Search Results - "GLEASON, S. D"

Obituary: J. David LEander, Ph.D. : (April 8, 1944-November 14, 2014) by Witkin, J M, Gleason, S D, Carter, R B, Dykstra, L A

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In vivo occupancy of dopamine D3 receptors by antagonists produces neurochemical and behavioral effects of potential relevance to attention-deficit-hyperactivity disorder by Barth, V, Need, A B, Tzavara, E T, Giros, B, Overshiner, C, Gleason, S D, Wade, M, Johansson, A M, Perry, K, Nomikos, G G, Witkin, J M

“…Dopamine D(3) receptors have eluded definitive linkage to neurologic and psychiatric disorders since their cloning over 20 years ago. We report a new method…”
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Blockade of phencyclidine-induced hyperlocomotion by olanzapine, clozapine and serotonin receptor subtype selective antagonists in mice by GLEASON, S. D, SHANNON, H. E

“…In humans, phencyclidine (PCP) is known to produce a syndrome of behavioral effects which have many characteristics in common with schizophrenia. Therefore,…”
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Perampanel, an antagonist of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors, for the treatment of epilepsy: studies in human epileptic brain and nonepileptic brain and in rodent models by Zwart, R, Sher, E, Ping, X, Jin, X, Sims, Jr, J R, Chappell, A S, Gleason, S D, Hahn, P J, Gardinier, K, Gernert, D L, Hobbs, J, Smith, J L, Valli, S N, Witkin, J M

“…Perampanel [Fycompa, 2-(2-oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl)benzonitrile hydrate 4:3; Eisai Inc., Woodcliff Lake, NJ] is an AMPA…”
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The α2,3-selective potentiator of GABA A receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats by Witkin, J M, Cerne, R, Davis, P G, Freeman, K B, do Carmo, J M, Rowlett, J K, Methuku, K R, Okun, A, Gleason, S D, Li, X, Krambis, M J, Poe, M, Li, G, Schkeryantz, J M, Jahan, R, Yang, L, Guo, W, Golani, L K, Anderson, W H, Catlow, J T, Jones, T M, Porreca, F, Smith, J L, Knopp, K L, Cook, J M

“…Clinical evidence indicates that positive allosteric modulators (PAMs) of GABA receptors have analgesic benefit in addition to efficacy in anxiety disorders…”
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Bioisosteres of ethyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo [1,5-a][1,4]diazepine-3-carboxylate (HZ-166) as novel alpha 2,3 selective potentiators of GABA A receptors: Improved bioavailability enhances anticonvulsant efficacy by Witkin, J M, Smith, J L, Ping, X, Gleason, S D, Poe, M M, Li, G, Jin, X, Hobbs, J, Schkeryantz, J M, McDermott, J S, Alatorre, A I, Siemian, J N, Cramer, J W, Airey, D C, Methuku, K R, Tiruveedhula, V V N P B, Jones, T M, Crawford, J, Krambis, M J, Fisher, J L, Cook, J M, Cerne, R

“…HZ-166 has previously been characterized as an α2,3-selective GABA receptor modulator with anticonvulsant, anxiolytic, and anti-nociceptive properties but…”
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Further evaluation of the potential anxiolytic activity of imidazo[1,5-a][1,4]diazepin agents selective for α2/3-containing GABAA receptors by Witkin, J.M., Cerne, R., Wakulchik, M., S., J., Gleason, S.D., Jones, T.M., Li, G., Arnold, L.A., Li, J.-X., Schkeryantz, J.M., Methuku, K.R., Cook, J.M., Poe, M.M.

“…Positive allosteric modulators of GABAA receptors transduce a host of beneficial effects including anxiolytic actions. We have recently shown that…”
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An antidepressant-related pharmacological signature for positive allosteric modulators of α2/3-containing GABA A receptors by Methuku, K R, Li, X, Cerne, R, Gleason, S D, Schkeryantz, J M, Tiruveedhula, V V N P B, Golani, L K, Li, G, Poe, M M, Rahman, Md T, Cook, J M, Fisher, J L, Witkin, J M

“…Data from transgenic animals and novel pharmacological agents has realigned scientific scrutiny on the therapeutic potential of positive allosteric modulators…”
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Obituary: J. David Leander, Ph.D: April 8, 1944–November 14, 2014 by Witkin, J. M., Gleason, S. D., Carter, R. B., Dykstra, L. A.

“…John David Leander, a pioneering behavioral pharmacologist, who dedicated his extraordinary wisdom and curiosity to the search for new drugs to treat…”
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Effects of dopamine D1 receptor full agonists in rats trained to discriminate SKF 38393 by Gleason, S. D, Witkin, J. M

“…Although the dopaminergic pharmacology of the D1 receptor full agonists, dinapsoline, dihydrexidine and the prodrug ABT-431 have been studied, no information…”
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The α2,3-selective potentiator of GABAA receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats by Witkin, J.M., Cerne, R., Davis, P.G., Freeman, K.B., do Carmo, J.M., Rowlett, J.K., Methuku, K.R., Okun, A., Gleason, S.D., Li, X., Krambis, M.J., Poe, M., Li, G., Schkeryantz, J.M., Jahan, R., Yang, L., Guo, W., Golani, L.K., Anderson, W.H., Catlow, J.T., Jones, T.M., Porreca, F., Smith, J.L., Knopp, K.L., Cook, J.M.

“…Clinical evidence indicates that positive allosteric modulators (PAMs) of GABAA receptors have analgesic benefit in addition to efficacy in anxiety disorders…”
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mGlu2/3 agonist-induced hyperthermia: an in vivo assay for detection of mGlu2/3 receptor antagonism and its relation to antidepressant-like efficacy in mice by Gleason, S D, Li, X, Smith, I A, Ephlin, J D, Wang, X-S, Heinz, B A, Carter, J H, Baez, M, Yu, J, Bender, D M, Witkin, J M

“…An assay to detect the on-target effects of mGlu2/3 receptor antagonists in vivo would be valuable in guiding dosing regimens for the exploration of biological…”
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Meta-chlorophenylpiperazine induced changes in locomotor activity are mediated by 5-HT1 as well as 5-HT2C receptors in mice by GLEASON, S. D, SHANNON, H. E

“…1-(Meta-chloro)phenylpiperazine (m-CPP) is a 5-HT receptor agonist which has been purported to be relatively selective for the 5-HT2C receptor. In particular,…”
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Behavioral pharmacology of olanzapine: A novel antipsychotic drug by MOORE, N. A, LEANDER, J. D, BENVENGA, M. J, GLEASON, S. D, SHANNON, H

“…In this paper, we review the behavioral pharmacology of olanzapine and compare it to its in vitro profile and to clozapine and a number of other antipsychotic…”
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Influence of light cycle on response to 5-HT1A ligands in punished responding in rats by Gleason, S D, Leander, J D

“…Since the introduction of buspirone, the 5-HT1A receptor has been a focal point for serotonergic research into the treatment of anxiety. Two of the more…”
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Renal and endocrine response to water deprivation in dog by Zucker, A, Gleason, S D, Schneider, E G

“…Plasma and urine sodium, potassium, osmolality, aldosterone, and plasma renin activity (PRA) were measured in time controls and during control dehydration and…”
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Nutrient, waste management, and hygiene systems for chemical protective suits by Cardello, A V, Darsch, G, Fitzgerald, C, Gleason, S D, Teixeira, R

“…Current United States military chemical protective ensembles do not provide for feeding, removing body wastes, or ensuring the hygiene of troops operating in a…”
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Lack of evidence for gastrointestinal control of sodium excretion in unanesthetized rabbits by Obika, L F, Fitzgerald, E M, Gleason, S D, Zucker, A, Schneider, E G

“…Experiments were performed to determine whether unanesthetized rabbits exhibit a greater natriuresis after oral administration of a hypertonic sodium chloride…”
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An antidepressant-related pharmacological signature for positive allosteric modulators of α2/3-containing GABAA receptors by Methuku, K.R., Li, X., Cerne, R., Gleason, S.D., Schkeryantz, J.M., Tiruveedhula, V.V.N.P.B., Golani, L.K., Li, G., Poe, M.M., Rahman, Md.T., Cook, J.M., Fisher, J.L., Witkin, J.M.

“…Data from transgenic animals and novel pharmacological agents has realigned scientific scrutiny on the therapeutic potential of positive allosteric modulators…”
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A novel, a‐2, 3‐selective GABA A receptor modulator with improved central penetrability and associated antiepileptic and anti‐pain efficacy by Witkin, Jeffrey M, Methuku, K R, Schkeryantz, J M, Gleason, S D, Okun, A, Porreca, F, Cramer, J W, Jones, T M, Catlow, J T, Li, X, Poe, M M, Li, G, Arnold, A, Cook, J M

“…Abstract only Background Positiveallosteric modulators of GABA A receptors transduce a host ofbeneficial effects but can have motor and sedative liabilities. A…”
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