Search Results - "GLAVINAS, Hristos"

Investigations of the mechanism behind the rapid absorption of nano-amorphous abiraterone acetate by Basa-Dénes, Orsolya, Solymosi, Tamás, Ötvös, Zsolt, Angi, Réka, Ujhelyi, Andrea, Jordán, Tamás, Heltovics, Gábor, Glavinas, Hristos

“…Abiraterone acetate is indicated for patients with metastatic castration resistant prostate cancer. The marketed drug product (Zytiga®) exhibits very low…”
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The role of ABC transporters in drug resistance, metabolism and toxicity by Glavinas, Hristos, Krajcsi, Péter, Cserepes, Judit, Sarkadi, Balázs

“…ATP Binding Cassette (ABC) transporters form a special family of membrane proteins, characterized by homologous ATP-binding, and large, multispanning…”
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Dose Finding and Food Effect Studies of a Novel Abiraterone Acetate Formulation for Oral Suspension in Comparison to a Reference Formulation in Healthy Male Subjects by Jordán, Tamás, Basa-Dénes, Orsolya, Angi, Réka, Orosz, János, Ötvös, Zsolt, Ujhelyi, Andrea, Filipcsei, Genovéva, Molnár, László, Solymosi, Tamás, Glavinas, Hristos, Capone, Dominic, Whitfield, Nicola, McDermott, John, McKenzie, Litza, Shurety, Lauren, Duus, Elizabeth Manning

“…Currently approved formulations of the androgen synthesis inhibitor abiraterone acetate (AA) consist of multiple tablets administered daily in a fasted state…”
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Utilization of membrane vesicle preparations to study drug-ABC transporter interactions by Glavinas, Hristos, Méhn, Dóra, Jani, Márton, Oosterhuis, Berend, Herédi-Szabó, Krisztina, Krajcsi, Péter

“…The last 15 years have marked an expansion in our understanding of how ABC transporters modulate the pharmacokinetic properties of drugs. Assays based on…”
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Kinetic Characterization of Sulfasalazine Transport by Human ATP-Binding Cassette G2 by Jani, Márton, Szabó, Pál, Kis, Emese, Molnár, Éva, Glavinas, Hristos, Krajcsi, Péter

“…The pharmacokinetics of sulfasalazine, an anti-inflammatory drug is influenced by ATP-binding cassette G2 (ABCG2) (breast cancer resistance protein (BCRP),…”
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Modulation of sinusoidal and canalicular elimination of bilirubin-glucuronides by rifampicin and other cholestatic drugs in a sandwich culture of rat hepatocytes by Lengyel, György, Veres, Zsuzsa, Tugyi, Regina, Vereczkey, László, Molnár, Tünde, Glavinas, Hristos, Krajcsi, Péter, Jemnitz, Katalin

“…Aim:  Drug‐induced hyperbilirubinemia has been shown to often be derived from modulation of the expression and activity of hepatobiliary transporters. In this…”
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Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization by Cserepes, Judit, Szentpétery, Zsófia, Seres, László, Özvegy-Laczka, Csilla, Langmann, Thomas, Schmitz, Gerd, Glavinas, Hristos, Klein, Izabella, Homolya, László, Váradi, András, Sarkadi, Balázs, Elkind, N.Barry

“…The closely related human ABC half-transporters, ABCG1 and ABCG4, have been suggested to play an important role in cellular lipid/sterol regulation but no…”
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ABCG2 (Breast Cancer Resistance Protein/Mitoxantrone Resistance-Associated Protein) ATPase Assay: A Useful Tool to Detect Drug-Transporter Interactions by GLAVINAS, Hristos, KIS, Emese, BATHORI, György, VON RICHTER, Oliver, KOOMEN, Gerrit-Jan, KRAJCSI, Péter, PAL, Akos, KOVACS, Rita, JANI, Marton, VAGI, Erika, MOLNAR, Eva, BANSAGHI, Szava, KELE, Zoltan, JANAKY, Tamas

“…The ATPase assay using membrane preparations from recombinant baculovirus-infected Spodoptera frugiperda ovarian (Sf9) cells is widely used to detect the…”
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Development of an abiraterone acetate formulation with improved oral bioavailability guided by absorption modeling based on in vitro dissolution and permeability measurements by Solymosi, Tamás, Ötvös, Zsolt, Angi, Réka, Ordasi, Betti, Jordán, Tamás, Semsey, Sándor, Molnár, László, Ránky, Soma, Filipcsei, Genovéva, Heltovics, Gábor, Glavinas, Hristos

“…[Display omitted] Particle size reduction of drug crystals in the presence of surfactants (often called “top-down” production methods) is a standard approach…”
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Novel formulation of abiraterone acetate might allow significant dose reduction and eliminates substantial positive food effect by Solymosi, Tamás, Ötvös, Zsolt, Angi, Réka, Ordasi, Betti, Jordán, Tamás, Molnár, László, McDermott, John, Zann, Vanessa, Church, Ann, Mair, Stuart, Filipcsei, Genovéva, Heltovics, Gábor, Glavinas, Hristos

“…Purpose Zytiga (abiraterone acetate, AA) is known to exhibit very low bioavailability and a significant positive food effect in men. The unfavorable…”
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Novel formulation of abiraterone acetate with significantly higher bioavailability and eliminated food effect might allow higher abiraterone exposure and better patient outcome by Glavinas, Hristos, Solymosi, Tamás, Otvos, Zsolt, Angi, Réka, Ordasi, Betti, Jordán, Tamás, Molnár, László, McDermott, John, Zann, Vanessa, Church, Ann, Mair, Stuart, Filipcsei, Genoveva, Heltovics, Gabor

“…Abstract only…”
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Novel oral nano-amorphous sirolimus formulation to exhibit comparable exposure to intravenously administered temsirolimus: An oral alternative to the treatment of mTOR-responsive malignancies by Glavinas, Hristos, Basa-Dénes, Orsolya, Angi, Réka, Kárpáti, Balázs, Jordán, Tamás, Solymosi, Tamás, McDermott, John, Roe, Chris, McKenzie, Litza, Heltovics, Gabor

“…Abstract only…”
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Solubility Measurements at 296 and 310 K and Physicochemical Characterization of Abiraterone and Abiraterone Acetate by Solymosi, Tamás, Tóth, Ferenc, Orosz, János, Basa-Dénes, Orsolya, Angi, Réka, Jordán, Tamás, Ötvös, Zsolt, Glavinas, Hristos

“…Comparative solubility tests at 296 ± 1 K and 310 ± 1 K in 11 solvents, PAMPA permeability measurements at 296 ± 1 K and 310 ± 1 K in water, FaSSIF-V2 and…”
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Novel continuous flow technology for the development of a nanostructured Aprepitant formulation with improved pharmacokinetic properties by Angi, Réka, Solymosi, Tamás, Ötvös, Zsolt, Ordasi, Betti, Glavinas, Hristos, Filipcsei, Genovéva, Heltovics, Gábor, Darvas, Ferenc

“…[Display omitted] The oral bioavailability of Aprepitant is limited by poor dissolution of the compound in the gastrointestinal tract which is more prominent…”
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Sirolimus formulation with improved pharmacokinetic properties produced by a continuous flow method by Solymosi, Tamás, Angi, Réka, Basa-Dénes, Orsolya, Ránky, Soma, Ötvös, Zsolt, Glavinas, Hristos, Filipcsei, Genovéva, Heltovics, Gábor

“…Blood Sirolimus concentrations (±S.E.M.) following the oral administration of Rapamune® or the nanostructured Sirolimus formula was prepared by continuous flow…”
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Preparation, Pre-clinical and Clinical Evaluation of a Novel Rapidly Absorbed Celecoxib Formulation by Angi, Réka, Solymosi, Tamás, Erdősi, Nikoletta, Jordán, Tamás, Kárpáti, Balázs, Basa-Dénes, Orsolya, Ujhelyi, Andrea, McDermott, John, Roe, Chris, Mair, Stuart, Ötvös, Zsolt, Molnár, László, Glavinas, Hristos

“…Celecoxib (Celebrex®) is the only widely used NSAID that selectively inhibits the COX-2 isoenzyme. Celebrex® is absorbed slowly in the fasted state and food…”
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Interaction of ivermectin with multidrug resistance proteins (MRP1, 2 and 3) by Lespine, Anne, Dupuy, Jacques, Orlowski, Stéphane, Nagy, Tünde, Glavinas, Hristos, Krajcsi, Peter, Alvinerie, Michel

“…Ivermectin is a potent antiparasitic drug from macrocyclic lactone (ML) family, which interacts with the ABC multidrug transporter P-glycoprotein (Pgp). We…”
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Dose Escalation Study to Assess the Pharmacokinetic Parameters of a Nano-amorphous Oral Sirolimus Formulation in Healthy Volunteers by Basa-Dénes, Orsolya, Angi, Réka, Kárpáti, Balázs, Jordán, Tamás, Ötvös, Zsolt, Erdősi, Nikoletta, Ujhelyi, Andrea, Ordasi, Betti, Molnár, László, McDermott, John, Roe, Chris, McKenzie, Litza, Solymosi, Tamás, Heltovics, Gábor, Glavinas, Hristos

“…Background and Objectives Sirolimus (Rapamune ® ) exhibits low bioavailability, high variability and moderate food effect following oral administration. This…”
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A novel screening strategy to identify ABCB1 substrates and inhibitors by von Richter, Oliver, Glavinas, Hristos, Krajcsi, Peter, Liehner, Stephanie, Siewert, Beate, Zech, Karl

“…We tested the hypothesis whether data on ABCB1 ATPase activity and passive permeability can be used in combination to identify ABCB1 substrates and inhibitors…”
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The role of lipopolysaccharide moieties in macrophage response to Escherichia coli by Eder, Katalin, Vizler, Csaba, Kusz, Erzsebet, Karcagi, Ildiko, Glavinas, Hristos, Balogh, Gabor E., Vigh, Laszlo, Duda, Erno, Gyorfy, Zsuzsanna

“…Lipopolysaccharide (LPS) is the main component of Gram-negative bacteria that – upon infection – activates the host immune system and is crucial in fighting…”
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