Search Results - "GOEDKEN, Michael"

Nanopolystyrene translocation and fetal deposition after acute lung exposure during late-stage pregnancy by Fournier, Sara B, D'Errico, Jeanine N, Adler, Derek S, Kollontzi, Stamatina, Goedken, Michael J, Fabris, Laura, Yurkow, Edward J, Stapleton, Phoebe A

“…Abstract Background Plastic is everywhere. It is used in food packaging, storage containers, electronics, furniture, clothing, and common single-use disposable…”
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Development of coronary dysfunction in adult progeny after maternal engineered nanomaterial inhalation during gestation by Fournier, Sara B., Lam, Vincent, Goedken, Michael J., Fabris, Laura, Stapleton, Phoebe A.

“…Maternal exposure to environmental contaminants during pregnancy can profoundly influence the risk of developing cardiovascular disease in adult offspring. Our…”
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Identification of micro- and nanoplastic particles in postnatal sprague-dawley rat offspring after maternal inhalation exposure throughout gestation by Moreno, Gina M., Brunson-Malone, Tanisha, Adams, Samantha, Nguyen, Calla, Seymore, Talia N., Cary, Chelsea M., Polunas, Marianne, Goedken, Michael J., Stapleton, Phoebe A.

“…Micro-nanoplastic particulates (MNPs) have been identified in both indoor and outdoor environments. From these real-world exposures, MNPs have been identified…”
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Single inhalation exposure to polyamide micro and nanoplastic particles impairs vascular dilation without generating pulmonary inflammation in virgin female Sprague Dawley rats by Cary, Chelsea M, Seymore, Talia N, Singh, Dilpreet, Vayas, Kinal N, Goedken, Michael J, Adams, Samantha, Polunas, Marianne, Sunil, Vasanthi R, Laskin, Debra L, Demokritou, Philip, Stapleton, Phoebe A

“…Exposure to micro- and nanoplastic particles (MNPs) in humans is being identified in both the indoor and outdoor environment. Detection of these materials in…”
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Cadmium reduces growth of male fetuses by impairing development of the placental vasculature and reducing expression of nutrient transporters by Kozlosky, Danielle, Lu, Alexander, Doherty, Cathleen, Buckley, Brian, Goedken, Michael J., Miller, Richard K., Barrett, Emily S., Aleksunes, Lauren M.

“…In utero exposure to the toxic metal cadmium (Cd) alters fetoplacental growth in rodents and has been inversely associated with birth weight and infant size in…”
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Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity by Aleksunes, Lauren M, Goedken, Michael J, Rockwell, Cheryl E, Thomale, Juergen, Manautou, Jose E, Klaassen, Curtis D

“…The use of the chemotherapeutic drug cisplatin is limited in part by nephrotoxicity. Cisplatin causes renal DNA adducts and oxidative stress in rodents. The…”
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Fetoplacental Disposition and Toxicity of Cadmium in Mice Lacking the Bcrp Transporter by Kozlosky, Danielle, Doherty, Cathleen, Buckley, Brian, Goedken, Michael J, Miller, Richard K, Huh, Dan Dongeun, Barrett, Emily S, Aleksunes, Lauren M

“…The environmental toxicant cadmium (Cd) impairs the growth of rodents and humans in utero which in turn heightens susceptibility to diseases later in life. We…”
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Acute feeding suppression and toxicity of raspberry ketone [4-(4-hydroxyphenyl)-2-butanone] in mice by Hao, Lihong, Kshatriya, Dushyant, Li, Xinyi, Badrinath, Aditi, Szmacinski, Zuzanna, Goedken, Michael J., Polunas, Marianne, Bello, Nicholas T.

“…Raspberry ketone (RK; [4-(4-hydroxyphenyl)-2-butanone]) is used by the food and cosmetic industry as a flavoring agent. RK is also marketed as a dietary…”
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Representative Rodent Models for Renal Transporter Alterations in Human Nonalcoholic Steatohepatitis by Frost, Kayla L, Jilek, Joseph L, Toth, Erica L, Goedken, Michael J, Wright, Stephen H, Cherrington, Nathan J

“…Alterations in renal elimination processes of glomerular filtration and active tubular secretion by renal transporters can result in adverse drug reactions…”
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Bile acid homeostasis in female mice deficient in Cyp7a1 and Cyp27a1 by Rizzolo, Daniel, Kong, Bo, Taylor, Rulaiha E., Brinker, Anita, Goedken, Michael, Buckley, Brian, Guo, Grace L.

“…Bile acids (BAs) are amphipathic molecules important for metabolism of cholesterol, absorption of lipids and lipid soluble vitamins, bile flow, and regulation…”
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Compensatory Induction of Liver Efflux Transporters in Response to ANIT-Induced Liver Injury Is Impaired in FXR-Null Mice by Cui, Yue J., Aleksunes, Lauren M., Tanaka, Yuji, Goedken, Michael J., Klaassen, Curtis D.

“…Alpha-naphthyl isothiocyanate (ANIT) is a hepatotoxicant that produces acute intrahepatic cholestasis in rodents. Farnesoid X receptor (FXR) and pregnane X…”
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Interactions Between Nuclear Receptor SHP and FOXA1 Maintain Oscillatory Homocysteine Homeostasis in Mice by Tsuchiya, Hiroyuki, da Costa, Kerry-Ann, Lee, Sangmin, Renga, Barbara, Jaeschke, Hartmut, Yang, Zhihong, Orena, Stephen J, Goedken, Michael J, Zhang, Yuxia, Kong, Bo, Lebofsky, Margitta, Rudraiah, Swetha, Smalling, Rana, Guo, Grace, Fiorucci, Stefano, Zeisel, Steven H, Wang, Li

“…Background & Aims Hyperhomocysteinemia is often associated with liver and metabolic diseases. We studied nuclear receptors that mediate oscillatory control of…”
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Synergistic interaction between genetics and disease on pravastatin disposition by Clarke, John D, Hardwick, Rhiannon N, Lake, April D, Lickteig, Andrew J, Goedken, Michael J, Klaassen, Curtis D, Cherrington, Nathan J

“…Background & Aims A genome wide association study and multiple pharmacogenetic studies have implicated the hepatic uptake transporter organic anion…”
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Transgenic Expression of the Human MRP2 Transporter Reduces Cisplatin Accumulation and Nephrotoxicity in Mrp2 -Null Mice by Wen, Xia, Buckley, Brian, McCandlish, Elizabeth, Goedken, Michael J, Syed, Samira, Pelis, Ryan, Manautou, José E, Aleksunes, Lauren M

“…The chemotherapeutic drug cisplatin is actively transported into proximal tubules, leading to acute renal injury. Previous studies suggest that the multidrug…”
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Ingested Polystyrene Nanospheres Translocate to Placenta and Fetal Tissues in Pregnant Rats: Potential Health Implications by Cary, Chelsea M, DeLoid, Glen M, Yang, Zhenning, Bitounis, Dimitrios, Polunas, Marianne, Goedken, Michael J, Buckley, Brian, Cheatham, Byron, Stapleton, Phoebe A, Demokritou, Philip

“…Recent studies in experimental animals found that oral exposure to micro- and nano-plastics (MNPs) during pregnancy had multiple adverse effects on outcomes…”
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Nuclear factor erythroid 2-related factor 2 deletion impairs glucose tolerance and exacerbates hyperglycemia in type 1 diabetic mice by Aleksunes, Lauren M, Reisman, Scott A, Yeager, Ronnie L, Goedken, Michael J, Klaassen, Curtis D

“…The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) induces a battery of cytoprotective genes after oxidative stress. Nrf2 aids in…”
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Is nuclear factor erythroid 2-related factor 2 responsible for sex differences in susceptibility to acetaminophen-induced hepatotoxicity in mice? by Rohrer, Philip R, Rudraiah, Swetha, Goedken, Michael J, Manautou, José E

“…Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that positively regulates the expression and activity of cytoprotective genes…”
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Increased susceptibility to methotrexate-induced toxicity in nonalcoholic steatohepatitis by Hardwick, Rhiannon N, Clarke, John D, Lake, April D, Canet, Mark J, Anumol, Tarun, Street, Stephanie M, Merrell, Matthew D, Goedken, Michael J, Snyder, Shane A, Cherrington, Nathan J

“…Hepatic drug metabolizing enzymes and transporters play a crucial role in determining the fate of drugs, and alterations in liver function can place…”
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Mechanism of Altered Metformin Distribution in Nonalcoholic Steatohepatitis by Clarke, John D, Dzierlenga, Anika L, Nelson, Nicholas R, Li, Hui, Werts, Samantha, Goedken, Michael J, Cherrington, Nathan J

“…Metformin is an antihyperglycemic drug that is widely prescribed for type 2 diabetes mellitus and is currently being investigated for the treatment of…”
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Role of nuclear factor-erythroid 2-related factor 2 (Nrf2) in the transcriptional regulation of brain ABC transporters during acute acetaminophen (APAP) intoxication in mice by Ghanem, Carolina I., Rudraiah, Swetha, Bataille, Amy M., Vigo, María B., Goedken, Michael J., Manautou, José E.

“…Changes in expression of liver ABC transporters have been described during acute APAP intoxication. However, the effect of APAP on brain ABC transporters is…”
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