Search Results - "GKIRTZIMANAKI, Katerina"

IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion by Gkirtzimanaki, Katerina, Kabrani, Eleni, Nikoleri, Dimitra, Polyzos, Alexander, Blanas, Athanasios, Sidiropoulos, Prodromos, Makrigiannakis, Antonis, Bertsias, George, Boumpas, Dimitrios T., Verginis, Panayotis

“…Interferon α (IFNα) is a prompt and efficient orchestrator of host defense against nucleic acids but upon chronicity becomes a potent mediator of autoimmunity…”
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Tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage by Goulielmaki, Evi, Ioannidou, Anna, Tsekrekou, Maria, Stratigi, Kalliopi, Poutakidou, Ioanna K., Gkirtzimanaki, Katerina, Aivaliotis, Michalis, Evangelou, Konstantinos, Topalis, Pantelis, Altmüller, Janine, Gorgoulis, Vassilis G., Chatzinikolaou, Georgia, Garinis, George A.

“…DNA damage and metabolic disorders are intimately linked with premature disease onset but the underlying mechanisms remain poorly understood. Here, we show…”
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NETs decorated with bioactive IL-33 infiltrate inflamed tissues and induce IFN-α production in patients with SLE by Georgakis, Spiros, Gkirtzimanaki, Katerina, Papadaki, Garyfalia, Gakiopoulou, Hariklia, Drakos, Elias, Eloranta, Maija-Leena, Makridakis, Manousos, Kontostathi, Georgia, Zoidakis, Jerome, Baira, Eirini, Rönnblom, Lars, Boumpas, Dimitrios T, Sidiropoulos, Prodromos, Verginis, Panayotis, Bertsias, George

“…IL-33, a nuclear alarmin released during cell death, exerts context-specific effects on adaptive and innate immune cells, eliciting potent inflammatory…”
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Suppression of Integrin α3β1 in Breast Cancer Cells Reduces Cyclooxygenase-2 Gene Expression and Inhibits Tumorigenesis, Invasion, and Cross-Talk to Endothelial Cells by MITCHELL, Kara, SVENSON, Kimberly B, LONGMATE, Whitney M, GKIRTZIMANAKI, Katerina, SADEJ, Rafal, XIANHUI WANG, JIHE ZHAO, ELIOPOULOS, Aristides G, BERDITCHEVSKI, Fedor, MICHAEL DIPERSIO, C

“…Integrin receptors for cell adhesion to extracellular matrix have important roles in promoting tumor growth and progression. Integrin α3β1 is highly expressed…”
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TPL2 kinase is a suppressor of lung carcinogenesis by Gkirtzimanaki, Katerina, Gkouskou, Kalliopi K, Oleksiewicz, Urszula, Nikolaidis, Georgios, Vyrla, Dimitra, Liontos, Michalis, Pelekanou, Vassiliki, Kanellis, Dimitris C, Evangelou, Kostantinos, Stathopoulos, Efstathios N, Field, John K, Tsichlis, Philip N, Gorgoulis, Vassilis, Liloglou, Triantafillos, Eliopoulos, Aristides G

“…Lung cancer is a heterogeneous disease at both clinical and molecular levels, posing conceptual and practical bottlenecks in defining key pathways affecting…”
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CD151 Regulates Tumorigenesis by Modulating the Communication between Tumor Cells and Endothelium by Sadej, Rafal, Romanska, Hanna, Baldwin, Gouri, Gkirtzimanaki, Katerina, Novitskaya, Vera, Filer, Andrew D, Krcova, Zuzana, Kusinska, Renata, Ehrmann, Jiri, Buckley, Christopher D, Kordek, Radzislaw, Potemski, Piotr, Eliopoulos, Aristides G, Lalani, El-Nasir, Berditchevski, Fedor

“…The tetraspanin CD151 forms stoichiometric complexes with laminin-binding integrins (e.g., α3β1, α6β1, and α6β4) and regulates their ligand-binding and…”
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Microglia-derived extracellular vesicles trigger age-related neurodegeneration upon DNA damage by Arvanitaki, Ermioni S, Goulielmaki, Evi, Gkirtzimanaki, Katerina, Niotis, George, Tsakani, Edisona, Nenedaki, Electra, Rouska, Iliana, Kefalogianni, Mary, Xydias, Dionysios, Kalafatakis, Ilias, Psilodimitrakopoulos, Sotiris, Karagogeos, Domna, Schumacher, Björn, Stratakis, Emmanuel, Garinis, George A

“…DNA damage and neurodegenerative disorders are intimately linked but the underlying mechanism remains elusive. Here, we show that persistent DNA lesions in…”
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R-loops trigger the release of cytoplasmic ssDNAs leading to chronic inflammation upon DNA damage by Chatzidoukaki, Ourania, Stratigi, Kalliopi, Goulielmaki, Evi, Niotis, George, Akalestou-Clocher, Alexia, Gkirtzimanaki, Katerina, Zafeiropoulos, Alexandros, Altmüller, Janine, Topalis, Pantelis, Garinis, George A

“…How DNA damage leads to chronic inflammation and tissue degeneration with aging remains to be fully resolved. Here, we show that DNA damage leads to cellular…”
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Enhanced therapeutic anti-tumor immunity induced by co-administration of 5-fluorouracil and adenovirus expressing CD40 ligand by Liljenfeldt, Lina, Gkirtzimanaki, Katerina, Vyrla, Dimitra, Svensson, Emma, Loskog, Angelica SI, Eliopoulos, Aristides G.

“…Bystander immune activation by chemotherapy has recently gained extensive interest and provided support for the clinical use of chemotherapeutic agents in…”
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TPL2 kinase is a suppressor of lung carcinogenesis by Gkirtzimanaki, Katerina, Gkouskou, Kalliopi K., Oleksiewicz, Urszula, Nikolaidis, Georgios, Vyrla, Dimitra, Liontos, Michalis, Pelekanou, Vassiliki, Kanellis, Dimitris C., Evangelou, Kostantinos, Stathopoulos, Efstathios N., Field, John K., Tsichlis, Philip N., Gorgoulis, Vassilis, Liloglou, Triantafillos, Eliopoulos, Aristides G.

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Suppression of integrin α3β1 in breast cancer cells reduces COX-2 gene expression and inhibits tumorigenesis, invasion, and crosstalk to endothelial cells by Mitchell, Kara, Svenson, Kimberly B., Longmate, Whitney M., Gkirtzimanaki, Katerina, Sadej, Rafal, Wang, Xianhui, Zhao, Jihe, Eliopoulos, Aristides G., Berditchevski, Fedor, DiPersio, C. Michael

“…Integrin receptors for cell adhesion to extracellular matrix have important roles in promoting tumor growth and progression. Integrin α3β1 is highly expressed…”
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Suppression of integrin alpha3beta1 in breast cancer cells reduces cyclooxygenase-2 gene expression and inhibits tumorigenesis, invasion, and cross-talk to endothelial cells by Mitchell, Kara, Svenson, Kimberly B, Longmate, Whitney M, Gkirtzimanaki, Katerina, Sadej, Rafal, Wang, Xianhui, Zhao, Jihe, Eliopoulos, Aristides G, Berditchevski, Fedor, Dipersio, C Michael

“…Integrin receptors for cell adhesion to extracellular matrix have important roles in promoting tumor growth and progression. Integrin alpha3beta1 is highly…”
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