Search Results - "GIVEN, B. D"

Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects by POLONSKY, K. S, GIVEN, B. D, VAN CAUTER, E

“…The pattern of endogenous insulin secretion over a 24-h period, which included three mixed meals, was evaluated in 14 normal volunteers and 15 obese subjects…”
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Quantitative study of insulin secretion and clearance in normal and obese subjects by POLONSKY, K. S, GIVEN, B. D, HIRSCH, L, SHAPIRO, E. T, TILLIL, H, BEEBE, C, GALLOWAY, J. A, FRANK, B. H, KARRISON, T, VAN CAUTER, E

“…The secretion and hepatic extraction of insulin were compared in 14 normal volunteers and 15 obese subjects using a previously validated mathematical model of…”
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Use of biosynthetic human-C peptide in the measurement of insulin secretion rates in normal volunteers and type I diabetic patients by POLONSKY, K. S, LICINIO-PAIXAO, J, GIVEN, B. D, PUGH, W, RUE, P, GALLOWAY, J, KARRISON, T, FRANK, B

“…We undertook this study to examine the accuracy of plasma C-peptide as a marker of insulin secretion. The peripheral kinetics of biosynthetic human C-peptide…”
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Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus by Polonsky, K S, Given, B D, Hirsch, L J, Tillil, H, Shapiro, E T, Beebe, C, Frank, B H, Galloway, J A, Van Cauter, E

“…To determine whether non-insulin-dependent diabetes is associated with specific alterations in the pattern of insulin secretion, we studied 16 patients with…”
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Diabetes due to secretion of a structurally abnormal insulin (insulin Wakayama): clinical and functional characteristics of [LeuA3] insulin by NANJO, K, SANKE, T, CHAN, S. J, TAGER, H. S, STEINER, D. F, RUBENSTEIN, A. H, MIYANO, M, OKAI, K, SOWA, R, KONDO, M, NISHIMURA, S, IWO, K, MIYAMURA, K, GIVEN, B. D

“…We have identified a non-insulin-dependent diabetic patient with fasting hyperinsulinemia (90 microU/ml), an elevated insulin:C-peptide molar ratio (1.68;…”
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Biochemical and clinical implications of proinsulin conversion intermediates by GIVEN, B. D, COHEN, R. M, SHOELSON, S. E, FRANK, B. H, RUBENSTEIN, A. H, TAGER, H. S

“…Since a complete map of insulin-related peptides in humans requires consideration of proinsulin, Arg32/Glu33-split proinsulin, Arg65/Gly66-split proinsulin,…”
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Hypoglycemia due to surreptitious injection of insulin. Identification of insulin species by high-performance liquid chromatography by B D Given, D M Ostrega, K S Polonsky, D Baldwin, Jr, R I Kelley, A H Rubenstein

“…Hypoglycemia due to surreptitious injection of insulin. Identification of insulin species by high-performance liquid chromatography. B D Given , D M Ostrega ,…”
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Ingestion of a mixed meal does not affect the metabolic clearance rate of biosynthetic human C-peptide by Licinio-Paixao, J, Polonsky, K S, Given, B D, Pugh, W, Ostrega, D, Frank, B F, Rubenstein, A H

“…The validity of C-peptide as a peripheral marker of insulin secretion during different physiological conditions depends on the demonstration that C-peptide…”
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Glyburide enhances the responsiveness of the beta-cell to glucose but does not correct the abnormal patterns of insulin secretion in noninsulin-dependent diabetes mellitus by Shapiro, E T, Van Cauter, E, Tillil, H, Given, B D, Hirsch, L, Beebe, C, Rubenstein, A H, Polonsky, K S

“…Eleven patients with noninsulin-dependent diabetes mellitus were studied before and after 6-10 weeks of glyburide therapy. Patients were studied during a 24-h…”
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Reevaluation of urine C-peptide as measure of insulin secretion by TILLIL, H, SHAPIRO, E. T, GIVEN, B. D, RUE, P, RUBENSTEIN, A. H, GALLOWAY, J. A, POLONSKY, K. S

“…Urine C-peptide (UCP) has been proposed as a measure of insulin secretion, because insulin and C-peptide are consecreted in equimolar concentrations by the…”
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Insulin Wakayama: familial mutant insulin syndrome in Japan by NANJO, K, MIYANO, M, TAGER, H. S, STEINER, D. F, RUBENSTEIN, A. H, KONDO, M, SANKE, T, NISHIMURA, S, MIYAMURA, K, INOUYE, K, GIVEN, B. D, CHAN, S. J, POLONSKY, K. S

“…We describe a family from Japan displaying the mutant insulin syndrome with hyperinsulinaemia and an increased insulin: C-peptide molar ratio. Serum insulin…”
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Calculation of the systemic delivery rate of insulin in normal man by Polonsky, K S, Given, B D, Pugh, W, Licinio-Paixao, J, Thompson, J E, Karrison, T, Rubenstein, A H

“…The accuracy with which the systemic delivery rate of insulin can be estimated from peripheral insulin concentrations was investigated in eight normal men…”
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Change in hexose distribution volume and fractional utilization of [18F]-2-deoxy-2-fluoro-D-glucose in brain during acute hypoglycemia in humans by Shapiro, E. T., Cooper, M., Chen, C. T., Given, B. D., Polonsky, K. S.

“…Change in hexose distribution volume and fractional utilization of [18F]-2-deoxy-2-fluoro-D-glucose in brain during acute hypoglycemia in humans. E T Shapiro ,…”
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Reevaluation of urine C-peptide as measure of insulin secretion by Tillil, H., Shapiro, E. T., Given, B. D., Rue, P., Rubenstein, A. H., Galloway, J. A., Polonsky, K. S.

“…Reevaluation of urine C-peptide as measure of insulin secretion. H Tillil , E T Shapiro , B D Given , P Rue , A H Rubenstein , J A Galloway and K S Polonsky…”
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Pharmacokinetics and pharmacodynamics of dilevalol by Tenero, D M, Bottorff, M B, Given, B D, Kramer, W G, Affrime, M B, Patrick, J E, Lalonde, R L

“…The pharmacokinetics and pharmacodynamics of dilevalol, the R,R stereoisomer of labetalol, were evaluated in nine subjects. Dilevalol was given as a single 50…”
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Duration of action and short-term hormonal responses to enalapril (MK 421) in normal subjects by Given, B D, Taylor, T, Hollenberg, N K, Williams, G H

“…Enalapril is a converting enzyme inhibitor with a prolonged duration of action. We investigated the arterial pressure and hormonal responses to angiotensin I…”
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Insulin Resistance due to a Defect Distal to the Insulin Receptor: Demonstration in a Patient with Leprechaunism by Kobayashi, Masashi, Olefsky, Jerrold M., Elders, Joycelyn, Mako, Mary E., Given, Bruce D., Schedwie, Heinrich K., Fiser, Robert H., Hintz, Raymond L., Horner, James A., Rubenstein, Arthur H.

“…We have studied a 2-year-old girl with acanthosis nigricans, glucose intolerance, marked hyperinsulinemia, and somatic features characteristic of the…”
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Procainamide cardioversion of fetal supraventricular tachyarrhythmia by Given, Bruce D., Phillippe, Mark, Sanders, Stephen P., Dzau, Victor J.

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Severe hypoglycemia attributable to surreptitious injection of insulin in a mare by Given, B D, Mostrom, M S, Tully, R, Ditkowsky, N, Rubenstein, A H

“…A mare with signs of hypoglycemia had high serum insulin concentrations before it was euthanatized. High pressure liquid chromatography revealed that the…”
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Prostaglandin E2 analogue elicits renal and hormonal compensatory mechanisms in human hypertension by Given, B D, Vita, N A, Black, H R, Francis, C, Lasseter, K, Morray, R L, Mickiewicz, C, Akester, J, Koury, K, Dzau, V J

“…Endogenous prostaglandin E2 appears to play an important role in cardiovascular homeostasis. When administered exogenously, it is a potent vasodilator, but the…”
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