Search Results - "GOLDMACHER, Victor S"

SAR650984, A Novel Humanized CD38-Targeting Antibody, Demonstrates Potent Antitumor Activity in Models of Multiple Myeloma and Other CD38+ Hematologic Malignancies by DECKERT, Jutta, WETZEL, Marie-Cécile, DUMONTET, Charles, PLESA, Adriana, CHIRON, Marielle, LEJEUNE, Pascale, CHITTENDEN, Thomas, PARK, Peter U, BLANC, Véronique, BARTLE, Laura M, SKALETSKAYA, Anna, GOLDMACHER, Victor S, VALLEE, François, QING, Zhou-Liu, FERRARI, Paul, POUZIEUX, Stéphanie, LAHOUTE, Charlotte

“…The CD38 cell surface antigen is expressed in diverse hematologic malignancies including multiple myeloma, B-cell non-Hodgkin lymphoma (NHL), B-cell chronic…”
Get full text

A CD123-targeting antibody-drug conjugate, IMGN632, designed to eradicate AML while sparing normal bone marrow cells by Kovtun, Yelena, Jones, Gregory E., Adams, Sharlene, Harvey, Lauren, Audette, Charlene A., Wilhelm, Alan, Bai, Chen, Rui, Lingyun, Laleau, Rassol, Liu, Fenghua, Ab, Olga, Setiady, Yulius, Yoder, Nicholas C., Goldmacher, Victor S., Chari, Ravi V.J., Pinkas, Jan, Chittenden, Thomas

“…The outlook for patients with refractory/relapsed acute myeloid leukemia (AML) remains poor, with conventional chemotherapeutic treatments often associated…”
Get full text

Synthesis and Evaluation of Hydrophilic Linkers for Antibody–Maytansinoid Conjugates by Zhao, Robert Y, Wilhelm, Sharon D, Audette, Charlene, Jones, Gregory, Leece, Barbara A, Lazar, Alexandru C, Goldmacher, Victor S, Singh, Rajeeva, Kovtun, Yelena, Widdison, Wayne C, Lambert, John M, Chari, Ravi V. J

“…The synthesis and biological evaluation of hydrophilic heterobifunctional cross-linkers for conjugation of antibodies with highly cytotoxic agents are…”
Get full text

Antibody-Maytansinoid Conjugates Designed to Bypass Multidrug Resistance by KOVTUN, Yelena V, AUDETTE, Charlene A, LAI, Katharine C, WIDDISON, Wayne C, KELLOGG, Brenda, JOHNSON, Holly, PINKAS, Jan, LUTZ, Robert J, SINGH, Rajeeva, GOLDMACHER, Victor S, CHARI, Ravi V. J, MAYO, Michele F, JONES, Gregory E, DOHERTY, Heather, MALONEY, Erin K, ERICKSON, Hans K, XIUXIA SUN, WILHELM, Sharon, AB, Olga

“…Conjugation of cytotoxic compounds to antibodies that bind to cancer-specific antigens makes these drugs selective in killing cancer cells. However, many of…”
Get full text

Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing by ERICKSON, Hans K, PARK, Peter U, WIDDISON, Wayne C, KOVTUN, Yelena V, GARRETT, Lisa M, HOFFMAN, Karen, LUTZ, Robert J, GOLDMACHER, Victor S, BLÄTTLER, Walter A

“…Antibody-drug conjugates are targeted anticancer agents consisting of a cytotoxic drug covalently linked to a monoclonal antibody for tumor antigen-specific…”
Get full text

High-affinity accumulation of a maytansinoid in cells via weak tubulin interaction by Goldmacher, Victor S, Audette, Charlene A, Guan, Yinghua, Sidhom, Eriene-Heidi, Shah, Jagesh V, Whiteman, Kathleen R, Kovtun, Yelena V

“…The microtubule-targeting maytansinoids accumulate in cells and induce mitotic arrest at 250- to 1000-fold lower concentrations than those required for their…”
Get full text

The isolation and characterization of renal cancer initiating cells from human Wilms' tumour xenografts unveils new therapeutic targets by Pode‐Shakked, Naomi, Shukrun, Rachel, Mark‐Danieli, Michal, Tsvetkov, Peter, Bahar, Sarit, Pri‐Chen, Sara, Goldstein, Ronald S., Rom‐Gross, Eithan, Mor, Yoram, Fridman, Edward, Meir, Karen, Simon, Amos, Magister, Marcus, Kaminski, Naftali, Goldmacher, Victor S., Harari‐Steinberg, Orit, Dekel, Benjamin

“…There are considerable differences in tumour biology between adult and paediatric cancers. The existence of cancer initiating cells/cancer stem cells (CIC/CSC)…”
Get full text

Cytomegalovirus Cell Death Suppressor vMIA Blocks Bax- but Not Bak-Mediated Apoptosis by Binding and Sequestering Bax at Mitochondria by Arnoult, Damien, Bartle, Laura M., Skaletskaya, Anna, Poncet, Delphine, Zamzami, Naoufal, Park, Peter U., Sharpe, Juanita, Youle, Richard J., Goldmacher, Victor S., Kieff, Elliott D.

“…We report that the cytomegalovirus-encoded cell death suppressor vMIA binds Bax and prevents Bax-mediated mitochondrial membrane permeabilization by…”
Get full text

murine cytomegalovirus cell death suppressor m38.5 binds Bax and blocks Bax-mediated mitochondrial outer membrane permeabilization by Arnoult, Damien, Skaletskaya, Anna, Estaquier, Jérôme, Dufour, Cecilie, Goldmacher, Victor S

“…Apoptosis is increasingly implicated as an early line of defense against viral infections. Viruses have devised numerous strategies to delay apoptosis of…”
Get full text

Cytopathic Effects of the Cytomegalovirus-Encoded Apoptosis Inhibitory Protein vMIA by Poncet, Delphine, Anne-Laure Pauleau, Szabadkai, Gyorgy, Angelo Vozza, Sebastian R. Scholz, Morgane Le Bras, Jean-Jacques Brière, Jalil, Abdelali, Ronan Le Moigne, Brenner, Catherine, Hahn, Gabriele, Ilka Wittig, Hermann Schägger, Lemaire, Christophe, Katiuscia Bianchi, Sylvie Souquère, Pierron, Gerard, Rustin, Pierre, Goldmacher, Victor S., Rizzuto, Rosario, Palmieri, Ferdinando, Kroemer, Guido

“…Replication of human cytomegalovirus (CMV) requires the expression of the viral mitochondria-localized inhibitor of apoptosis (vMIA). vMIA inhibits apoptosis…”
Get full text

A clinically relevant SCID-hu in vivo model of human multiple myeloma by Tassone, Pierfrancesco, Neri, Paola, Carrasco, Daniel R., Burger, Renate, Goldmacher, Victor S., Fram, Robert, Munshi, Vidit, Shammas, Masood A., Catley, Laurence, Jacob, Gary S., Venuta, Salvatore, Anderson, Kenneth C., Munshi, Nikhil C.

“…We developed a novel in vivo multiple myeloma (MM) model by engrafting the interleukin 6 (IL-6)-dependent human MM cell line INA-6 into severe combined…”
Get full text

A Cytomegalovirus-Encoded Mitochondria-Localized Inhibitor of Apoptosis Structurally Unrelated to Bcl-2 by Goldmacher, Victor S., Bartle, Laura M., Skaletskaya, Anna, Dionne, Cheryl A., Kedersha, Nancy L., Vater, Carol A., Han, Jia-wen, Lutz, Robert J., Watanabe, Shinya, Ellen D. Cahir Mc Farland, Kieff, Elliott D., Mocarski, Edward S., Chittenden, Thomas

“…Human cytomegalovirus (CMV), a herpesvirus that causes congenital disease and opportunistic infections in immunocompromised individuals, encodes functions that…”
Get full text

Cytotoxic activity of the maytansinoid immunoconjugate B-B4–DM1 against CD138+ multiple myeloma cells by Tassone, Pierfrancesco, Goldmacher, Victor S., Neri, Paola, Gozzini, Antonella, Shammas, Masood A., Whiteman, Kathleen R., Hylander-Gans, Linda L., Carrasco, Daniel R., Hideshima, Teru, Shringarpure, Reshma, Shi, Jialan, Allam, Charles K., Wijdenes, John, Venuta, Salvatore, Munshi, Nikhil C., Anderson, Kenneth C.

“…We tested the in vitro and in vivo antitumor activity of the maytansinoid DM1 (N2′-deacetyl-N2′-(3-mercapto-1-oxopropyl)-maytansine), a potent antimicrotubule…”
Get full text

Differential function and expression of the viral inhibitor of caspase 8-induced apoptosis (vICA) and the viral mitochondria-localized inhibitor of apoptosis (vMIA) cell death suppressors conserved in primate and rodent cytomegaloviruses by McCormick, A.Louise, Skaletskaya, Anna, Barry, Peter A, Mocarski, Edward S, Goldmacher, Victor S

“…Human cytomegalovirus (CMV) genes UL36 and UL37 encode viral inhibitor of caspase-8-induced apoptosis (vICA) and viral mitochondria inhibitor of apoptosis…”
Get full text

An Anti-apoptotic Viral Protein That Recruits Bax to Mitochondria by Poncet, Delphine, Larochette, Nathanael, Pauleau, Anne-Laure, Boya, Patricia, Jalil, Abdel-Ali, Cartron, Pierre-Francois, Vallette, Francois, Schnebelen, Céline, Bartle, Laura M, Skaletskaya, Anna, Boutolleau, David, Martinou, Jean-Claude, Goldmacher, Victor S, Kroemer, Guido, Zamzami, Naoufal

“…The viral mitochondria-localized inhibitor of apoptosis (vMIA), encoded by the UL37 gene of human cytomegalovirus, inhibits apoptosis-associated mitochondrial…”
Get full text

IMGN853, a Folate Receptor-α (FRα)-Targeting Antibody-Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FRα-Expressing Tumors by Ab, Olga, Whiteman, Kathleen R, Bartle, Laura M, Sun, Xiuxia, Singh, Rajeeva, Tavares, Daniel, LaBelle, Alyssa, Payne, Gillian, Lutz, Robert J, Pinkas, Jan, Goldmacher, Victor S, Chittenden, Thomas, Lambert, John M

“…A majority of ovarian and non-small cell lung adenocarcinoma cancers overexpress folate receptor α (FRα). Here, we report the development of an anti-FRα…”
Get full text

Cell killing by antibody–drug conjugates by Kovtun, Yelena V, Goldmacher, Victor S

“…Abstract Antibody–drug conjugates (ADCs) are designed to specifically bind to and kill cells expressing their target antigens. In addition to the obvious…”
Get full text

Processing of Human Cytomegalovirus UL37 Mutant Glycoproteins in the Endoplasmic Reticulum Lumen prior to Mitochondrial Importation by Mavinakere, Manohara S, Williamson, Chad D, Goldmacher, Victor S, Colberg-Poley, Anamaris M

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Beyond ADCs: harnessing bispecific antibodies to directly induce apoptosis for targeted tumor eradication by Goldmacher, Victor S, Gershteyn, Iosif M, Kovtun, Yelena

“…Abstract Bispecific apoptosis triggers (BATs) are innovative bispecific antibodies designed to simultaneously target both a tumor-associated antigen and a…”
Get full text

Statistics of the Distribution of the Abundance of Molecules with Various Drug Loads in Maytansinoid Antibody–Drug Conjugates by Goldmacher, Victor S, Amphlett, Godfrey, Wang, Lintao, Lazar, Alexandru C

“…The maytansinoid antibody–drug conjugates (ADCs) in clinical development for cancer therapy each contain a derivative of the microtubule-targeting agent,…”
Get full text