Search Results - "GLYNN, Sharon A"

The Role of Nitric Oxide in Cancer: Master Regulator or NOt? by Khan, Faizan H, Dervan, Eoin, Bhattacharyya, Dibyangana D, McAuliffe, Jake D, Miranda, Katrina M, Glynn, Sharon A

“…Nitric oxide (NO) is a key player in both the development and suppression of tumourigenesis depending on the source and concentration of NO. In this review, we…”
Get full text

Coexpression of NOS2 and COX2 accelerates tumor growth and reduces survival in estrogen receptor-negative breast cancer by Basudhar, Debashree, Glynn, Sharon A., Greer, Madison, Somasundaram, Veena, No, Jae Hong, Scheiblin, David A., Garrido, Pablo, Heinz, William F., Ryan, Aideen E., Weiss, Jonathan M., Cheng, Robert Y. S., Ridnour, Lisa A., Lockett, Stephen J., McVicar, Daniel W., Ambs, Stefan, Wink, David A.

“…Proinflammatory signaling pathways are commonly up-regulated in breast cancer. In estrogen receptor-negative (ER⁻) and triple-negative breast cancer (TNBC),…”
Get full text

Tumor microenvironment-based feed-forward regulation of NOS2 in breast cancer progression by Heinecke, Julie L., Ridnour, Lisa A., Cheng, Robert Y. S., Switzer, Christopher H., Lizardo, Michael M., Khanna, Chand, Glynn, Sharon A., Hussain, S. Perwez, Young, Howard A., Ambs, Stefan, Wink, David A.

“…Inflammation is widely recognized as an inducer of cancer progression. The inflammation-associated enzyme, inducible nitric oxide synthase (NOS2), has emerged…”
Get full text

Nitric Oxide Synthase-2-Derived Nitric Oxide Drives Multiple Pathways of Breast Cancer Progression by Basudhar, Debashree, Somasundaram, Veena, de Oliveira, Graciele Almeida, Kesarwala, Aparna, Heinecke, Julie L, Cheng, Robert Y, Glynn, Sharon A, Ambs, Stefan, Wink, David A, Ridnour, Lisa A

“…Breast cancer is the second leading cause of cancer-related deaths among women in the United States. Development and progression of malignancy are associated…”
Get more information

Ancient Adversary – HERV-K (HML-2) in Cancer by Dervan, Eoin, Bhattacharyya, Dibyangana D., McAuliffe, Jake D., Khan, Faizan H., Glynn, Sharon A.

“…Human endogenous retroviruses (HERV), ancient integrations of exogenous viruses, make up 8% of our genome. Long thought of as mere vestigial genetic elements,…”
Get full text

The impact of nitric oxide on HER family post-translational modification and downstream signaling in cancer by O'Neill, Ciara E, Sun, Kai, Sundararaman, Sugunapriyadharshini, Chang, Jenny C, Glynn, Sharon A

“…The human epidermal growth factor receptor (HER) family consists of four members, activated by two families of ligands. They are known for mediating cell-cell…”
Get full text

Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients by Glynn, Sharon A, Boersma, Brenda J, Dorsey, Tiffany H, Yi, Ming, Yfantis, Harris G, Ridnour, Lisa A, Martin, Damali N, Switzer, Christopher H, Hudson, Robert S, Wink, David A, Lee, Dong H, Stephens, Robert M, Ambs, Stefan

“…Inducible nitric oxide synthase (NOS2) is involved in wound healing, angiogenesis, and carcinogenesis. NOS2 upregulation and increased nitric oxide (NO)…”
Get full text

Candidate pathways linking inducible nitric oxide synthase to a basal-like transcription pattern and tumor progression in human breast cancer by Ambs, Stefan, Glynn, Sharon A.

“…Inducible nitric oxide synthase (NOS2) is an inflammation responsive enzyme (EC 1.14.13.39) that is induced during acute and chronic inflammation and tissue…”
Get full text

A close connection between the PERK and IRE arms of the UPR and the transcriptional regulation of autophagy by Deegan, Shane, Koryga, Izabela, Glynn, Sharon A., Gupta, Sanjeev, Gorman, Adrienne M., Samali, Afshin

“…•Microarray of HCT116 cells.•Autophagy genes upregulated.•PERK and IRE1 important for regulation. Endoplasmic reticulum (ER) stress is known to lead to…”
Get full text

Immunotherapeutic Potential of Anti-Human Endogenous Retrovirus-K Envelope Protein Antibodies in Targeting Breast Tumors by Wang-Johanning, Feng, Rycaj, Kiera, Plummer, Joshua B., Li, Ming, Yin, Bingnan, Frerich, Katherine, Garza, Jeremy G., Shen, Jianjun, Lin, Kevin, Yan, Peisha, Glynn, Sharon A., Dorsey, Tiffany H., Hunt, Kelly K., Ambs, Stefan, Johanning, Gary L.

“…Background The envelope (env) protein of the human endogenous retrovirus type K (HERV-K) family is commonly expressed on the surface of breast cancer cells. We…”
Get full text

Nitric Oxide Modulates Metabolic Processes in the Tumor Immune Microenvironment by McGinity, Christopher L, Palmieri, Erika M, Somasundaram, Veena, Bhattacharyya, Dibyangana D, Ridnour, Lisa A, Cheng, Robert Y S, Ryan, Aideen E, Glynn, Sharon A, Thomas, Douglas D, Miranda, Katrina M, Anderson, Stephen K, Lockett, Stephen J, McVicar, Daniel W, Wink, David A

“…The metabolic requirements and functions of cancer and normal tissues are vastly different. Due to the rapid growth of cancer cells in the tumor…”
Get full text

Ets-1 is a transcriptional mediator of oncogenic nitric oxide signaling in estrogen receptor-negative breast cancer by Switzer, Christopher H, Cheng, Robert Y-S, Ridnour, Lisa A, Glynn, Sharon A, Ambs, Stefan, Wink, David A

“…The Ets-1 transcription factor is a candidate breast cancer oncogene that regulates the expression of genes involved in tumor progression and metastasis. Ets-1…”
Get full text

Facile Synthesis of Hemin Derivatives with Modulated Aggregation Behaviour and Enhanced Nitric‐Oxide Scavenging Properties as New Therapeutics for Breast Cancer by Alsharabasy, Amir M., Cherukaraveedu, Durgadas, Warneke, Jonas, Warneke, Ziyan, Galán‐Mascarós, José Ramón, Glynn, Sharon A., Farràs, Pau, Pandit, Abhay

“…Nitric oxide (•NO) plays various pathophysiological roles in breast cancer, significantly influencing the migration of tumour cells through concentration…”
Get full text

Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer by Switzer, Christopher H, Glynn, Sharon A, Ridnour, Lisa A, Cheng, Robert Y.-S, Vitek, Michael P, Ambs, Stefan, Wink, David A

“…Basal-like breast cancer is an aggressive disease with limited therapeutic options because these tumors frequently express the ‘triple-negative’ phenotype. We…”
Get full text

Mesenchymal stem cells: key players in cancer progression by Ridge, Sarah M, Sullivan, Francis J, Glynn, Sharon A

“…Tumour progression is dependent on the interaction between tumour cells and cells of the surrounding microenvironment. The tumour is a dynamic milieu…”
Get full text

Nitric oxide synthase and breast cancer: role of TIMP-1 in NO-mediated Akt activation by Ridnour, Lisa A, Barasch, Kimberly M, Windhausen, Alisha N, Dorsey, Tiffany H, Lizardo, Michael M, Yfantis, Harris G, Lee, Dong H, Switzer, Christopher H, Cheng, Robert Y S, Heinecke, Julie L, Brueggemann, Ernst, Hines, Harry B, Khanna, Chand, Glynn, Sharon A, Ambs, Stefan, Wink, David A

“…Prediction of therapeutic response and cancer patient survival can be improved by the identification of molecular markers including tumor Akt status. A direct…”
Get full text

The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, simvastatin, lovastatin and mevastatin inhibit proliferation and invasion of melanoma cells by Glynn, Sharon A, O'Sullivan, Dermot, Eustace, Alex J, Clynes, Martin, O'Donovan, Norma

“…A number of recent studies have suggested that cancer incidence rates may be lower in patients receiving statin treatment for hypercholesterolemia. We examined…”
Get full text

COX-2 activation is associated with Akt phosphorylation and poor survival in ER-negative, HER2-positive breast cancer by Glynn, Sharon A, Prueitt, Robyn L, Ridnour, Lisa A, Boersma, Brenda J, Dorsey, Tiffany M, Wink, David A, Goodman, Julie E, Yfantis, Harris G, Lee, Dong H, Ambs, Stefan

“…Inducible cyclooxgenase-2 (COX-2) is commonly overexpressed in breast tumors and is a target for cancer therapy. Here, we studied the association of COX-2 with…”
Get full text

Exploring the nuances of nitric oxide in cancer by Glynn, Sharon A., Filomeni, Giuseppe

Get full text

A Mitochondrial Target Sequence Polymorphism in Manganese Superoxide Dismutase Predicts Inferior Survival in Breast Cancer Patients Treated with Cyclophosphamide by Glynn, Sharon A, Boersma, Brenda J, Howe, Tiffany M, Edvardsen, Hege, Geisler, Stephanie B, Goodman, Julie E, Ridnour, Lisa A, Lønning, Per E, Børresen-Dale, Anne-Lise, Naume, Bjorn, Kristensen, Vessela N, Chanock, Stephen J, Wink, David A, Ambs, Stefan

“…Purpose: Manganese superoxide dismutase protects against oxidative damage and modulates the efficacy of chemotherapeutic drugs. A functional single-nucleotide…”
Get full text