Search Results - "GODDARD, Sophie"

Regulation of Estrogen Rapid Signaling through Arginine Methylation by PRMT1 by Le Romancer, Muriel, Treilleux, Isabelle, Leconte, Nicolas, Robin-Lespinasse, Yannis, Sentis, Stéphanie, Bouchekioua-Bouzaghou, Katia, Goddard, Sophie, Gobert-Gosse, Stéphanie, Corbo, Laura

“…Evidence is emerging that estrogen receptor α (ERα) is central to the rapid transduction of estrogen signaling to the downstream kinase cascades; however, the…”
Get full text

Activation of rapid oestrogen signalling in aggressive human breast cancers by Poulard, Coralie, Treilleux, Isabelle, Lavergne, Emilie, Bouchekioua‐Bouzaghou, Katia, Goddard‐Léon, Sophie, Chabaud, Sylvie, Trédan, Olivier, Corbo, Laura, Le Romancer, Muriel

“…Oestrogen receptors can mediate rapid activation of cytoplasmic signalling cascades by recruiting Src and PI3K. However, the involvement of this pathway in…”
Get full text

Dendritic Cell Infiltration and Prognosis of Early Stage Breast Cancer by TREILLEUX, Isabelle, BLAY, Jean-Yves, LEBECQUE, Serge, BENDRISS-VERMARE, Nathalie, RAY-COQUARD, Isabelle, BACHELOT, Thomas, GUASTALLA, Jean-Paul, BREMOND, Alain, GODDARD, Sophie, PIN, Jean-Jacques, BARTHELEMY-DUBOIS, Clarisse

“…Purpose: Although dendritic cells (DC) and T cells can infiltrate primary breast carcinoma, it remains unclear whether the immune response influences the…”
Get full text

High incidence of mammary intraepithelial neoplasia development in Men1-disrupted murine mammary glands by Seigne, Christelle, Auret, Magdalena, Treilleux, Isabelle, Bonnavion, Rémy, Assade, Fouzia, Carreira, Christine, Goddard-Léon, Sophie, Lavergne, Emilie, Chabaud, Sylvie, Garcia, Amandine, Mazoyer, Sylvie, Lu, Jieli, Bachelot, Thomas, Frappart, Lucien, Zhang, Chang Xian

“…Mutations of the MEN1 tumour suppressor gene predispose patients to the development of multiple endocrine neoplasia type 1 (MEN1) syndrome, which is…”
Get full text

Silencing of FLRG, an antagonist of activin, inhibits human breast tumor cell growth by RAZANAJAONA, Diane, JOGUET, Stéphanie, AY, Anne-Sophie, TREILLEUX, Isabelle, GODDARD-LEON, Sophie, BARTHOLIN, Laurent, RIMOKH, Ruth

“…Activin, a member of the transforming growth factor beta (TGFbeta) superfamily, regulates diverse processes, such as cellular growth and differentiation. There…”
Get full text

Maternal Tgif is required for vascularization of the embryonic placenta by Bartholin, Laurent, Melhuish, Tiffany A., Powers, Shannon E., Goddard-Léon, Sophie, Treilleux, Isabelle, Sutherland, Ann E., Wotton, David

“…The mammalian placenta is the site of exchange of nutrients and waste between mother and embryo. In humans, placental insufficiency can result in intrauterine…”
Get full text

Generation of mice with conditionally activated transforming growth factor beta signaling through the TβRI/ALK5 receptor by Bartholin, Laurent, Cyprian, Farhan S., Vincent, David, Garcia, Céline N., Martel, Sylvie, Horvat, Branka, Berthet, Cyril, Goddard-Léon, Sophie, Treilleux, Isabelle, Rimokh, Ruth, Marie, Julien C.

“…We generated a transgenic mouse strain (LSL‐TβRICA) containing a latent constitutively active TGFβ type I receptor (TβRI/ALK5) by using a knock‐in strategy…”
Get full text

Prognostic value of the expression of C-Chemokine Receptor 6 and 7 and their ligands in non-metastatic breast cancer by Cassier, Philippe A, Treilleux, Isabelle, Bachelot, Thomas, Ray-Coquard, Isabelle, Bendriss-Vermare, Nathalie, Ménétrier-Caux, Christine, Trédan, Olivier, Goddard-Léon, Sophie, Pin, Jean-Jacques, Mignotte, Hervé, Bathélémy-Dubois, Clarisse, Caux, Christophe, Lebecque, Serge, Blay, Jean-Yves

“…Chemokines and chemokine receptors are major actors of leukocytes trafficking and some have been shown to play an important role in cancer metastasis…”
Get full text

Plasmacytoid dendritic cells infiltrating ovarian cancer are associated with poor prognosis by Labidi-Galy, Sana Intidhar, Treilleux, Isabelle, Goddard-Leon, Sophie, Combes, Jean-Damien, Blay, Jean-Yves, Ray-Coquard, Isabelle, Caux, Christophe, Bendriss-Vermare, Nathalie

“…Using two different and complementary approaches (flow cytometry and immunohistochemistry) on two independent cohorts of ovarian cancer patients, we found that…”
Get full text

Early Detection of Tumor Cells by Innate Immune Cells Leads to Treg Recruitment through CCL22 Production by Tumor Cells by FAGET, Julien, BIOTA, Cathy, MENETRIER-CAUX, Christine, BACHELOT, Thomas, GOBERT, Michael, TREILLEUX, Isabelle, GOUTAGNY, Nadege, DURAND, Isabelle, LEON-GODDARD, Sophie, YVES BLAY, Jean, CAUX, Christophe

“…Abstract In breast carcinomas, patient survival seems to be negatively affected by the recruitment of regulatory T cells (Treg) within lymphoid aggregates by…”
Get full text

“Any Strange Beast There Makes a Man”: Interaction and Self-Reflection in the Arctic (1576-1578) by Lemercier-Goddard, Sophie

“…The Arctic regions were the first contact zones in the New World where English explorers negotiated otherness and difference, before Francis Drake’s stay in…”
Get full text

ADP ribosylation factor like 2 (Arl2) regulates breast tumor aggressivity in immunodeficient mice by Beghin, Anne, Belin, Stéphane, Hage-Sleiman, Rouba, Hage Sleiman, Rouba, Brunet Manquat, Stéphanie, Goddard, Sophie, Tabone, Eric, Jordheim, Lars P, Treilleux, Isabelle, Poupon, Marie-France, Diaz, Jean-Jacques, Dumontet, Charles

“…We have previously reported that ADP ribosylation factor like 2 (Arl2), a small GTPase, content influences microtubule dynamics and cell cycle distribution in…”
Get full text

CD208/Dendritic Cell-Lysosomal Associated Membrane Protein Is a Marker of Normal and Transformed Type II Pneumocytes by Salaun, Bruno, de Saint-Vis, Blandine, Pacheco, Nathalie, Pacheco, Yves, Riesler, Arnaud, Isaac, Sylvie, Leroux, Caroline, Clair-Moninot, Valérie, Pin, Jean-Jacques, Griffith, Janice, Treilleux, Isabelle, Goddard, Sophie, Davoust, Jean, Kleijmeer, Monique, Lebecque, Serge

“…Dendritic cell-lysosomal associated membrane protein (DC-LAMP)/CD208, a member of the lysosomal associated membrane protein (LAMP) family, is specifically…”
Get full text

Immune effector cell-associated acute stroke: A novel entity? by Mauget, Matteo, Lemercier, Sophie, Houot, Roch, Manson, Guillaume

Get full text

Tif1γ Suppresses Murine Pancreatic Tumoral Transformation by a Smad4-Independent Pathway by Vincent, David F, Gout, Johann, Chuvin, Nicolas, Arfi, Vanessa, Pommier, Roxane M, Bertolino, Philippe, Jonckheere, Nicolas, Ripoche, Doriane, Kaniewski, Bastien, Martel, Sylvie, Langlois, Jean-Baptiste, Goddard-Léon, Sophie, Colombe, Amélie, Janier, Marc, Van Seuningen, Isabelle, Losson, Régine, Valcourt, Ulrich, Treilleux, Isabelle, Dubus, Pierre, Bardeesy, Nabeel, Bartholin, Laurent

“…Transcriptional intermediary factor 1γ (TIF1γ; alias, TRIM33/RFG7/PTC7/ectodermin) belongs to an evolutionarily conserved family of nuclear factors that have…”
Get full text

Acinar-to-Ductal Metaplasia Induced by Transforming Growth Factor Beta Facilitates KRAS G12D -driven Pancreatic Tumorigenesis by Chuvin, Nicolas, Vincent, David F, Pommier, Roxane M, Alcaraz, Lindsay B, Gout, Johann, Caligaris, Cassandre, Yacoub, Karam, Cardot, Victoire, Roger, Elodie, Kaniewski, Bastien, Martel, Sylvie, Cintas, Celia, Goddard-Léon, Sophie, Colombe, Amélie, Valantin, Julie, Gadot, Nicolas, Servoz, Emilie, Morton, Jennifer, Goddard, Isabelle, Couvelard, Anne, Rebours, Vinciane, Guillermet, Julie, Sansom, Owen J, Treilleux, Isabelle, Valcourt, Ulrich, Sentis, Stéphanie, Dubus, Pierre, Bartholin, Laurent

“…Transforming growth factor beta (TGFβ) acts either as a tumor suppressor or as an oncogene, depending on the cellular context and time of activation. TGFβ…”
Get full text

A functional interplay between ZNF217 and Estrogen Receptor alpha exists in luminal breast cancers by Nguyen, Nhan T., Vendrell, Julie A., Poulard, Coralie, Győrffy, Balázs, Goddard-Léon, Sophie, Bièche, Ivan, Corbo, Laura, Le Romancer, Muriel, Bachelot, Thomas, Treilleux, Isabelle, Cohen, Pascale A.

“…We aimed at highlighting the role of ZNF217, a Krüppel-like finger protein, in Estrogen Receptor-α (ERα)-positive (ER+) and luminal breast cancers. Here we…”
Get full text

Inactivation of TIF1gamma cooperates with Kras to induce cystic tumors of the pancreas by Vincent, David F, Yan, Kai-Ping, Treilleux, Isabelle, Gay, Fabien, Arfi, Vanessa, Kaniewski, Bastien, Kaniewsky, Bastien, Marie, Julien C, Lepinasse, Florian, Martel, Sylvie, Goddard-Leon, Sophie, Iovanna, Juan L, Dubus, Pierre, Garcia, Stéphane, Puisieux, Alain, Rimokh, Ruth, Bardeesy, Nabeel, Scoazec, Jean-Yves, Losson, Régine, Bartholin, Laurent

“…Inactivation of the Transforming Growth Factor Beta (TGFbeta) tumor suppressor pathway contributes to the progression of Pancreatic Ductal AdenoCarcinoma…”
Get full text

“Any Strange Beast There Makes a Man”: Interaction and Self-Reflection in the Arctic (1576-1578) by Lemercier-Goddard, Sophie

“…Avant le voyage de Francis Drake qui l’amène jusqu’en Californie (1579) et la colonie de Roanoke (1584-1587), c’est en Arctique que les explorateurs anglais…”
Get full text

ICOS-Ligand Expression on Plasmacytoid Dendritic Cells Supports Breast Cancer Progression by Promoting the Accumulation of Immunosuppressive CD4+ T Cells by FAGET, Julien, BENDRISS-VERMARE, Nathalie, CHABAUD, Sylvie, BLAY, Jean Yves, CAUX, Christophe, MENETRIER-CAUX, Christine, GOBERT, Michael, DURAND, Isabelle, OLIVE, Daniel, BIOTA, Cathy, BACHELOT, Thomas, TREILLEUX, Isabelle, GODDARD-LEON, Sophie, LAVERGNE, Emilie

“…Human breast tumors are infiltrated by memory CD4(+) T cells along with increased numbers of regulatory T cells (Treg) and plasmacytoid dendritic cells (pDC)…”
Get full text