Search Results - "GOERDT, Sergij"

Angiodiversity and organotypic functions of sinusoidal endothelial cells by Koch, Philipp-Sebastian, Lee, Ki Hong, Goerdt, Sergij, Augustin, Hellmut G.

“…‘Angiodiversity’ refers to the structural and functional heterogeneity of endothelial cells (EC) along the segments of the vascular tree and especially within…”
Get full text

Differentiation and gene expression profile of tumor-associated macrophages by Schmieder, Astrid, Michel, Julia, Schönhaar, Kathrin, Goerdt, Sergij, Schledzewski, Kai

“…Abstract Tumor microenvironment is composed of proliferating neoplastic cells, a vascular network of endothelial cells, extra cellular matrix produced by…”
Get full text

Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling by Winkler, Manuel, Staniczek, Theresa, Kürschner, Sina Wietje, Schmid, Christian David, Schönhaber, Hiltrud, Cordero, Julio, Kessler, Linda, Mathes, Arthur, Sticht, Carsten, Neßling, Michelle, Uvarovskii, Alexey, Anders, Simon, Zhang, Xue-jun, von Figura, Guido, Hartmann, Daniel, Mogler, Carolin, Dobreva, Gergana, Schledzewski, Kai, Géraud, Cyrill, Koch, Philipp-Sebastian, Goerdt, Sergij

“…Angiocrine signaling by liver sinusoidal endothelial cells (LSECs) regulates hepatic functions such as growth, metabolic maturation, and regeneration…”
Get full text

Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling by Felcht, Moritz, Luck, Robert, Schering, Alexander, Seidel, Philipp, Srivastava, Kshitij, Hu, Junhao, Bartol, Arne, Kienast, Yvonne, Vettel, Christiane, Loos, Elias K, Kutschera, Simone, Bartels, Susanne, Appak, Sila, Besemfelder, Eva, Terhardt, Dorothee, Chavakis, Emmanouil, Wieland, Thomas, Klein, Christian, Thomas, Markus, Uemura, Akiyoshi, Goerdt, Sergij, Augustin, Hellmut G

“…Angiopoietin-2 (ANG-2) is a key regulator of angiogenesis that exerts context-dependent effects on ECs. ANG-2 binds the endothelial-specific receptor tyrosine…”
Get full text

Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice by Leibing, Thomas, Géraud, Cyrill, Augustin, Iris, Boutros, Michael, Augustin, Hellmut G., Okun, Jürgen G., Langhans, Claus‐Dieter, Zierow, Johanna, Wohlfeil, Sebastian A., Olsavszky, Victor, Schledzewski, Kai, Goerdt, Sergij, Koch, Philipp‐Sebastian

“…Postnatal liver development is characterized by hepatocyte growth, proliferation, and functional maturation. Notably, canonical Wnt signaling in hepatocytes…”
Get full text

The endothelial cell receptor stabilin-2 regulates VWF-FVIII complex half-life and immunogenicity by Swystun, Laura L, Lai, Jesse D, Notley, Colleen, Georgescu, Ilinca, Paine, A Simonne, Mewburn, Jeff, Nesbitt, Kate, Schledzewski, Kai, Géraud, Cyrill, Kzhyshkowska, Julia, Goerdt, Sergij, Hopman, Wilma, Montgomery, Robert R, James, Paula D, Lillicrap, David

“…Quantitative abnormalities of the von Willebrand factor-factor VIII (VWF-FVIII) complex associate with inherited bleeding or thrombotic disorders…”
Get full text

Hepatic Endothelial Notch Activation Protects against Liver Metastasis by Regulating Endothelial-Tumor Cell Adhesion Independent of Angiocrine Signaling by Wohlfeil, Sebastian A, Häfele, Verena, Dietsch, Bianca, Schledzewski, Kai, Winkler, Manuel, Zierow, Johanna, Leibing, Thomas, Mohammadi, Mona Malek, Heineke, Joerg, Sticht, Carsten, Olsavszky, Victor, Koch, Philipp-Sebastian, Géraud, Cyrill, Goerdt, Sergij

“…: The interaction of tumor cells with organ-specific endothelial cells (EC) is an important step during metastatic progression. Notch signaling in…”
Get full text

Patient Preferences for Treatment of Psoriasis with Biologicals: A Discrete Choice Experiment by Kromer, Christian, Schaarschmidt, Marthe-Lisa, Schmieder, Astrid, Herr, Raphael, Goerdt, Sergij, Peitsch, Wiebke K

“…Treatment dissatisfaction and non-adherence are common among patients with psoriasis, partly due to discordance between individual preferences and recommended…”
Get full text

Dimethyl fumarate (DMF) therapy in CTCL: results from a clinical phase II study by Nicolay, Jan P., Albrecht, Jana D., Assaf, Chalid, Dippel, Edgar, Stadler, Rudolf, Wehkamp, Ulrike, Wobser, Marion, Guelow, Karsten, Goerdt, Sergij, Krammer, Peter H.

Get full text

Corrigendum: Treatment Satisfaction of Patients with Psoriasis by Schaarschmidt, Marthe-Lisa, Kromer, Christian, Herr, Raphael, Schmieder, Astrid, Goerdt, Sergij, Peitsch, Wiebke K

“…Abstract is missing (Corrigendum) This Corrigendum relates to the following article: https://doi.org/10.2340/00015555-2011…”
Get full text

Hepatic passaging of NRAS-mutant melanoma influences adhesive properties and metastatic pattern by Dietsch, Bianca, Weller, Céline, Sticht, Carsten, de la Torre, Carolina, Kramer, Martin, Goerdt, Sergij, Géraud, Cyrill, Wohlfeil, Sebastian A

“…Liver metastasis is a poor prognostic factor for treatment of advanced cutaneous melanoma with either immunotherapy or targeted therapies. In this study we…”
Get full text

Pianp deficiency links GABAB receptor signaling and hippocampal and cerebellar neuronal cell composition to autism-like behavior by Winkler, Manuel, Biswas, Siladitta, Berger, Stefan M., Küchler, Moritz, Preisendörfer, Laurens, Choo, Myeongjeong, Früh, Simon, Rem, Pascal D., Enkel, Thomas, Arnold, Bernd, Komljenovic, Dorde, Sticht, Carsten, Goerdt, Sergij, Bettler, Bernhard, von Bohlen und Halbach, Oliver, Bartsch, Dusan, Géraud, Cyrill

“…Pianp (also known as Leda-1) is a type I transmembrane protein with preferential expression in the mammalian CNS. Its processing is characterized by…”
Get full text

Angiogenic and molecular diversity determine hepatic melanoma metastasis and response to anti-angiogenic treatment by Wohlfeil, Sebastian A, Häfele, Verena, Dietsch, Bianca, Weller, Céline, Sticht, Carsten, Jauch, Anna Sophia, Winkler, Manuel, Schmid, Christian David, Irkens, Anna Lena, Olsavszky, Ana, Schledzewski, Kai, Reiners-Koch, Philipp-Sebastian, Goerdt, Sergij, Géraud, Cyrill

“…Cutaneous melanoma exhibits heterogeneous metastatic patterns and prognosis. In this regard, liver metastasis, which is detected in ~ 10-20% of stage 4…”
Get full text

Non-pegylated and Pegylated Interferon Alpha-2a in Cutaneous T-cell Lymphoma and the Risk of Severe Ocular Side-effects by Albrecht, Jana D, Ninosu, Nadia, Barry, Denise, Albrecht, Thomas, Schaarschmidt, Marthe-Lisa, Goerdt, Sergij, Nicolay, Jan P

“…Abstract is missing (Short communication)…”
Get full text

Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors by Schledzewski, Kai, Géraud, Cyrill, Arnold, Bernd, Wang, Shijun, Gröne, Hermann-Josef, Kempf, Tibor, Wollert, Kai C, Straub, Beate K, Schirmacher, Peter, Demory, Alexandra, Schönhaber, Hiltrud, Gratchev, Alexei, Dietz, Lisa, Thierse, Hermann-Josef, Kzhyshkowska, Julia, Goerdt, Sergij

“…Tissue homeostasis and remodeling are processes that involve high turnover of biological macromolecules. Many of the waste molecules that are by-products or…”
Get full text

Patient Preferences for Biologicals in Psoriasis: Top Priority of Safety for Cardiovascular Patients by Schaarschmidt, Marthe-Lisa, Kromer, Christian, Herr, Raphael, Schmieder, Astrid, Sonntag, Diana, Goerdt, Sergij, Peitsch, Wiebke K

“…Patients with psoriasis are often affected by comorbidities, which largely influence treatment decisions. Here we performed conjoint analysis to assess the…”
Get full text

Lyve-1 deficiency enhances the hepatic immune microenvironment entailing altered susceptibility to melanoma liver metastasis by Jauch, Anna Sophia, Wohlfeil, Sebastian A, Weller, Céline, Dietsch, Bianca, Häfele, Verena, Stojanovic, Ana, Kittel, Maximilian, Nolte, Hendrik, Cerwenka, Adelheid, Neumaier, Michael, Schledzewski, Kai, Sticht, Carsten, Reiners-Koch, Philipp-Sebastian, Goerdt, Sergij, Géraud, Cyrill

“…Hyaluronan receptor LYVE-1 is expressed by liver sinusoidal endothelial cells (LSEC), lymphatic endothelial cells and specialized macrophages. Besides binding…”
Get full text

Autism-like behavior in Pianp-deficient mice is associated with decreased neuronal Erdr1 expression and altered GABAB receptor signaling by Winkler, Manuel, Biswas, Siladitta, Berger, Stefan M., Küchler, Moritz, Preisendörfer, Laurens, Choo, Myeongjeong, Früh, Simon, Rem, Pascal D., Enkel, Thomas, Arnold, Bernd, Komljenovic, Dorde, Sticht, Carsten, Goerdt, Sergij, Bettler, Bernhard, von Bohlen und Halbach, Oliver, Bartsch, Dusan, Géraud, Cyrill

Get full text

IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration by Ovsiy, Ilja, Riabov, Vladimir, Manousaridis, Ioannis, Michel, Julia, Moganti, Kondaiah, Yin, Shuiping, Liu, Tengfei, Sticht, Carsten, Kremmer, Elisabeth, Harmsen, Martin C., Goerdt, Sergij, Gratchev, Alexei, Kzhyshkowska, Julia

“…Monocytes are actively recruited at sites of chronic inflammation. However, molecular factors involved in this process are not fully elucidated. Here, we show…”
Get full text

Human Chitinases and Chitinase-Like Proteins as Indicators for Inflammation and Cancer by Kzhyshkowska, Julia, Gratchev, Alexei, Goerdt, Sergij

“…Human Glyco_18 domain-containing proteins constitute a family of chitinases and chitinase-like proteins. Chitotriosidase and AMCase are true enzymes which…”
Get full text