High Species Variation within the Repertoire of Trace Amine Receptors

High Species Variation within the Repertoire of Trace Amine Receptors

: Using a variety of search strategies, we obtained the complete or nearly complete repertoire of trace amine receptors from humans, mice, rats, zebrafish, pufferfish, and a number of invertebrates. We found that the number of functional receptors varies from 5 to 50 in each genome, showing that thi...

Full description

Saved in:
Bibliographic Details
Published in:Annals of the New York Academy of Sciences Vol. 1040; no. 1; pp. 323 - 327
Main Authors: GLORIAM, D E I, BJARNADÓTTIR, T K, SCHIÖTH, H B, FREDRIKSSON, R.
Format: Journal Article
Language:English
Published: Oxford, UK Blackwell Publishing Ltd 01-04-2005
Subjects:
Amines
Amino Acid Sequence
Animals
Danio rerio
evolution
Genes
Genetic Variation - genetics
GPCRs
Humans
Insects
Molecular Sequence Data
Mollusca
Mollusks
Multigene Family
Phylogeny
pufferfish
Receptors
Receptors, G-Protein-Coupled - chemistry
Receptors, G-Protein-Coupled - genetics
Serotonin
Species Specificity
Strategy
trace amine receptors
Zebrafish
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:: Using a variety of search strategies, we obtained the complete or nearly complete repertoire of trace amine receptors from humans, mice, rats, zebrafish, pufferfish, and a number of invertebrates. We found that the number of functional receptors varies from 5 to 50 in each genome, showing that this family of GPCRs has a very dynamic gene repertoire. We show that the previously cloned and characterized GPCRs from insects and mollusks are more closely related to mammalian serotonin, dopamine, and adrenalin receptors than to mammalian TA receptors. This suggests that the ability to bind TAs has arisen independently in different developmental lineages.
Bibliography:ark:/67375/WNG-XMVLRZPB-B
istex:8EB1997A80C4DC26DC58D2268FF4F551EB9C5583
ArticleID:NYAS323
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Article-2
ObjectType-Feature-3
ObjectType-Review-1
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1327.052