Search Results - "GODDARD, A. C"

A comparison of linear and branched polyethylenimine (PEI) with DCChol/DOPE liposomes for gene delivery to epithelial cells in vitro and in vivo by WISEMAN, J. W, GODDARD, C. A, MCLELLAND, D, COLLEDGE, W. H

“…Polyethylenimine (PEI), a polycation with high ionic charge density, has recently been used as a gene therapy delivery agent. We have defined the optimal…”
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Repeat administration of DNA/liposomes to the nasal epithelium of patients with cystic fibrosis by HYDE, S. C, SOUTHERN, K. W, EGAN, J. J, SORGI, F. L, HUANG, L, CUTHBERT, A. W, EVANS, M. J, COLLEDGE, W. H, HIGGINS, C. F, WEBB, A. K, GILL, D. R, GILEADI, U, FITZJOHN, E. M, MOFFORD, K. A, WADDELL, B. E, GOOI, H. C, GODDARD, C. A, HANNAVY, K, SMYTH, S. E

“…The major cause of mortality in patients with cystic fibrosis (CF) is lung disease. Expression of the cystic fibrosis transmembrane conductance regulator…”
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Physiological consequences of the P2328S mutation in the ryanodine receptor (RyR2) gene in genetically modified murine hearts by Goddard, C.A, Ghais, N.S, Zhang, Y, Williams, A.J, Colledge, W.H, Grace, A.A, Huang, C.L.-H

“…To explore the physiological consequences of the ryanodine receptor (RyR2)-P2328S mutation associated with catecholaminergic polymorphic ventricular…”
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Arrhythmogenic mechanisms in the isolated perfused hypokalaemic murine heart by Killeen, M. J., Thomas, G., Gurung, I. S., Goddard, C. A., Fraser, J. A., Mahaut-Smith, M. P., Colledge, W. H., Grace, A. A., Huang, C. L.-H.

“…Aim:  Hypokalaemia is associated with a lethal form of ventricular tachycardia (VT), torsade de pointes, through pathophysiological mechanisms requiring…”
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Increased persistence of lung gene expression using plasmids containing the ubiquitin C or elongation factor 1α promoter by GILL, D. R, SMYTH, S. E, GODDARD, C. A, PRINGLE, I. A, HIGGINS, C. F, COLLEDGE, W. H, HYDE, S. C

“…For effective gene therapy of chronic disease, persistent transgene expression at therapeutic levels is required. Clinical studies of airway gene transfer in…”
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Optimisation of real-time quantitative RT-PCR for the evaluation of non-viral mediated gene transfer to the airways by ROSE, A. C, GODDARD, C. A, COLLEDGE, W. H, CHENG, S. H, GILL, D. R, HYDE, S. C

“…Naked plasmid DNA and DNA/liposome complexes are currently being considered as gene therapy treatments for cystic fibrosis (CF) pulmonary disease. Current…”
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Steroid hormone enhancement of gene delivery to a human airway epithelial cell line in vitro and mouse airways in vivo by WISEMAN, J. W, GODDARD, C. A, COLLEDGE, W. H

“…Current liposome-based delivery protocols for gene therapy are relatively inefficient. In a pharmacological approach to enhance liposome-mediated gene delivery…”
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A second dose of a CFTR cDNA-liposome complex is as effective as the first dose in restoring cAMP-dependent chloride secretion to null CF mice trachea by GODDARD, C. A, RATCLIFF, R, CUTHBERT, A. W, EVANS, M. J, COLLEDGE, W. H, ANDERSON, J. R, GLENN, E, BROWN, S, GILL, D. R, HYDE, S. C, MACVINISH, L. J, HUANG, L, HIGGINS, C. F

“…Phase I clinical trials have provided encouraging data suggesting that gene transfer could provide a treatment for cystic fibrosis (CF). However, for all the…”
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A murine tracheal culture system to investigate parameters affecting gene therapy for cystic fibrosis by SCOTT, E. S, GODDARD, C. A, WISEMAN, J. W, EVANS, M. J, COLLEDGE, W. H

“…Cystic fibrosis (CF) is a life-threatening condition caused by mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR). Delivery of…”
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Potential Contribution of Combined Atmospheric Ca2＋ and Mg2＋ Wet Deposition Within the Continental U.S. to Soil Inorganic Carbon Sequestration by MIKHAILOVA, E.A., GODDARD, M.A., POST, C.J., SCHLAUTMAN, M.A., GALBRAITH, J.M.

“…Soil inorganic carbon （SIC） stocks continuously change from the formation of pedogenic carbonates, a process requiring inputs of Ca2＋ and Mg2＋ ions. This study…”
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Mouse model of SCN5A-linked hereditary lenègre's disease : Age-related conduction slowing and myocardial fibrosis by ROYER, Anne, VAN VEEN, Toon A. B, RICHER, Christine, ESCOUBET, Brigitte, JARRY-GUICHARD, Thérèse, COLLEDGE, William H, GROS, Daniel, DE BAKKER, Jacques M. T, GRACE, Andrew A, ESCANDE, Denis, CHARPENTIER, Flavien, LE BOUTER, Sabrina, MARIONNEAU, Céline, GRIOL-CHARHBILI, Violaine, LEONI, Anne-Laure, STEENMAN, Marja, VAN RIJEN, Harold V. M, DEMOLOMBE, Sophie, GODDARD, Catharine A

“…We have previously linked hereditary progressive cardiac conduction defect (hereditary Lenègre's disease) to a loss-of-function mutation in the gene encoding…”
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The Kuwait-Scotland eHealth Innovation Network (KSeHIN): a sustainable approach to quality improvement in healthcare by Conway, N T, Wotayan, R Al, Alkuzam, A, Al-Refaei, F F, Badawi, D, Barake, R, Bell, A, Boyle, G, Chisholm, S, Connell, J, Emslie-Smith, A, Goddard, C A, Greene, S A, Halawa, N, Judson, A, Kelly, C, Ker, J, Scott, M, Shaltout, A, Sukkar, F, Wake, D, Morris, A, Sibbald, D, Behbehani, K

“…The rising prevalence of obesity and diabetes in Kuwait represents a significant challenge for the country's healthcare system. Diabetes care in Scotland has…”
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Toying with titles by Goddard-Hill, A C

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Which dose should it be? by Goddard-Hill, A C

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Does risk of miscarriage increase? by Goddard-Hill, A C

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Parallel midbrain microcircuits perform independent temporal transformations by Goddard, C Alex, Huguenard, John, Knudsen, Eric

“…The capacity to select the most important information and suppress distracting information is crucial for survival. The midbrain contains a network critical…”
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Genistein activates CFTR-mediated Cl(-) secretion in the murine trachea and colon by Goddard, C A, Evans, M J, Colledge, W H

“…The action of the isoflavone genistein on the cystic fibrosis transmembrane conductance regulator (CFTR) has been studied in many cell systems but not in…”
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Pollution and health by Goddard-Hill, AC

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Applications of Imaging Spectroscopy in Molecular Biology II. Colony Screening Based on Absorption Spectra by Arkin, Adam P, Goldman, Ellen R, Robles, Steven J, Goddard, Christine A, Coleman, William J, Yang, Mary M, Youvan, Douglas C

“…Digital imaging spectroscopy has been used to obtain the grayscale spectrum of colored bacterial colonies directly from petri dishes. Up to 500 individual…”
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Increased persistence of lung gene expression using plasmids containing the ubiquitin C or elongation factor1α promoter by Gill, DR, Smyth, SE, Goddard, CA, Pringle, IA, Higgins, CF, Colledge, WH, Hyde, SC

“…For effective gene therapy of chronic disease, persistent transgene expression at therapeutic levels is required. Clinical studies of airway gene transfer in…”
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