Search Results - "GIROTTI, A. W"

Photodynamic lipid peroxidation in biological systems by Girotti, A W

“…Oxidative degradation of cell membrane lipids in the presence of molecular oxygen, a sensitizing agent and exciting light is termed photodynamic lipid…”
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Protective action of phospholipid hydroperoxide glutathione peroxidase against membrane-damaging lipid peroxidation. In situ reduction of phospholipid and cholesterol hydroperoxides by THOMAS, J. P, MAIORINO, M, URSINI, F, GIROTTI, A. W

“…The general reactivity of membrane lipid hydroperoxides (LOOHs) with the selenoenzyme phospholipid hydroperoxide glutathione peroxidase (PHGPX) has been…”
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Spontaneous Intermembrane Transfer of Various Cholesterol-Derived Hydroperoxide Species:  Kinetic Studies with Model Membranes and Cells by Vila, Andrew, Korytowski, Witold, Girotti, Albert W

“…Whereas spontaneous and protein-mediated transfer/exchange of cholesterol (Ch) between membranes has been widely studied, relatively little is known about the…”
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Lethal damage to endothelial cells by oxidized low density lipoprotein: role of selenoperoxidases in cytoprotection against lipid hydroperoxide- and iron-mediated reactions by Thomas, JP, Geiger, PG, Girotti, AW

“…Oxidized low density lipoprotein (LDLox) is believed to be an important contributor to endothelial cytodamage and atherogenesis. The purpose of this study was…”
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Photosensitized oxidation of membrane lipids: reaction pathways, cytotoxic effects, and cytoprotective mechanisms by Girotti, Albert W.

“…Unsaturated lipids in cell membranes, including phospholipids and cholesterol, are well-known targets of oxidative modification, which can be induced by a…”
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Lipid hydroperoxide generation, turnover, and effector action in biological systems by Girotti, A W

“…Lipid peroxidation is a well known example of oxidative damage in cell membranes, lipoproteins, and other lipid-containing structures. Peroxidative…”
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Photosensitized oxidation of cholesterol in biological systems: reaction pathways, cytotoxic effects and defense mechanisms by Girotti, A W

“…Cholesterol resembles other unsaturated lipids in being susceptible to peroxidative degradation when exposed to a sensitizing agent, exciting light of suitable…”
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Photodynamic Action of Merocyanine 540 on Artificial and Natural Cell Membranes: Involvement of Singlet Molecular Oxygen by Kalyanaraman, B., Feix, J. B., Sieber, F., Thomas, J. P., Girotti, A. W.

“…The photochemistry of merocyanine 540 (MC 540), a sensitizing dye that binds preferentially to leukemia and electrically excitable cells, has been…”
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Reactivity of plasma glutathione peroxidase with hydroperoxide substrates and glutathione by Esworthy, R S, Chu, F F, Geiger, P, Girotti, A W, Doroshow, J H

“…We studied enzyme kinetics parameters of plasma glutathione peroxidase (GSHPx-P) and the major cellular enzyme, GSHPx-1, for the substrates, H2O2, linoleic…”
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Damaging effects of oxygen radicals on resealed erythrocyte ghosts by Girotti, A W, Thomas, J P

“…Resealed ghosts of human erythrocytes are sensitive to oxidative damage induced by xanthine oxidase acting on xanthine in the presence of iron. Damage was…”
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Hyperresistance of leukemia cells to photodynamic inactivation after long-term exposure to hemin by LIN, F, GIROTTI, A. W

“…Merocyanine 540 (MC540)-mediated photodynamic action is a novel approach for purging tumor cells from autologous remission bone marrow explants. The purpose of…”
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Chromatographic separation and electrochemical determination of cholesterol hydroperoxides generated by photodynamic action by Korytowski, W, Bachowski, G J, Girotti, A W

“…Reverse-phase HPLC with electrochemical detection (HPLC-EC) was used to separate and quantitate photochemically generated cholesterol hydroperoxides. The EC…”
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Analysis of cholesterol and phospholipid hydroperoxides by high-performance liquid chromatography with mercury drop electrochemical detection by Korytowski, W, Bachowski, G J, Girotti, A W

“…High-performance liquid chromatography (HPLC) with reductive mode electrochemical detection on a mercury drop has been employed for the separation and…”
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Photodynamic action of merocyanine 540 on leukemia cells: iron-stimulated lipid peroxidation and cell killing by Lin, F, Girotti, A W

“…Merocyanine 540 (MC540) is a lipophilic photosensitizing dye of biomedical interest in connection with its ability to preferentially inactivate leukemia cells…”
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Selenoperoxidase-mediated cytoprotection against the damaging effects of tert-butyl hydroperoxide on leukemia cells by Geiger, P G, Lin, F, Girotti, A W

“…Murine leukemia L1210 cells grown for 5-7 d in the presence of 1% serum without added selenium [Se(-) cells] expressed < 5% of the glutathione peroxidase (GPX)…”
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Cholesterol as a singlet oxygen detector in biological systems by Girotti, A W, Korytowski, W

“…In cells under oxidative attack, membrane Ch, through the formation of its signature hydroperoxide and diol products, can serve as a unique detector in situ,…”
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Selenoperoxidase-mediated cytoprotection against merocyanine 540-sensitized photoperoxidation and photokilling of leukemia cells by FUBAO LIN, GEIGER, P. G, GIROTTI, A. W

“…Photodynamic therapy with the lipophilic sensitizing dye merocyanine 540 (MC540) is a promising new approach for extracorporeal purging of neoplastic cells…”
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Photosensitized lipid peroxidation and enzyme inactivation by membrane-bound merocyanine 540: reaction mechanisms in the absence and presence of ascorbate by Bachowski, G J, Pintar, T J, Girotti, A W

“…The lipophilic photosensitizing dye merocyanine 540 (MC540) is being studied intensively as an antitumor and antiviral agent. Since plasma membranes are…”
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Lethal damage to murine L1210 cells by exogenous lipid hydroperoxides: protective role of glutathione-dependent selenoperoxidases by Geiger, P G, Thomas, J P, Girotti, A W

“…The effect of selenium deprivation on the viability of murine L1210 cells exposed to various exogenous lipid hydroperoxides has been investigated…”
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Role of lipid peroxidation in hematoporphyrin derivative-sensitized photokilling of tumor cells: protective effects of glutathione peroxidase by THOMAS, J. P, GIROTTI, A. W

“…The ability of cells to detoxify lipid hydroperoxides (LOOHs) generated by hematoporphyrin derivative (HPD)-sensitized photooxidation was investigated for the…”
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