Search Results - "GNANAPRAGASAM, Priyanthi N. P"

Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers by Cohen, Alexander A, Yang, Zhi, Gnanapragasam, Priyanthi N P, Ou, Susan, Dam, Kim-Marie A, Wang, Haoqing, Bjorkman, Pamela J

“…Current influenza vaccines do not elicit broadly protective immune responses against multiple strains. New strategies to focus the humoral immune response to…”
Get full text

Increasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational Design by Diskin, Ron, Scheid, Johannes F., Marcovecchio, Paola M., West, Anthony P., Klein, Florian, Gao, Han, Gnanapragasam, Priyanthi N. P., Abadir, Alexander, Seaman, Michael S., Nussenzweig, Michel C., Bjorkman, Pamela J.

“…Antibodies against the CD4 binding site (CD4bs) on the HIV-1 spike protein gp120 can show exceptional potency and breadth. We determined structures of…”
Get full text

Detection and characterization of the SARS-CoV-2 lineage B.1.526 in New York by West, Anthony P., Wertheim, Joel O., Wang, Jade C., Vasylyeva, Tetyana I., Havens, Jennifer L., Chowdhury, Moinuddin A., Gonzalez, Edimarlyn, Fang, Courtney E., Di Lonardo, Steve S., Hughes, Scott, Rakeman, Jennifer L., Lee, Henry H., Barnes, Christopher O., Gnanapragasam, Priyanthi N. P., Yang, Zhi, Gaebler, Christian, Caskey, Marina, Nussenzweig, Michel C., Keeffe, Jennifer R., Bjorkman, Pamela J.

“…Wide-scale SARS-CoV-2 genome sequencing is critical to tracking viral evolution during the ongoing pandemic. We develop the software tool, Variant Database…”
Get full text

HIV-1 CD4-binding site germline antibody–Env structures inform vaccine design by Dam, Kim-Marie A., Barnes, Christopher O., Gristick, Harry B., Schoofs, Till, Gnanapragasam, Priyanthi N. P., Nussenzweig, Michel C., Bjorkman, Pamela J.

“…BG24, a VRC01-class broadly neutralizing antibody (bNAb) against HIV-1 Env with relatively few somatic hypermutations (SHMs), represents a promising target for…”
Get full text

Inhibitory effect of HIV-specific neutralizing IgA on mucosal transmission of HIV in humanized mice by Hur, Eun Mi, Patel, Sonal N., Shimizu, Saki, Rao, Dinesh S., Gnanapragasam, Priyanthi N.P., An, Dong Sung, Yang, Lili, Baltimore, David

“…HIV-1 infections are generally initiated at mucosal sites. Thus, IgA antibody, which plays pivotal roles in mucosal immunity, might efficiently prevent HIV…”
Get full text

Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice by Cohen, Alexander A, Gnanapragasam, Priyanthi N P, Lee, Yu E, Hoffman, Pauline R, Ou, Susan, Kakutani, Leesa M, Keeffe, Jennifer R, Wu, Hung-Jen, Howarth, Mark, West, Anthony P, Barnes, Christopher O, Nussenzweig, Michel C, Bjorkman, Pamela J

“…Protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and SARS-related emergent zoonotic coronaviruses is urgently needed. We made…”
Get full text

Examination of the contributions of size and avidity to the neutralization mechanisms of the anti-HIV antibodies b12 and 4E10 by Klein, Joshua S, Gnanapragasam, Priyanthi N.P, Galimidi, Rachel P, Foglesong, Christopher P, West, Anthony P. Jr, Bjorkman, Pamela J

“…Monoclonal antibodies b12 and 4E10 are broadly neutralizing against a variety of strains of the human immunodeficiency virus type 1 (HIV-1). The epitope for…”
Get full text

Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models by Cohen, Alexander A, van Doremalen, Neeltje, Greaney, Allison J, Andersen, Hanne, Sharma, Ankur, Starr, Tyler N, Keeffe, Jennifer R, Fan, Chengcheng, Schulz, Jonathan E, Gnanapragasam, Priyanthi N P, Kakutani, Leesa M, West, Jr, Anthony P, Saturday, Greg, Lee, Yu E, Gao, Han, Jette, Claudia A, Lewis, Mark G, Tan, Tiong K, Townsend, Alain R, Bloom, Jesse D, Munster, Vincent J, Bjorkman, Pamela J

“…To combat future severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and spillovers of SARS-like betacoronaviruses (sarbecoviruses)…”
Get full text

Designed oligomers of cyanovirin-N show enhanced HIV neutralization by Keeffe, Jennifer R, Gnanapragasam, Priyanthi N. P, Gillespie, Sarah K, Yong, John, Bjorkman, Pamela J, Mayo, Stephen L

“…Cyanovirin-N (CV-N) is a small, cyanobacterial lectin that neutralizes many enveloped viruses, including human immunodeficiency virus type I (HIV-1). This…”
Get full text

Single-Chain Fv-Based Anti-HIV Proteins: Potential and Limitations by WEST, Anthony P, GALIMIDI, Rachel P, GNANAPRAGASAM, Priyanthi N. P, BJORKMAN, Pamela J

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies by Mouquet, Hugo, Scharf, Louise, Euler, Zelda, Liu, Yan, Eden, Caroline, Scheid, Johannes F., Halper-Stromberg, Ariel, Gnanapragasam, Priyanthi N. P., Spencer, Daniel I. R., Seaman, Michael S., Schuitemaker, Hanneke, Feizi, Ten, Nussenzweig, Michel C., Bjorkman, Pamela J.

“…Broadly neutralizing HIV antibodies (bNAbs) can recognize carbohydrate-dependent epitopes on gp120. In contrast to previously characterized glycan-dependent…”
Get full text

Evaluation of CD4-CD4i Antibody Architectures Yields Potent, Broadly Cross-Reactive Anti-Human Immunodeficiency Virus Reagents by WEST, Anthony P, GALIMIDI, Rachel P, FOGLESONG, Christopher P, GNANAPRAGASAM, Priyanthi N. P, KLEIN, Joshua S, BJORKMAN, Pamela J

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Design and Expression of a Dimeric Form of Human Immunodeficiency Virus Type 1 Antibody 2G12 with Increased Neutralization Potency by WEST, Anthony P, GALIMIDI, Rachel P, FOGLESONG, Christopher P, GNANAPRAGASAM, Priyanthi N. P, HUEY-TUBMAN, Kathryn E, KLEIN, Joshua S, SUZUKI, Maria D, TIANGCO, Noreen E, VIELMETTER, Jost, BJORKMAN, Pamela J

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Antibody elicited by HIV-1 immunogen vaccination in macaques displaces Env fusion peptide and destroys a neutralizing epitope by Abernathy, Morgan E., Gristick, Harry B., Vielmetter, Jost, Keeffe, Jennifer R., Gnanapragasam, Priyanthi N. P., Lee, Yu E., Escolano, Amelia, Gautam, Rajeev, Seaman, Michael S., Martin, Malcolm A., Nussenzweig, Michel C., Bjorkman, Pamela J.

“…HIV-1 vaccine design aims to develop an immunogen that elicits broadly neutralizing antibodies against a desired epitope, while eliminating responses to…”
Get full text

Proactive vaccination using multiviral Quartet Nanocages to elicit broad anti-coronavirus responses by Hills, Rory A., Tan, Tiong Kit, Cohen, Alexander A., Keeffe, Jennifer R., Keeble, Anthony H., Gnanapragasam, Priyanthi N. P., Storm, Kaya N., Rorick, Annie V., West, Anthony P., Hill, Michelle L., Liu, Sai, Gilbert-Jaramillo, Javier, Afzal, Madeeha, Napier, Amy, Admans, Gabrielle, James, William S., Bjorkman, Pamela J., Townsend, Alain R., Howarth, Mark R.

“…Defending against future pandemics requires vaccine platforms that protect across a range of related pathogens. Nanoscale patterning can be used to address…”
Get full text

A dimeric form of the HIV-1 antibody 2G12 elicits potent antibody-dependent cellular cytotoxicity by KLEIN, Joshua S, WEBSTER, Alexandre, GNANAPRAGASAM, Priyanthi N. P, GALIMIDI, Rachel P, BJORKMAN, Pamela J

“…Increasing data support a role for antibody-dependent cellular cytotoxicity (ADCC) in controlling HIV-1 infection. We recently isolated a naturally occurring…”
Get full text

Nanoparticles presenting clusters of CD4 expose a universal vulnerability of HIV-1 by mimicking target cells by Hoffmann, Magnus A. G., Bar-On, Yotam, Yang, Zhi, Gristick, Harry B., Gnanapragasam, Priyanthi N. P., Vielmetter, Jost, Nussenzweig, Michel C., Bjorkman, Pamela J.

“…CD4-based decoy approaches against HIV-1 are attractive options for long-term viral control, but initial designs, including soluble CD4 (sCD4) and CD4-Ig, were…”
Get full text

Sequential immunization of macaques elicits heterologous neutralizing antibodies targeting the V3-glycan patch of HIV-1 Env by Escolano, Amelia, Gristick, Harry B, Gautam, Rajeev, DeLaitsch, Andrew T, Abernathy, Morgan E, Yang, Zhi, Wang, Haoqing, Hoffmann, Magnus A G, Nishimura, Yoshiaki, Wang, Zijun, Koranda, Nicholas, Kakutani, Leesa M, Gao, Han, Gnanapragasam, Priyanthi N P, Raina, Henna, Gazumyan, Ana, Cipolla, Melissa, Oliveira, Thiago Y, Ramos, Victor, Irvine, Darrell J, Silva, Murillo, West, Jr, Anthony P, Keeffe, Jennifer R, Barnes, Christopher O, Seaman, Michael S, Nussenzweig, Michel C, Martin, Malcolm A, Bjorkman, Pamela J

“…Broadly neutralizing antibodies (bNAbs) against HIV-1 develop after prolonged virus and antibody coevolution. Previous studies showed that sequential…”
Get more information

Electron tomography visualization of HIV-1 fusion with target cells using fusion inhibitors to trap the pre-hairpin intermediate by Ladinsky, Mark S, Gnanapragasam, Priyanthi Np, Yang, Zhi, West, Anthony P, Kay, Michael S, Bjorkman, Pamela J

“…Fusion of HIV-1 with the membrane of its target cell, an obligate first step in virus infectivity, is mediated by binding of the viral envelope (Env) spike…”
Get full text

CD4 binding site immunogens elicit heterologous anti-HIV-1 neutralizing antibodies in transgenic and wild-type animals by Gristick, Harry B, Hartweger, Harald, Loewe, Maximilian, van Schooten, Jelle, Ramos, Victor, Oliveira, Thiago Y, Nishimura, Yoshiaki, Koranda, Nicholas S, Wall, Abigail, Yao, Kai-Hui, Poston, Daniel, Gazumyan, Anna, Wiatr, Marie, Horning, Marcel, Keeffe, Jennifer R, Hoffmann, Magnus A G, Yang, Zhi, Abernathy, Morgan E, Dam, Kim-Marie A, Gao, Han, Gnanapragasam, Priyanthi N P, Kakutani, Leesa M, Pavlovitch-Bedzyk, Ana Jimena, Seaman, Michael S, Howarth, Mark, McGuire, Andrew T, Stamatatos, Leonidas, Martin, Malcolm A, West, Jr, Anthony P, Nussenzweig, Michel C, Bjorkman, Pamela J

“…Passive transfer of broadly neutralizing anti-HIV-1 antibodies (bNAbs) protects against infection, and therefore, eliciting bNAbs by vaccination is a major…”
Get more information