and the incidence of gastrointestinal haemorrhage in users of meloxicam, coxibs, and older, non-specific non-steroidal anti-inflammatory drugs by MacDonald, T M, Morant, S V, Goldstein, J L, Burke, T A, Pettitt, D

“…Background: Although clinical trial results suggest that meloxicam has less gastrointestinal toxicity than most other non-steroidal anti-inflammatory drugs…”
Get full text

Reduced risk of upper gastrointestinal ulcer complications with celecoxib, a novel COX-2 inhibitor by Goldstein, Jay L, Silverstein, Fred E, Agrawal, Naurang M, Hubbard, Richard C, Kaiser, June, Maurath, Clement J, Verburg, Kenneth M, Geis, Steven G

“…The aim of this study was to assess the rate of upper gastrointestinal (UGI) ulcer complications (bleeding, perforation, or gastric outlet obstruction)…”
Get full text

Cyclo‐oxygenase‐2 inhibitors or nonselective NSAIDs plus gastroprotective agents: what to prescribe in daily clinical practice? by Masclee, G. M. C., Valkhoff, V. E., Soest, E. M., Schade, R., Mazzaglia, G., Molokhia, M., Trifirò, G., Goldstein, J. L., Hernández‐Díaz, S., Kuipers, E. J., Sturkenboom, M. C. J. M.

“…Summary Background Two strategies for prevention of upper gastrointestinal (UGI) events for nonselective nonsteroidal anti‐inflammatory drug (nsNSAID) users…”
Get full text

Reduced incidence of gastroduodenal ulcers with celecoxib, a novel cyclooxygenase-2 inhibitor, compared to naproxen in patients with arthritis by Goldstein, J L, Correa, P, Zhao, W W, Burr, A M, Hubbard, R C, Verburg, K M, Geis, G S

“…Nonsteroidal anti-inflammatory drugs (NSAIDs) block prostaglandin production by inhibiting cyclooxygenase (COX); they are believed to cause gastroduodenal…”
Get full text

Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice by ISHIBASHI, S, GOLDSTEIN, J. L, BROWN, M. S, HERZ, J, BURNS, D. K

“…Mice that are homozygous for a targeted disruption of the LDL receptor gene (LDLR-/- mice) were fed a diet that contained 1.25% cholesterol, 7.5% cocoa butter,…”
Get full text

Does concomitant use of paracetamol potentiate the gastroduodenal mucosal injury associated with aspirin? A prospective, randomised, pilot study by Boike, J. R., Kao, R., Meyer, D., Markle, B., Rosenberg, J., Niebruegge, J., Stein, A. C., Berkes, J., Goldstein, J. L.

“…Summary Background Paracetamol is commonly prescribed for first‐line symptomatic treatment in patients with osteoarthritis and aspirin is often co‐administered…”
Get full text

Docetaxel Combined With Trastuzumab Is an Active Regimen in HER-2 3+ Overexpressing and Fluorescent In Situ Hybridization–Positive Metastatic Breast Cancer: A Multi-Institutional Phase II Trial by TEDESCO, K. L, THOR, A. D, EDGERTON, S, SLEDGE, G. W, JOHNSON, D. H, SHYR, Y, BLUM, K. A, GOLDSTEIN, L. J, GRADISHAR, W. J, NICHOLSON, B. P, MERKEL, D. E, MURREY, D

“…To determine the efficacy and safety of weekly docetaxel and trastuzumab as first- or second-line therapy in women with HER-2-overexpressing metastatic breast…”
Get full text

Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2 by Horton, J D, Shimomura, I, Brown, M S, Hammer, R E, Goldstein, J L, Shimano, H

“…We produced transgenic mice that express a dominant-positive truncated form of sterol regulatory element-binding protein-2 (SREBP-2) in liver and adipose…”
Get full text

Adherence to proton pump inhibitors or H2‐receptor antagonists during the use of non‐steroidal anti‐inflammatory drugs by Sturkenboom, M. C. J. M., Burke, T. A., Tangelder, M. J. D., Dieleman, J. P., Walton, S., Goldstein, J. L.

“…Summary Background : The efficacy of proton pump inhibitors (PPIs) or histamine‐2 receptor antagonists (H2RAs) prescribed as prophylaxis for NSAID‐related…”
Get full text

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells by Shimano, H, Horton, J D, Shimomura, I, Hammer, R E, Brown, M S, Goldstein, J L

“…We have produced transgenic mice whose livers express a dominant positive NH2-terminal fragment of sterol regulatory element binding protein-1c (SREBP-1c)…”
Get full text