Search Results - "GOLDE, Todd E"

Alzheimer's disease - the journey of a healthy brain into organ failure by Golde, Todd E

“…As the most common dementia, Alzheimer's disease (AD) exacts an immense personal, societal, and economic toll. AD was first described at the neuropathological…”
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MAPT mutations, tauopathy, and mechanisms of neurodegeneration by Strang, Kevin H., Golde, Todd E., Giasson, Benoit I.

“…In multiple neurodegenerative diseases, including Alzheimer's disease (AD), a prominent pathological feature is the aberrant aggregation and inclusion…”
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Alzheimer's disease: The right drug, the right time by Golde, Todd E, DeKosky, Steven T, Galasko, Douglas

“…Lessons from failed clinical trials can improve the development of Alzheimer's disease–modifying therapies Alzheimer's disease (AD) is an age-associated…”
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Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice by Sacino, Amanda N., Brooks, Mieu, Thomas, Michael A., McKinney, Alex B., Lee, Sooyeon, Regenhardt, Robert W., McGarvey, Nicholas H., Ayers, Jacob I., Notterpek, Lucia, Borchelt, David R., Golde, Todd E., Giasson, Benoit I.

“…It has been hypothesized that α-synuclein (αS) misfolding may begin in peripheral nerves and spread to the central nervous system (CNS), leading to Parkinson…”
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Capsid serotype and timing of injection determines AAV transduction in the neonatal mice brain by Chakrabarty, Paramita, Rosario, Awilda, Cruz, Pedro, Siemienski, Zoe, Ceballos-Diaz, Carolina, Crosby, Keith, Jansen, Karen, Borchelt, David R, Kim, Ji-Yoen, Jankowsky, Joanna L, Golde, Todd E, Levites, Yona

“…Adeno-associated virus (AAV) mediated gene expression is a powerful tool for gene therapy and preclinical studies. A comprehensive analysis of CNS cell type…”
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γ‐Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct by Ran, Yong, Hossain, Fokhrul, Pannuti, Antonio, Lessard, Christian B, Ladd, Gabriela Z, Jung, Joo In, Minter, Lisa M, Osborne, Barbara A, Miele, Lucio, Golde, Todd E

“…γ‐Secretase inhibitors (GSIs) are being actively repurposed as cancer therapeutics based on the premise that inhibition of NOTCH1 signaling in select cancers…”
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Increased free water in the substantia nigra of Parkinson's disease: a single-site and multi-site study by Ofori, Edward, Pasternak, Ofer, Planetta, Peggy J, Burciu, Roxana, Snyder, Amy, Febo, Marcelo, Golde, Todd E, Okun, Michael S, Vaillancourt, David E

“…Abstract Measures from diffusion magnetic resonance imaging reflect changes in the substantia nigra of Parkinson's disease. It is the case, however, that…”
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Intracerebroventricular viral injection of the neonatal mouse brain for persistent and widespread neuronal transduction by Kim, Ji-Yoen, Grunke, Stacy D, Levites, Yona, Golde, Todd E, Jankowsky, Joanna L

“…With the pace of scientific advancement accelerating rapidly, new methods are needed for experimental neuroscience to quickly and easily manipulate gene…”
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Accelerated neurodegeneration through chaperone-mediated oligomerization of tau by Blair, Laura J, Nordhues, Bryce A, Hill, Shannon E, Scaglione, K Matthew, O'Leary, 3rd, John C, Fontaine, Sarah N, Breydo, Leonid, Zhang, Bo, Li, Pengfei, Wang, Li, Cotman, Carl, Paulson, Henry L, Muschol, Martin, Uversky, Vladimir N, Klengel, Torsten, Binder, Elisabeth B, Kayed, Rakez, Golde, Todd E, Berchtold, Nicole, Dickey, Chad A

“…Aggregation of tau protein in the brain is associated with a class of neurodegenerative diseases known as tauopathies. FK506 binding protein 51 kDa (FKBP51,…”
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Thinking laterally about neurodegenerative proteinopathies by Golde, Todd E, Borchelt, David R, Giasson, Benoit I, Lewis, Jada

“…Many neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and frontotemporal dementia, are proteinopathies…”
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Neurite orientation dispersion and density imaging reveals white matter and hippocampal microstructure changes produced by Interleukin-6 in the TgCRND8 mouse model of amyloidosis by Colon-Perez, Luis M., Ibanez, Kristen R., Suarez, Mallory, Torroella, Kristin, Acuna, Kelly, Ofori, Edward, Levites, Yona, Vaillancourt, David E., Golde, Todd E., Chakrabarty, Paramita, Febo, Marcelo

“…Extracellular β-amyloid (Aβ) plaque deposits and inflammatory immune activation are thought to alter various aspects of tissue microstructure, such as…”
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Alzheimer’s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph by Magno, Lorenza, Lessard, Christian B., Martins, Marta, Lang, Verena, Cruz, Pedro, Asi, Yasmine, Katan, Matilda, Bilsland, Jamie, Lashley, Tammaryn, Chakrabarty, Paramita, Golde, Todd E., Whiting, Paul J.

“…© The Author(s). 2019 Open Access © This article is distributed under the terms of the Creative Commons Attribution 4.0 International License…”
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High‐affinity interactions and signal transduction between Aβ oligomers and TREM2 by Lessard, Christian B, Malnik, Samuel L, Zhou, Yingyue, Ladd, Thomas B, Cruz, Pedro E, Ran, Yong, Mahan, Thomas E, Chakrabaty, Paramita, Holtzman, David M, Ulrich, Jason D, Colonna, Marco, Golde, Todd E

“…Rare coding variants in the triggering receptor expressed on myeloid cells 2 (TREM2) are associated with increased risk for Alzheimer's disease (AD), but how…”
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Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity by Zhang, Yong-Jie, Xu, Ya-Fei, Cook, Casey, Gendron, Tania F, Roettges, Paul, Link, Christopher D, Lin, Wen-Lang, Tong, Jimei, Castanedes-Casey, Monica, Ash, Peter, Gass, Jennifer, Rangachari, Vijayaraghavan, Buratti, Emanuele, Baralle, Francisco, Golde, Todd E, Dickson, Dennis W, Petrucelli, Leonard

“…Inclusions of TAR DNA-binding protein-43 (TDP-43), a nuclear protein that regulates transcription and RNA splicing, are the defining histopathological feature…”
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Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease by Born, Heather A, Kim, Ji-Yoen, Savjani, Ricky R, Das, Pritam, Dabaghian, Yuri A, Guo, Qinxi, Yoo, Jong W, Schuler, Dorothy R, Cirrito, John R, Zheng, Hui, Golde, Todd E, Noebels, Jeffrey L, Jankowsky, Joanna L

“…Alzheimer's disease (AD) is associated with an elevated risk for seizures that may be fundamentally connected to cognitive dysfunction. Supporting this link,…”
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Precision therapeutic targets for COVID-19 by Krumm, Zachary A, Lloyd, Grace M, Francis, Connor P, Nasif, Lith H, Mitchell, Duane A, Golde, Todd E, Giasson, Benoit I, Xia, Yuxing

“…Beginning in late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged as a novel pathogen that causes coronavirus disease 2019…”
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Integrative approach to sporadic Alzheimer’s disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau by Audrain, Mickael, Haure-Mirande, Jean-Vianney, Wang, Minghui, Kim, Soong Ho, Fanutza, Tomas, Chakrabarty, Paramita, Fraser, Paul, St George-Hyslop, Peter H., Golde, Todd E., Blitzer, Robert D., Schadt, Eric E., Zhang, Bin, Ehrlich, Michelle E., Gandy, Sam

“…TYROBP/DAP12 forms complexes with ectodomains of immune receptors (TREM2, SIRPβ1, CR3) associated with Alzheimer’s disease (AD) and is a network hub and driver…”
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A novel panel of α-synuclein antibodies reveal distinctive staining profiles in synucleinopathies by Dhillon, Jess-Karan S, Riffe, Cara, Moore, Brenda D, Ran, Yong, Chakrabarty, Paramita, Golde, Todd E, Giasson, Benoit I

“…Synucleinopathies are a spectrum of neurodegenerative diseases characterized by the intracellular deposition of the protein α-synuclein leading to multiple…”
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Increased brain hemopexin levels improve outcomes after intracerebral hemorrhage by Leclerc, Jenna L, Santiago-Moreno, Juan, Dang, Alex, Lampert, Andrew S, Cruz, Pedro E, Rosario, Awilda M, Golde, Todd E, Doré, Sylvain

“…Following intracerebral hemorrhage (ICH), extracellular heme precipitates secondary brain injury, which results in irreversible brain damage and enduring…”
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Notch signaling is activated by TLR stimulation and regulates macrophage functions by Palaga, Tanapat, Buranaruk, Chayanit, Rengpipat, Sirirat, Fauq, Abdul H, Golde, Todd E, Kaufmann, Stefan H.E, Osborne, Barbara A

“…Notch signaling is a well-conserved pathway involved in cell fate decisions, proliferation and apoptosis. We report on the involvement of Notch signaling in…”
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