Search Results - "GOLDBERG, Alexander"

Cobalt-Catalyzed Hydrogenation of Esters to Alcohols: Unexpected Reactivity Trend Indicates Ester Enolate Intermediacy by Srimani, Dipankar, Mukherjee, Arup, Goldberg, Alexander F. G., Leitus, Gregory, Diskin-Posner, Yael, Shimon, Linda J. W., Ben David, Yehoshoa, Milstein, David

“…The atom‐efficient and environmentally benign catalytic hydrogenation of carboxylic acid esters to alcohols has been accomplished in recent years mainly with…”
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Distinct Contribution of Adult-Born Hippocampal Granule Cells to Context Encoding by Danielson, Nathan B., Kaifosh, Patrick, Zaremba, Jeffrey D., Lovett-Barron, Matthew, Tsai, Joseph, Denny, Christine A., Balough, Elizabeth M., Goldberg, Alexander R., Drew, Liam J., Hen, René, Losonczy, Attila, Kheirbek, Mazen A.

“…Adult-born granule cells (abGCs) have been implicated in cognition and mood; however, it remains unknown how these cells behave in vivo. Here, we have used…”
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Label-free detection of single nanoparticles and biological molecules using microtoroid optical resonators by Su, Judith, Goldberg, Alexander FG, Stoltz, Brian M

“…Single-molecule detection is one of the fundamental challenges of modern biology. Such experiments often use labels that can be expensive, difficult to…”
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Stereoselective Lewis Acid Mediated (3+2) Cycloadditions of N-H- and N-Sulfonylaziridines with Heterocumulenes by Craig II, Robert A., O'Connor, Nicholas R., Goldberg, Alexander F. G., Stoltz, Brian M.

“…Alkyl and aryl isothiocyanates and carbodiimides are effective substrates in (3+2) cycloadditions with N‐sulfonyl‐2‐substituted aziridines and…”
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A Palladium-Catalyzed Vinylcyclopropane (3 + 2) Cycloaddition Approach to the Melodinus Alkaloids by Goldberg, Alexander F. G, Stoltz, Brian M

“…A palladium-catalyzed (3 + 2) cycloaddition of a vinylcyclopropane and a β-nitrostyrene is employed to rapidly assemble the cyclopentane core of the Melodinus…”
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Anxiety Cells in a Hippocampal-Hypothalamic Circuit by Jimenez, Jessica C., Su, Katy, Goldberg, Alexander R., Luna, Victor M., Biane, Jeremy S., Ordek, Gokhan, Zhou, Pengcheng, Ong, Samantha K., Wright, Matthew A., Zweifel, Larry, Paninski, Liam, Hen, René, Kheirbek, Mazen A.

“…The hippocampus is traditionally thought to transmit contextual information to limbic structures where it acquires valence. Using freely moving calcium imaging…”
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Lewis Acid Mediated (3 + 2) Cycloadditions of Donor–Acceptor Cyclopropanes with Heterocumulenes by Goldberg, Alexander F. G, O’Connor, Nicholas R, Craig, Robert A, Stoltz, Brian M

“…Isocyanates, isothiocyanates, and carbodiimides are effective substrates in (3 + 2) cycloadditions with donor–acceptor cyclopropanes for the synthesis of…”
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Oxidative Fragmentations and Skeletal Rearrangements of Oxindole Derivatives by Klare, Hendrik F. T, Goldberg, Alexander F. G, Duquette, Douglas C, Stoltz, Brian M

“…An oxidative sequence for the conversion of oxindoles to structurally distinct heterocyclic scaffolds and aniline derivatives is disclosed by the combination…”
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Metal-Catalyzed Ring-Opening of Alkylidenecyclopropanes: New Access to Building Blocks with an Acyclic Quaternary Stereogenic Center by Simaan, Samah, F. G. Goldberg, Alexander, Rosset, Stephane, Marek, Ilan

“…Open sesame! A selective metal‐catalyzed ring opening of alkylidenecyclopropane derivatives leads to various functionalized acyclic derivatives possessing…”
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Reducing luteinizing hormone levels after ovariectomy improves spatial memory: Possible role of brain-derived neurotrophic factor by Bohm-Levine, Nathaniel, Goldberg, Alexander R., Mariani, Monica, Frankfurt, Maya, Thornton, Janice

“…Alzheimer's disease and other forms of cognitive decline are significantly more prevalent in post-menopausal women. Decreased estrogen levels, due to menopause…”
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The Molecular Mechanism of Positive Allosteric Modulation at the Dopamine D1 Receptor by Goldberg, Alexander, Xie, Bing, Shi, Lei

“…The dopamine D1 receptor (D1R) is a promising target for treating various psychiatric disorders. While upregulation of D1R activity has shown potential in…”
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Use of NDVI and Land Surface Temperature for Drought Assessment: Merits and Limitations by Karnieli, Arnon, Agam, Nurit, Pinker, Rachel T, Anderson, Martha, Imhoff, Marc L, Gutman, Garik G, Panov, Natalya, Goldberg, Alexander

“…A large number of water- and climate-related applications, such as drought monitoring, are based on spaceborne-derived relationships between land surface…”
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A covalent p97/VCP ATPase inhibitor can overcome resistance to CB-5083 and NMS-873 in colorectal cancer cells by Zhang, Gang, Li, Shan, Wang, Feng, Jones, Amanda C., Goldberg, Alexander F.G., Lin, Benjamin, Virgil, Scott, Stoltz, Brian M., Deshaies, Raymond J., Chou, Tsui-Fen

“…Small-molecule inhibitors of p97 are useful tools to study p97 function. Human p97 is an important AAA ATPase due to its diverse cellular functions and…”
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PAT-Facilitated Pharmaceutical Crystallization Development through Mechanistic Understanding by Fung, Peter, Mah, Helen, Goldberg, Alexander F. G, Rieder, Curtis, Sun, Ho-Yan, Su, Zhuoyi, Du, Juana, Lai, Chiajen

“…Process analytical technology (PAT; Raman spectroscopy and FBRM) was used to monitor the salt formation step of a development compound in real time. The data…”
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Re-convolving the compositional landscape of primary and recurrent glioblastoma reveals prognostic and targetable tissue states by Al-Dalahmah, Osama, Argenziano, Michael G., Kannan, Adithya, Mahajan, Aayushi, Furnari, Julia, Paryani, Fahad, Boyett, Deborah, Save, Akshay, Humala, Nelson, Khan, Fatima, Li, Juncheng, Lu, Hong, Sun, Yu, Tuddenham, John F., Goldberg, Alexander R., Dovas, Athanassios, Banu, Matei A., Sudhakar, Tejaswi, Bush, Erin, Lassman, Andrew B., McKhann, Guy M., Gill, Brian J. A., Youngerman, Brett, Sisti, Michael B., Bruce, Jeffrey N., Sims, Peter A., Menon, Vilas, Canoll, Peter

“…Glioblastoma (GBM) diffusely infiltrates the brain and intermingles with non-neoplastic brain cells, including astrocytes, neurons and microglia/myeloid cells…”
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Diindolylmethane and its halogenated derivatives induce protective autophagy in human prostate cancer cells via induction of the oncogenic protein AEG-1 and activation of AMP-activated protein kinase (AMPK) by Draz, Hossam, Goldberg, Alexander A., Titorenko, Vladimir I., Tomlinson Guns, Emma S., Safe, Stephen H., Sanderson, J. Thomas

“…3,3′-Diindolylmethane (DIM) and its synthetic halogenated derivatives 4,4′-Br2- and 7,7′-Cl2DIM (ring-DIMs) have recently been shown to induce protective…”
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Regulation of ULK1 Expression and Autophagy by STAT1 by Goldberg, Alexander A., Nkengfac, Bernard, Sanchez, Anthony M.J., Moroz, Nikolay, Qureshi, Salman T., Koromilas, Antonis E., Wang, Shuo, Burelle, Yan, Hussain, Sabah N., Kristof, Arnold S.

“…Autophagy involves the lysosomal degradation of cytoplasmic contents for regeneration of anabolic substrates during nutritional or inflammatory stress. Its…”
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Spectroscopic and Computational Investigations of The Thermodynamics of Boronate Ester and Diazaborole Self-Assembly by Goldberg, Alexander R, Northrop, Brian H

“…The solution phase self-assembly of boronate esters, diazaboroles, oxathiaboroles, and dithiaboroles from the condensation of arylboronic acids with aromatic…”
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The impact of transient and persistent acute kidney injury on long-term outcomes after acute myocardial infarction by Goldberg, Alexander, Kogan, Elena, Hammerman, Haim, Markiewicz, Walter, Aronson, Doron

“…Acute kidney injury is a common complication of acute myocardial infarction and is generally associated with adverse outcomes. We studied the incidence and…”
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A comprehensive evaluation of the potential binding poses of fentanyl and its analogs at the µ-opioid receptor by Xie, Bing, Goldberg, Alexander, Shi, Lei

“…[Display omitted] Fentanyl and its analogs are selective agonists of the µ-opioid receptor (MOR). Among novel synthetic opioids (NSOs), they dominate the…”
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