Omentin Plasma Levels and Gene Expression Are Decreased in Obesity
Omentin Plasma Levels and Gene Expression Are Decreased in Obesity Celia M. de Souza Batista 1 2 , Rong-Ze Yang 1 , Mi-Jeong Lee 1 , Nicole M. Glynn 1 , Dao-Zhan Yu 1 , Jessica Pray 1 , Kelechi Ndubuizu 3 , Susheel Patil 4 , Alan Schwartz 4 , Mark Kligman 5 , Susan K. Fried 1 6 , Da-Wei Gong 1 2 , A...
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| Published in: | Diabetes (New York, N.Y.) Vol. 56; no. 6; pp. 1655 - 1661 |
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| Main Authors: | , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Alexandria, VA
American Diabetes Association
01-06-2007
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Omentin Plasma Levels and Gene Expression Are Decreased in Obesity
Celia M. de Souza Batista 1 2 ,
Rong-Ze Yang 1 ,
Mi-Jeong Lee 1 ,
Nicole M. Glynn 1 ,
Dao-Zhan Yu 1 ,
Jessica Pray 1 ,
Kelechi Ndubuizu 3 ,
Susheel Patil 4 ,
Alan Schwartz 4 ,
Mark Kligman 5 ,
Susan K. Fried 1 6 ,
Da-Wei Gong 1 2 ,
Alan R. Shuldiner 1 2 6 ,
Toni I. Pollin 1 and
John C. McLenithan 1 2 6
1 Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore,
Maryland
2 Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland
3 Department of Biology, University of Maryland Baltimore County, Baltimore, Maryland
4 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
5 Division of General Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland
6 Geriatric Research, Education and Clinical Center, Baltimore Veterans Affairs Medical Center, Baltimore, Maryland
Address correspondence and reprint requests to John C. McLenithan, 660 West Redwood St., Room 490, Baltimore, MD 21201. E-mail:
jmcle001{at}umaryland.edu
Abstract
Central obesity and the accumulation of visceral fat are risk factors for the development of type 2 diabetes and cardiovascular
disease. Omentin is a protein expressed and secreted from visceral but not subcutaneous adipose tissue that increases insulin
sensitivity in human adipocytes. To determine the impact of obesity-dependent insulin resistance on the regulation of two
omentin isoforms, gene expression and plasma levels were measured in lean, overweight, and obese subjects. Omentin 1 was shown
to be the major circulating isoform in human plasma. Lean subjects had significantly higher plasma omentin 1 levels than obese
and overweight subjects. In addition, higher plasma omentin 1 levels were detected in women compared with men. Plasma omentin
1 levels were inversely correlated with BMI, waist circumference, leptin levels, and insulin resistance as measured by homeostasis
model assessment and positively correlated with adiponectin and HDL levels. Both omentin 1 and omentin 2 gene expression were
decreased with obesity and were highly correlated with each other in visceral adipose tissue. In summary, decreased omentin
levels are associated with increasing obesity and insulin resistance. Therefore, omentin levels may be predictive of the metabolic
consequences or co-morbidities associated with obesity.
AFDS, Amish Family Diabetes Study
HOMA, homeostasis model assessment
pI, isoelectric point
Footnotes
Published ahead of print at http://diabetes.diabetesjournals.org on 28 February 2007. DOI: 10.2337/db06-1506.
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore
be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
Accepted February 20, 2007.
Received October 26, 2006.
DIABETES |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 0012-1797 1939-327X |
| DOI: | 10.2337/db06-1506 |