Search Results - "GOEDEGEBUURE, P. S"

Preclinical and clinical development of neoantigen vaccines by Li, L, Goedegebuure, S P, Gillanders, W E

“…Cancer neoantigens are antigens that result from somatic mutations present in individual cancers. Neoantigens are considered important targets for cancer…”
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Breast and Ovarian Cancer-Specific Cytotoxic T Lymphocytes Recognize the Same HER2/Neu-Derived Peptide by Peoples, George E., Goedegebuure, Peter S., Smith, Roy, Linehan, David C., Yoshino, Ichiro, Eberlein, Timothy J.

“…The identification of antigenic peptides presented on the tumor cell surface by HLA class I molecules and recognized by tumor-specific cytotoxic T lymphocytes…”
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Adoptive immunotherapy with tumor-infiltrating lymphocytes and interleukin-2 in patients with metastatic malignant melanoma and renal cell carcinoma: a pilot study by Goedegebuure, P S, Douville, L M, Li, H, Richmond, G C, Schoof, D D, Scavone, M, Eberlein, T J

“…The objective of this study was to determine the tolerance and effect of moderate-dose recombinant human interleukin-2 (rHu IL-2) and tumor-infiltrating…”
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Pancreatic cancer cells can evade immune surveillance via nonfunctional Fas (APO-1/CD95) receptors and aberrant expression of functional Fas ligand by v. Bernstorff, Wolfram, Spanjaard, Remco A., Chan, Allen K., Lockhart, Diane C., Sadanaga, Noriaki, Wood, Isabelle, Peiper, Matthias, Goedegebuure, Peter S., Eberlein, Timothy J.

“…Background: The Fas (APO-1/CD95) receptor/Fas ligand (FasR/FasL) system plays a key role in immune surveillance. We investigated the possibility of a tumor…”
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Prevalence of Regulatory T Cells Is Increased in Peripheral Blood and Tumor Microenvironment of Patients with Pancreas or Breast Adenocarcinoma by Liyanage, Udaya K, Moore, Todd T, Joo, Hong-Gu, Tanaka, Yoshiyuki, Herrmann, Virginia, Doherty, Gerard, Drebin, Jeffrey A, Strasberg, Steven M, Eberlein, Timothy J, Goedegebuure, Peter S, Linehan, David C

“…Regulatory T cells (T(reg)) that prevent autoimmune diseases by suppression of self-reactive T cells may also suppress the immune response against cancer. In…”
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Identification and translational validation of novel mammaglobin-A CD8 T cell epitopes by Soysal, S. D., Muenst, S., Kan-Mitchell, J., Huarte, E., Zhang, X., Wilkinson-Ryan, I., Fleming, T., Tiriveedhi, V., Mohanakumar, T., Li, L., Herndon, J., Oertli, D., Goedegebuure, S. P., Gillanders, W. E.

“…Mammaglobin-A (MAM-A) is a secretory protein that is overexpressed in 80 % of human breast cancers. Its near-universal expression in breast cancer as well as…”
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Association of HER2/neu expression with sensitivity to tumor-specific CTL in human ovarian cancer by Yoshino, I, Peoples, GE, Goedegebuure, PS, Maziarz, R, Eberlein, TJ

“…To study potential sources of tumor-associated Ags in human ovarian cancer, we have established two ovarian tumor cell lines (OvS1 and OvA2) from two ovarian…”
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HLA-A2 presents shared tumor-associated antigens derived from endogenous proteins in ovarian cancer by Peoples, GE, Goedegebuure, PS, Andrews, JV, Schoof, DD, Eberlein, TJ

“…Tumor-associated lymphocytes (TAL) from the malignant ascites and tumor-infiltrating lymphocytes (TIL) from the solid tumor were isolated from six consecutive…”
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Local secretion of IFN-gamma induces an antitumor response: comparison between T cells plus IL-2 and IFN-gamma transfected tumor cells by Sadanaga, N, Nagoshi, M, Lederer, J A, Joo, H G, Eberlein, T J, Goedegebuure, P S

“…Previously we described that the adoptive transfer of tumor-infiltrating lymphocytes (TIL) + interleukin-2 (IL-2) leads to eradication of established…”
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T-cell recognition of ovarian cancer by Peoples, G E, Schoof, D D, Andrews, J V, Goedegebuure, P S, Eberlein, T J

“…The existence of a tumor-specific T-cell immune response to human malignant melanoma has been well documented. In contrast, the existence of tumor-specific…”
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Pancreatic cancer associated ascites-derived CTL recognize a nine-amino-acid peptide GP2 derived from HER2/neu by Peiper, M, Goedegebuure, P S, Izbicki, J R, Eberlein, T J

“…The proto-oncogene HER2/neu encodes a 185 kDa transmembrane protein with extensive homology to the epidermal growth factor receptor. It is overexpressed in…”
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Tumor‐specific cytokine release by donor T cells induces an effective host anti‐tumor response through recruitment of host naive antigen presenting cells by Nagoshi, Makoto, Sadanaga, Noriaki, Joo, Hong‐Gu, Goedegebuure, Peter S., Eberlein, Timothy J.

“…We recently reported that tumor eradication induced by immunotherapy (IT) in a congenic mouse model using tumor infiltrating lymphocytes (TIL) + recombinant…”
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Expression and function of galectin-3, a β-galactoside-binding protein in activated T lymphocytes by Joo, Hong‐Gu, Goedegebuure, Peter S, Sadanaga, Noriaki, Nagoshi, Makoto, Bernstorff, Wolfram, Eberlein, Timothy J.

“…A soluble beta‐galactoside‐binding lectin, galectin‐3 has been shown tobe involved in cell adhesion and activation of immune cells. Althoughgalectin‐3 is known…”
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Clone 10d/BM28 (CDCL1), an early S-phase protein, is an important growth regulator of melanoma by SPANJAARD, R. A, LEE, P. J, SARKAR, S, GOEDEGEBUURE, P. S, EBERLEIN, T. J

“…Retinoic acid (RA) induces growth arrest and differentiation of many different tumor cells. RA activates RA receptors, which function as ligand-dependent…”
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B7.1 costimulation increases T-cell proliferation and cytotoxicity via selective expansion of specific variable alpha and beta genes of the T-cell receptor by Chan, Allen K., Goedegebuure, Peter S., von Bernstorff, Wolfram, Carritte, Amanda L., Chung, Min, Stewart, Robyn A., Montgomery, Leslie, Spanjaard, Remco A., McKenzie, Allison B., Eberlein, Timothy J.

“…Background: Optimal T-cell activation requires not only ligation of the T-cell receptor (TcR) but also delivery of costimulatory signals by various accessory…”
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Immunoregulatory effects of CD4 + T helper subsets in human melanoma by Lee, Kyung-Yung, Goedegebuure, Peter S., Linehan, David C., Eberlein, Timothy J.

“…Background. The elucidation of CD4 + T helper (Th) cell traits is important for the understanding of immunoregulatory mechanisms in patients with cancer, in…”
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HER2/neu-derived peptides are shared antigens among human non-small cell lung cancer and ovarian cancer by YOSHINO, I, GOEDEGEBUURE, P. S, PEOPLES, G. E, PARIKH, A. S, DIMAIO, J. M, LYERLY, H. K, GAZDAR, A.F, EBERLEIN, T. J

“…Previously, we have reported a correlation between the expression of HER2/neu and sensitivity to HLA-A2-restricted cytotoxic T-cells (CTL) in ovarian cancer…”
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ICAM- melanoma cells are relatively resistant to CD3-mediated T-cell lysis by Braakman, E, Goedegebuure, P S, Vreugdenhil, R J, Segal, D M, Shaw, S, Bolhuis, R L

“…The primary activation pathway of T cells is via the T-cell receptor (TCR)/CD3 complex, which is functionally interrelated with various accessory molecules. We…”
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Soluble MUC1 secreted by human epithelial cancer cells mediates immune suppression by blocking T‐cell activation by Chan, Allen K., Lockhart, Diane C., Bernstorff, Wolfram von, Spanjaard, Remco A., Joo, Hong‐Gu, Eberlein, Timothy J., Goedegebuure, Peter S.

“…Solid tumors may secrete factors that mediate immune suppression in patients. We investigated the effect of supernatants from 25 human tumor cell lines on…”
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Recruitment of host CD8 + T cells by tumor-infiltrating lymphocytes and recombinant interleukin-2 during adoptive immunotherapy of cancer by Burger, Ulrike L., Chang, Maximilian P., Goedegebuure, Peter S., Eberlein, Timothy J.

“…Background. Previously we demonstrated that optimal doses of tumor-infiltrating lymphocytes (TIL) concomitant with recombinant interleukin-2 (rIL-2)…”
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