Search Results - "GLUCHOWSKI, C"

Estimation of Contaminant Loads from the Sacramento-San Joaquin River Delta to San Francisco Bay by David, N., Gluchowski, D. C., Leatherbarrow, J. E., Yee, D., McKee, L. J.

“…Contaminant concentrations from the Sacramento-San Joaquin River watershed were determined in water samples mainly during flood flows in an ongoing effort to…”
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Facile access to the ABC ring system of the taxane diterpenes via anionic oxy-Cope rearrangements by Martin, S.F., Assercq, J.-M., Austin, R.E., Dantanarayana, A.P., Fishpaugh, J.R., Gluchowski, C., Guinn, D.E., Hartmann, M., Tanaka, T., Wagner, R., White, J.B.

“…The anionic oxy-Cope rearrangement of bicyclo[2.2.2]octadienols serves as a key step for the construction of substituted bicyclo[5.3.1]undecenones and provides…”
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Modeling the G-protein-coupled neuropeptide Y Y1 receptor agonist and antagonist binding sites by Du, P, Salon, J A, Tamm, J A, Hou, C, Cui, W, Walker, M W, Adham, N, Dhanoa, D S, Islam, I, Vaysse, P J, Dowling, B, Shifman, Y, Boyle, N, Rueger, H, Schmidlin, T, Yamaguchi, Y, Branchek, T A, Weinshank, R L, Gluchowski, C

“…Neuropeptide Y (NPY) receptors belong to the G-protein-coupled receptor (GPCR) superfamily and mediate several physiological responses, such as blood pressure,…”
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Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site by Borden, L A, Dhar, T G, Smith, K E, Branchek, T A, Gluchowski, C, Weinshank, R L

“…Molecular cloning has revealed the presence of four high-affinity GABA transporters in the brain. The existence of three of these sites, GAT-2, GAT-3, and…”
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Identification of a dihydropyridine as a potent alpha1a adrenoceptor-selective antagonist that inhibits phenylephrine-induced contraction of the human prostate by Wong, W C, Chiu, G, Wetzel, J M, Marzabadi, M R, Nagarathnam, D, Wang, D, Fang, J, Miao, S W, Hong, X, Forray, C, Vaysse, P J, Branchek, T A, Gluchowski, C, Tang, R, Lepor, H

“…A number of novel dihydropyridine derivatives based upon 1, 4-dihydro-3-(methoxycarbonyl)-2, 6-dimethyl-4-(4-nitrophenyl)-5-((3-(4,…”
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Design and synthesis of novel dihydropyridine alpha-1A antagonists by Marzabadi, Mohammad R., Xingfang Hong, Nagarathnam, Dhanapalan, ShouWu Miao, Chiu, George, Wong, Wai C., Wetzel, John M., Fang, James, Forray, Carlos, Chen, Tsing B., O'Malley, Stacey S., Chang, Raymond S.L., Gluchowski, Charles

“…A series of analogs of SNAP 5150 containing heteroatoms at C 2 or C 6 positions is described. Herein, we report that the presence of alkyl substituted…”
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Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 1. Structure-activity relationship in dihydropyrimidinones by Nagarathnam, D, Miao, S W, Lagu, B, Chiu, G, Fang, J, Murali Dhar, T G, Zhang, J, Tyagarajan, S, Marzabadi, M R, Zhang, F, Wong, W C, Sun, W, Tian, D, Wetzel, J M, Forray, C, Chang, R S, Broten, T P, Ransom, R W, Schorn, T W, Chen, T B, O'Malley, S, Kling, P, Schneck, K, Bendesky, R, Harrell, C M

“…Dihydropyrimidinones such as compound 12 exhibited high binding affinity and subtype selectivity for the cloned human alpha(1a) receptor. Systematic…”
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Studies on the ocular hypotensive effects of prostaglandin F2 alpha ester prodrugs and receptor selective prostaglandin analogs by Woodward, D F, Chan, M F, Burke, J A, Cheng-Bennett, A, Chen, G, Fairbairn, C E, Gac, T, Garst, M E, Gluchowski, C, Kaplan, L J

“…The use of natural prostaglandins (PG), such as PGD2, PGE2, PGF2 alpha, and PGI2, for treating glaucoma is limited by their ocular side effects. One approach…”
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Synthesis and structure-activity relationship of fluoro analogues of 8-{2-[4-(4-methoxyphenyl)piperazin-1yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione as selective alpha(1d)-adrenergic receptor antagonists by Konkel, Michael J, Wetzel, John M, Cahir, Marie, Craig, Douglas A, Noble, Stewart A, Gluchowski, Charles

“…We have discovered high-affinity antagonists (exemplified by 11 and 12) that are the most selective for alpha(1d)-adrenergic receptors (alpha(1d)-AR) reported…”
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Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 2. Approaches to eliminate opioid agonist metabolites via modification of linker and 4-methoxycarbonyl-4-phenylpiperidine moiety by Murali Dhar, T G, Nagarathnam, D, Marzabadi, M R, Lagu, B, Wong, W C, Chiu, G, Tyagarajan, S, Miao, S W, Zhang, F, Sun, W, Tian, D, Shen, Q, Zhang, J, Wetzel, J M, Forray, C, Chang, R S, Broten, T P, Schorn, T W, Chen, T B, O'Malley, S, Ransom, R, Schneck, K, Bendesky, R, Harrell, C M, Vyas, K P

“…We have previously described compound 1a as a high-affinity subtype selective alpha(1a) antagonist. In vitro and in vivo evaluation of compound 1a showed its…”
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Design, synthesis and SAR of a series of 2-substituted 4-amino-quinazoline neuropeptide Y Y5 receptor antagonists by RUEEGER, H, RIGOLLIER, P, ISLAM, I, ZHANG, J, GLUCHOWSKI, C, YAMAGUCHI, Y, SCHMIDLIN, T, SCHILLING, W, CRISCIONE, L, WHITEBREAD, S, CHIESI, M, WALKER, M. W, DHANOA, D

“…The design of a novel series of NPY-Y5 receptor antagonists is described. Key elements for the design were the identification of weak Y5 hits from a Y1…”
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Design, Synthesis and Evaluation of Substituted Triarylnipecotic Acid Derivatives as GABA Uptake Inhibitors: Identification of a Ligand with Moderate Affinity and Selectivity for the Cloned Human GABA Transporter GAT-3 by Dhar, T. G. Murali, Borden, Laurence A, Tyagarajan, Sriram, Smith, Kelli E, Branchek, Theresa A, Weinshank, Richard L, Gluchowski, Charles

“…gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian central nervous system. Molecular biology has revealed the presence of…”
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Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 3. Approaches to eliminate opioid agonist metabolites by using substituted phenylpiperazine side chains by Lagu, B, Tian, D, Nagarathnam, D, Marzabadi, M R, Wong, W C, Miao, S W, Zhang, F, Sun, W, Chiu, G, Fang, J, Forray, C, Chang, R S, Ransom, R W, Chen, T B, O'Malley, S, Zhang, K, Vyas, K P, Gluchowski, C

“…Dihydropyrimidinones, such as 1, represent a novel class of alpha(1a) adrenoceptor antagonists with potential for the treatment of benign prostatic hyperplasia…”
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2-amino-2-oxazolines as subtype selective alpha(2) adrenoceptor agonists by Wong, W C, Sun, W, Cui, W, Chen, Y, Forray, C, Vaysse, P J, Branchek, T A, Gluchowski, C

“…Cyclohexylamino oxazoline 1 (AGN 190837), an analogue of 2 (Bay a6781), is a potent alpha(2) adrenoceptor agonist. On the basis of a design generated by…”
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Localization of the alpha 1A-adrenoceptor in the human prostate by Lepor, H, Tang, R, Kobayashi, S, Shapiro, E, Forray, C, Wetzel, J M, Gluchowski, C

“…We determined the tissue localization of the alpha 1a-adrenoceptor in the human prostate. Autoradiographic localization of the alpha 1a-adrenoceptor in the…”
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Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 4. Structure-activity relationship in the dihydropyrimidine series by Wong, W C, Sun, W, Lagu, B, Tian, D, Marzabadi, M R, Zhang, F, Nagarathnam, D, Miao, S W, Wetzel, J M, Peng, J, Forray, C, Chang, R S, Chen, T B, Ransom, R, O'Malley, S, Broten, T P, Kling, P, Vyas, K P, Zhang, K, Gluchowski, C

“…We have previously disclosed dihydropyridines such as 1a,b as selective alpha(1a) antagonists as a potential treatment for benign prostatic hyperplasia (BPH)…”
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A double protection strategy for the synthesis of 3,5-disubstituted dihydropyridines by Marzabadi, Mohammad R., Hong, Xingfang, Gluchowski, Charles

“…A double protection strategy for the synthesis of the biologically important dihydropyridines is described. Deprotection followed by independent chemical…”
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Phenylacetamides as selective alpha-1A adrenergic receptor antagonists by Patane, M A, DiPardo, R M, Newton, R C, Price, R P, Broten, T P, Chang, R S, Ransom, R W, Di Salvo, J, Nagarathnam, D, Forray, C, Gluchowski, C, Bock, M G

“…A novel class of potent and selective alpha-1a receptor antagonists has been identified. The structures of these antagonists were derived from truncating the…”
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Phenylacetamides as selective α-1A adrenergic receptor antagonists by Patane, Michael A., DiPardo, Robert M., Newton, Randall C., Price, RoseAnn P., Broten, Theodore P., Chang, Raymond S.L., Ransom, Richard W., Di Salvo, Jerry, Nagarathnam, Dhanapalan, Forray, Carlos, Gluchowski, Charles, Bock, Mark G.

“…A novel class of potent and selective α-1a receptor antagonists has been identified. The structures of these antagonists were derived from truncating the…”
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Localization of mRNA and receptor binding sites for the alpha 1a-adrenoceptor subtype in the rat, monkey and human urinary bladder and prostate by Walden, P D, Durkin, M M, Lepor, H, Wetzel, J M, Gluchowski, C, Gustafson, E L

“…To localize the mRNAs and receptor binding sites for the alpha 1a/A, alpha 1b/B and alpha 1d/D- adrenoceptor (AR) subtypes in the rat, monkey and human urinary…”
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