Search Results - "GLANT, T. T."

Genetics of Rheumatoid Arthritis — A Comprehensive Review by Kurkó, Júlia, Besenyei, Timea, Laki, Judit, Glant, Tibor T., Mikecz, Katalin, Szekanecz, Zoltán

“…The “Bermuda triangle” of genetics, environment and autoimmunity is involved in the pathogenesis of rheumatoid arthritis (RA). Various aspects of genetic…”
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Enigma of IL-17 and Th17 Cells in Rheumatoid Arthritis and in Autoimmune Animal Models of Arthritis by Boldizsar, F., Rauch, Tibor A., Mikecz, K., Olasz, Katalin, Kohl, Zoltan, Kugyelka, Reka, Glant, T. T.

“…The present scientific contribution is dedicated to the 650th anniversary of the foundation of the University of Pécs, Hungary…”
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Animals lacking link protein have attenuated perineuronal nets and persistent plasticity by Carulli, Daniela, Pizzorusso, Tommaso, Kwok, Jessica C. F., Putignano, Elena, Poli, Andrea, Forostyak, Serhiy, Andrews, Melissa R., Deepa, Sathyaseelan S., Glant, Tibor T., Fawcett, James W.

“…Chondroitin sulphate proteoglycans in the extracellular matrix restrict plasticity in the adult central nervous system and their digestion with chondroitinase…”
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Regulation of autoimmune arthritis by the SHP-1 tyrosine phosphatase by Markovics, Adrienn, Toth, Daniel M, Glant, Tibor T, Mikecz, Katalin

“…The Src homology region 2 domain-containing phosphatase-1 (SHP-1) is known to exert negative regulatory effects on immune cell signaling. Mice with mutations…”
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Epigenetics in the pathogenesis of rheumatoid arthritis by Glant, Tibor T, Mikecz, Katalin, Rauch, Tibor A

“…An increasing number of studies show that besides the inherited genetic architecture (that is, genomic DNA), various environmental factors significantly…”
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Suppression of proteoglycan-induced autoimmune arthritis by myeloid-derived suppressor cells generated in vitro from murine bone marrow by Kurkó, Júlia, Vida, András, Ocskó, Tímea, Tryniszewska, Beata, Rauch, Tibor A, Glant, Tibor T, Szekanecz, Zoltán, Mikecz, Katalin

“…Myeloid-derived suppressor cells (MDSCs) are innate immune cells capable of suppressing T-cell responses. We previously reported the presence of MDSCs with a…”
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IL-27 Induces a Th1 Immune Response and Susceptibility to Experimental Arthritis by Cao, Yanxia, Doodes, Paul D, Glant, Tibor T, Finnegan, Alison

“…IL-27 is the newest member of the cytokine family comprised of IL-12 and IL-23. IL-27 was originally described as a cytokine that along with IL-12 induces the…”
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Impaired cumulus mucification and female sterility in tumor necrosis factor-induced protein-6 deficient mice by Fülöp, Csaba, Szántó, Sándor, Mukhopadhyay, Durba, Bárdos, Tamás, Kamath, Rajesh V., Rugg, Marylin S., Day, Anthony J., Salustri, Antonietta, Hascall, Vincent C., Glant, Tibor T., Mikecz, Katalin

“…Mucification of the cumulus layer around the oocyte is an obligatory process for female fertility. Tumor necrosis factor-induced protein-6 (TNFIP6 or TSG6) has…”
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The Effects of Particulate Wear Debris, Cytokines, and Growth Factors on the Functions of MG-63 Osteoblasts by Vermes, Csaba, Chandrasekaran, Raman, Jacobs, Joshua J, Galante, Jorge O, Roebuck, Kenneth A, Glant, Tibor T

“…BackgroundParticle-challenged cells release cytokines, chemokines, and eicosanoids, which contribute to periprosthetic osteolysis. The particle-induced…”
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Immune Recognition of Citrullinated Proteoglycan Aggrecan Epitopes in Mice with Proteoglycan-Induced Arthritis and in Patients with Rheumatoid Arthritis by Markovics, Adrienn, Ocskó, Tímea, Katz, Robert S, Buzás, Edit I, Glant, Tibor T, Mikecz, Katalin

“…Rheumatoid arthritis (RA) is an autoimmune inflammatory disease affecting the joints. Anti-citrullinated protein antibodies (ACPA) are frequently found in RA…”
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Osteolysis: basic science by Jacobs, J J, Roebuck, K A, Archibeck, M, Hallab, N J, Glant, T T

“…Since the recognition of aseptic loosening by Charnley in the early 1960s, much information has been gained on the basic science of periprosthetic bone loss…”
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Antigen-Specific B Cells Are Required as APCs and Autoantibody-Producing Cells for Induction of Severe Autoimmune Arthritis by O'Neill, Shannon K, Shlomchik, Mark J, Glant, Tibor T, Cao, Yanxia, Doodes, Paul D, Finnegan, Alison

“…B cells play an important role in rheumatoid arthritis, but whether they are required as autoantibody-producing cells as well as APCs has not been determined…”
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Characterization and Localization of Citrullinated Proteoglycan Aggrecan in Human Articular Cartilage by Glant, Tibor T, Ocsko, Timea, Markovics, Adrienn, Szekanecz, Zoltan, Katz, Robert S, Rauch, Tibor A, Mikecz, Katalin

“…Rheumatoid arthritis (RA) is an autoimmune disease of the synovial joints. The autoimmune character of RA is underscored by prominent production of…”
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Activation of nucleotide oligomerization domain 2 exacerbates a murine model of proteoglycan-induced arthritis by Rosenzweig, H. L., Jann, M. M., Glant, T. T., Martin, T. M., Planck, S. R., Eden, W., Kooten, P. J. S., Flavell, R. A., Kobayashi, K. S., Rosenbaum, J. T., Davey, M. P.

“…In addition to its role in innate immunity, nucleotide oligomerization domain 2 (NOD2) has been shown to play a suppressive role in models of colitis. Notably,…”
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Location of CD4+ T cell priming regulates the differentiation of Th1 and Th17 cells and their contribution to arthritis by Rodeghero, Rachel, Cao, Yanxia, Olalekan, Susan A, Iwakua, Yoichiro, Glant, Tibor T, Finnegan, Alison

“…Th cytokines IFN-γ and IL-17 are linked to the development of autoimmune disease. In models of rheumatoid arthritis, that is, proteoglycan (PG)-induced…”
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IL-10 is critically involved in mycobacterial HSP70 induced suppression of proteoglycan-induced arthritis by Wieten, Lotte, Berlo, Suzanne E, Ten Brink, Corlinda B, van Kooten, Peter J, Singh, Mahavir, van der Zee, Ruurd, Glant, Tibor T, Broere, Femke, van Eden, Willem

“…The anti-inflammatory capacity of heat shock proteins (HSP) has been demonstrated in various animal models of inflammatory diseases and in patients. However,…”
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Alteration in the Gene Encoding Protein Tyrosine Phosphatase Nonreceptor Type 6 ( PTPN6/SHP1 ) May Contribute to Neutrophilic Dermatoses by Nesterovitch, Andrew B, Gyorfy, Zsuzsa, Hoffman, Mark D, Moore, Ellen C, Elbuluk, Nada, Tryniszewska, Beata, Rauch, Tibor A, Simon, Melinda, Kang, Sewon, Fisher, Gary J, Mikecz, Katalin, Tharp, Michael D, Glant, Tibor T

“…We have found a B2 repeat insertion in the gene encoding protein tyrosine phosphatase nonreceptor type 6 (PTPN6) in a mouse that developed a skin disorder with…”
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Early anti-inflammatory intervention ameliorates axial disease in the proteoglycan-induced spondylitis mouse model of ankylosing spondylitis by Tseng, Hsu-Wen, Glant, Tibor T, Brown, Matthew A, Kenna, Tony J, Thomas, Gethin P, Pettit, Allison R

“…Ankylosing spondylitis (AS) is characterised by immune-mediated arthritis and osteoproliferation, ultimately leading to joint ankylosis. Whether inflammation…”
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CD44-specific antibody treatment and CD44 deficiency exert distinct effects on leukocyte recruitment in experimental arthritis by Hutás, Gábor, Bajnok, Éva, Gál, István, Finnegan, Alison, Glant, Tibor T., Mikecz, Katalin

“…CD44, the leukocyte adhesion receptor for hyaluronan, has been considered a therapeutic target on the basis of the robust anti-inflammatory effect of…”
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Vaccination by Two DerG LEAPS Conjugates Incorporating Distinct Proteoglycan (PG, Aggrecan) Epitopes Provides Therapy by Different Immune Mechanisms in a Mouse Model of Rheumatoid Arthritis by Zimmerman, Daniel H., Mikecz, Katalin, Markovics, Adrienn, Carambula, Roy E., Ciemielewski, Jason C., Toth, Daniel M., Glant, Tibor T., Rosenthal, Ken S.

“…Rheumatoid arthritis (RA) can be initiated and driven by immune responses to multiple antigenic epitopes including those in cartilage proteoglycan (PG,…”
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