Search Results - "GLUZMAN, I. Y"

Structure and Inhibition of Plasmepsin II, a Hemoglobin-Degrading Enzyme from Plasmodium falciparum by Silva, A. M., Lee, A. Y., Gulnik, S. V., Majer, P., Collins, J., Bhat, T. N., Collins, P. J., Cachau, R. E., Luker, K. E., Gluzman, I. Y., Francis, S. E., Oksman, A., Goldberg, D. E., Erickson, J. W.

“…Plasmodium falciparum is the major causative agent of malaria, a disease of worldwide importance. Resistance to current drugs such as chloroquine and…”
Get full text

On the Molecular Mechanism of Chloroquine's Antimalarial Action by Sullivan, David J., Gluzman, Ilya Y., Russell, David G., Goldberg, Daniel E.

“…Chloroquine is thought to exert its antimalarial effect by preventing the polymerization of toxic heme released during proteolysis of hemoglobin in the…”
Get full text

Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway by GLUZMAN, I. Y, FRANCIS, S. E, OKSMAN, A, SMITH, C. E, DUFFIN, K. L, GOLDBERG, D. E

“…The human malaria parasite, Plasmodium falciparum, degrades nearly all its host cell hemoglobin during a short segment of its intraerythrocytic development…”
Get full text

Plasmodium Hemozoin Formation Mediated by Histidine-Rich Proteins by Sullivan, David J., Gluzman, Llya Y., Goldberg, Daniel E.

“…The digestive vacuole of Plasmodium falciparum is the site of hemoglobin degradation, heme polymerization into crystalline hemozoin, and antimalarial drug…”
Get full text

Potent, Low-Molecular-Weight Non-Peptide Inhibitors of Malarial Aspartyl Protease Plasmepsin II by Haque, Tasir S, Skillman, A. Geoffrey, Lee, Christina E, Habashita, Hiromu, Gluzman, Ilya Y, Ewing, Todd J. A, Goldberg, Daniel E, Kuntz, Irwin D, Ellman, Jonathan A

“…A number of single-digit nanomolar, low-molecular-weight plasmepsin II aspartyl protease inhibitors have been identified using combinatorial chemistry and…”
Get full text

Co‐ordinated programme of gene expression during asexual intraerythrocytic development of the human malaria parasite Plasmodium falciparum revealed by microarray analysis by Mamoun, Choukri Ben, Gluzman, Ilya Y., Hott, Christian, MacMillan, Sandra K., Amarakone, Aloka S., Anderson, Dustin L., Carlton, Jane M.‐R., Dame, John B., Chakrabarti, Debopam, Martin, Rodger K., Brownstein, Bernard H., Goldberg, Daniel E.

“…Plasmodium falciparum is a protozoan parasite responsible for the most severe forms of human malaria. All the clinical symptoms and pathological changes seen…”
Get full text

Molecular characterization and inhibition of a Plasmodium falciparum aspartic hemoglobinase by Francis, S.E., Gluzman, I.Y., Oksman, A., Knickerbocker, A., Mueller, R., Bryant, M.L., Sherman, D.R., Russell, D.G., Goldberg, D.E.

“…Intraerythrocytic malaria parasites rapidly degrade virtually all of the host cell hemoglobin. We have cloned the gene for an aspartic hemoglobinase that…”
Get full text

Chloroquine resistance not linked to mdr -like genes in a Plasmodium falciparum cross by Wellems, Thomas E, Panton, Lindsey J, Gluzman, Ilya Y, do Rosario, Virgilio E, Gwadz, Robert W, Walker-Jonah, Annie, Krogstad, Donald J

“…Chloroquine is thought to act against falciparum malaria by accumulating in the acid vesicles of the parasite and interfering with their function. Parasites…”
Get full text

Evaluation of a structure-based statine cyclic diamino amide encoded combinatorial library against plasmepsin II and cathepsin D by Carroll, Carolyn DiIanni, Johnson, Theodore O., Tao, Shewei, Lauri, Giorgio, Orlowski, Marc, Gluzman, Ilya Y., Goldberg, Daniel E., Dolle, Roland E.

“…A structure-based 18,900-member combinatorial library was synthesized containing a statine template and three cyclic diamino acids as potential P 1′, P 2–P 4…”
Get full text

Antimalarials Increase Vesicle pH in Plasmodium falciparum by Krogstad, Donald J., Schlesinger, Paul H., Gluzman, Ilya Y.

“…The asexual erythrocytic stage of the malarial parasite ingests and degrades the hemoglobin of its host red cell. To study this process, we labeled the…”
Get full text

Energy dependence of chloroquine accumulation and chloroquine efflux in Plasmodium falciparum by Krogstad, D J, Gluzman, I Y, Herwaldt, B L, Schlesinger, P H, Wellems, T E

“…Chloroquine inhibits the growth of susceptible malaria parasites at low (nanomolar) concentrations because of an energy-requiring drug-concentrating mechanism…”
Get more information

Plasmodium falciparum maturation abolishes physiologic red cell deformability by Cranston, H.A, Boylan, C.W, Carroll, G.L, Sutera, S.P, Williamson, J.R

“…Plasmodium falciparum, effects of infection and parasite maturation on deformability of parasitized red cells exposed to fluid shear stress in vitro examined…”
Get full text

Inoculum effect with chloroquine and Plasmodium falciparum by GLUZMAN, I. Y, SCHLESINGER, P. H, KROGSTAD, D. J

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

A Set of Independent Selectable Markers for Transfection of the Human Malaria Parasite Plasmodium falciparum by Ben Mamoun, Choukri, Gluzman, Ilya Y., Goyard, Sophie, Beverley, Stephen M., Goldberg, Daniel E.

“…Genomic information is rapidly accumulating for the human malaria pathogen, Plasmodium falciparum. Our ability to perform genetic manipulations to understand…”
Get full text

Generation of hemoglobin peptides in the acidic digestive vacuole of Plasmodium falciparum implicates peptide transport in amino acid production by Kolakovich, Kathleen A, Gluzman, Ilya Y, Duffin, Kevin L, Goldberg, Daniel E

“…Intraerythrocytic malaria parasites avidly consume hemoglobin as a source of amino acids for incorporation into parasite proteins. An acidic organelle, the…”
Get full text

Identification of potent inhibitors of Plasmodium falciparum plasmepsin II from an encoded statine combinatorial library by Carroll, Carolyn DiIanni, Patel, Hitesh, Johnson, Theodore O., Guo, Tao, Orlowski, Marc, He, Zhen-Min, Cavallaro, Cullen L., Guo, Joan, Oksman, Anna, Gluzman, Ilya Y., Connelly, James, Chelsky, Daniel, Goldberg, Daniel E., Dolle, Roland E.

“…An encoded 13,020-member combinatorial library was synthesized containing a statine core. Evaluation of this library with plasmepsin II, an aspartyl protease…”
Get full text

Clindamycin Activity Against Chloroquine-Resistant Plasmodium falciparum by Seaberg, Lavanya S., Parquette, Arlene R., Gluzman, I1ya Y., Phillips, Grady W., Brodasky, Thomas F., Krogstad, Donald J.

“…The clindamycin dose-response curves observed with both chloroquine-resistant and chloroquine-susceptible strains of Plasmodium falciparum in vitro…”
Get full text

A rapid in vitro test for chloroquine-resistant Plasmodium falciparum by Gluzman, I Y, Krogstad, D J, Orjih, A U, Nkangineme, K, Wellems, T E, Martin, J T, Schlesinger, P H

“…We report a rapid (2-3 hr) in vitro test for chloroquine resistance in Plasmodium falciparum. The test is based on the inhibition of chloroquine efflux by…”
Get more information

Probing the Chloroquine Resistance Locus of Plasmodium falciparum with a Novel Class of Multidentate Metal(III) Coordination Complexes by Goldberg, Daniel E., Sharma, Vijay, Oksman, Anna, Gluzman, Ilya Y., Wellems, Thomas E., Piwnica-Worms, David

“…The malaria organism Plasmodium falciparum detoxifies heme released during degradation of host erythrocyte hemoglobin by sequestering it within the parasite…”
Get full text

Characterization of native falcipain, an enzyme involved in Plasmodium falciparum hemoglobin degradation by Francis, Susan E., Gluzman, Ilya Y., Oksman, Anna, Banerjee, Dolly, Goldberg, Daniel E.

“…In Plasmodium falciparum, a cysteine protease known as falcipain has been implicated in the essential metabolic process of hemoglobin degradation. Parallel…”
Get full text