Search Results - "GOHIL, Vishal M"

The role of nonbilayer phospholipids in mitochondrial structure and function by Basu Ball, Writoban, Neff, John K., Gohil, Vishal M.

“…Mitochondrial structure and function are influenced by the unique phospholipid composition of its membranes. While mitochondria contain all the major classes…”
Get full text

FDX1-dependent and independent mechanisms of elesclomol-mediated intracellular copper delivery by Zulkifli, Mohammad, Spelbring, Amy N, Zhang, Yuteng, Soma, Shivatheja, Chen, Si, Li, Luxi, Le, Trung, Shanbhag, Vinit, Petris, Michael J, Chen, Tai-Yen, Ralle, Martina, Barondeau, David P, Gohil, Vishal M

“…Recent studies have uncovered the therapeutic potential of elesclomol (ES), a copper-ionophore, for copper deficiency disorders. However, we currently do not…”
Get full text

Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice by Guthrie, Liam M, Soma, Shivatheja, Yuan, Sai, Silva, Andres, Zulkifli, Mohammad, Snavely, Thomas C, Greene, Hannah Faith, Nunez, Elyssa, Lynch, Brogan, De Ville, Courtney, Shanbhag, Vinit, Lopez, Franklin R, Acharya, Arjun, Petris, Michael J, Kim, Byung-Eun, Gohil, Vishal M, Sacchettini, James C

“…Loss-of-function mutations in the copper (Cu) transporter ATP7A cause Menkes disease. Menkes is an infantile, fatal, hereditary copper-deficiency disorder that…”
Get full text

Specific requirements of nonbilayer phospholipids in mitochondrial respiratory chain function and formation by Baker, Charli D, Basu Ball, Writoban, Pryce, Erin N, Gohil, Vishal M

“…Mitochondrial membrane phospholipid composition affects mitochondrial function by influencing the assembly of the mitochondrial respiratory chain (MRC)…”
Get full text

The Role of COA6 in the Mitochondrial Copper Delivery Pathway to Cytochrome c Oxidase by Swaminathan, Abhinav B, Gohil, Vishal M

“…Copper is essential for the stability and activity of cytochrome oxidase (CcO), the terminal enzyme of the mitochondrial respiratory chain. Copper is bound to…”
Get full text

Mitochondrial dysfunctions in barth syndrome by Ghosh, Sagnika, Iadarola, Donna M., Ball, Writoban Basu, Gohil, Vishal M.

“…ABSTRACT Barth syndrome (BTHS) is a rare multisystemic genetic disorder caused by mutations in the TAZ gene. TAZ encodes a mitochondrial enzyme that remodels…”
Get full text

Atomic vacancies of molybdenum disulfide nanoparticles stimulate mitochondrial biogenesis by Singh, Kanwar Abhay, Soukar, John, Zulkifli, Mohammad, Kersey, Anna, Lokhande, Giriraj, Ghosh, Sagnika, Murali, Aparna, Garza, Natalie M., Kaur, Harman, Keeney, Justin N., Banavath, Ramu, Ceylan Koydemir, Hatice, Sitcheran, Raquel, Singh, Irtisha, Gohil, Vishal M., Gaharwar, Akhilesh K.

“…Diminished mitochondrial function underlies many rare inborn errors of energy metabolism and contributes to more common age-associated metabolic and…”
Get full text

A computational screen for regulators of oxidative phosphorylation implicates SLIRP in mitochondrial RNA homeostasis by Baughman, Joshua M, Nilsson, Roland, Gohil, Vishal M, Arlow, Daniel H, Gauhar, Zareen, Mootha, Vamsi K

“…The human oxidative phosphorylation (OxPhos) system consists of approximately 90 proteins encoded by nuclear and mitochondrial genomes and serves as the…”
Get full text

Vps39 is required for ethanolamine-stimulated elevation in mitochondrial phosphatidylethanolamine by Iadarola, Donna M., Basu Ball, Writoban, Trivedi, Prachi P., Fu, Guo, Nan, Beiyan, Gohil, Vishal M.

“…Mitochondrial membrane biogenesis requires the import of phospholipids; however, the molecular mechanisms underlying this process remain elusive. Recent work…”
Get full text

COA6 Is Structurally Tuned to Function as a Thiol-Disulfide Oxidoreductase in Copper Delivery to Mitochondrial Cytochrome c Oxidase by Soma, Shivatheja, Morgada, Marcos N., Naik, Mandar T., Boulet, Aren, Roesler, Anna A., Dziuba, Nathaniel, Ghosh, Alok, Yu, Qinhong, Lindahl, Paul A., Ames, James B., Leary, Scot C., Vila, Alejandro J., Gohil, Vishal M.

“…In eukaryotes, cellular respiration is driven by mitochondrial cytochrome c oxidase (CcO), an enzyme complex that requires copper cofactors for its catalytic…”
Get full text

Yeast homologs of human MCUR1 regulate mitochondrial proline metabolism by Zulkifli, Mohammad, Neff, John K., Timbalia, Shrishiv A., Garza, Natalie M., Chen, Yingqi, Watrous, Jeramie D., Murgia, Marta, Trivedi, Prachi P., Anderson, Steven K., Tomar, Dhanendra, Nilsson, Roland, Madesh, Muniswamy, Jain, Mohit, Gohil, Vishal M.

“…Mitochondria house evolutionarily conserved pathways of carbon and nitrogen metabolism that drive cellular energy production. Mitochondrial bioenergetics is…”
Get full text

Mitochondrial dysfunction reactivates α-fetoprotein expression that drives copper-dependent immunosuppression in mitochondrial disease models by Jett, Kimberly A, Baker, Zakery N, Hossain, Amzad, Boulet, Aren, Cobine, Paul A, Ghosh, Sagnika, Ng, Philip, Yilmaz, Orhan, Barreto, Kris, DeCoteau, John, Mochoruk, Karen, Ioannou, George N, Savard, Christopher, Yuan, Sai, Abdalla, Osama Hmh, Lowden, Christopher, Kim, Byung-Eun, Cheng, Hai-Ying Mary, Battersby, Brendan J, Gohil, Vishal M, Leary, Scot C

“…Signaling circuits crucial to systemic physiology are widespread, yet uncovering their molecular underpinnings remains a barrier to understanding the etiology…”
Get full text

Ethanolamine ameliorates mitochondrial dysfunction in cardiolipin-deficient yeast cells by Basu Ball, Writoban, Baker, Charli D., Neff, John K., Apfel, Gabriel L., Lagerborg, Kim A., Žun, Gašper, Petrovič, Uroš, Jain, Mohit, Gohil, Vishal M.

“…Cardiolipin (CL) is a signature phospholipid of the mitochondria required for the formation of mitochondrial respiratory chain (MRC) supercomplexes. The…”
Get full text

Editorial: Function and formation of mitochondrial metalloproteome by Wasilewski, Michał, Gohil, Vishal M, Khalimonchuk, Oleh

Get full text

Noncanonical role of singleminded-2s in mitochondrial respiratory chain formation in breast cancer by Wall, Steven W., Sanchez, Lilia, Tuttle, Kelly Scribner, Pearson, Scott J., Soma, Shivatheja, Wyatt, Garhett L., Carter, Hannah N., Jenschke, Ramsey M., Tan, Lin, Martinez, Sara A., Lorenzi, Philip L., Gohil, Vishal M., Rijnkels, Monique, Porter, Weston W.

“…Dysregulation of cellular metabolism is a hallmark of breast cancer progression and is associated with metastasis and therapeutic resistance. Here, we show…”
Get full text

Repurposing elesclomol, an investigational drug for the treatment of copper metabolism disorders by Gohil, Vishal M

Get more information

Synthetic Lethal Interaction of the Mitochondrial Phosphatidylethanolamine and Cardiolipin Biosynthetic Pathways in Saccharomyces cerevisiae by Gohil, Vishal M., Thompson, Morgan N., Greenberg, Miriam L.

“…Saccharomyces cerevisiae mitochondria contain enzymes required for synthesis of the phospholipids cardiolipin (CL) and phosphatidylethanolamine (PE), which are…”
Get full text

Cardiolipin deficiency leads to the destabilization of mitochondrial magnesium channel MRS2 in Barth syndrome by Joshi, Alaumy, Gohil, Vishal M

“…Abstract Barth syndrome (BTHS) is a debilitating X-linked cardio-skeletal myopathy caused by loss-of-function mutations in TAFAZZIN, a cardiolipin…”
Get full text

Molecular nature and physiological role of the mitochondrial calcium uniporter channel by Alevriadou, B Rita, Patel, Akshar, Noble, Megan, Ghosh, Sagnika, Gohil, Vishal M, Stathopulos, Peter B, Madesh, Muniswamy

“…Calcium (Ca ) signaling is critical for cell function and cell survival. Mitochondria play a major role in regulating the intracellular Ca concentration ([Ca ]…”
Get more information

Cardiolipin Biosynthesis and Mitochondrial Respiratory Chain Function Are Interdependent by Gohil, Vishal M, Hayes, Paulette, Matsuyama, Shigemi, Schägger, Hermann, Schlame, Michael, Greenberg, Miriam L

“…Cardiolipin (CL) is an acidic phospholipid present almost exclusively in membranes harboring respiratory chain complexes. We have previously shown that, in…”
Get full text