Search Results - "GOLDBERG, Erwin"

The sperm-specific form of lactate dehydrogenase is required for fertility and is an attractive target for male contraception (a review) by Goldberg, Erwin

“…There has been a recent upsurge in the interest about contraceptive development, evidenced by the Contraceptive Special Issue of Biology of Reproduction [1],…”
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Male fertility and obesity: are ghrelin, leptin and glucagon-like peptide-1 pharmacologically relevant? by Alves, Marco G, Jesus, Tito T, Sousa, Mário, Goldberg, Erwin, Silva, Branca M, Oliveira, Pedro F

“…Obesity is rising to unprecedented numbers, affecting a growing number of children, adolescents and young adult men. These individuals face innumerous health…”
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Editorial: Endocrine and paracrine regulation of spermatogenesis by Goldberg, Erwin, Lishko, Polina V., Papadopoulos, Vassilios, Zirkin, Barry

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Exposed and Sequestered Antigens in Testes and Their Protection by Regulatory T Cell-Dependent Systemic Tolerance by Harakal, Jessica, Qiao, Hui, Wheeler, Karen, Rival, Claudia, Paul, Alberta G A, Hardy, Daniel M, Cheng, C Yan, Goldberg, Erwin, Tung, Kenneth S K

“…Continuous exposure of tissue antigen (Ag) to the autoantigen-specific regulatory T cells (Treg) is required to maintain Treg-dependent systemic tolerance…”
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LDHC: The Ultimate Testis‐Specific Gene by Goldberg, Erwin, Eddy, Edward M., Duan, Chongwen, Odet, Fanny

“…Lactate dehydrogenase C (LDHC) was, to the best of our knowledge, the first testis‐specific isozyme discovered in male germ cells. In fact, this was…”
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Generation and in Vitro Differentiation of a Spermatogonial Cell Line by Feng, Li-Xin, Chen, Yali, Dettin, Luis, Renee A. Reijo Pera, Herr, John C., Goldberg, Erwin, Dym, Martin

“…Spermatogenesis is the process by which spermatogonial stem cells divide and differentiate to produce sperm. In vitro sperm production has been difficult to…”
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Regulation of Murine Lactate Dehydrogenase C (Ldhc) Gene Expression by Tang, HuangHui, Kung, Aisha, Goldberg, Erwin

“…Expression of Ldhc begins with the onset of meiosis in male germ cells and continues throughout spermatogenesis. Transcriptional regulatory mechanisms,…”
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Glycolysis and Mitochondrial Respiration in Mouse LDHC-Null Sperm1 by Odet, Fanny, Gabel, Scott, London, Robert E, Goldberg, Erwin, Eddy, Edward M

“…We demonstrated previously that a knockout (KO) of the lactate dehydrogenase type C (Ldhc) gene disrupted male fertility and caused a considerable reduction in…”
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Testis-Specific Cytochrome c-Null Mice Produce Functional Sperm but Undergo Early Testicular Atrophy by Narisawa, Sonoko, Hecht, Norman B, Goldberg, Erwin, Boatright, Kelly M, Reed, John C, Millán, José Luis

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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An interview with Dr. Erwin Goldberg by Yan, Wei

“…Dr. Erwin Goldberg is a Professor Emeritus of Molecular Biosciences at Northwestern University, Evanston, IL. After finishing college at the State University…”
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Regulation of Murine Lactate Dehydrogenase C (Ldhc) Gene Expression1 by Tang, HuangHui, Kung, Aisha, Goldberg, Erwin

“…Expression of Ldhc begins with the onset of meiosis in male germ cells and continues throughout spermatogenesis. Transcriptional regulatory mechanisms,…”
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Utilization of citrate and lactate through a lactate dehydrogenase and ATP-regulated pathway in boar spermatozoa by Medrano, Antonio, Fernández-Novell, Josep Ma, Ramió, Laura, Alvarez, Juan, Goldberg, Erwin, Montserrat Rivera, Ma, Guinovart, Joan J., Rigau, Teresa, Rodríguez-Gil, Joan E.

“…Incubation of boar spermatozoa in Krebs–Ringer–Henseleit medium with either 10 mM lactate or 10 mM citrate induced a fast and robust increase in the…”
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Preclinical contraceptive development for men and women by Johnston, Daniel S, Goldberg, Erwin

“…This manuscript endeavors to present research considerations for the preclinical development of non-hormonal contraceptives. Topics include (1) how advances in…”
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Expression of the Gene for Mouse Lactate Dehydrogenase C (Ldhc) Is Required for Male Fertility1 by Odet, Fanny, Duan, Chongwen, Willis, William D, Goulding, Eugenia H, Kung, Aisha, Eddy, Edward M, Goldberg, Erwin

“…The lactate dehydrogenase (LDH) protein family members characteristically are distributed in tissue- and cell type-specific patterns and serve as the terminal…”
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ldhc Expression in Non-germ Cell Nuclei Is Repressed by NF-I Binding by Jethanandani, Poonam, Goldberg, Erwin

“…Developmental and testis-specific expression of the mouse lactate dehydrogenase C (mldhc) gene requires mechanisms for activation in germ cells and repression…”
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Testis-Specific Lactate Dehydrogenase (LDH-C4; Ldh3) in Murine Oocytes and Preimplantation Embryos by Coonrod, Scott, Vitale, Alejandra, Duan, Chongwen, Bristol-Gould, Sarah, Herr, John, Goldberg, Erwin

“…LDH‐C4 (Ldh3) is a member of the lactate dehydrogenase family of isozymes that catalyze the terminal reaction in the glycolytic pathway. In mammals, 3 genes,…”
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Transgenic Mice Demonstrate a Testis-specific Promoter for Lactate Dehydrogenase, LDHC by Li, Siming, Zhou, Wentong, Doglio, Lynn, Goldberg, Erwin

“…The mammalian genome encodes a family of lactate dehydrogenase (LDH) isozymes. Two of these, ldha and ldhb, are expressed ubiquitously. The ldhc gene is active…”
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Identification of a Novel Testis-Specific Leucine-Rich Protein in Humans and Mice by Xue, J C, Goldberg, E

“…A novel testis-specific protein, termed LRTP, was identified by screening both human and mouse testis and mouse pachytene spermatocyte cDNA libraries. Sequence…”
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GLI1 Localization in the Germinal Epithelial Cells Alternates Between Cytoplasm and Nucleus: Upregulation in Transgenic Mice Blocks Spermatogenesis in Pachytene by KROFT, Tim L, PATTERSON, John, JOON WON YOON, DOGLIO, Lynn, WALTERHOUSE, David O, IANNACCONE, Phillip M, GOLDBERG, Erwin

“…The zinc finger transcription factor GLI1 is the mediator of signaling by members of the Hedgehog (Hh) family. Male mice in which Desert hedgehog (Dhh), an Hh…”
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A Novel N-Terminal Domain Directs Membrane Localization of Mouse Testis-Specific Calpastatin1 by Li, Siming, Goldberg, Erwin

“…Multiple isoforms of calpastatin have been identified with unique N-terminal regions followed by identical calpain inhibitory domains (II–IV). In many…”
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